Institutional Manager · CIK 0001335325
HighVista Strategies LLC
BOSTON, MA · File #028-14212
Latest AUM
$388.3M
Positions
145
Top-10 Concentration
39.0%
Filings
9
Portfolio Value Over Time
2024-03
2024-06
2024-09
2024-12
2025-03
2025-06
2025-09
2025-12
Biggest QoQ Changes
Ranked by conviction flow (share change × current price) so mark-to-market moves don't dominate. Price effect column shows how much of the $ change was just the stock moving.
| Action | Issuer | Ticker / CUSIP | Δ Shares | Flow ($) | Price Effect |
|---|---|---|---|---|---|
| REDUCE | PRAXIS PRECISION MEDICINES I | PRAX | -69,161 | -$20.4M | +$23.0M |
| REDUCE | ABIVAX SA | AAVXF | -112,283 | -$15.1M | +$9.2M |
| EXITED | MERUS N V | N5749R100 | -133,321 | -$12.6M | $0 |
| REDUCE | CIDARA THERAPEUTICS INC | 171757206 | -47,976 | -$10.6M | +$8.9M |
| REDUCE | SANDISK CORP | SNDK | -43,073 | -$10.2M | +$5.9M |
| REDUCE | INVESCO DB COMMDY INDX TRCK | IVZ | -378,898 | -$8.5M | -$244,143 |
| NEW | TERNS PHARMACEUTICALS INC | TERN | +175,462 | +$7.1M | $0 |
| NEW | MAZE THERAPEUTICS INC | MAZE | +170,353 | +$7.1M | $0 |
| ADD | SOLENO THERAPEUTICS INC | SLNO | +116,369 | +$5.4M | -$398,310 |
| EXITED | AKERO THERAPEUTICS INC | 00973Y108 | -110,079 | -$5.2M | $0 |
Sector Allocation
Filing History
- 13F HOLDINGS REPORTQ/E Dec 2025145 pos · $388.3M
- 13F HOLDINGS REPORTQ/E Sep 2025148 pos · $408.0M
- 13F HOLDINGS REPORTQ/E Jun 2025146 pos · $272.1M
- 13F HOLDINGS REPORTQ/E Mar 2025148 pos · $259.5M
- 13F HOLDINGS REPORTQ/E Dec 2024137 pos · $268.8M
- 13F HOLDINGS REPORTQ/E Sep 2024142 pos · $290.0M
- 13F HOLDINGS REPORTQ/E Jun 2024138 pos · $273.8M
- 13F HOLDINGS REPORTQ/E Mar 2024131 pos · $280.4M
- 13F HOLDINGS REPORTQ/E Dec 2023132 pos · $216.1M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | INVESCO DB COMMDY INDX TRCK | IVZ | 1,057,238 | $23.6M | 8.44% |
| 2 | STRUCTURE THERAPEUTICS INC | GPCR | 193,001 | $13.4M | 4.79% |
| 3 | COGENT BIOSCIENCES INC | COGT | 336,667 | $12.0M | 4.27% |
| 4 | VIRIDIAN THERAPEUTICS INC | VRDN | 372,472 | $11.6M | 4.14% |
| 5 | ABIVAX SA | AAVXF | 72,185 | $9.7M | 3.47% |
| 6 | REVOLUTION MEDICINES INC | RVMDW | 120,240 | $9.6M | 3.42% |
| 7 | PRAXIS PRECISION MEDICINES I | PRAX | 25,841 | $7.6M | 2.72% |
| 8 | NUVALENT INC | NUVL | 73,287 | $7.4M | 2.63% |
| 9 | CYTOKINETICS INC | CYTK | 114,564 | $7.3M | 2.60% |
| 10 | TERNS PHARMACEUTICALS INC | TERN | 175,462 | $7.1M | 2.53% |
| 11 | MAZE THERAPEUTICS INC | MAZE | 170,353 | $7.1M | 2.52% |
| 12 | INSMED INC | INSM | 39,400 | $6.9M | 2.45% |
| 13 | APOGEE THERAPEUTICS INC | APGE | 89,229 | $6.7M | 2.40% |
| 14 | PROTAGONIST THERAPEUTICS INC | PTGX | 73,545 | $6.4M | 2.29% |
| 15 | SOLENO THERAPEUTICS INC | SLNO | 135,069 | $6.3M | 2.23% |
| 16 | SPYRE THERAPEUTICS INC | SYRE | 188,206 | $6.2M | 2.20% |
| 17 | BRIDGEBIO PHARMA INC | BBIO | 80,205 | $6.1M | 2.19% |
| 18 | OLEMA PHARMACEUTICALS INC | OLMA | 241,489 | $6.0M | 2.15% |
| 19 | IMMUNOVANT INC | IMVT | 221,883 | $5.6M | 2.01% |
| 20 | LIQUIDIA CORPORATION | LQDA | 156,003 | $5.4M | 1.92% |