13F QoQ Ownership Changes
GPCR Institutional Holders
Period 2025-12-31 · prior 2025-09-30 · 70 new · 54 added · 73 reduced · 32 exited
New Positions(70)
Added To(54)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FMR LLC | 8,712,251 | +3,461,883 | $605.9M | +$458.9M | 65.9% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,121,984 | +1,432,797 | $495.3M | +$336.0M | 25.2% |
| Avoro Capital Advisors LLC | 6,555,555 | +1,150,000 | $455.9M | +$309.3M | 21.3% |
| JANUS HENDERSON GROUP PLC | 5,090,148 | +641,322 | $354.0M | +$229.4M | 14.4% |
| BVF INC/IL | 3,479,022 | +275,105 | $242.0M | +$152.3M | 8.6% |
| MORGAN STANLEY | 2,087,834 | +1,510,093 | $145.2M | +$129.0M | 261.4% |
| Driehaus Capital Management LLC | 1,642,444 | +768,940 | $114.2M | +$89.8M | 88.0% |
| PRINCIPAL FINANCIAL GROUP INC | 1,284,210 | +496,726 | $89.3M | +$67.3M | 63.1% |
| ALLIANCEBERNSTEIN L.P. | 848,851 | +819,292 | $59.0M | +$58.2M | 2771.7% |
| ORBIMED ADVISORS LLC | 1,161,803 | +22,503 | $80.8M | +$48.9M | 2.0% |
| Siren, L.L.C. | 1,078,698 | +51,887 | $75.0M | +$46.3M | 5.0% |
| CITADEL ADVISORS LLC | 906,618 | +269,318 | $63.1M | +$45.2M | 42.3% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 767,993 | +394,586 | $53.4M | +$43.0M | 105.7% |
| FRANKLIN RESOURCES INC | 870,582 | +124,848 | $60.5M | +$39.7M | 16.7% |
| BlackRock, Inc. | 430,082 | +166,144 | $29.9M | +$22.5M | 62.9% |
| AMERICAN CENTURY COMPANIES INC | 506,959 | +20,173 | $35.3M | +$21.6M | 4.1% |
| STEMPOINT CAPITAL LP | 351,073 | +221,738 | $24.4M | +$20.8M | 171.4% |
| NATIONAL BANK OF CANADA /FI/ | 265,400 | +121,400 | $18.5M | +$14.4M | 84.3% |
| JANE STREET GROUP, LLC | 220,717 | +107,517 | $15.4M | +$12.2M | 95.0% |
| TD Asset Management Inc | 174,674 | +138,588 | $12.1M | +$11.1M | 384.0% |
| Monashee Investment Management LLC | 225,000 | +25,000 | $15.6M | +$10.0M | 12.5% |
| Woodline Partners LP | 123,902 | +58,462 | $8.6M | +$6.8M | 89.3% |
| SIMPLEX TRADING, LLC | 92,668 | +67,507 | $6.4M | +$6.4M | 268.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 96,387 | +67,855 | $6.5M | +$5.7M | 237.8% |
| Trexquant Investment LP | 89,945 | +69,753 | $6.3M | +$5.7M | 345.4% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83,052 | +67,338 | $5.8M | +$5.3M | 428.5% |
| Verition Fund Management LLC | 78,149 | +38,800 | $5.4M | +$4.3M | 98.6% |
| Birchview Capital, LP | 90,000 | +12,000 | $6.3M | +$4.1M | 15.4% |
| Voya Investment Management LLC | 55,300 | +38,875 | $3.8M | +$3.4M | 236.7% |
| Susquehanna Portfolio Strategies, LLC | 68,089 | +12,147 | $4.7M | +$3.2M | 21.7% |
| ANTIPODES PARTNERS Ltd | 46,291 | +42,213 | $3.2M | +$3.1M | 1035.1% |
| ALPS ADVISORS INC | 49,726 | +21,768 | $3.5M | +$2.7M | 77.8% |
| Headlands Technologies LLC | 43,729 | +16,915 | $3.0M | +$2.3M | 63.1% |
| STATE STREET CORP | 48,224 | +2,207 | $3.4M | +$2.1M | 4.8% |
| Mariner, LLC | 44,155 | +19 | $3.1M | +$1.8M | 0.0% |
| BANK OF AMERICA CORP /DE/ | 31,678 | +17,899 | $2.2M | +$1.8M | 129.9% |
| NOMURA ASSET MANAGEMENT CO LTD | 29,152 | +3,296 | $2.0M | +$1.3M | 12.7% |
| Walleye Capital LLC | 26,502 | +6,312 | $1.8M | +$1.3M | 31.3% |
| BRANDYWINE MANAGERS, LLC | 13,357 | +2,300 | $929.0K | +$619.4K | 20.8% |
| CITIGROUP INC | 7,335 | +5,879 | $510.1K | +$469.4K | 403.8% |
| China Universal Asset Management Co., Ltd. | 10,888 | +444 | $757.3K | +$464.8K | 4.3% |
| HighTower Advisors, LLC | 9,320 | +320 | $648.2K | +$396.2K | 3.5% |
| Mirae Asset Global Investments Co., Ltd. | 5,267 | +1,211 | $366.3K | +$252.8K | 29.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,671,138 | +1,381,745 | $116.2K | +$108.1K | 477.5% |
| State of Wyoming | 1,761 | +403 | $122.5K | +$84.5K | 29.7% |
| JONES FINANCIAL COMPANIES LLLP | 1,046 | +859 | $72.7K | +$68.1K | 459.4% |
| GF FUND MANAGEMENT CO. LTD. | 1,312 | +34 | $91.3K | +$55.5K | 2.7% |
| GAMMA Investing LLC | 930 | +112 | $64.7K | +$41.8K | 13.7% |
| Farther Finance Advisors, LLC | 690 | +20 | $48.0K | +$29.2K | 3.0% |
| BARCLAYS PLC | 6,328 | +2,555 | $131.2K | +$25.6K | 67.7% |
| WOLFF WIESE MAGANA LLC | 400 | +114 | $27.8K | +$19.8K | 39.9% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 17,297 | +6,546 | $1.2K | +$902 | 60.9% |
| Larson Financial Group LLC | 5 | +2 | $348 | +$264 | 66.7% |
| CWM, LLC | 480 | +125 | $33 | +$23 | 35.2% |
Reduced(73)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Deep Track Capital, LP | 4,111,782 | -104,029 | $286.0M | +$167.9M | -2.5% |
| BAKER BROS. ADVISORS LP | 1,432,529 | -123,580 | $99.6M | +$56.1M | -7.9% |
| Casdin Capital, LLC | 1,175,000 | -380,000 | $81.7M | +$38.2M | -24.4% |
| TCG Crossover Management, LLC | 920,857 | -142,143 | $64.0M | +$34.3M | -13.4% |
| Pacific Heights Asset Management LLC | 700,000 | 0 | $48.7M | +$29.1M | 0.0% |
| Rock Springs Capital Management LP | 748,236 | -202,918 | $52.0M | +$25.4M | -21.3% |
| MILLENNIUM MANAGEMENT LLC | 152,560 | -1,121,991 | $10.6M | -$25.1M | -88.0% |
| HSG Holding Ltd | 266,062 | 0 | $24.4M | +$19.8M | 0.0% |
| Logos Global Management LP | 600,000 | -250,000 | $41.7M | +$17.9M | -29.4% |
| AMERIPRISE FINANCIAL INC | 285,518 | -938,626 | $19.9M | -$14.4M | -76.7% |
| GOLDMAN SACHS GROUP INC | 397,832 | -106,564 | $27.7M | +$13.5M | -21.1% |
| Invesco Ltd. | 3,200 | -440,537 | $222.6K | -$12.2M | -99.3% |
| ArrowMark Colorado Holdings LLC | 271,213 | -51,953 | $18.9M | +$9.8M | -16.1% |
| UBS Group AG | 202,877 | -26,315 | $14.1M | +$7.7M | -11.5% |
| HighVista Strategies LLC | 193,001 | -43,235 | $13.4M | +$6.8M | -18.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 368,799 | -326,709 | $25.6M | +$6.2M | -47.0% |
| Rhenman & Partners Asset Management AB | 147,600 | -32,500 | $10.3M | +$5.2M | -18.0% |
| SECTORAL ASSET MANAGEMENT INC | 23,872 | -198,000 | $1.7M | -$4.6M | -89.2% |
| Ikarian Capital, LLC | 4,824 | -158,413 | $335.5K | -$4.2M | -97.0% |
| Eversept Partners, LP | 127,561 | -38,830 | $8.9M | +$4.2M | -23.3% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 99,617 | 0 | $6.9M | +$4.1M | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 115,200 | -38,700 | $8.0M | +$3.7M | -25.1% |
| SPHERA FUNDS MANAGEMENT LTD. | 41,000 | -182,931 | $2.9M | -$3.4M | -81.7% |
| OSAIC HOLDINGS, INC. | 59,238 | -3,601 | $4.1M | +$2.9M | -5.7% |
| PLATINUM INVESTMENT MANAGEMENT LTD | 87,874 | -34,884 | $6.1M | +$2.7M | -28.4% |
| Jefferies Financial Group Inc. | 102,993 | -67,352 | $7.2M | +$2.4M | -39.5% |
| BANQUE PICTET & CIE SA | 59,881 | -4,304 | $4.2M | +$2.4M | -6.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 55,148 | -2,810 | $3.8M | +$2.2M | -4.8% |
| Pier Capital, LLC | 48,757 | -148,752 | $3.4M | -$2.1M | -75.3% |
| Balyasny Asset Management L.P. | 216,199 | -245,354 | $15.0M | +$2.1M | -53.1% |
| Aberdeen Group plc | 264,869 | -322,000 | $18.4M | +$2.0M | -54.9% |
| BANK OF MONTREAL /CAN/ | 54,341 | -6,381 | $3.7M | +$2.0M | -10.5% |
| BNP PARIBAS FINANCIAL MARKETS | 8,746 | -81,685 | $608.3K | -$1.9M | -90.3% |
| PFM Health Sciences, LP | 68,248 | -46,825 | $4.7M | +$1.5M | -40.7% |
| TWO SIGMA INVESTMENTS, LP | 95,543 | -87,368 | $6.6M | +$1.5M | -47.8% |
| TrueMark Investments, LLC | 33,893 | -968 | $2.4M | +$1.4M | -2.8% |
| Bellevue Group AG | 145,167 | -170,690 | $10.1M | +$1.3M | -54.0% |
| Walleye Trading LLC | 72,900 | -67,000 | $5.1M | +$1.2M | -47.9% |
| Alyeska Investment Group, L.P. | 115,000 | -129,848 | $8.0M | +$1.1M | -53.0% |
| DAFNA Capital Management LLC | 37,000 | -22,000 | $2.6M | +$921.4K | -37.3% |
| JPMORGAN CHASE & CO | 12,956 | -45,192 | $901.1K | -$727.1K | -77.7% |
| Catalio Capital Management, LP | 252,901 | -398,909 | $17.6M | -$661.4K | -61.2% |
| Quinn Opportunity Partners LLC | 25,000 | -17,000 | $1.7M | +$562.8K | -40.5% |
| DNB Asset Management AS | 12,639 | -249 | $879.0K | +$518.2K | -1.9% |
| Royal Bank of Canada | 10,200 | -1,093 | $709.0K | +$488.0K | -9.7% |
| ENVESTNET ASSET MANAGEMENT INC | 11,570 | -650 | $804.7K | +$462.5K | -5.3% |
| D. E. Shaw & Co., Inc. | 8,623 | -27,723 | $599.7K | -$418.0K | -76.3% |
| MISSION WEALTH MANAGEMENT, LP | 9,583 | 0 | $666.5K | +$398.2K | 0.0% |
| Parallel Advisors, LLC | 7,352 | -912 | $511.3K | +$279.9K | -11.0% |
| SIGNATUREFD, LLC | 6,650 | 0 | $462.5K | +$276.3K | 0.0% |
| WELLS FARGO & COMPANY/MN | 5,664 | -394 | $393.9K | +$224.3K | -6.5% |
| EXCHANGE TRADED CONCEPTS, LLC | 25,981 | -32,241 | $1.8M | +$176.8K | -55.4% |
| PNC Financial Services Group, Inc. | 3,926 | -902 | $273.1K | +$137.9K | -18.7% |
| Bleichroeder LP | 10,000 | -10,000 | $695.5K | +$135.5K | -50.0% |
| Virtus Investment Advisers, LLC | 3,967 | -1,154 | $275.9K | +$132.5K | -22.5% |
| Steward Partners Investment Advisory, LLC | 2,540 | -100 | $176.7K | +$102.7K | -3.8% |
| LPL Financial LLC | 8,109 | -14,894 | $564.0K | -$80.1K | -64.7% |
| ASSETMARK, INC | 2,095 | -289 | $145.7K | +$79.0K | -12.1% |
| PEAK6 LLC | 7,955 | -14,045 | $553.3K | -$62.7K | -63.8% |
| Rockefeller Capital Management L.P. | 731 | -11 | $50.8K | +$30.1K | -1.5% |
| COUNTRY TRUST BANK | 500 | 0 | $34.8K | +$20.8K | 0.0% |
| North Star Investment Management Corp. | 330 | 0 | $23.0K | +$13.7K | 0.0% |
| EverSource Wealth Advisors, LLC | 578 | -493 | $40.2K | +$10.2K | -46.0% |
| Tower Research Capital LLC (TRC) | 41 | -353 | $2.9K | -$8.2K | -89.6% |
| Private Wealth Management Group, LLC | 196 | 0 | $13.6K | +$8.1K | 0.0% |
| Dynamic Wealth Strategies, LLC | 150 | -400 | $10.4K | -$5.0K | -72.7% |
| SG Americas Securities, LLC | 10,147 | -29,553 | $706 | -$406 | -74.4% |
| Cullen/Frost Bankers, Inc. | 8 | 0 | $556 | +$332 | 0.0% |
| Janney Capital Management LLC | 8,513 | -5,205 | $592 | +$208 | -37.9% |
| HUNTINGTON NATIONAL BANK | 2 | 0 | $139 | +$83 | 0.0% |
| Daiwa Securities Group Inc. | 186 | -40 | $13 | +$7 | -17.7% |
| BESSEMER GROUP INC | 29 | 0 | $2 | +$1 | 0.0% |
| Capital Analysts, LLC | 18 | 0 | $1 | $0 | 0.0% |