New Positions
69 managers initiated
Top five by reported value
Taysha Gene Therapies Inc NASDAQ NMS - GLOBAL MARKET:TSHA
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
69 new61 added66 reduced23 exited
Total Institutional Holders
196
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$129.6M
Largest QoQ Increase
Vestal Point Capital, LP
+8,250,000 sh
Largest QoQ Decrease
RTW INVESTMENTS, LP
-7,955,994 sh
New Positions(69)
Added To(61)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Vestal Point Capital, LP | 13,750,000 | +8,250,000 | $75.6M | +$57.6M | 150.0% |
| BlackRock, Inc. | 18,643,129 | +2,278,268 | $102.5M | +$49.0M | 13.9% |
| STATE STREET CORP | 10,790,084 | +3,553,619 | $59.3M | +$35.7M | 49.1% |
| GOLDMAN SACHS GROUP INC | 13,692,739 | +309,031 | $75.3M | +$31.5M | 2.3% |
| VANGUARD GROUP INC | 13,267,805 | +418,192 | $73.0M | +$31.0M | 3.3% |
| Polar Capital Holdings Plc | 7,931,403 | +2,637,524 | $43.6M | +$26.3M | 49.8% |
| D. E. Shaw & Co., Inc. | 4,013,635 | +1,307,201 | $22.1M | +$13.2M | 48.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,387,026 | +212,510 | $29.6M | +$12.7M | 4.1% |
| CITADEL ADVISORS LLC | 1,956,455 | +1,563,446 | $10.8M | +$9.5M | 397.8% |
| Affinity Asset Advisors, LLC | 3,300,000 | +300,000 | $18.1M | +$8.3M | 10.0% |
| Invesco Ltd. | 1,332,780 | +1,052,987 | $7.3M | +$6.4M | 376.3% |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,270,645 | +692,527 | $7.0M | +$5.1M | 119.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,902,978 | +56,468 | $10.5M | +$4.4M | 3.0% |
| JPMORGAN CHASE & CO | 774,412 | +478,168 | $4.3M | +$3.3M | 161.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 711,235 | +143,229 | $3.9M | +$2.1M | 25.2% |
| Squarepoint Ops LLC | 471,577 | +273,225 | $2.6M | +$1.9M | 137.7% |
| TWO SIGMA INVESTMENTS, LP | 351,126 | +285,021 | $1.9M | +$1.7M | 431.2% |
| DIMENSIONAL FUND ADVISORS LP | 490,472 | +145,309 | $2.7M | +$1.6M | 42.1% |
| AMERICAN CENTURY COMPANIES INC | 288,535 | +249,979 | $1.6M | +$1.5M | 648.4% |
| Nuveen, LLC | 545,286 | +38,076 | $3.0M | +$1.3M | 7.5% |
| WELLS FARGO & COMPANY/MN | 305,086 | +159,988 | $1.7M | +$1.2M | 110.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,675 | +184,133 | $1.5M | +$1.2M | 220.4% |
| Rafferty Asset Management, LLC | 344,784 | +104,999 | $1.9M | +$1.1M | 43.8% |
| Voya Investment Management LLC | 218,185 | +181,685 | $1.2M | +$1.1M | 497.8% |
| VICTORY CAPITAL MANAGEMENT INC | 195,764 | +170,164 | $1.1M | +$993.0K | 664.7% |
| WEXFORD CAPITAL LP | 180,853 | +177,353 | $994.7K | +$983.2K | 5067.2% |
| BNP PARIBAS ARBITRAGE, SNC | 172,482 | +126,448 | $948.7K | +$798.1K | 274.7% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,580 | +128,207 | $762.2K | +$728.3K | 1236.0% |
| Legal & General Group Plc | 133,146 | +109,997 | $732.3K | +$656.6K | 475.2% |
| PROFUND ADVISORS LLC | 128,590 | +75,224 | $707.2K | +$532.7K | 140.9% |
| Militia Capital Partners, LP | 159,800 | +93,000 | $729.9K | +$511.5K | 139.2% |
| DEUTSCHE BANK AG\ | 160,779 | +37,980 | $884.3K | +$482.7K | 30.9% |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,178 | +70,229 | $622.5K | +$482.0K | 163.5% |
| Privium Fund Management B.V. | 164,900 | +30,000 | $907.0K | +$465.8K | 22.2% |
| Palumbo Wealth Management LLC | 178,007 | +20,654 | $979.0K | +$464.5K | 13.1% |
| AQR CAPITAL MANAGEMENT LLC | 168,862 | +17,862 | $928.7K | +$435.0K | 11.8% |
| PRUDENTIAL FINANCIAL INC | 86,730 | +58,385 | $477.0K | +$384.3K | 206.0% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 122,639 | +11,615 | $677.7K | +$316.0K | 10.5% |
| GROUP ONE TRADING, L.P. | 44,195 | +42,441 | $243.1K | +$237.3K | 2419.7% |
| CITIGROUP INC | 63,015 | +29,520 | $346.6K | +$237.1K | 88.1% |
| Creative Planning | 63,235 | +11,009 | $347.8K | +$177.0K | 21.1% |
| INTECH INVESTMENT MANAGEMENT LLC | 71,069 | +2,443 | $390.9K | +$166.5K | 3.5% |
| FIRST MANHATTAN CO | 43,500 | +15,000 | $239.3K | +$146.1K | 52.6% |
| ProShare Advisors LLC | 52,463 | +6,424 | $288.5K | +$138.0K | 13.9% |
| Virtus Investment Advisers, Inc. | 45,946 | +3,008 | $252.7K | +$112.3K | 7.0% |
| SIMPLEX TRADING, LLC | 19,782 | +17,060 | $108.8K | +$108.8K | 626.7% |
| Allegheny Financial Group LTD | 26,350 | +11,350 | $144.9K | +$95.9K | 75.7% |
| Cetera Investment Advisers | 21,154 | +4,992 | $116.3K | +$63.5K | 30.9% |
| Ameritas Investment Partners, Inc. | 17,672 | +2,000 | $97.2K | +$45.9K | 12.8% |
| Chicago Partners Investment Group LLC | 166,541 | +2,504 | $776.1K | -$42.5K | 1.5% |
| XPONANCE, INC. | 17,218 | +643 | $94.7K | +$40.5K | 3.9% |
| Mirae Asset Global Investments Co., Ltd. | 13,311 | +2,765 | $73.2K | +$38.7K | 26.2% |
| MACKENZIE FINANCIAL CORP | 13,308 | +2,094 | $75.2K | +$38.5K | 18.7% |
| Caitong International Asset Management Co., Ltd | 7,811 | +4,607 | $43.0K | +$32.5K | 143.8% |
| BANK OF MONTREAL /CAN/ | 13,708 | +40 | $75.4K | +$30.7K | 0.3% |
| Sterling Capital Management LLC | 1,411 | +896 | $7.8K | +$6.1K | 174.0% |
| SG Americas Securities, LLC | 781,474 | +748,525 | $4.3K | +$4.2K | 2271.8% |
| ADVISOR GROUP HOLDINGS, INC. | 277 | +143 | $1.5K | +$1.1K | 106.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121,814 | +7,979 | $670 | +$297 | 7.0% |
| CWM, LLC | 13,093 | +208 | $72 | +$30 | 1.6% |
| AMALGAMATED BANK | 6,939 | +1,405 | $38 | +$20 | 25.4% |
Reduced(66)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | 0 | $129.6M | +$52.5M | 0.0% |
| Avoro Capital Advisors LLC | 21,700,000 | 0 | $119.3M | +$48.4M | 0.0% |
| MORGAN STANLEY | 18,078,518 | -1,229,085 | $99.4M | +$36.3M | -6.4% |
| FMR LLC | 13,528,366 | -1,065,046 | $74.4M | +$26.7M | -7.3% |
| Siren, L.L.C. | 10,129,913 | -884,824 | $55.7M | +$19.7M | -8.0% |
| Octagon Capital Advisors LP | 8,859,911 | -207,589 | $48.7M | +$19.1M | -2.3% |
| BARCLAYS PLC | 450,501 | -4,697,611 | $1.0M | -$15.8M | -91.2% |
| RTW INVESTMENTS, LP | 16,398,297 | -7,955,994 | $90.2M | +$10.6M | -32.7% |
| BAKER BROS. ADVISORS LP | 4,004,756 | 0 | $22.0M | +$8.9M | 0.0% |
| Jefferies Financial Group Inc. | 25,000 | -2,131,642 | $137.5K | -$6.9M | -98.8% |
| ADAR1 Capital Management, LLC | 2,495,809 | -339,871 | $13.7M | +$4.5M | -12.0% |
| B Group, Inc. | 1,800,556 | 0 | $9.9M | +$4.0M | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,328,000 | -2,000,000 | $7.3M | -$3.6M | -60.1% |
| Point72 Asset Management, L.P. | 3,868,682 | -3,462,788 | $21.3M | -$2.7M | -47.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 2,722,165 | -2,663,835 | $15.0M | -$2.6M | -49.5% |
| Palo Alto Investors LP | 1,183,195 | -62,838 | $6.5M | +$2.4M | -5.0% |
| MILLENNIUM MANAGEMENT LLC | 3,178,863 | -1,454,659 | $17.5M | +$2.3M | -31.4% |
| BANK OF AMERICA CORP /DE/ | 1,152,680 | -154,607 | $6.3M | +$2.1M | -11.8% |
| Quantum Private Wealth, LLC | 819,715 | -2,361 | $4.5M | +$1.8M | -0.3% |
| STEMPOINT CAPITAL LP | 182,130 | -657,539 | $1.0M | -$1.7M | -78.3% |
| Sands Capital Ventures, LLC | 724,873 | 0 | $4.0M | +$1.6M | 0.0% |
| Bank of New York Mellon Corp | 624,367 | -472 | $3.4M | +$1.4M | -0.1% |
| NORTHERN TRUST CORP | 1,237,987 | -479,191 | $6.8M | +$1.2M | -27.9% |
| Woodline Partners LP | 500,000 | 0 | $2.8M | +$1.1M | 0.0% |
| Royal Bank of Canada | 6,302 | -490,471 | $34.0K | -$1.1M | -98.7% |
| ACUTA CAPITAL PARTNERS, LLC | 454,827 | 0 | $2.5M | +$1.0M | 0.0% |
| Ally Bridge Group (NY) LLC | 957,132 | -940,980 | $5.3M | -$942.6K | -49.6% |
| SPHERA FUNDS MANAGEMENT LTD. | 368,146 | -40,000 | $2.0M | +$690.2K | -9.8% |
| RHUMBLINE ADVISERS | 257,440 | -31,419 | $1.4M | +$471.4K | -10.9% |
| JANE STREET GROUP, LLC | 265,446 | -304,739 | $1.5M | -$404.6K | -53.4% |
| ALLIANCEBERNSTEIN L.P. | 179,640 | 0 | $988.0K | +$400.6K | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 309,481 | -106,126 | $1.7M | +$343.1K | -25.5% |
| COMMONWEALTH EQUITY SERVICES, LLC | 55,657 | -2,600 | $306.1K | +$305.9K | -4.5% |
| FRANKLIN RESOURCES INC | 108,399 | 0 | $596.2K | +$241.7K | 0.0% |
| Granahan Investment Management, LLC | 703,971 | -412,658 | $3.9M | +$220.5K | -37.0% |
| MetLife Investment Management, LLC | 113,266 | -13,778 | $623.0K | +$207.5K | -10.8% |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,500 | -100 | $371.3K | +$150.2K | -0.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,085 | -2,772 | $369.0K | +$140.5K | -4.0% |
| Police & Firemen's Retirement System of New Jersey | 57,168 | 0 | $314.4K | +$127.5K | 0.0% |
| Williams & Novak, LLC | 45,000 | 0 | $247.5K | +$100.3K | 0.0% |
| China Universal Asset Management Co., Ltd. | 44,635 | -3,182 | $245.5K | +$89.1K | -6.7% |
| AXQ CAPITAL, LP | 37,804 | -11,873 | $207.9K | +$45.5K | -23.9% |
| Lee Financial Co | 20,000 | 0 | $110.0K | +$44.6K | 0.0% |
| Ethic Inc. | 22,735 | -3,049 | $125.0K | +$40.7K | -11.8% |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 57,975 | -22,757 | $304.4K | +$40.4K | -28.2% |
| Russell Investments Group, Ltd. | 16,929 | -1,236 | $93.1K | +$33.7K | -6.8% |
| Capital Investment Advisors, LLC | 10,000 | 0 | $55.0K | +$22.3K | 0.0% |
| ST GERMAIN D J CO INC | 9,633 | 0 | $53.0K | +$21.5K | 0.0% |
| Tower Research Capital LLC (TRC) | 475 | -6,132 | $2.6K | -$19.0K | -92.8% |
| PRINCIPAL FINANCIAL GROUP INC | 12,823 | -3,428 | $70.5K | +$17.4K | -21.1% |
| UBS Group AG | 383,043 | -256,313 | $2.1M | +$16.0K | -40.1% |
| Rockefeller Capital Management L.P. | 5,000 | 0 | $27.5K | +$11.2K | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 5,512 | -360 | $30.3K | +$11.1K | -6.1% |
| GF FUND MANAGEMENT CO. LTD. | 5,383 | -486 | $29.6K | +$10.4K | -8.3% |
| Optiver Holding B.V. | 934 | -1,335 | $5.1K | -$2.3K | -58.8% |
| US BANCORP \DE\ | 912 | 0 | $5.0K | +$2.0K | 0.0% |
| PNC Financial Services Group, Inc. | 1,054 | -254 | $5.8K | +$1.5K | -19.4% |
| Parallel Advisors, LLC | 280 | 0 | $1.5K | +$624 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 208,016 | -269,733 | $1.1K | -$418 | -56.5% |
| EverSource Wealth Advisors, LLC | 91 | 0 | $501 | +$203 | 0.0% |
| Farther Finance Advisors, LLC | 55 | 0 | $303 | +$123 | 0.0% |
| Daiwa Securities Group Inc. | 691 | -21,129 | $4 | -$67 | -96.8% |
| True Wealth Design, LLC | 30 | 0 | $165 | +$66 | 0.0% |
| Cambridge Investment Research Advisors, Inc. | 22,080 | -1,610 | $121 | +$44 | -6.8% |
| SBI Securities Co., Ltd. | 15 | -1 | $83 | +$31 | -6.3% |
| Capital Advisors, Ltd. LLC | 77 | -2 | $12 | +$12 | -2.5% |
Sold Out(23)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | $129.6M | 0 | 0.0% |
| Avoro Capital Advisors LLC | 21,700,000 | $119.3M | 0 | 0.0% |
| BlackRock, Inc. | 18,643,129 | $102.5M | +2,278,268 | 13.9% |
| MORGAN STANLEY | 18,078,518 | $99.4M | -1,229,085 | -6.4% |
| RTW INVESTMENTS, LP | 16,398,297 | $90.2M | -7,955,994 | -32.7% |
| Vestal Point Capital, LP | 13,750,000 | $75.6M | +8,250,000 | 150.0% |
| GOLDMAN SACHS GROUP INC | 13,692,739 | $75.3M | +309,031 | 2.3% |
| FMR LLC | 13,528,366 | $74.4M | -1,065,046 | -7.3% |
| VANGUARD GROUP INC | 13,267,805 | $73.0M | +418,192 | 3.3% |
| STATE STREET CORP | 10,790,084 | $59.3M | +3,553,619 | 49.1% |
| Siren, L.L.C. | 10,129,913 | $55.7M | -884,824 | -8.0% |
| Octagon Capital Advisors LP | 8,859,911 | $48.7M | -207,589 | -2.3% |
| Polar Capital Holdings Plc | 7,931,403 | $43.6M | +2,637,524 | 49.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,387,026 | $29.6M | +212,510 | 4.1% |
| D. E. Shaw & Co., Inc. | 4,013,635 | $22.1M | +1,307,201 | 48.3% |
| BAKER BROS. ADVISORS LP | 4,004,756 | $22.0M | 0 | 0.0% |
| Point72 Asset Management, L.P. | 3,868,682 | $21.3M | -3,462,788 | -47.2% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3,722,000 | $20.5M | +3,722,000 | — |
| Affinity Asset Advisors, LLC | 3,300,000 | $18.1M | +300,000 | 10.0% |
| MILLENNIUM MANAGEMENT LLC | 3,178,863 | $17.5M | -1,454,659 | -31.4% |
New & Closed Positions this quarter
Closed Positions
23 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for TSHA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.