Institutional Manager · CIK 0001990717
TRV GP V, LLC
Boston, MA · File #028-25079
Latest AUM
$429.2M
Positions
3
Top-10 Concentration
100.0%
Filings
5
Portfolio Value Over Time
2024-12
2025-03
2025-06
2025-09
2025-12
Biggest QoQ Changes
Ranked by conviction flow (share change × current price) so mark-to-market moves don't dominate. Price effect column shows how much of the $ change was just the stock moving.
| Action | Issuer | Ticker / CUSIP | Δ Shares | Flow ($) | Price Effect |
|---|---|---|---|---|---|
| REDUCE | RAPPORT THERAPEUTICS, INC. | RAPP | 0 | $0 | +$4.6M |
| REDUCE | SEPTERNA, INC. | SEPN | 0 | $0 | +$56.4M |
| REDUCE | MAZE THERAPEUTICS, INC. | MAZE | 0 | $0 | +$14.7M |
Sector Allocation
Filing History
- 13F HOLDINGS REPORTQ/E Dec 20253 pos · $429.2M
- 13F HOLDINGS REPORTQ/E Sep 20253 pos · $353.5M
- 13F HOLDINGS REPORTQ/E Jun 20254 pos · $165.7M
- 13F HOLDINGS REPORTQ/E Mar 20254 pos · $125.1M
- 13F HOLDINGS REPORTQ/E Dec 20243 pos · $294.0M
Top 3 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | RAPPORT THERAPEUTICS, INC. | RAPP | 7,135,233 | $216.5M | 50.44% |
| 2 | SEPTERNA, INC. | SEPN | 6,215,591 | $173.3M | 40.38% |
| 3 | MAZE THERAPEUTICS, INC. | MAZE | 950,800 | $39.4M | 9.18% |