Institutional Manager · CIK 0001855655
Paradigm Biocapital Advisors LP
NEW YORK, NY · File #028-21950
Latest AUM
$3.92B
Positions
30
Top-10 Concentration
70.9%
Filings
12
Sector Allocation
Filing History
View all filings →- 13F HOLDINGS REPORTQ/E Dec 202530 pos · $3.92B
- 13F HOLDINGS REPORTQ/E Sep 202536 pos · $3.52B
- 13F HOLDINGS REPORTQ/E Jun 202528 pos · $2.34B
- 13F HOLDINGS REPORTQ/E Mar 202528 pos · $2.18B
- 13F HOLDINGS REPORTQ/E Dec 202428 pos · $2.87B
- 13F HOLDINGS REPORTQ/E Sep 202433 pos · $2.96B
- 13F HOLDINGS REPORTQ/E Jun 202435 pos · $2.61B
- 13F HOLDINGS REPORTQ/E Mar 202434 pos · $2.84B
- 13F HOLDINGS REPORTQ/E Dec 202331 pos · $1.47B
- 13F HOLDINGS REPORTQ/E Sep 202330 pos · $1.29B
- 13F HOLDINGS REPORTQ/E Jun 202325 pos · $1.06B
- 13F HOLDINGS REPORTQ/E Mar 202323 pos · $851.9M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | NUVALENT INC | NUVL | 5,269,433 | $530.1M | 13.53% |
| 2 | REVOLUTION MEDICINES INC | RVMDW | 6,644,403 | $529.2M | 13.51% |
| 3 | ARCELLX INC | ACLX | 5,724,016 | $373.2M | 9.53% |
| 4 | GENMAB A/S | GNMSF | 7,039,834 | $216.8M | 5.53% |
| 5 | TARSUS PHARMACEUTICALS INC | TARS | 2,562,154 | $209.8M | 5.35% |
| 6 | ABIVAX SA | AAVXF | 1,417,473 | $191.2M | 4.88% |
| 7 | OLEMA PHARMACEUTICALS INC | OLMA | 7,544,172 | $188.6M | 4.81% |
| 8 | VAXCYTE INC | PCVX | 4,068,020 | $187.7M | 4.79% |
| 9 | SPDR SERIES TRUST | 78464A870 | 1,500,000 | $182.9M | 4.67% |
| 10 | CIDARA THERAPEUTICS INC | 171757206 | 759,565 | $167.8M | 4.28% |
| 11 | EDGEWISE THERAPEUTICS INC | EWTX | 6,541,210 | $162.3M | 4.14% |
| 12 | SCHOLAR ROCK HLDG CORP | SRRK | 3,062,157 | $134.9M | 3.44% |
| 13 | UROGEN PHARMA LTD | URGN | 4,473,648 | $104.8M | 2.67% |
| 14 | CRINETICS PHARMACEUTICALS IN | CRNX | 2,210,774 | $102.9M | 2.63% |
| 15 | APOGEE THERAPEUTICS INC | APGE | 1,123,243 | $84.8M | 2.16% |
| 16 | EYEPOINT INC | EYPT | 3,691,475 | $67.4M | 1.72% |
| 17 | ERASCA INC | ERAS | 14,159,095 | $52.7M | 1.34% |
| 18 | BRIDGEBIO PHARMA INC | BBIO | 684,277 | $52.3M | 1.34% |
| 19 | ORUKA THERAPEUTICS INC | ORKA | 1,710,316 | $51.8M | 1.32% |
| 20 | SPYRE THERAPEUTICS INC | SYRE | 1,467,266 | $48.1M | 1.23% |