New Positions
61 managers initiated
Top five by reported value
Nuvalent, Inc NASDAQ NMS - GLOBAL MARKET:NUVL
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
61 new103 added75 reduced19 exited
Total Institutional Holders
238
as of 2025-12-31
Top Holder
DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)
$1.74B
Largest QoQ Increase
Bellevue Group AG
+1,037,468 sh
Largest QoQ Decrease
Vestal Point Capital, LP
-1,054,000 sh
New Positions(61)
Added To(103)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FMR LLC | 10,852,884 | +839,647 | $1.09B | +$225.7M | 8.4% |
| BlackRock, Inc. | 4,805,261 | +719,466 | $483.4M | +$130.0M | 17.6% |
| VANGUARD GROUP INC | 5,244,271 | +639,264 | $527.5M | +$129.3M | 13.9% |
| RA CAPITAL MANAGEMENT, L.P. | 1,880,057 | +633,601 | $189.1M | +$81.3M | 50.8% |
| JPMORGAN CHASE & CO | 2,205,251 | +531,242 | $221.8M | +$77.1M | 31.7% |
| ALLIANCEBERNSTEIN L.P. | 785,445 | +735,477 | $79.0M | +$74.7M | 1471.9% |
| Polar Capital Holdings Plc | 1,536,859 | +514,634 | $154.6M | +$66.2M | 50.3% |
| STATE STREET CORP | 1,864,675 | +289,928 | $187.6M | +$51.4M | 18.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,823 | +160,958 | $247.6M | +$48.7M | 7.0% |
| Invesco Ltd. | 439,300 | +405,543 | $44.2M | +$41.3M | 1201.3% |
| PERCEPTIVE ADVISORS LLC | 1,665,105 | +102,769 | $167.5M | +$32.4M | 6.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,238,234 | +144,241 | $124.6M | +$30.0M | 13.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 483,504 | +266,948 | $48.6M | +$29.9M | 123.3% |
| NORGES BANK | 574,242 | +299,598 | $57.8M | +$29.7M | 109.1% |
| FRANKLIN RESOURCES INC | 411,354 | +251,220 | $41.4M | +$27.5M | 156.9% |
| UBS Group AG | 399,053 | +185,932 | $40.1M | +$21.7M | 87.2% |
| GOLDMAN SACHS GROUP INC | 594,459 | +150,023 | $59.8M | +$21.4M | 33.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 643,000 | +68,500 | $64.7M | +$15.0M | 11.9% |
| CITADEL ADVISORS LLC | 212,156 | +120,930 | $21.3M | +$13.5M | 132.6% |
| Rhenman & Partners Asset Management AB | 163,350 | +110,850 | $16.4M | +$11.9M | 211.1% |
| AMERIPRISE FINANCIAL INC | 564,298 | +37,248 | $56.8M | +$11.2M | 7.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 453,311 | +48,758 | $45.6M | +$10.6M | 12.1% |
| abrdn plc | 165,177 | +88,489 | $16.6M | +$10.0M | 115.4% |
| NORTHERN TRUST CORP | 410,450 | +28,954 | $41.3M | +$8.3M | 7.6% |
| Candriam S.C.A. | 358,013 | +28,292 | $36.0M | +$7.5M | 8.6% |
| UBS ASSET MANAGEMENT AMERICAS INC | 124,555 | +59,138 | $12.5M | +$6.9M | 90.4% |
| Verition Fund Management LLC | 72,015 | +66,313 | $7.2M | +$6.8M | 1163.0% |
| AMERICAN CENTURY COMPANIES INC | 374,232 | +11,301 | $37.6M | +$6.3M | 3.1% |
| TD Asset Management Inc | 153,360 | +43,776 | $15.4M | +$5.9M | 39.9% |
| Voya Investment Management LLC | 172,527 | +37,785 | $17.4M | +$5.7M | 28.0% |
| BNP PARIBAS ARBITRAGE, SNC | 174,066 | +36,121 | $17.5M | +$5.6M | 26.2% |
| Squarepoint Ops LLC | 61,746 | +54,321 | $6.2M | +$5.6M | 731.6% |
| Nicholas Investment Partners, LP | 160,483 | +36,305 | $16.1M | +$5.4M | 29.2% |
| BANK OF AMERICA CORP /DE/ | 180,369 | +19,183 | $18.1M | +$4.2M | 11.9% |
| RAYMOND JAMES FINANCIAL INC | 151,969 | +20,941 | $15.3M | +$3.9M | 16.0% |
| Bank of New York Mellon Corp | 161,599 | +16,195 | $16.3M | +$3.7M | 11.1% |
| WELLS FARGO & COMPANY/MN | 62,155 | +31,283 | $6.3M | +$3.6M | 101.3% |
| Nuveen, LLC | 107,620 | +15,987 | $10.8M | +$2.9M | 17.4% |
| Jump Financial, LLC | 27,955 | +24,439 | $2.8M | +$2.5M | 695.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,275 | +13,813 | $7.9M | +$2.3M | 21.4% |
| Connor, Clark & Lunn Investment Management Ltd. | 42,360 | +18,573 | $4.3M | +$2.2M | 78.1% |
| DEUTSCHE BANK AG\ | 83,039 | +11,339 | $8.4M | +$2.2M | 15.8% |
| COMERICA BANK | 20,224 | +20,144 | $2.0M | +$2.0M | 25180.0% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 46,690 | +13,606 | $4.7M | +$1.8M | 41.1% |
| SEI INVESTMENTS CO | 23,160 | +17,192 | $2.3M | +$1.8M | 288.1% |
| FRED ALGER MANAGEMENT, LLC | 92,021 | +3,518 | $9.3M | +$1.6M | 4.0% |
| Swiss National Bank | 78,900 | +1,700 | $7.9M | +$1.3M | 2.2% |
| Legato Capital Management LLC | 21,732 | +9,081 | $2.2M | +$1.1M | 71.8% |
| Creative Planning | 29,940 | +7,420 | $3.0M | +$1.1M | 32.9% |
| NEOS Investment Management LLC | 37,003 | +3,996 | $3.7M | +$867.7K | 12.1% |
| PROFUND ADVISORS LLC | 17,536 | +6,849 | $1.8M | +$839.7K | 64.1% |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,460 | +4,398 | $3.3M | +$838.3K | 15.7% |
| TEMA ETFS LLC | 36,458 | +3,451 | $3.7M | +$812.9K | 10.4% |
| MetLife Investment Management, LLC | 27,631 | +2,544 | $2.8M | +$609.9K | 10.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,547 | +1,580 | $3.3M | +$599.3K | 5.1% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,284 | +398 | $3.9M | +$574.6K | 1.1% |
| CITIGROUP INC | 35,831 | +671 | $3.6M | +$563.6K | 1.9% |
| BARCLAYS PLC | 160,406 | +24,926 | $12.2M | +$522.7K | 18.4% |
| Walleye Capital LLC | 7,956 | +4,530 | $800.3K | +$504.0K | 132.2% |
| STRS OHIO | 11,700 | +3,600 | $1.2M | +$476.4K | 44.4% |
| INTECH INVESTMENT MANAGEMENT LLC | 17,184 | +2,231 | $1.7M | +$435.4K | 14.9% |
| ProShare Advisors LLC | 12,318 | +2,595 | $1.2M | +$398.2K | 26.7% |
| JANE STREET GROUP, LLC | 16,700 | +1,700 | $1.7M | +$382.7K | 11.3% |
| Police & Firemen's Retirement System of New Jersey | 13,542 | +1,648 | $1.4M | +$333.6K | 13.8% |
| FARALLON CAPITAL MANAGEMENT LLC | 6,000 | +3,000 | $561.2K | +$301.8K | 100.0% |
| VICTORY CAPITAL MANAGEMENT INC | 10,101 | +366 | $1.0M | +$174.2K | 3.8% |
| China Universal Asset Management Co., Ltd. | 11,769 | +83 | $1.2M | +$173.2K | 0.7% |
| KENNEDY CAPITAL MANAGEMENT LLC | 10,932 | +163 | $1.1M | +$168.3K | 1.5% |
| Farther Finance Advisors, LLC | 2,506 | +1,289 | $252.1K | +$146.8K | 105.9% |
| Mirae Asset Global Investments Co., Ltd. | 3,510 | +933 | $353.1K | +$130.2K | 36.2% |
| Virtus Investment Advisers, Inc. | 2,538 | +1,077 | $255.3K | +$128.9K | 73.7% |
| KLP KAPITALFORVALTNING AS | 8,500 | +100 | $855.0K | +$128.6K | 1.2% |
| Vanguard Personalized Indexing Management, LLC | 4,771 | +518 | $479.9K | +$112.0K | 12.2% |
| XPONANCE, INC. | 3,965 | +585 | $398.8K | +$106.5K | 17.3% |
| Ameritas Investment Partners, Inc. | 4,064 | +474 | $408.8K | +$98.3K | 13.2% |
| US BANCORP \DE\ | 2,614 | +544 | $262.9K | +$83.9K | 26.3% |
| ENVESTNET ASSET MANAGEMENT INC | 5,226 | +2 | $525.7K | +$73.9K | 0.0% |
| MARTINGALE ASSET MANAGEMENT L P | 4,209 | +3 | $423.4K | +$59.6K | 0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,146,938 | +336,518 | $216.0K | +$59.4K | 18.6% |
| T. Rowe Price Investment Management, Inc. | 1,319,963 | +298,727 | $132.8K | +$44.5K | 29.3% |
| AlphaQuest LLC | 1,011 | +300 | $101.7K | +$40.2K | 42.2% |
| Sterling Capital Management LLC | 327 | +223 | $32.9K | +$23.9K | 214.4% |
| GAMMA Investing LLC | 335 | +108 | $33.7K | +$14.1K | 47.6% |
| Larson Financial Group LLC | 176 | +121 | $17.7K | +$12.9K | 220.0% |
| ADVISOR GROUP HOLDINGS, INC. | 368 | +67 | $37.0K | +$11.0K | 22.3% |
| Global Retirement Partners, LLC | 88 | +83 | $8.9K | +$8.4K | 1660.0% |
| Smartleaf Asset Management LLC | 88 | +69 | $8.8K | +$7.2K | 363.1% |
| NISA INVESTMENT ADVISORS, LLC | 499 | +1 | $50.2K | +$7.1K | 0.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 61,130 | +60,819 | $6.1K | +$6.1K | 19555.9% |
| Bare Financial Services, Inc | 52 | +36 | $5.2K | +$3.8K | 225.0% |
| SIGNATUREFD, LLC | 188 | +13 | $18.9K | +$3.8K | 7.4% |
| J.Safra Asset Management Corp | 55 | +30 | $5.5K | +$3.6K | 120.0% |
| ASSETMARK, INC | 35 | +8 | $3.5K | +$1.2K | 29.6% |
| ROTHSCHILD INVESTMENT LLC | 53 | +3 | $5.3K | +$1.0K | 6.0% |
| Parallel Advisors, LLC | 48 | +1 | $4.8K | +$763 | 2.1% |
| Parkside Financial Bank & Trust | 22 | +5 | $2.2K | +$742 | 29.4% |
| SouthState Corp | 12 | +5 | $1.2K | +$602 | 71.4% |
| MASSMUTUAL TRUST CO FSB/ADV | 8 | +4 | $805 | +$459 | 100.0% |
| SG Americas Securities, LLC | 20,326 | +1,490 | $2.0K | +$416 | 7.9% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 11,761 | +915 | $1.2K | +$245 | 8.4% |
| SBI Securities Co., Ltd. | 3 | +1 | $302 | +$129 | 50.0% |
| AMALGAMATED BANK | 1,573 | +356 | $158 | +$53 | 29.3% |
| CWM, LLC | 1,317 | +16 | $132 | +$19 | 1.2% |
Reduced(75)
Sold Out(19)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | -88,000 | $0 | -$7.6M | — |
| ALPS ADVISORS INC | 0 | -30,886 | $0 | -$2.7M | — |
| D. E. Shaw & Co., Inc. | 0 | -27,311 | $0 | -$2.4M | — |
| Jefferies Financial Group Inc. | 0 | -25,160 | $0 | -$2.2M | — |
| ExodusPoint Capital Management, LP | 0 | -7,289 | $0 | -$630.4K | — |
| Sandia Investment Management LP | 0 | -5,500 | $0 | -$475.6K | — |
| Empire Financial Management Company, LLC | 0 | -5,000 | $0 | -$432.4K | — |
| CIBC Bancorp USA Inc. | 0 | -4,581 | $0 | -$396.2K | — |
| Schonfeld Strategic Advisors LLC | 0 | -4,026 | $0 | -$348.2K | — |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | -4,532 | $0 | -$345.8K | — |
| Freestone Grove Partners LP | 0 | -3,960 | $0 | -$342.5K | — |
| Compass Wealth Management LLC | 0 | -1,984 | $0 | -$294.8K | — |
| J. Goldman & Co LP | 0 | -2,936 | $0 | -$253.9K | — |
| SRS Capital Advisors, Inc. | 0 | -1,076 | $0 | -$93.1K | — |
| CROWLEY WEALTH MANAGEMENT, INC. | 0 | -350 | $0 | -$30.3K | — |
| Spire Wealth Management | 0 | -140 | $0 | -$12.1K | — |
| Rise Advisors, LLC | 0 | -124 | $0 | -$10.7K | — |
| SIMPLEX TRADING, LLC | 0 | -1,709 | $0 | -$147 | — |
| CI INVESTMENTS INC. | 0 | -69 | $0 | -$6 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 17,248,450 | $1.74B | -742,574 | -4.1% |
| FMR LLC | 10,852,884 | $1.09B | +839,647 | 8.4% |
| Paradigm Biocapital Advisors LP | 5,269,433 | $530.1M | 0 | 0.0% |
| VANGUARD GROUP INC | 5,244,271 | $527.5M | +639,264 | 13.9% |
| BlackRock, Inc. | 4,805,261 | $483.4M | +719,466 | 17.6% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,823 | $247.6M | +160,958 | 7.0% |
| JPMORGAN CHASE & CO | 2,205,251 | $221.8M | +531,242 | 31.7% |
| RA CAPITAL MANAGEMENT, L.P. | 1,880,057 | $189.1M | +633,601 | 50.8% |
| STATE STREET CORP | 1,864,675 | $187.6M | +289,928 | 18.4% |
| PERCEPTIVE ADVISORS LLC | 1,665,105 | $167.5M | +102,769 | 6.6% |
| Polar Capital Holdings Plc | 1,536,859 | $154.6M | +514,634 | 50.3% |
| JANUS HENDERSON GROUP PLC | 1,499,574 | $150.8M | -689,100 | -31.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,238,234 | $124.6M | +144,241 | 13.2% |
| Bellevue Group AG | 1,037,468 | $104.4M | +1,037,468 | — |
| BRAIDWELL LP | 821,406 | $82.6M | -191,576 | -18.9% |
| ALLIANCEBERNSTEIN L.P. | 785,445 | $79.0M | +735,477 | 1471.9% |
| Fairmount Funds Management LLC | 727,563 | $73.2M | 0 | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 643,000 | $64.7M | +68,500 | 11.9% |
| Woodline Partners LP | 610,459 | $61.4M | -459,061 | -42.9% |
| GOLDMAN SACHS GROUP INC | 594,459 | $59.8M | +150,023 | 33.8% |
New & Closed Positions this quarter
Closed Positions
19 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for NUVL against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.