| FMR LLC | 5,450,222 | +515,063 | $432.8M | +$106.7M | 10.4% |
| JPMORGAN CHASE & CO | 1,581,127 | +828,248 | $125.6M | +$75.8M | 110.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,976,132 | +399,026 | $156.9M | +$52.7M | 25.3% |
| BlackRock, Inc. | 2,274,980 | +255,697 | $180.7M | +$47.2M | 12.7% |
| VANGUARD GROUP INC | 1,767,680 | +319,621 | $140.4M | +$44.7M | 22.1% |
| Pictet Asset Management Holding SA | 394,374 | +390,811 | $31.3M | +$31.1M | 10968.6% |
| Assenagon Asset Management S.A. | 357,836 | +347,403 | $28.4M | +$27.7M | 3329.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,518,274 | +108,197 | $120.6M | +$27.4M | 7.7% |
| First Light Asset Management, LLC | 523,167 | +291,981 | $41.5M | +$26.3M | 126.3% |
| Vestal Point Capital, LP | 735,000 | +235,000 | $58.4M | +$25.3M | 47.0% |
| STATE STREET CORP | 1,187,991 | +142,394 | $94.3M | +$25.2M | 13.6% |
| GOLDMAN SACHS GROUP INC | 754,195 | +225,114 | $59.9M | +$24.9M | 42.5% |
| Woodline Partners LP | 957,833 | +90,878 | $76.1M | +$18.8M | 10.5% |
| Siren, L.L.C. | 988,401 | +75,000 | $78.5M | +$18.1M | 8.2% |
| Aberdeen Group plc | 234,358 | +202,297 | $18.6M | +$16.5M | 631.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 684,958 | +56,807 | $54.4M | +$12.9M | 9.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,392 | +87,349 | $31.4M | +$11.0M | 28.4% |
| ARMISTICE CAPITAL, LLC | 499,391 | +63,391 | $39.7M | +$10.8M | 14.5% |
| Logos Global Management LP | 510,000 | +60,000 | $40.5M | +$10.8M | 13.3% |
| Palo Alto Investors LP | 317,456 | +93,156 | $25.2M | +$10.4M | 41.5% |
| Sofinnova Investments, Inc. | 111,010 | +97,457 | $8.8M | +$7.9M | 719.1% |
| Checkpoint Capital L.P. | 452,992 | +22,992 | $36.0M | +$7.6M | 5.3% |
| BNP PARIBAS FINANCIAL MARKETS | 122,153 | +84,543 | $9.7M | +$7.2M | 224.8% |
| DNB Asset Management AS | 84,255 | +78,733 | $6.7M | +$6.3M | 1425.8% |
| MILLENNIUM MANAGEMENT LLC | 208,779 | +47,779 | $16.6M | +$5.9M | 29.7% |
| Verition Fund Management LLC | 63,535 | +57,402 | $5.0M | +$4.6M | 936.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,039 | +20,384 | $19.6M | +$4.6M | 9.0% |
| RENAISSANCE TECHNOLOGIES LLC | 62,820 | +56,020 | $5.0M | +$4.5M | 823.8% |
| CITADEL ADVISORS LLC | 100,395 | +46,101 | $8.0M | +$4.4M | 84.9% |
| NORTHERN TRUST CORP | 228,070 | +8,581 | $18.1M | +$3.6M | 3.9% |
| Atle Fund Management AB | 47,967 | +2,277 | $3.8M | +$3.5M | 5.0% |
| Invesco Ltd. | 61,070 | +39,627 | $4.8M | +$3.4M | 184.8% |
| Opaleye Management Inc. | 200,000 | +6,227 | $15.9M | +$3.1M | 3.2% |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 114,351 | +22,971 | $9.1M | +$3.0M | 25.1% |
| TimesSquare Capital Management, LLC | 187,777 | +5,607 | $14.9M | +$2.9M | 3.1% |
| CITIGROUP INC | 36,176 | +32,131 | $2.9M | +$2.6M | 794.3% |
| MORGAN STANLEY | 74,826 | +18,751 | $5.9M | +$2.2M | 33.4% |
| Russell Investments Group, Ltd. | 23,683 | +21,245 | $1.9M | +$1.7M | 871.4% |
| AMERIPRISE FINANCIAL INC | 82,984 | +8,634 | $6.6M | +$1.7M | 11.6% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,109 | +14,292 | $4.3M | +$1.7M | 35.9% |
| TD Asset Management Inc | 69,634 | +10,386 | $5.5M | +$1.6M | 17.5% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 27,301 | +15,863 | $2.2M | +$1.4M | 138.7% |
| ALPS ADVISORS INC | 31,002 | +14,210 | $2.5M | +$1.4M | 84.6% |
| Bank of New York Mellon Corp | 67,707 | +2,907 | $5.4M | +$1.1M | 4.5% |
| Campbell & CO Investment Adviser LLC | 17,399 | +12,109 | $1.4M | +$1.0M | 228.9% |
| Swiss National Bank | 48,000 | +4,400 | $3.8M | +$930.6K | 10.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,510 | +4,933 | $4.1M | +$928.0K | 10.4% |
| Squarepoint Ops LLC | 15,754 | +10,377 | $1.3M | +$895.7K | 193.0% |
| WELLS FARGO & COMPANY/MN | 33,265 | +6,210 | $2.6M | +$853.7K | 22.9% |
| BANK OF MONTREAL /CAN/ | 24,826 | +7,041 | $2.0M | +$796.2K | 39.6% |
| Voya Investment Management LLC | 13,186 | +8,920 | $1.0M | +$765.2K | 209.1% |
| Nuveen, LLC | 48,471 | +777 | $3.8M | +$697.5K | 1.6% |
| AMERICAN CENTURY COMPANIES INC | 30,328 | +2,390 | $2.4M | +$562.2K | 8.6% |
| STATE OF WISCONSIN INVESTMENT BOARD | 17,106 | +4,733 | $1.4M | +$540.8K | 38.3% |
| PROFUND ADVISORS LLC | 13,478 | +5,360 | $1.1M | +$533.9K | 66.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,256 | +1,163 | $1.8M | +$386.9K | 5.3% |
| DEUTSCHE BANK AG\ | 20,523 | +1,637 | $1.6M | +$381.7K | 8.7% |
| PNC Financial Services Group, Inc. | 25,200 | +54 | $2.0M | +$339.5K | 0.2% |
| STRS OHIO | 6,000 | +3,800 | $476.5K | +$331.1K | 172.7% |
| INTECH INVESTMENT MANAGEMENT LLC | 9,910 | +1,904 | $787.0K | +$257.9K | 23.8% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,711 | +1,065 | $1.1M | +$249.8K | 8.4% |
| AQR CAPITAL MANAGEMENT LLC | 14,007 | +29 | $1.1M | +$188.6K | 0.2% |
| ProShare Advisors LLC | 6,227 | +1,039 | $494.5K | +$151.7K | 20.0% |
| China Universal Asset Management Co., Ltd. | 7,751 | +657 | $615.5K | +$146.7K | 9.3% |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,324 | +296 | $740.4K | +$143.8K | 3.3% |
| KLP KAPITALFORVALTNING AS | 5,200 | +600 | $412.9K | +$109.0K | 13.0% |
| Police & Firemen's Retirement System of New Jersey | 6,716 | +215 | $533.3K | +$103.7K | 3.3% |
| Arizona State Retirement System | 6,798 | +144 | $539.8K | +$100.1K | 2.2% |
| Virtus Investment Advisers, LLC | 2,897 | +739 | $230.1K | +$87.5K | 34.2% |
| Mirae Asset Global Investments Co., Ltd. | 1,834 | +490 | $145.6K | +$56.8K | 36.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,698,005 | +371,576 | $134.8K | +$47.2K | 28.0% |
| Avanza Fonder AB | 1,903 | +235 | $151.1K | +$40.9K | 14.1% |
| Ameritas Investment Partners, Inc. | 2,059 | +128 | $163.5K | +$35.9K | 6.6% |
| Sterling Capital Management LLC | 163 | +107 | $12.9K | +$9.2K | 191.1% |
| AlphaQuest LLC | 366 | +39 | $29.1K | +$7.5K | 11.9% |
| GAMMA Investing LLC | 304 | +28 | $24.1K | +$5.9K | 10.1% |
| J.Safra Asset Management Corp | 63 | +45 | $5.0K | +$4.0K | 250.0% |
| OSAIC HOLDINGS, INC. | 273 | +3 | $21.7K | +$3.8K | 1.1% |
| Farther Finance Advisors, LLC | 53 | +46 | $4.2K | +$3.7K | 657.1% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 40,203 | +39,990 | $3.2K | +$3.2K | 18774.6% |
| Larson Financial Group LLC | 112 | +4 | $8.9K | +$1.8K | 3.7% |
| SG Americas Securities, LLC | 21,122 | +13,058 | $1.7K | +$1.1K | 161.9% |
| iA Global Asset Management Inc. | 66,430 | +918 | $5.3K | +$946 | 1.4% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 16,156 | +3,305 | $1.3K | +$434 | 25.7% |
| CWM, LLC | 1,033 | +6 | $82 | +$14 | 0.6% |