Institutional Manager · CIK 0001595855
Opaleye Management Inc.
Boston, MA · File #028-15896
Latest AUM
$758.0M
Positions
54
Top-10 Concentration
65.6%
Filings
14
Sector Allocation
Filing History
View all filings →- 13F HOLDINGS REPORTQ/E Dec 202554 pos · $758.0M
- 13F HOLDINGS REPORTQ/E Sep 202543 pos · $707.3M
- 13F HOLDINGS REPORT (Amended)Q/E Jun 202541 pos · $494.1M
- 13F HOLDINGS REPORTQ/E Jun 202541 pos · $498.9M
- 13F HOLDINGS REPORTQ/E Mar 202545 pos · $449.2M
- 13F HOLDINGS REPORTQ/E Dec 202439 pos · $571.4M
- 13F HOLDINGS REPORTQ/E Sep 202444 pos · $599.6M
- 13F HOLDINGS REPORTQ/E Jun 202451 pos · $437.7M
- 13F HOLDINGS REPORT (Amended)Q/E Mar 202452 pos · $458.9M
- 13F HOLDINGS REPORTQ/E Mar 202451 pos · $436.9M
- 13F HOLDINGS REPORTQ/E Dec 202341 pos · $307.4M
- 13F HOLDINGS REPORTQ/E Sep 202347 pos · $418.1M
- 13F HOLDINGS REPORTQ/E Jun 202341 pos · $333.9M
- 13F HOLDINGS REPORTQ/E Mar 202340 pos · $287.4M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | HARROW HEALTH INC | HROW | 3,905,000 | $191.3M | 25.29% |
| 2 | LIQUIDIA CORPORATION | LQDA | 2,435,000 | $85.0M | 11.23% |
| 3 | ETON PHARMACEUTICALS INC | ETON | 2,860,000 | $48.4M | 6.39% |
| 4 | RHYTHM PHARMACEUTICALS INC | RYTM | 330,000 | $35.3M | 4.67% |
| 5 | APOGEE THERAPEUTICS INC | APGE | 388,257 | $29.3M | 3.87% |
| 6 | SANUWAVE HEALTH INC | SNWV | 981,267 | $29.3M | 3.87% |
| 7 | STOKE THERAPEUTICS INC | STOK | 695,000 | $22.1M | 2.92% |
| 8 | OCULAR THERAPEUTIX INC | OCUL | 1,595,000 | $19.4M | 2.56% |
| 9 | SOL GEL TECHNOLOGIES | SLGL | 453,739 | $19.1M | 2.53% |
| 10 | CG ONCOLOGY INC | CGON | 410,000 | $17.0M | 2.25% |
| 11 | TG THERAPEUTICS INC | TGTX | 535,000 | $15.9M | 2.11% |
| 12 | DISC MEDICINE INC | IRON | 200,000 | $15.9M | 2.10% |
| 13 | REZOLUTE INC | RZLT | 6,287,156 | $14.8M | 1.96% |
| 14 | CRESCENT BIOPHARMA INC | CBIO | 1,178,300 | $14.0M | 1.85% |
| 15 | ALKERMES PLC | ALKS | 490,000 | $13.7M | 1.81% |
| 16 | ALPHA COGNITION INC | ACOG | 2,070,784 | $13.5M | 1.78% |
| 17 | ANNEXON INC | ANNX | 2,600,000 | $13.1M | 1.73% |
| 18 | EDGEWISE THERAPEUTICS INC | EWTX | 500,000 | $12.4M | 1.64% |
| 19 | CODEXIS INC | CDXS | 6,789,738 | $11.1M | 1.46% |
| 20 | PROTAGONIST THERAPEUTICS INC | PTGX | 105,000 | $9.2M | 1.21% |