New Positions
58 managers initiated
Top five by reported value
- Bellevue Group AG$36.8M
- Caligan Partners LP$22.8M
- Squadron Capital Management LLC$20.3M
- CITADEL ADVISORS LLC$18.6M
- EVENTIDE ASSET MANAGEMENT, LLC$13.4M
Maze Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:MAZE
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
58 new45 added41 reduced7 exited
Total Institutional Holders
144
as of 2025-12-31
Top Holder
Frazier Life Sciences Management, L.P.
$189.2M
Largest QoQ Increase
JANUS HENDERSON GROUP PLC
+2,390,713 sh
Largest QoQ Decrease
TRV GP IV, LLC
-1,600,000 sh
New Positions(58)
Added To(45)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,142,587 | +2,390,713 | $130.2M | +$110.7M | 318.0% |
| Deep Track Capital, LP | 4,246,440 | +297,530 | $175.9M | +$73.5M | 7.5% |
| BlackRock, Inc. | 2,287,155 | +971,139 | $94.8M | +$60.6M | 73.8% |
| VANGUARD GROUP INC | 1,697,015 | +362,060 | $70.3M | +$35.7M | 27.1% |
| VR Adviser, LLC | 1,548,569 | +317,800 | $64.2M | +$32.2M | 25.8% |
| ArrowMark Colorado Holdings LLC | 767,383 | +222,251 | $31.8M | +$17.7M | 40.8% |
| MARSHALL WACE, LLP | 847,472 | +69,771 | $35.1M | +$14.9M | 9.0% |
| FMR LLC | 728,605 | +72,991 | $30.2M | +$13.2M | 11.1% |
| STATE STREET CORP | 533,005 | +148,303 | $22.1M | +$12.1M | 38.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 527,281 | +53,732 | $21.9M | +$9.6M | 11.3% |
| BOOTHBAY FUND MANAGEMENT, LLC | 409,372 | +57,497 | $17.0M | +$7.8M | 16.3% |
| ADAR1 Capital Management, LLC | 179,532 | +153,487 | $7.4M | +$6.8M | 589.3% |
| WASHINGTON UNIVERSITY | 280,802 | +70,121 | $11.6M | +$6.2M | 33.3% |
| Ensign Peak Advisors, Inc | 185,794 | +115,129 | $7.7M | +$5.9M | 162.9% |
| MORGAN STANLEY | 258,086 | +45,324 | $10.7M | +$5.2M | 21.3% |
| Alyeska Investment Group, L.P. | 196,124 | +71,124 | $8.1M | +$4.9M | 56.9% |
| Parkman Healthcare Partners LLC | 209,266 | +9,266 | $8.7M | +$3.5M | 4.6% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,969 | +8,041 | $7.3M | +$2.9M | 4.8% |
| Invesco Ltd. | 134,033 | +1,971 | $5.6M | +$2.1M | 1.5% |
| FRANKLIN RESOURCES INC | 55,229 | +37,031 | $2.3M | +$1.8M | 203.5% |
| ADVISOR GROUP HOLDINGS, INC. | 59,762 | +29,237 | $2.5M | +$1.7M | 95.8% |
| Nuveen, LLC | 57,258 | +26,954 | $2.4M | +$1.6M | 88.9% |
| Bank of New York Mellon Corp | 60,436 | +15,196 | $2.5M | +$1.3M | 33.6% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,295 | +22,217 | $1.3M | +$1.1M | 244.7% |
| Russell Investments Group, Ltd. | 22,545 | +20,638 | $934.0K | +$884.6K | 1082.2% |
| XTX Topco Ltd | 33,021 | +6,154 | $1.4M | +$671.4K | 22.9% |
| JPMORGAN CHASE & CO | 20,007 | +12,117 | $828.9K | +$624.3K | 153.6% |
| WELLS FARGO & COMPANY/MN | 24,008 | +9,229 | $994.7K | +$611.4K | 62.4% |
| BANK OF AMERICA CORP /DE/ | 18,381 | +8,807 | $761.5K | +$513.3K | 92.0% |
| UBS Group AG | 28,698 | +905 | $1.2M | +$468.3K | 3.3% |
| CITIGROUP INC | 11,252 | +10,983 | $466.2K | +$459.2K | 4082.9% |
| RHUMBLINE ADVISERS | 23,731 | +2,761 | $983.2K | +$439.4K | 13.2% |
| China Universal Asset Management Co., Ltd. | 11,441 | +9,441 | $474.0K | +$422.1K | 472.1% |
| DEUTSCHE BANK AG\ | 15,522 | +6,637 | $643.1K | +$412.7K | 74.7% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,400 | +3,235 | $803.7K | +$384.6K | 20.0% |
| Police & Firemen's Retirement System of New Jersey | 5,961 | +931 | $247.0K | +$116.5K | 18.5% |
| Legal & General Group Plc | 5,379 | +160 | $222.9K | +$87.5K | 3.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,321 | +766 | $54.7K | +$40.3K | 138.0% |
| NISA INVESTMENT ADVISORS, LLC | 204 | +178 | $8.5K | +$7.8K | 684.6% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 115,711 | +105,237 | $4.8K | +$4.5K | 1004.7% |
| GAMMA Investing LLC | 172 | +13 | $7.1K | +$3.0K | 8.2% |
| SBI Securities Co., Ltd. | 67 | +6 | $2.8K | +$1.2K | 9.8% |
| SG Americas Securities, LLC | 8,493 | +3,478 | $352 | +$222 | 69.3% |
| CWM, LLC | 2,229 | +91 | $92 | +$37 | 4.3% |
| AMALGAMATED BANK | 674 | +369 | $28 | +$20 | 121.0% |
Reduced(41)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,567,274 | 0 | $189.2M | +$70.8M | 0.0% |
| ARCH Venture Management, LLC | 4,120,053 | 0 | $170.7M | +$63.9M | 0.0% |
| TRV GP IV, LLC | 4,473,958 | -1,600,000 | $185.4M | +$27.9M | -26.3% |
| AH CAPITAL MANAGEMENT, L.L.C. | 1,702,225 | 0 | $70.5M | +$26.4M | 0.0% |
| Matrix Capital Management Company, LP | 480,000 | -1,173,684 | $19.9M | -$23.0M | -71.0% |
| General Catalyst Group Management, LLC | 1,035,910 | 0 | $42.9M | +$16.1M | 0.0% |
| Woodline Partners LP | 1,035,229 | 0 | $42.9M | +$16.0M | 0.0% |
| TRV GP V, LLC | 950,800 | 0 | $39.4M | +$14.7M | 0.0% |
| Casdin Capital, LLC | 758,857 | 0 | $31.4M | +$11.8M | 0.0% |
| Foresite Capital Management IV, LLC | 522,657 | 0 | $21.7M | +$8.1M | 0.0% |
| Logos Global Management LP | 950,000 | -277,300 | $39.4M | +$7.5M | -22.6% |
| Ikarian Capital, LLC | 644,680 | -96,145 | $26.7M | +$7.5M | -13.0% |
| HHLR ADVISORS, LTD. | 457,535 | 0 | $19.0M | +$7.1M | 0.0% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 378,015 | 0 | $15.7M | +$5.9M | 0.0% |
| Alphabet Inc. | 1,388,583 | -1,023,888 | $57.5M | -$5.0M | -42.4% |
| Balyasny Asset Management LLC | 199,212 | -234,513 | $8.3M | -$3.0M | -54.1% |
| NORTHERN TRUST CORP | 176,259 | -631 | $7.3M | +$2.7M | -0.3% |
| Foresite Capital Management V, LLC | 86,291 | 0 | $3.6M | +$1.3M | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 27,100 | -59,000 | $1.1M | -$1.1M | -68.5% |
| SPHERA FUNDS MANAGEMENT LTD. | 71,843 | -82,500 | $3.0M | -$1.0M | -53.5% |
| Schonfeld Strategic Advisors LLC | 48,200 | -65,849 | $2.0M | -$960.4K | -57.7% |
| BARCLAYS PLC | 14,641 | -12,875 | $179.6K | -$533.8K | -46.8% |
| AQR CAPITAL MANAGEMENT LLC | 27,439 | -176 | $1.1M | +$420.7K | -0.6% |
| MetLife Investment Management, LLC | 11,801 | 0 | $488.9K | +$182.9K | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 33,220 | -26,880 | $1.4M | -$182.1K | -44.7% |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,700 | 0 | $277.6K | +$103.8K | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 5,473 | -6,545 | $226.7K | -$84.9K | -54.5% |
| Virtus Investment Advisers, Inc. | 6,846 | -1,551 | $283.6K | +$65.9K | -18.5% |
| Ameritas Investment Partners, Inc. | 1,632 | 0 | $67.6K | +$25.3K | 0.0% |
| Sterling Capital Management LLC | 1,161 | -99 | $48.1K | +$15.4K | -7.8% |
| Royal Bank of Canada | 646 | -573 | $27.0K | +$13.0K | -47.0% |
| TWO SIGMA INVESTMENTS, LP | 7,245 | -3,905 | $300.2K | +$11.0K | -35.0% |
| BESSEMER GROUP INC | 481,790 | 0 | $20.0K | +$7.5K | 0.0% |
| Farther Finance Advisors, LLC | 359 | -24 | $14.9K | +$4.9K | -6.3% |
| Tower Research Capital LLC (TRC) | 1,349 | -663 | $55.9K | +$3.7K | -33.0% |
| EverSource Wealth Advisors, LLC | 149 | 0 | $6.2K | +$2.3K | 0.0% |
| Sunbelt Securities, Inc. | 12 | 0 | $497 | +$186 | 0.0% |
| ROTHSCHILD INVESTMENT LLC | 10 | 0 | $414 | +$155 | 0.0% |
| STRS OHIO | 11,200 | -6,700 | $464.0K | -$131 | -37.4% |
| True Wealth Design, LLC | 5 | 0 | $208 | +$78 | 0.0% |
| PNC Financial Services Group, Inc. | 58 | -35 | $2.4K | -$8 | -37.6% |
Sold Out(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | -177,667 | $0 | -$4.6M | — |
| Nantahala Capital Management, LLC | 0 | -93,351 | $0 | -$2.4M | — |
| HARVARD MANAGEMENT CO INC | 0 | -92,396 | $0 | -$2.4M | — |
| Caption Management, LLC | 0 | -34,000 | $0 | -$881.6K | — |
| WINTON GROUP Ltd | 0 | -14,487 | $0 | -$375.6K | — |
| ALPS ADVISORS INC | 0 | -13,742 | $0 | -$356.3K | — |
| SRS Capital Advisors, Inc. | 0 | -307 | $0 | -$8.0K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,567,274 | $189.2M | 0 | 0.0% |
| TRV GP IV, LLC | 4,473,958 | $185.4M | -1,600,000 | -26.3% |
| Deep Track Capital, LP | 4,246,440 | $175.9M | +297,530 | 7.5% |
| ARCH Venture Management, LLC | 4,120,053 | $170.7M | 0 | 0.0% |
| JANUS HENDERSON GROUP PLC | 3,142,587 | $130.2M | +2,390,713 | 318.0% |
| BlackRock, Inc. | 2,287,155 | $94.8M | +971,139 | 73.8% |
| AH CAPITAL MANAGEMENT, L.L.C. | 1,702,225 | $70.5M | 0 | 0.0% |
| VANGUARD GROUP INC | 1,697,015 | $70.3M | +362,060 | 27.1% |
| VR Adviser, LLC | 1,548,569 | $64.2M | +317,800 | 25.8% |
| Alphabet Inc. | 1,388,583 | $57.5M | -1,023,888 | -42.4% |
| General Catalyst Group Management, LLC | 1,035,910 | $42.9M | 0 | 0.0% |
| Woodline Partners LP | 1,035,229 | $42.9M | 0 | 0.0% |
| TRV GP V, LLC | 950,800 | $39.4M | 0 | 0.0% |
| Logos Global Management LP | 950,000 | $39.4M | -277,300 | -22.6% |
| Bellevue Group AG | 887,708 | $36.8M | +887,708 | — |
| MARSHALL WACE, LLP | 847,472 | $35.1M | +69,771 | 9.0% |
| ArrowMark Colorado Holdings LLC | 767,383 | $31.8M | +222,251 | 40.8% |
| Casdin Capital, LLC | 758,857 | $31.4M | 0 | 0.0% |
| FMR LLC | 728,605 | $30.2M | +72,991 | 11.1% |
| Ikarian Capital, LLC | 644,680 | $26.7M | -96,145 | -13.0% |
New & Closed Positions this quarter
Closed Positions
7 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for MAZE against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.