Institutional Manager · CIK 0001799883
5AM Venture Management, LLC
SAN FRANCISCO, CA · File #028-19757
Latest AUM
$318.1M
Positions
21
Top-10 Concentration
73.5%
Filings
9
Portfolio Value Over Time
2024-03
2024-06
2024-09
2024-12
2025-03
2025-06
2025-09
2025-12
Biggest QoQ Changes
Ranked by conviction flow (share change × current price) so mark-to-market moves don't dominate. Price effect column shows how much of the $ change was just the stock moving.
| Action | Issuer | Ticker / CUSIP | Δ Shares | Flow ($) | Price Effect |
|---|---|---|---|---|---|
| NEW | MAPLIGHT THERAPEUTICS INC | MPLT | +950,011 | +$16.7M | $0 |
| EXITED | DIANTHUS THERAPEUTICS INC | 252828108 | -365,053 | -$14.4M | $0 |
| EXITED | PRAXIS PRECISION MEDICINES I | 74006W207 | -170,000 | -$9.0M | $0 |
| ADD | ZENTALIS PHARMACEUTICALS INC | ZNTL | +3,457,913 | +$4.7M | -$78,400 |
| ADD | PROTARA THERAPEUTICS INC | TARA | +569,782 | +$3.0M | +$784,000 |
| EXITED | ALECTOR INC | 014442107 | -995,841 | -$2.9M | $0 |
| ADD | BIOHAVEN LTD | BHVN | +260,000 | +$2.9M | -$1.8M |
| REDUCE | CENTESSA PHARMACEUTICALS PLC | CNTA | -100,000 | -$2.5M | +$517,518 |
| EXITED | ADVERUM BIOTECHNOLOGIES INC | 00773U207 | -541,666 | -$2.5M | $0 |
| ADD | TYRA BIOSCIENCES INC | TYRA | +90,000 | +$2.4M | +$11.6M |
Sector Allocation
Filing History
- 13F HOLDINGS REPORTQ/E Dec 202521 pos · $318.1M
- 13F HOLDINGS REPORTQ/E Sep 202525 pos · $273.0M
- 13F HOLDINGS REPORTQ/E Jun 202529 pos · $260.1M
- 13F HOLDINGS REPORTQ/E Mar 202531 pos · $264.4M
- 13F HOLDINGS REPORTQ/E Dec 202431 pos · $419.1M
- 13F HOLDINGS REPORTQ/E Sep 202428 pos · $484.0M
- 13F HOLDINGS REPORTQ/E Jun 202428 pos · $447.1M
- 13F HOLDINGS REPORTQ/E Mar 202426 pos · $446.6M
- 13F HOLDINGS REPORTQ/E Dec 202326 pos · $347.5M
Top 20 Holdings — Dec 2025
| # | Issuer | Ticker | Shares | Value | % of Portfolio |
|---|---|---|---|---|---|
| 1 | ENTRADA THERAPEUTICS INC | TRDA | 4,056,379 | $41.7M | 13.11% |
| 2 | CAMP4 THERAPEUTICS CORP | CAMP | 5,869,091 | $36.0M | 11.31% |
| 3 | TYRA BIOSCIENCES INC | TYRA | 1,029,298 | $27.1M | 8.51% |
| 4 | VIRIDIAN THERAPEUTICS INC | VRDN | 736,595 | $22.9M | 7.21% |
| 5 | PHARVARIS N V | PHVS | 797,600 | $22.1M | 6.96% |
| 6 | ERASCA INC | ERAS | 5,405,404 | $20.1M | 6.32% |
| 7 | EYEPOINT INC | EYPT | 1,050,000 | $19.2M | 6.03% |
| 8 | MAPLIGHT THERAPEUTICS INC | MPLT | 950,011 | $16.7M | 5.25% |
| 9 | CENTESSA PHARMACEUTICALS PLC | CNTA | 580,945 | $14.5M | 4.57% |
| 10 | CELLDEX THERAPEUTICS INC NEW | CLDX | 497,270 | $13.5M | 4.25% |
| 11 | TECTONIC THERAPEUTIC INC | TECX | 606,660 | $12.7M | 3.98% |
| 12 | ENLIVEN THERAPEUTICS INC | ELVN | 772,477 | $11.9M | 3.74% |
| 13 | ARTIVA BIOTHERAPEUTICS INC | ARTV | 2,353,304 | $10.1M | 3.17% |
| 14 | SURROZEN INC | SRZNW | 387,500 | $8.8M | 2.75% |
| 15 | BIOHAVEN LTD | BHVN | 738,972 | $8.3M | 2.62% |
| 16 | PROTARA THERAPEUTICS INC | TARA | 1,369,782 | $7.3M | 2.30% |
| 17 | GH RESEARCH PLC | GHRS | 572,665 | $7.3M | 2.29% |
| 18 | SKYE BIOSCIENCE INC | SKYE | 9,681,763 | $7.3M | 2.28% |
| 19 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 3,947,913 | $5.3M | 1.68% |
| 20 | SILENCE THERAPEUTICS PLC | SLNCF | 476,200 | $2.9M | 0.91% |