Institutional Manager · CIK 0001055951
ORBIMED ADVISORS LLC
New York, NY · File #028-06774
Latest AUM
$4.90B
Positions
108
Top-10 Concentration
46.5%
Filings
12
Sector Allocation
Filing History
View all filings →- 13F HOLDINGS REPORTQ/E Dec 2025108 pos · $4.90B
- 13F HOLDINGS REPORTQ/E Sep 2025110 pos · $4.26B
- 13F HOLDINGS REPORTQ/E Jun 2025103 pos · $4.00B
- 13F HOLDINGS REPORTQ/E Mar 2025111 pos · $4.19B
- 13F HOLDINGS REPORTQ/E Dec 2024119 pos · $4.86B
- 13F HOLDINGS REPORTQ/E Sep 2024119 pos · $5.50B
- 13F HOLDINGS REPORTQ/E Jun 2024115 pos · $5.06B
- 13F HOLDINGS REPORTQ/E Mar 2024115 pos · $5.46B
- 13F HOLDINGS REPORTQ/E Dec 2023128 pos · $4.71B
- 13F HOLDINGS REPORTQ/E Sep 2023127 pos · $5.52B
- 13F HOLDINGS REPORTQ/E Jun 2023125 pos · $5.09B
- 13F HOLDINGS REPORTQ/E Mar 2023116 pos · $5.23B
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | EDGEWISE THERAPEUTICS INC | EWTX | 15,518,492 | $385.1M | 9.05% |
| 2 | ELI LILLY & CO | LLY | 301,200 | $323.7M | 7.61% |
| 3 | BOSTON SCIENTIFIC CORP | BSX | 2,419,300 | $230.7M | 5.42% |
| 4 | SINOVAC BIOTECH LTD | SVA | 2,718,735 | $184.5M | 4.34% |
| 5 | EDWARDS LIFESCIENCES CORP | EW | 1,842,900 | $157.1M | 3.69% |
| 6 | UPSTREAM BIO INC | UPB | 5,693,589 | $154.6M | 3.63% |
| 7 | INTUITIVE SURGICAL INC | ISRG | 263,400 | $149.2M | 3.51% |
| 8 | SIONNA THERAPEUTICS INC | SION | 3,561,655 | $146.5M | 3.44% |
| 9 | MBX BIOSCIENCES INC | MBX | 3,935,203 | $124.1M | 2.92% |
| 10 | ARGENX SE | ARGX | 146,000 | $122.8M | 2.89% |
| 11 | ENLIVEN THERAPEUTICS INC | ELVN | 7,959,538 | $122.6M | 2.88% |
| 12 | ALNYLAM PHARMACEUTICALS INC | ALNY | 288,800 | $114.8M | 2.70% |
| 13 | STRYKER CORPORATION | SYK | 325,000 | $114.2M | 2.69% |
| 14 | ARS PHARMACEUTICALS INC | SPRY | 8,288,510 | $96.6M | 2.27% |
| 15 | TERNS PHARMACEUTICALS INC | TERN | 2,153,300 | $87.0M | 2.05% |
| 16 | DISC MEDICINE INC | IRON | 1,067,550 | $84.8M | 1.99% |
| 17 | CARIS LIFE SCIENCES INC | CAI | 3,116,011 | $84.1M | 1.98% |
| 18 | NATERA INC | NTRA | 365,800 | $83.8M | 1.97% |
| 19 | COMPASS THERAPEUTICS INC | CMPX | 15,219,994 | $81.7M | 1.92% |
| 20 | STRUCTURE THERAPEUTICS INC | GPCR | 1,161,803 | $80.8M | 1.90% |