New Positions
118 managers initiated
Top five by reported value
Praxis Precision Medicines Inc NASDAQ NMS - GLOBAL MARKET:PRAX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
118 new87 added51 reduced16 exited
Total Institutional Holders
255
as of 2025-12-31
Top Holder
JANUS HENDERSON GROUP PLC
$954.8M
Largest QoQ Increase
FMR LLC
+1,315,464 sh
Largest QoQ Decrease
ADAGE CAPITAL PARTNERS GP, L.L.C.
-1,408,772 sh
New Positions(118)
Added To(87)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,240,086 | +476,227 | $954.8M | +$808.4M | 17.2% |
| BlackRock, Inc. | 2,078,500 | +277,420 | $612.6M | +$517.2M | 15.4% |
| PERCEPTIVE ADVISORS LLC | 1,995,986 | +431,432 | $588.3M | +$505.4M | 27.6% |
| FMR LLC | 1,358,675 | +1,315,464 | $400.5M | +$398.2M | 3044.3% |
| VANGUARD GROUP INC | 1,460,933 | +193,647 | $430.6M | +$363.4M | 15.3% |
| BAKER BROS. ADVISORS LP | 1,126,488 | +437,000 | $332.0M | +$295.5M | 63.4% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,061 | +432,510 | $275.0M | +$248.5M | 86.4% |
| MORGAN STANLEY | 889,889 | +246,394 | $262.3M | +$228.2M | 38.3% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 903,351 | +62,500 | $266.3M | +$221.7M | 7.4% |
| GOLDMAN SACHS GROUP INC | 716,184 | +123,163 | $211.1M | +$179.7M | 20.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 562,379 | +105,347 | $165.8M | +$141.6M | 23.1% |
| BANK OF AMERICA CORP /DE/ | 522,763 | +39,902 | $154.1M | +$128.5M | 8.3% |
| Logos Global Management LP | 375,000 | +250,000 | $110.5M | +$103.9M | 200.0% |
| FRANKLIN RESOURCES INC | 356,074 | +41,917 | $104.9M | +$88.3M | 13.3% |
| Vivo Capital, LLC | 328,895 | +130,000 | $96.9M | +$86.4M | 65.4% |
| Caption Management, LLC | 243,300 | +49,943 | $71.7M | +$61.5M | 25.8% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 224,343 | +12,006 | $66.1M | +$54.9M | 5.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,301 | +36,640 | $58.4M | +$49.9M | 22.7% |
| WELLINGTON MANAGEMENT GROUP LLP | 176,562 | +115,321 | $52.0M | +$48.8M | 188.3% |
| NORTHERN TRUST CORP | 192,284 | +23,931 | $56.7M | +$47.8M | 14.2% |
| Qube Research & Technologies Ltd | 168,897 | +111,593 | $49.8M | +$46.7M | 194.7% |
| CITADEL ADVISORS LLC | 139,117 | +94,819 | $41.0M | +$38.7M | 214.0% |
| JANE STREET GROUP, LLC | 122,500 | +62,313 | $36.1M | +$32.9M | 103.5% |
| Candriam S.C.A. | 110,590 | +47,724 | $32.6M | +$29.3M | 75.9% |
| FIRST TRUST ADVISORS LP | 88,704 | +59,738 | $26.1M | +$24.6M | 206.2% |
| DIADEMA PARTNERS LP | 100,600 | +600 | $29.7M | +$24.4M | 0.6% |
| ACUTA CAPITAL PARTNERS, LLC | 83,036 | +33,285 | $24.5M | +$21.8M | 66.9% |
| Invesco Ltd. | 77,088 | +56,220 | $22.7M | +$21.6M | 269.4% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 82,465 | +31,255 | $24.3M | +$21.6M | 61.0% |
| AMERICAN CENTURY COMPANIES INC | 75,366 | +60,098 | $22.2M | +$21.4M | 393.6% |
| Bank of New York Mellon Corp | 77,897 | +21,609 | $23.0M | +$20.0M | 38.4% |
| MARSHALL WACE, LLP | 69,242 | +1,101 | $20.4M | +$16.8M | 1.6% |
| JPMORGAN CHASE & CO | 55,300 | +29,092 | $16.3M | +$14.9M | 111.0% |
| DEUTSCHE BANK AG\ | 50,811 | +36,955 | $15.0M | +$14.2M | 266.7% |
| D. E. Shaw & Co., Inc. | 47,481 | +27,685 | $14.0M | +$12.9M | 139.8% |
| Nuveen, LLC | 49,970 | +11,421 | $14.7M | +$12.7M | 29.6% |
| TD Asset Management Inc | 46,146 | +5,262 | $13.6M | +$11.4M | 12.9% |
| SummitTX Capital, L.P. | 41,629 | +6,701 | $12.3M | +$10.4M | 19.2% |
| Swiss National Bank | 40,500 | +5,000 | $11.9M | +$10.1M | 14.1% |
| UBS ASSET MANAGEMENT AMERICAS INC | 35,288 | +11,532 | $10.4M | +$9.1M | 48.5% |
| B Group, Inc. | 33,237 | +1,737 | $9.8M | +$8.1M | 5.5% |
| CONGRESS ASSET MANAGEMENT CO /MA | 31,246 | +807 | $9.2M | +$7.6M | 2.6% |
| AQR CAPITAL MANAGEMENT LLC | 28,828 | +6,924 | $8.5M | +$7.3M | 31.6% |
| RHUMBLINE ADVISERS | 28,324 | +1,530 | $8.3M | +$6.9M | 5.7% |
| WELLS FARGO & COMPANY/MN | 25,235 | +11,630 | $7.4M | +$6.7M | 85.5% |
| TWO SIGMA INVESTMENTS, LP | 23,098 | +17,590 | $6.8M | +$6.5M | 319.4% |
| ALLIANCEBERNSTEIN L.P. | 25,070 | +7,010 | $7.4M | +$6.4M | 38.8% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,559 | +2,723 | $7.5M | +$6.3M | 11.9% |
| Russell Investments Group, Ltd. | 20,612 | +16,208 | $6.1M | +$5.8M | 368.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,671 | +1,088 | $5.8M | +$4.8M | 5.8% |
| Legal & General Group Plc | 17,981 | +1,157 | $5.3M | +$4.4M | 6.9% |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,231 | +6,198 | $4.5M | +$4.0M | 68.6% |
| MetLife Investment Management, LLC | 12,424 | +1,904 | $3.7M | +$3.1M | 18.1% |
| MILLENNIUM MANAGEMENT LLC | 11,900 | +3,900 | $3.5M | +$3.1M | 48.8% |
| Creative Planning | 10,843 | +4,183 | $3.2M | +$2.8M | 62.8% |
| INTECH INVESTMENT MANAGEMENT LLC | 8,734 | +980 | $2.6M | +$2.2M | 12.6% |
| PROFUND ADVISORS LLC | 8,455 | +376 | $2.5M | +$2.1M | 4.7% |
| NISA INVESTMENT ADVISORS, LLC | 7,770 | +641 | $2.3M | +$1.9M | 9.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | +700 | $2.2M | +$1.8M | 10.6% |
| Police & Firemen's Retirement System of New Jersey | 6,057 | +1,142 | $1.8M | +$1.5M | 23.2% |
| CITIGROUP INC | 5,586 | +2,779 | $1.6M | +$1.5M | 99.0% |
| Arizona State Retirement System | 5,723 | +306 | $1.7M | +$1.4M | 5.6% |
| ProShare Advisors LLC | 5,214 | +1,388 | $1.5M | +$1.3M | 36.3% |
| China Universal Asset Management Co., Ltd. | 4,875 | +1,186 | $1.4M | +$1.2M | 32.1% |
| BNP PARIBAS ARBITRAGE, SNC | 4,626 | +241 | $1.4M | +$1.1M | 5.5% |
| KLP KAPITALFORVALTNING AS | 4,400 | +400 | $1.3M | +$1.1M | 10.0% |
| Coastal Bridge Advisors, LLC | 4,154 | +308 | $1.2M | +$1.0M | 8.0% |
| US BANCORP \DE\ | 1,825 | +1,713 | $537.9K | +$532.0K | 1529.5% |
| Ameritas Investment Partners, Inc. | 1,866 | +347 | $550.0K | +$469.5K | 22.8% |
| BARCLAYS PLC | 88,724 | +12,087 | $3.7M | -$330.9K | 15.8% |
| Mirae Asset Global Investments Co., Ltd. | 1,215 | +401 | $358.1K | +$315.0K | 49.3% |
| Sterling Capital Management LLC | 1,211 | +65 | $356.9K | +$296.2K | 5.7% |
| PNC Financial Services Group, Inc. | 714 | +690 | $210.4K | +$209.2K | 2875.0% |
| GF FUND MANAGEMENT CO. LTD. | 490 | +37 | $144.4K | +$120.4K | 8.2% |
| Farther Finance Advisors, LLC | 368 | +138 | $108.5K | +$96.3K | 60.0% |
| GAMMA Investing LLC | 238 | +88 | $70.1K | +$62.2K | 58.7% |
| Larson Financial Group LLC | 90 | +19 | $26.5K | +$22.8K | 26.8% |
| ADVISOR GROUP HOLDINGS, INC. | 83 | +3 | $24.5K | +$20.3K | 3.8% |
| Rockefeller Capital Management L.P. | 64 | +62 | $18.9K | +$18.8K | 3100.0% |
| ROTHSCHILD INVESTMENT LLC | 50 | +5 | $14.7K | +$12.4K | 11.1% |
| EverSource Wealth Advisors, LLC | 25 | +7 | $7.4K | +$6.4K | 38.9% |
| Parkside Financial Bank & Trust | 14 | +4 | $4.1K | +$3.6K | 40.0% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 2,390 | +2,173 | $704 | +$692 | 1001.4% |
| CWM, LLC | 874 | +117 | $258 | +$218 | 15.4% |
| AMALGAMATED BANK | 708 | +109 | $209 | +$177 | 18.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 279 | +116 | $82 | +$73 | 71.2% |
| Daiwa Securities Group Inc. | 72 | +10 | $21 | +$18 | 16.1% |
Reduced(51)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 950,000 | -50,000 | $280.0M | +$227.0M | -5.0% |
| Point72 Asset Management, L.P. | 992,346 | -503,640 | $292.5M | +$213.2M | -33.7% |
| STATE STREET CORP | 882,215 | -24,893 | $260.0M | +$211.9M | -2.7% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 965,313 | -1,408,772 | $284.5M | +$158.7M | -59.3% |
| Assenagon Asset Management S.A. | 408,787 | -992 | $120.5M | +$98.8M | -0.2% |
| Soleus Capital Management, L.P. | 362,966 | -496,200 | $107.0M | +$61.4M | -57.8% |
| Sofinnova Investments, Inc. | 125,722 | -47,111 | $37.1M | +$27.9M | -27.3% |
| Velan Capital Investment Management LP | 100,781 | -32,024 | $29.7M | +$22.7M | -24.1% |
| UBS Group AG | 89,200 | -7,612 | $26.3M | +$21.2M | -7.9% |
| CIBC Asset Management Inc | 900 | -387,859 | $265.3K | -$20.3M | -99.8% |
| Ikarian Capital, LLC | 86,581 | -41,990 | $25.5M | +$18.7M | -32.6% |
| 72 Investment Holdings, LLC | 65,933 | 0 | $19.4M | +$15.9M | 0.0% |
| Alyeska Investment Group, L.P. | 74,376 | -67,140 | $21.9M | +$14.4M | -47.4% |
| Exome Asset Management LLC | 58,122 | -43,874 | $17.1M | +$11.7M | -43.0% |
| Woodline Partners LP | 105,412 | -312,257 | $31.1M | +$8.9M | -74.8% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,291 | -2,538 | $9.9M | +$8.0M | -7.1% |
| SPHERA FUNDS MANAGEMENT LTD. | 40,000 | -67,901 | $11.8M | +$6.1M | -62.9% |
| PFM Health Sciences, LP | 31,163 | -29,415 | $9.2M | +$6.0M | -48.5% |
| Susquehanna Portfolio Strategies, LLC | 23,251 | 0 | $6.9M | +$5.6M | 0.0% |
| READYSTATE ASSET MANAGEMENT LP | 36,792 | -72,385 | $10.8M | +$5.1M | -66.3% |
| DIMENSIONAL FUND ADVISORS LP | 23,543 | -13,871 | $6.9M | +$5.0M | -37.1% |
| Rafferty Asset Management, LLC | 22,240 | -15,333 | $6.6M | +$4.6M | -40.8% |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,038 | -12,064 | $4.7M | +$3.2M | -42.9% |
| HighVista Strategies LLC | 25,841 | -69,161 | $7.6M | +$2.6M | -72.8% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,140 | -3,758 | $3.0M | +$2.3M | -27.0% |
| Trexquant Investment LP | 8,331 | -574 | $2.5M | +$2.0M | -6.4% |
| HUSSMAN STRATEGIC ADVISORS, INC. | 8,400 | -2,100 | $2.5M | +$1.9M | -20.0% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 5,806 | -619 | $1.7M | +$1.4M | -9.6% |
| Y-Intercept (Hong Kong) Ltd | 1,856 | -30,330 | $547.0K | -$1.2M | -94.2% |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,974 | -75,086 | $6.2M | +$1.1M | -78.2% |
| Lion Point Capital, LP | 4,450 | -1,250 | $1.3M | +$1.0M | -21.9% |
| NORGES BANK | 4,354 | -646 | $1.3M | +$995.6K | -12.9% |
| Cerity Partners LLC | 3,927 | -1,523 | $1.2M | +$868.6K | -27.9% |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 3,500 | -400 | $1.0M | +$824.9K | -10.3% |
| GROUP ONE TRADING, L.P. | 5,539 | -11,089 | $1.6M | +$751.3K | -66.7% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 3,053 | -1,416 | $899.8K | +$663.0K | -31.7% |
| Ally Bridge Group (NY) LLC | 19,882 | -80,118 | $5.9M | +$560.0K | -80.1% |
| AlphaQuest LLC | 1,075 | -924 | $316.8K | +$210.9K | -46.2% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 785,987 | -217,503 | $231.7K | +$178.5K | -21.7% |
| Virtus Investment Advisers, Inc. | 989 | -1,538 | $291.5K | +$157.6K | -60.9% |
| Quarry LP | 4,000 | -16,001 | $1.2M | +$118.9K | -80.0% |
| Tower Research Capital LLC (TRC) | 611 | -1,516 | $180.1K | +$67.4K | -71.3% |
| Royal Bank of Canada | 3,378 | -19,323 | $995.0K | +$41.0K | -85.1% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 98 | 0 | $28.9K | +$23.7K | 0.0% |
| SBI Securities Co., Ltd. | 74 | -9 | $21.8K | +$17.4K | -10.8% |
| ALGERT GLOBAL LLC | 80,640 | -80,178 | $23.8K | +$15.2K | -49.9% |
| SRS Capital Advisors, Inc. | 64 | -88 | $18.9K | +$10.8K | -57.9% |
| Optiver Holding B.V. | 60 | -80 | $17.7K | +$10.3K | -57.1% |
| SG Americas Securities, LLC | 9,965 | -3,531 | $2.9K | +$2.2K | -26.2% |
| Covestor Ltd | 2 | 0 | $1 | +$1 | 0.0% |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | $0 | $0 | — |
Sold Out(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 0 | -170,000 | $0 | -$9.0M | — |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | -76,218 | $0 | -$4.0M | — |
| Tri Locum Partners LP | 0 | -75,986 | $0 | -$4.0M | — |
| Jefferies Financial Group Inc. | 0 | -29,000 | $0 | -$1.5M | — |
| Knott David M Jr | 0 | -28,000 | $0 | -$1.5M | — |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | -21,684 | $0 | -$1.1M | — |
| PCG Wealth Advisors, LLC | 0 | -14,483 | $0 | -$767.6K | — |
| Phoenix Holdings Ltd. | 0 | -13,634 | $0 | -$723.0K | — |
| HSBC HOLDINGS PLC | 0 | -11,172 | $0 | -$594.7K | — |
| ALPS ADVISORS INC | 0 | -10,424 | $0 | -$552.5K | — |
| Freestone Grove Partners LP | 0 | -8,269 | $0 | -$438.3K | — |
| CLEAR STREET MARKETS LLC | 0 | -164 | $0 | -$8.7K | — |
| SIMPLEX TRADING, LLC | 0 | -22,529 | $0 | -$1.2K | — |
| FSA Wealth Management LLC | 0 | -21 | $0 | -$1.1K | — |
| GSA CAPITAL PARTNERS LLP | 0 | -5,740 | $0 | -$304 | — |
| Hemington Wealth Management | 0 | -30 | $0 | -$1 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,240,086 | $954.8M | +476,227 | 17.2% |
| BlackRock, Inc. | 2,078,500 | $612.6M | +277,420 | 15.4% |
| PERCEPTIVE ADVISORS LLC | 1,995,986 | $588.3M | +431,432 | 27.6% |
| VANGUARD GROUP INC | 1,460,933 | $430.6M | +193,647 | 15.3% |
| FMR LLC | 1,358,675 | $400.5M | +1,315,464 | 3044.3% |
| Orbis Allan Gray Ltd | 1,255,162 | $369.9M | +1,255,162 | — |
| BAKER BROS. ADVISORS LP | 1,126,488 | $332.0M | +437,000 | 63.4% |
| Point72 Asset Management, L.P. | 992,346 | $292.5M | -503,640 | -33.7% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 965,313 | $284.5M | -1,408,772 | -59.3% |
| Cormorant Asset Management, LP | 950,000 | $280.0M | -50,000 | -5.0% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,061 | $275.0M | +432,510 | 86.4% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 903,351 | $266.3M | +62,500 | 7.4% |
| MORGAN STANLEY | 889,889 | $262.3M | +246,394 | 38.3% |
| STATE STREET CORP | 882,215 | $260.0M | -24,893 | -2.7% |
| GOLDMAN SACHS GROUP INC | 716,184 | $211.1M | +123,163 | 20.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 562,379 | $165.8M | +105,347 | 23.1% |
| BANK OF AMERICA CORP /DE/ | 522,763 | $154.1M | +39,902 | 8.3% |
| Assenagon Asset Management S.A. | 408,787 | $120.5M | -992 | -0.2% |
| Logos Global Management LP | 375,000 | $110.5M | +250,000 | 200.0% |
| RA CAPITAL MANAGEMENT, L.P. | 373,787 | $110.2M | +373,787 | — |
New & Closed Positions this quarter
Closed Positions
16 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PRAX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.