Institutional Manager · CIK 0001274403
ARCH Venture Management, LLC
CHICAGO, IL · File #028-19358
Latest AUM
$651.7M
Positions
9
Top-10 Concentration
100.0%
Filings
9
Portfolio Value Over Time
2024-03
2024-06
2024-09
2024-12
2025-03
2025-06
2025-09
2025-12
Biggest QoQ Changes
Ranked by conviction flow (share change × current price) so mark-to-market moves don't dominate. Price effect column shows how much of the $ change was just the stock moving.
| Action | Issuer | Ticker / CUSIP | Δ Shares | Flow ($) | Price Effect |
|---|---|---|---|---|---|
| NEW | 10X GENOMICS INC. | TXG | +737,539 | +$12.0M | $0 |
| EXITED | CERO THERAPEUTICS HOLDINGS INC. | 71902K402 | -22,389 | -$113,960 | $0 |
| REDUCE | BEAM THERAPEUTICS INC. | BEAM | 0 | $0 | +$15.7M |
| REDUCE | ERASCA INC. | ERAS | 0 | $0 | +$17.0M |
| REDUCE | GOSSAMER BIO INC. | GOSS | 0 | $0 | +$3.8M |
| REDUCE | LYELL IMMUNOPHARMA INC. | LYEL | 0 | $0 | +$40.1M |
| REDUCE | MAZE THERAPEUTICS INC. | MAZE | 0 | $0 | +$63.9M |
| REDUCE | Q32 BIO INC. | QTTB | 0 | $0 | +$429,446 |
| REDUCE | RAPPORT THERAPEUTICS INC. | RAPP | 0 | $0 | +$2.4M |
| REDUCE | VIR BIOTECHNOLOGY INC. | VIR | 0 | $0 | +$4.1M |
Sector Allocation
Filing History
- 13F HOLDINGS REPORTQ/E Dec 20259 pos · $651.7M
- 13F HOLDINGS REPORTQ/E Sep 20259 pos · $492.4M
- 13F HOLDINGS REPORTQ/E Jun 202511 pos · $299.1M
- 13F HOLDINGS REPORTQ/E Mar 20259 pos · $206.2M
- 13F HOLDINGS REPORTQ/E Dec 20249 pos · $230.2M
- 13F HOLDINGS REPORTQ/E Sep 20249 pos · $260.6M
- 13F HOLDINGS REPORTQ/E Jun 20249 pos · $266.0M
- 13F HOLDINGS REPORTQ/E Mar 20248 pos · $80.3M
- 13F HOLDINGS REPORTQ/E Dec 20237 pos · $154.0M
Top 9 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | MAZE THERAPEUTICS INC. | MAZE | 4,120,053 | $170.7M | 26.19% |
| 2 | BEAM THERAPEUTICS INC. | BEAM | 4,540,132 | $125.9M | 19.31% |
| 3 | RAPPORT THERAPEUTICS INC. | RAPP | 3,728,738 | $113.1M | 17.36% |
| 4 | LYELL IMMUNOPHARMA INC. | LYEL | 2,759,072 | $84.9M | 13.03% |
| 5 | VIR BIOTECHNOLOGY INC. | VIR | 12,916,663 | $77.9M | 11.95% |
| 6 | ERASCA INC. | ERAS | 11,055,554 | $41.1M | 6.31% |
| 7 | GOSSAMER BIO INC. | GOSS | 8,055,916 | $25.0M | 3.83% |
| 8 | 10X GENOMICS INC. | TXG | 737,539 | $12.0M | 1.85% |
| 9 | Q32 BIO INC. | QTTB | 320,482 | $1.1M | 0.16% |