Institutional Manager · CIK 0001839948
TCG Crossover Management, LLC
PALO ALTO, CA · File #028-22283
Latest AUM
$3.02B
Positions
43
Top-10 Concentration
64.3%
Filings
9
Portfolio Value Over Time
2024-03
2024-06
2024-09
2024-12
2025-03
2025-06
2025-09
2025-12
Biggest QoQ Changes
Ranked by conviction flow (share change × current price) so mark-to-market moves don't dominate. Price effect column shows how much of the $ change was just the stock moving.
| Action | Issuer | Ticker / CUSIP | Δ Shares | Flow ($) | Price Effect |
|---|---|---|---|---|---|
| NEW | MONTE ROSA THERAPEUTICS INC | GLUE | +4,622,151 | +$72.5M | $0 |
| EXITED | TOURMALINE BIO INC | 89157D105 | -1,311,783 | -$62.7M | $0 |
| NEW | BIOHAVEN LTD | BHVN | +4,631,317 | +$52.3M | $0 |
| NEW | IMMUNOVANT INC | IMVT | +1,660,933 | +$42.2M | $0 |
| ADD | TANGO THERAPEUTICS INC | TNGX | +4,225,898 | +$37.4M | +$3.9M |
| REDUCE | UPSTREAM BIO INC | UPB | -1,373,217 | -$37.3M | +$17.7M |
| ADD | ADC THERAPEUTICS SA | ADCT | +10,000,000 | +$35.3M | -$653,382 |
| REDUCE | COGENT BIOSCIENCES INC | COGT | -930,000 | -$33.0M | +$143.8M |
| ADD | RAPT THERAPEUTICS INC | 75382E208 | +946,133 | +$32.0M | +$13.2M |
| EXITED | DISC MEDICINE INC | 254604101 | -465,257 | -$30.7M | $0 |
Sector Allocation
Filing History
- 13F HOLDINGS REPORTQ/E Dec 202543 pos · $3.02B
- 13F HOLDINGS REPORTQ/E Sep 202540 pos · $2.03B
- 13F HOLDINGS REPORTQ/E Jun 202538 pos · $875.5M
- 13F HOLDINGS REPORTQ/E Mar 202538 pos · $733.1M
- 13F HOLDINGS REPORTQ/E Dec 202438 pos · $1.02B
- 13F HOLDINGS REPORTQ/E Sep 202436 pos · $1.18B
- 13F HOLDINGS REPORTQ/E Jun 202432 pos · $959.5M
- 13F HOLDINGS REPORTQ/E Mar 202433 pos · $1.26B
- 13F HOLDINGS REPORTQ/E Dec 202326 pos · $679.1M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | ABIVAX SA AMERICAN DEPOSITARY SHARES | AAVXF | 7,111,596 | $959.0M | 31.74% |
| 2 | COGENT BIOSCIENCES INC | COGT | 5,868,162 | $208.4M | 6.90% |
| 3 | CG ONCOLOGY INC | CGON | 3,670,206 | $152.4M | 5.04% |
| 4 | TANGO THERAPEUTICS INC | TNGX | 12,762,094 | $113.1M | 3.74% |
| 5 | CENTESSA PHARMACEUTICALS PLC | CNTA | 4,286,480 | $107.2M | 3.55% |
| 6 | DYNE THERAPEUTICS INC | DYN | 4,615,144 | $90.3M | 2.99% |
| 7 | RAPT THERAPEUTICS INC | 75382E208 | 2,582,408 | $87.5M | 2.89% |
| 8 | TYRA BIOSCIENCES INC | TYRA | 2,898,103 | $76.2M | 2.52% |
| 9 | AMYLYX PHARMACEUTICALS INC | AMLX | 6,243,812 | $75.4M | 2.50% |
| 10 | SAVARA INC | SVRA | 12,362,205 | $74.5M | 2.47% |
| 11 | MONTE ROSA THERAPEUTICS INC | GLUE | 4,622,151 | $72.5M | 2.40% |
| 12 | OCULAR THERAPEUTIX INC | OCUL | 5,740,231 | $69.7M | 2.31% |
| 13 | DIANTHUS THERAPEUTICS INC | DNTH | 1,676,624 | $69.1M | 2.29% |
| 14 | EYEPOINT PHARMACEUTICALS INC | EYPT | 3,572,335 | $65.3M | 2.16% |
| 15 | STRUCTURE THERAPEUTICS INC | GPCR | 920,857 | $64.0M | 2.12% |
| 16 | SPYRE THERAPEUTICS INC | SYRE | 1,900,582 | $62.3M | 2.06% |
| 17 | FULCRUM THERAPEUTICS INC | FULC | 5,250,000 | $59.4M | 1.97% |
| 18 | LIQUIDIA TECHNOLOGIES INC | LQDA | 1,710,084 | $59.0M | 1.95% |
| 19 | BIOHAVEN LTD | BHVN | 4,631,317 | $52.3M | 1.73% |
| 20 | IMMUNOVANT INC | IMVT | 1,660,933 | $42.2M | 1.40% |