| Bellevue Group AG | 887,708 | +887,708 | $36.8M | +$36.8M | — |
| Caligan Partners LP | 550,191 | +550,191 | $22.8M | +$22.8M | — |
| Squadron Capital Management LLC | 490,000 | +490,000 | $20.3M | +$20.3M | — |
| CITADEL ADVISORS LLC | 448,217 | +448,217 | $18.6M | +$18.6M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 324,041 | +324,041 | $13.4M | +$13.4M | — |
| Mass General Brigham, Inc | 239,994 | +239,994 | $9.9M | +$9.9M | — |
| TCG Crossover Management, LLC | 173,816 | +173,816 | $7.2M | +$7.2M | — |
| HighVista Strategies LLC | 170,353 | +170,353 | $7.1M | +$7.1M | — |
| MILLENNIUM MANAGEMENT LLC | 154,470 | +154,470 | $6.4M | +$6.4M | — |
| STEMPOINT CAPITAL LP | 125,877 | +125,877 | $5.2M | +$5.2M | — |
| Freestone Grove Partners LP | 118,876 | +118,876 | $4.9M | +$4.9M | — |
| GOLDMAN SACHS GROUP INC | 114,455 | +114,455 | $4.7M | +$4.7M | — |
| Integral Health Asset Management, LLC | 100,000 | +100,000 | $4.1M | +$4.1M | — |
| AMERIPRISE FINANCIAL INC | 96,688 | +96,688 | $4.0M | +$4.0M | — |
| MPM BIOIMPACT LLC | 81,145 | +81,145 | $3.4M | +$3.4M | — |
| SummitTX Capital, L.P. | 69,560 | +69,560 | $2.9M | +$2.9M | — |
| RAYMOND JAMES FINANCIAL INC | 67,718 | +67,718 | $2.8M | +$2.8M | — |
| WELLINGTON MANAGEMENT GROUP LLP | 61,205 | +61,205 | $2.5M | +$2.5M | — |
| Trexquant Investment LP | 52,459 | +52,459 | $2.2M | +$2.2M | — |
| SEVEN GRAND MANAGERS, LLC | 50,000 | +50,000 | $2.1M | +$2.1M | — |
| D. E. Shaw & Co., Inc. | 33,694 | +33,694 | $1.4M | +$1.4M | — |
| Cinctive Capital Management LP | 29,134 | +29,134 | $1.2M | +$1.2M | — |
| TUDOR INVESTMENT CORP ET AL | 24,059 | +24,059 | $996.8K | +$996.8K | — |
| GILDER GAGNON HOWE & CO LLC | 23,282 | +23,282 | $964.6K | +$964.6K | — |
| Verition Fund Management LLC | 22,512 | +22,512 | $932.7K | +$932.7K | — |
| AMERICAN CENTURY COMPANIES INC | 21,509 | +21,509 | $891.1K | +$891.1K | — |
| ACUTA CAPITAL PARTNERS, LLC | 20,000 | +20,000 | $828.6K | +$828.6K | — |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,100 | +19,100 | $634.5K | +$634.5K | — |
| TWO SIGMA ADVISERS, LP | 14,800 | +14,800 | $613.2K | +$613.2K | — |
| PSP Research LLC | 12,672 | +12,672 | $525.0K | +$525.0K | — |
| Falcon Wealth Planning | 10,030 | +10,030 | $415.5K | +$415.5K | — |
| PEAK6 LLC | 9,200 | +9,200 | $381.2K | +$381.2K | — |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,897 | +6,897 | $285.7K | +$285.7K | — |
| Persistent Asset Partners Ltd | 6,605 | +6,605 | $273.6K | +$273.6K | — |
| INTECH INVESTMENT MANAGEMENT LLC | 6,443 | +6,443 | $266.9K | +$266.9K | — |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 6,050 | +6,050 | $250.7K | +$250.7K | — |
| ProShare Advisors LLC | 6,047 | +6,047 | $250.5K | +$250.5K | — |
| PROFUND ADVISORS LLC | 6,016 | +6,016 | $249.2K | +$249.2K | — |
| SEI INVESTMENTS CO | 5,668 | +5,668 | $234.8K | +$234.8K | — |
| CIBC Private Wealth Group LLC | 5,400 | +5,400 | $223.7K | +$223.7K | — |
| Rafferty Asset Management, LLC | 5,244 | +5,244 | $217.3K | +$217.3K | — |
| Quantbot Technologies LP | 5,221 | +5,221 | $216.3K | +$216.3K | — |
| WestHill Financial Advisors, Inc. | 5,186 | +5,186 | $214.9K | +$214.9K | — |
| Brevan Howard Capital Management LP | 5,042 | +5,042 | $208.9K | +$208.9K | — |
| IFP Advisors, Inc | 3,514 | +3,514 | $145.6K | +$145.6K | — |
| Mirae Asset Global Investments Co., Ltd. | 2,338 | +2,338 | $96.9K | +$96.9K | — |
| Caitong International Asset Management Co., Ltd | 1,032 | +1,032 | $42.8K | +$42.8K | — |
| GF FUND MANAGEMENT CO. LTD. | 944 | +944 | $39.1K | +$39.1K | — |
| Torren Management, LLC | 112 | +112 | $4.6K | +$4.6K | — |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 99 | +99 | $4.1K | +$4.1K | — |
| JONES FINANCIAL COMPANIES LLLP | 90 | +90 | $3.7K | +$3.7K | — |
| SageView Advisory Group, LLC | 54 | +54 | $2.2K | +$2.2K | — |
| US BANCORP \DE\ | 41 | +41 | $1.7K | +$1.7K | — |
| Cornerstone Financial Management LLC | 28 | +28 | $1.2K | +$1.2K | — |
| SIGNATUREFD, LLC | 14 | +14 | $580 | +$580 | — |
| Rachor Investment Advisory Services, LLC | 6 | +6 | $249 | +$249 | — |
| Allworth Financial LP | 5 | +5 | $208 | +$208 | — |
| Daiwa Securities Group Inc. | 160 | +160 | $7 | +$7 | — |