Institutional Manager · CIK 0001496201
SPHERA FUNDS MANAGEMENT LTD.
TEL AVIV, L3 · File #028-15863
Latest AUM
$517.3M
Positions
100
Top-10 Concentration
38.1%
Filings
12
Sector Allocation
Filing History
View all filings →- 13F HOLDINGS REPORTQ/E Dec 2025100 pos · $517.3M
- 13F HOLDINGS REPORTQ/E Sep 2025115 pos · $474.1M
- 13F HOLDINGS REPORTQ/E Jun 2025111 pos · $426.1M
- 13F HOLDINGS REPORTQ/E Mar 2025116 pos · $434.3M
- 13F HOLDINGS REPORTQ/E Dec 2024108 pos · $553.1M
- 13F HOLDINGS REPORTQ/E Sep 2024116 pos · $628.4M
- 13F HOLDINGS REPORTQ/E Jun 2024119 pos · $733.2M
- 13F HOLDINGS REPORTQ/E Mar 2024105 pos · $711.7M
- 13F HOLDINGS REPORTQ/E Dec 202383 pos · $549.0M
- 13F HOLDINGS REPORTQ/E Sep 202388 pos · $640.4M
- 13F HOLDINGS REPORTQ/E Jun 202381 pos · $598.4M
- 13F HOLDINGS REPORTQ/E Mar 202364 pos · $465.9M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 998,525 | $31.2M | 7.45% |
| 2 | BIOGEN INC | BIIB | 94,738 | $16.7M | 3.98% |
| 3 | MINERALYS THERAPEUTICS INC | MLYS | 449,003 | $16.3M | 3.89% |
| 4 | SYNDAX PHARMACEUTICALS INC | SNDX | 762,563 | $16.0M | 3.83% |
| 5 | NOVA LTD | NVMI | 47,846 | $15.7M | 3.76% |
| 6 | TOWER SEMICONDUCTOR LTD | TSEM | 122,513 | $14.4M | 3.44% |
| 7 | COGENT BIOSCIENCES INC | COGT | 378,500 | $13.4M | 3.21% |
| 8 | ASTRAZENECA PLC | AZN | 135,060 | $12.4M | 2.97% |
| 9 | PRAXIS PRECISION MEDICINES I | PRAX | 40,000 | $11.8M | 2.82% |
| 10 | SANOFI SA | SNYNF | 239,515 | $11.6M | 2.77% |
| 11 | ELI LILLY & CO | LLY | 9,040 | $9.7M | 2.32% |
| 12 | AMICUS THERAPEUTICS INC | FOLD | 658,377 | $9.4M | 2.24% |
| 13 | IMMATICS N.V | IMTX | 861,105 | $9.0M | 2.16% |
| 14 | BIOMARIN PHARMACEUTICAL INC | BMRN | 147,000 | $8.7M | 2.09% |
| 15 | SPDR SERIES TRUST | 78464A870 | 70,000 | $8.5M | 2.04% |
| 16 | BRIDGEBIO PHARMA INC | BBIO | 107,746 | $8.2M | 1.97% |
| 17 | ORIC PHARMACEUTICALS INC | ORIC | 1,004,378 | $8.2M | 1.96% |
| 18 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 350,000 | $8.1M | 1.92% |
| 19 | DYNE THERAPEUTICS INC | DYN | 392,894 | $7.7M | 1.84% |
| 20 | TREVI THERAPEUTICS INC | TRVI | 598,534 | $7.5M | 1.79% |