New Positions
70 managers initiated
Top five by reported value
Structure Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:GPCR
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
70 new54 added73 reduced32 exited
Total Institutional Holders
197
as of 2025-12-31
Top Holder
FMR LLC
$605.9M
Largest QoQ Increase
FMR LLC
+3,461,883 sh
Largest QoQ Decrease
RA CAPITAL MANAGEMENT, L.P.
-1,517,418 sh
New Positions(70)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Capitolis Liquid Global Markets LLC | 878,300 | +878,300 | $61.1M | +$61.1M | — |
| DEUTSCHE BANK AG\ | 841,162 | +841,162 | $58.5M | +$58.5M | — |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 467,800 | +467,800 | $32.5M | +$32.5M | — |
| FARALLON CAPITAL MANAGEMENT LLC | 454,000 | +454,000 | $31.6M | +$31.6M | — |
| EcoR1 Capital, LLC | 334,380 | +334,380 | $23.3M | +$23.3M | — |
| Capricorn Fund Managers Ltd | 252,600 | +252,600 | $17.6M | +$17.6M | — |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 250,000 | +250,000 | $17.4M | +$17.4M | — |
| Sio Capital Management, LLC | 201,500 | +201,500 | $14.0M | +$14.0M | — |
| DIADEMA PARTNERS LP | 191,700 | +191,700 | $13.3M | +$13.3M | — |
| MARSHALL WACE, LLP | 168,584 | +168,584 | $11.7M | +$11.7M | — |
| RTW INVESTMENTS, LP | 100,000 | +100,000 | $7.0M | +$7.0M | — |
| Jain Global LLC | 99,996 | +99,996 | $7.0M | +$7.0M | — |
| SummitTX Capital, L.P. | 94,671 | +94,671 | $6.6M | +$6.6M | — |
| NEXTBio Capital Management LP | 94,443 | +94,443 | $6.6M | +$6.6M | — |
| B Group, Inc. | 90,000 | +90,000 | $6.3M | +$6.3M | — |
| Soleus Capital Management, L.P. | 90,000 | +90,000 | $6.3M | +$6.3M | — |
| Brevan Howard Capital Management LP | 86,310 | +86,310 | $6.0M | +$6.0M | — |
| PEREGRINE CAPITAL MANAGEMENT LLC | 84,324 | +84,324 | $5.9M | +$5.9M | — |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 82,645 | +82,645 | $5.7M | +$5.7M | — |
| Boxer Capital Management, LLC | 75,000 | +75,000 | $5.2M | +$5.2M | — |
| Burkehill Global Management, LP | 60,000 | +60,000 | $4.2M | +$4.2M | — |
| Longaeva Partners L.P. | 60,000 | +60,000 | $4.2M | +$4.2M | — |
| Parkman Healthcare Partners LLC | 55,000 | +55,000 | $3.8M | +$3.8M | — |
| Buckland Partners Management Co LLC | 50,000 | +50,000 | $3.5M | +$3.5M | — |
| Integral Health Asset Management, LLC | 50,000 | +50,000 | $3.5M | +$3.5M | — |
| SEVEN GRAND MANAGERS, LLC | 50,000 | +50,000 | $3.5M | +$3.5M | — |
| RAYMOND JAMES FINANCIAL INC | 44,388 | +44,388 | $3.1M | +$3.1M | — |
| ACT CAPITAL MANAGEMENT, LLC | 38,500 | +38,500 | $2.7M | +$2.7M | — |
| EAM Investors, LLC | 38,054 | +38,054 | $2.6M | +$2.6M | — |
| TUDOR INVESTMENT CORP ET AL | 35,053 | +35,053 | $2.4M | +$2.4M | — |
| Vestal Point Capital, LP | 35,000 | +35,000 | $2.4M | +$2.4M | — |
| DCF Advisers, LLC | 30,000 | +30,000 | $2.1M | +$2.1M | — |
| Russell Investments Group, Ltd. | 26,274 | +26,274 | $1.8M | +$1.8M | — |
| Maven Securities LTD | 20,000 | +20,000 | $1.4M | +$1.4M | — |
| XTX Topco Ltd | 19,193 | +19,193 | $1.3M | +$1.3M | — |
| SEI INVESTMENTS CO | 14,903 | +14,903 | $1.0M | +$1.0M | — |
| WEXFORD CAPITAL LP | 14,835 | +14,835 | $1.0M | +$1.0M | — |
| J. Goldman & Co LP | 13,601 | +13,601 | $946.0K | +$946.0K | — |
| Quadrature Capital Ltd | 12,761 | +12,761 | $887.5K | +$887.5K | — |
| Allianz Asset Management GmbH | 12,000 | +12,000 | $834.6K | +$834.6K | — |
| Y-Intercept (Hong Kong) Ltd | 10,132 | +10,132 | $704.7K | +$704.7K | — |
| SmartHarvest Portfolios, LLC | 9,056 | +9,056 | $629.8K | +$629.8K | — |
| Schonfeld Strategic Advisors LLC | 8,727 | +8,727 | $607.0K | +$607.0K | — |
| MML INVESTORS SERVICES, LLC | 7,825 | +7,825 | $544.2K | +$544.2K | — |
| Vestmark Advisory Solutions, Inc. | 7,534 | +7,534 | $524.0K | +$524.0K | — |
| PSP Research LLC | 6,719 | +6,719 | $467.3K | +$467.3K | — |
| Cetera Investment Advisers | 6,596 | +6,596 | $458.8K | +$458.8K | — |
| Gilbert & Cook, Inc. | 5,682 | +5,682 | $395.2K | +$395.2K | — |
| Blueshift Asset Management, LLC | 5,213 | +5,213 | $362.6K | +$362.6K | — |
| Quadcap Wealth Management, LLC | 7,483 | +7,483 | $354.8K | +$354.8K | — |
| Concurrent Investment Advisors, LLC | 5,000 | +5,000 | $347.8K | +$347.8K | — |
| STIFEL FINANCIAL CORP | 4,830 | +4,830 | $335.9K | +$335.9K | — |
| Independent Advisor Alliance | 4,543 | +4,543 | $316.0K | +$316.0K | — |
| E. Ohman J:or Asset Management AB | 4,518 | +4,518 | $314.2K | +$314.2K | — |
| GABELLI FUNDS LLC | 4,000 | +4,000 | $278.2K | +$278.2K | — |
| Merit Financial Group, LLC | 3,688 | +3,688 | $256.5K | +$256.5K | — |
| NORTHERN TRUST CORP | 3,645 | +3,645 | $253.5K | +$253.5K | — |
| Bank of New York Mellon Corp | 3,604 | +3,604 | $250.6K | +$250.6K | — |
| PROFUND ADVISORS LLC | 3,507 | +3,507 | $243.9K | +$243.9K | — |
| CIBC WORLD MARKET INC. | 3,248 | +3,248 | $225.9K | +$225.9K | — |
| ProShare Advisors LLC | 2,957 | +2,957 | $205.7K | +$205.7K | — |
| Banque Cantonale Vaudoise | 2,945 | +2,945 | $205.0K | +$205.0K | — |
| Persistent Asset Partners Ltd | 2,436 | +2,436 | $169.4K | +$169.4K | — |
| Police & Firemen's Retirement System of New Jersey | 1,829 | +1,829 | $127.2K | +$127.2K | — |
| SOA Wealth Advisors, LLC. | 350 | +350 | $24.3K | +$24.3K | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | +60 | $4.2K | +$4.2K | — |
| ACADIAN ASSET MANAGEMENT LLC | 17,606 | +17,606 | $1.2K | +$1.2K | — |
| BELLEVUE ASSET MANAGEMENT, LLC | 15 | +15 | $1.0K | +$1.0K | — |
| Aventura Private Wealth, LLC | 28 | +28 | $759 | +$759 | — |
| FNY Investment Advisers, LLC | 1,700 | +1,700 | $47 | +$47 | — |
Added To(54)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FMR LLC | 8,712,251 | +3,461,883 | $605.9M | +$458.9M | 65.9% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,121,984 | +1,432,797 | $495.3M | +$336.0M | 25.2% |
| Avoro Capital Advisors LLC | 6,555,555 | +1,150,000 | $455.9M | +$309.3M | 21.3% |
| JANUS HENDERSON GROUP PLC | 5,090,148 | +641,322 | $354.0M | +$229.4M | 14.4% |
| BVF INC/IL | 3,479,022 | +275,105 | $242.0M | +$152.3M | 8.6% |
| MORGAN STANLEY | 2,087,834 | +1,510,093 | $145.2M | +$129.0M | 261.4% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,642,444 | +768,940 | $114.2M | +$89.8M | 88.0% |
| PRINCIPAL FINANCIAL GROUP INC | 1,284,210 | +496,726 | $89.3M | +$67.3M | 63.1% |
| ALLIANCEBERNSTEIN L.P. | 848,851 | +819,292 | $59.0M | +$58.2M | 2771.7% |
| ORBIMED ADVISORS LLC | 1,161,803 | +22,503 | $80.8M | +$48.9M | 2.0% |
| Siren, L.L.C. | 1,078,698 | +51,887 | $75.0M | +$46.3M | 5.0% |
| CITADEL ADVISORS LLC | 906,618 | +269,318 | $63.1M | +$45.2M | 42.3% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 767,993 | +394,586 | $53.4M | +$43.0M | 105.7% |
| FRANKLIN RESOURCES INC | 870,582 | +124,848 | $60.5M | +$39.7M | 16.7% |
| BlackRock, Inc. | 430,082 | +166,144 | $29.9M | +$22.5M | 62.9% |
| AMERICAN CENTURY COMPANIES INC | 506,959 | +20,173 | $35.3M | +$21.6M | 4.1% |
| STEMPOINT CAPITAL LP | 351,073 | +221,738 | $24.4M | +$20.8M | 171.4% |
| NATIONAL BANK OF CANADA /FI/ | 265,400 | +121,400 | $18.5M | +$14.4M | 84.3% |
| JANE STREET GROUP, LLC | 220,717 | +107,517 | $15.4M | +$12.2M | 95.0% |
| TD Asset Management Inc | 174,674 | +138,588 | $12.1M | +$11.1M | 384.0% |
| Monashee Investment Management LLC | 225,000 | +25,000 | $15.6M | +$10.0M | 12.5% |
| Woodline Partners LP | 123,902 | +58,462 | $8.6M | +$6.8M | 89.3% |
| SIMPLEX TRADING, LLC | 92,668 | +67,507 | $6.4M | +$6.4M | 268.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 96,387 | +67,855 | $6.5M | +$5.7M | 237.8% |
| Trexquant Investment LP | 89,945 | +69,753 | $6.3M | +$5.7M | 345.4% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83,052 | +67,338 | $5.8M | +$5.3M | 428.5% |
| Verition Fund Management LLC | 78,149 | +38,800 | $5.4M | +$4.3M | 98.6% |
| Birchview Capital, LP | 90,000 | +12,000 | $6.3M | +$4.1M | 15.4% |
| Voya Investment Management LLC | 55,300 | +38,875 | $3.8M | +$3.4M | 236.7% |
| Susquehanna Portfolio Strategies, LLC | 68,089 | +12,147 | $4.7M | +$3.2M | 21.7% |
| ANTIPODES PARTNERS Ltd | 46,291 | +42,213 | $3.2M | +$3.1M | 1035.1% |
| ALPS ADVISORS INC | 49,726 | +21,768 | $3.5M | +$2.7M | 77.8% |
| Headlands Technologies LLC | 43,729 | +16,915 | $3.0M | +$2.3M | 63.1% |
| STATE STREET CORP | 48,224 | +2,207 | $3.4M | +$2.1M | 4.8% |
| Mariner, LLC | 44,155 | +19 | $3.1M | +$1.8M | 0.0% |
| BANK OF AMERICA CORP /DE/ | 31,678 | +17,899 | $2.2M | +$1.8M | 129.9% |
| NOMURA ASSET MANAGEMENT CO LTD | 29,152 | +3,296 | $2.0M | +$1.3M | 12.7% |
| Walleye Capital LLC | 26,502 | +6,312 | $1.8M | +$1.3M | 31.3% |
| BRANDYWINE MANAGERS, LLC | 13,357 | +2,300 | $929.0K | +$619.4K | 20.8% |
| CITIGROUP INC | 7,335 | +5,879 | $510.1K | +$469.4K | 403.8% |
| China Universal Asset Management Co., Ltd. | 10,888 | +444 | $757.3K | +$464.8K | 4.3% |
| HighTower Advisors, LLC | 9,320 | +320 | $648.2K | +$396.2K | 3.5% |
| Mirae Asset Global Investments Co., Ltd. | 5,267 | +1,211 | $366.3K | +$252.8K | 29.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,671,138 | +1,381,745 | $116.2K | +$108.1K | 477.5% |
| State of Wyoming | 1,761 | +403 | $122.5K | +$84.5K | 29.7% |
| JONES FINANCIAL COMPANIES LLLP | 1,046 | +859 | $72.7K | +$68.1K | 459.4% |
| GF FUND MANAGEMENT CO. LTD. | 1,312 | +34 | $91.3K | +$55.5K | 2.7% |
| GAMMA Investing LLC | 930 | +112 | $64.7K | +$41.8K | 13.7% |
| Farther Finance Advisors, LLC | 690 | +20 | $48.0K | +$29.2K | 3.0% |
| BARCLAYS PLC | 6,328 | +2,555 | $131.2K | +$25.6K | 67.7% |
| WOLFF WIESE MAGANA LLC | 400 | +114 | $27.8K | +$19.8K | 39.9% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 17,297 | +6,546 | $1.2K | +$902 | 60.9% |
| Larson Financial Group LLC | 5 | +2 | $348 | +$264 | 66.7% |
| CWM, LLC | 480 | +125 | $33 | +$23 | 35.2% |
Reduced(73)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Deep Track Capital, LP | 4,111,782 | -104,029 | $286.0M | +$167.9M | -2.5% |
| BAKER BROS. ADVISORS LP | 1,432,529 | -123,580 | $99.6M | +$56.1M | -7.9% |
| Casdin Capital, LLC | 1,175,000 | -380,000 | $81.7M | +$38.2M | -24.4% |
| TCG Crossover Management, LLC | 920,857 | -142,143 | $64.0M | +$34.3M | -13.4% |
| Pacific Heights Asset Management LLC | 700,000 | 0 | $48.7M | +$29.1M | 0.0% |
| Rock Springs Capital Management LP | 748,236 | -202,918 | $52.0M | +$25.4M | -21.3% |
| MILLENNIUM MANAGEMENT LLC | 152,560 | -1,121,991 | $10.6M | -$25.1M | -88.0% |
| SC CHINA HOLDING Ltd | 266,062 | 0 | $24.4M | +$19.8M | 0.0% |
| Logos Global Management LP | 600,000 | -250,000 | $41.7M | +$17.9M | -29.4% |
| AMERIPRISE FINANCIAL INC | 285,518 | -938,626 | $19.9M | -$14.4M | -76.7% |
| GOLDMAN SACHS GROUP INC | 397,832 | -106,564 | $27.7M | +$13.5M | -21.1% |
| Invesco Ltd. | 3,200 | -440,537 | $222.6K | -$12.2M | -99.3% |
| ArrowMark Colorado Holdings LLC | 271,213 | -51,953 | $18.9M | +$9.8M | -16.1% |
| UBS Group AG | 202,877 | -26,315 | $14.1M | +$7.7M | -11.5% |
| HighVista Strategies LLC | 193,001 | -43,235 | $13.4M | +$6.8M | -18.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 368,799 | -326,709 | $25.6M | +$6.2M | -47.0% |
| Rhenman & Partners Asset Management AB | 147,600 | -32,500 | $10.3M | +$5.2M | -18.0% |
| SECTORAL ASSET MANAGEMENT INC | 23,872 | -198,000 | $1.7M | -$4.6M | -89.2% |
| Ikarian Capital, LLC | 4,824 | -158,413 | $335.5K | -$4.2M | -97.0% |
| Eversept Partners, LP | 127,561 | -38,830 | $8.9M | +$4.2M | -23.3% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 99,617 | 0 | $6.9M | +$4.1M | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 115,200 | -38,700 | $8.0M | +$3.7M | -25.1% |
| SPHERA FUNDS MANAGEMENT LTD. | 41,000 | -182,931 | $2.9M | -$3.4M | -81.7% |
| ADVISOR GROUP HOLDINGS, INC. | 59,238 | -3,601 | $4.1M | +$2.9M | -5.7% |
| PLATINUM INVESTMENT MANAGEMENT LTD | 87,874 | -34,884 | $6.1M | +$2.7M | -28.4% |
| Jefferies Financial Group Inc. | 102,993 | -67,352 | $7.2M | +$2.4M | -39.5% |
| BANQUE PICTET & CIE SA | 59,881 | -4,304 | $4.2M | +$2.4M | -6.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 55,148 | -2,810 | $3.8M | +$2.2M | -4.8% |
| Pier Capital, LLC | 48,757 | -148,752 | $3.4M | -$2.1M | -75.3% |
| Balyasny Asset Management LLC | 216,199 | -245,354 | $15.0M | +$2.1M | -53.1% |
| abrdn plc | 264,869 | -322,000 | $18.4M | +$2.0M | -54.9% |
| BANK OF MONTREAL /CAN/ | 54,341 | -6,381 | $3.7M | +$2.0M | -10.5% |
| BNP PARIBAS ARBITRAGE, SNC | 8,746 | -81,685 | $608.3K | -$1.9M | -90.3% |
| PFM Health Sciences, LP | 68,248 | -46,825 | $4.7M | +$1.5M | -40.7% |
| TWO SIGMA INVESTMENTS, LP | 95,543 | -87,368 | $6.6M | +$1.5M | -47.8% |
| TrueMark Investments, LLC | 33,893 | -968 | $2.4M | +$1.4M | -2.8% |
| Bellevue Group AG | 145,167 | -170,690 | $10.1M | +$1.3M | -54.0% |
| Walleye Trading LLC | 72,900 | -67,000 | $5.1M | +$1.2M | -47.9% |
| Alyeska Investment Group, L.P. | 115,000 | -129,848 | $8.0M | +$1.1M | -53.0% |
| DAFNA Capital Management LLC | 37,000 | -22,000 | $2.6M | +$921.4K | -37.3% |
| JPMORGAN CHASE & CO | 12,956 | -45,192 | $901.1K | -$727.1K | -77.7% |
| Catalio Capital Management, LP | 252,901 | -398,909 | $17.6M | -$661.4K | -61.2% |
| Quinn Opportunity Partners LLC | 25,000 | -17,000 | $1.7M | +$562.8K | -40.5% |
| DNB Asset Management AS | 12,639 | -249 | $879.0K | +$518.2K | -1.9% |
| Royal Bank of Canada | 10,200 | -1,093 | $709.0K | +$488.0K | -9.7% |
| ENVESTNET ASSET MANAGEMENT INC | 11,570 | -650 | $804.7K | +$462.5K | -5.3% |
| D. E. Shaw & Co., Inc. | 8,623 | -27,723 | $599.7K | -$418.0K | -76.3% |
| MISSION WEALTH MANAGEMENT, LP | 9,583 | 0 | $666.5K | +$398.2K | 0.0% |
| Parallel Advisors, LLC | 7,352 | -912 | $511.3K | +$279.9K | -11.0% |
| SIGNATUREFD, LLC | 6,650 | 0 | $462.5K | +$276.3K | 0.0% |
| WELLS FARGO & COMPANY/MN | 5,664 | -394 | $393.9K | +$224.3K | -6.5% |
| EXCHANGE TRADED CONCEPTS, LLC | 25,981 | -32,241 | $1.8M | +$176.8K | -55.4% |
| PNC Financial Services Group, Inc. | 3,926 | -902 | $273.1K | +$137.9K | -18.7% |
| Bleichroeder LP | 10,000 | -10,000 | $695.5K | +$135.5K | -50.0% |
| Virtus Investment Advisers, Inc. | 3,967 | -1,154 | $275.9K | +$132.5K | -22.5% |
| Steward Partners Investment Advisory, LLC | 2,540 | -100 | $176.7K | +$102.7K | -3.8% |
| LPL Financial LLC | 8,109 | -14,894 | $564.0K | -$80.1K | -64.7% |
| ASSETMARK, INC | 2,095 | -289 | $145.7K | +$79.0K | -12.1% |
| PEAK6 LLC | 7,955 | -14,045 | $553.3K | -$62.7K | -63.8% |
| Rockefeller Capital Management L.P. | 731 | -11 | $50.8K | +$30.1K | -1.5% |
| COUNTRY TRUST BANK | 500 | 0 | $34.8K | +$20.8K | 0.0% |
| North Star Investment Management Corp. | 330 | 0 | $23.0K | +$13.7K | 0.0% |
| EverSource Wealth Advisors, LLC | 578 | -493 | $40.2K | +$10.2K | -46.0% |
| Tower Research Capital LLC (TRC) | 41 | -353 | $2.9K | -$8.2K | -89.6% |
| Private Wealth Management Group, LLC | 196 | 0 | $13.6K | +$8.1K | 0.0% |
| Dynamic Wealth Strategies, LLC | 150 | -400 | $10.4K | -$5.0K | -72.7% |
| SG Americas Securities, LLC | 10,147 | -29,553 | $706 | -$406 | -74.4% |
| CULLEN/FROST BANKERS, INC. | 8 | 0 | $556 | +$332 | 0.0% |
| Janney Capital Management LLC | 8,513 | -5,205 | $592 | +$208 | -37.9% |
| HUNTINGTON NATIONAL BANK | 2 | 0 | $139 | +$83 | 0.0% |
| Daiwa Securities Group Inc. | 186 | -40 | $13 | +$7 | -17.7% |
| BESSEMER GROUP INC | 29 | 0 | $2 | +$1 | 0.0% |
| Capital Analysts, LLC | 18 | 0 | $1 | $0 | 0.0% |
Sold Out(32)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FMR LLC | 8,712,251 | $605.9M | +3,461,883 | 65.9% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,121,984 | $495.3M | +1,432,797 | 25.2% |
| Avoro Capital Advisors LLC | 6,555,555 | $455.9M | +1,150,000 | 21.3% |
| JANUS HENDERSON GROUP PLC | 5,090,148 | $354.0M | +641,322 | 14.4% |
| Deep Track Capital, LP | 4,111,782 | $286.0M | -104,029 | -2.5% |
| BVF INC/IL | 3,479,022 | $242.0M | +275,105 | 8.6% |
| MORGAN STANLEY | 2,087,834 | $145.2M | +1,510,093 | 261.4% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,642,444 | $114.2M | +768,940 | 88.0% |
| BAKER BROS. ADVISORS LP | 1,432,529 | $99.6M | -123,580 | -7.9% |
| PRINCIPAL FINANCIAL GROUP INC | 1,284,210 | $89.3M | +496,726 | 63.1% |
| Casdin Capital, LLC | 1,175,000 | $81.7M | -380,000 | -24.4% |
| ORBIMED ADVISORS LLC | 1,161,803 | $80.8M | +22,503 | 2.0% |
| Siren, L.L.C. | 1,078,698 | $75.0M | +51,887 | 5.0% |
| TCG Crossover Management, LLC | 920,857 | $64.0M | -142,143 | -13.4% |
| CITADEL ADVISORS LLC | 906,618 | $63.1M | +269,318 | 42.3% |
| Capitolis Liquid Global Markets LLC | 878,300 | $61.1M | +878,300 | — |
| FRANKLIN RESOURCES INC | 870,582 | $60.5M | +124,848 | 16.7% |
| ALLIANCEBERNSTEIN L.P. | 848,851 | $59.0M | +819,292 | 2771.7% |
| DEUTSCHE BANK AG\ | 841,162 | $58.5M | +841,162 | — |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 767,993 | $53.4M | +394,586 | 105.7% |
New & Closed Positions this quarter
Closed Positions
32 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for GPCR against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.