CUSIP 02083G100
ALPINE IMMUNE SCIENCES INC
192 institutions · $2.44B total · 74,177,479 shares
| # | Manager | Shares | Value | % of Total | Period |
|---|---|---|---|---|---|
| 1 | Decheng Capital LLC | 8,317,924 | $329.7M | 11.21% | 2024-03-31 |
| 2 | Avoro Capital Advisors LLC | 5,775,000 | $228.9M | 7.78% | 2024-03-31 |
| 3 | Frazier Life Sciences Management, L.P. | 3,131,008 | $124.1M | 4.22% | 2024-03-31 |
| 4 | STATE STREET CORP | 2,845,839 | $112.8M | 3.83% | 2024-03-31 |
| 5 | Cormorant Asset Management, LP | 2,700,000 | $107.0M | 3.63% | 2024-03-31 |
| 6 | ORBIMED ADVISORS LLC | 2,680,496 | $106.3M | 3.61% | 2024-03-31 |
| 7 | VANGUARD GROUP INC | 2,624,251 | $104.0M | 3.53% | 2024-03-31 |
| 8 | Lynx1 Capital Management LP | 2,253,183 | $89.3M | 3.03% | 2024-03-31 |
| 9 | Paradigm Biocapital Advisors LP | 2,121,163 | $84.1M | 2.85% | 2024-03-31 |
| 10 | Darwin Global Management, Ltd. | 1,982,016 | $78.6M | 2.67% | 2024-03-31 |
| 11 | Decheng Capital Management III (Cayman), LLC | 6,708,288 | $76.8M | 9.04% | 2023-12-31 |
| 12 | BlackRock Inc. | 1,828,367 | $72.5M | 2.46% | 2024-03-31 |
| 13 | Commodore Capital LP | 1,375,000 | $54.5M | 1.85% | 2024-03-31 |
| 14 | RA CAPITAL MANAGEMENT, L.P. | 4,691,178 | $53.7M | 6.32% | 2023-12-31 |
| 15 | Octagon Capital Advisors LP | 1,241,300 | $49.2M | 1.67% | 2024-03-31 |
| 16 | Avidity Partners Management LP | 1,174,700 | $46.6M | 1.58% | 2024-03-31 |
| 17 | GREAT POINT PARTNERS LLC | 1,128,499 | $44.7M | 1.52% | 2024-03-31 |
| 18 | FRANKLIN RESOURCES INC | 1,093,203 | $43.3M | 1.47% | 2024-03-31 |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 910,599 | $36.1M | 1.22% | 2024-03-31 |
| 20 | TWO SIGMA ADVISERS, LP | 668,775 | $26.5M | 0.90% | 2024-03-31 |
| 21 | MORGAN STANLEY | 642,991 | $25.5M | 0.86% | 2024-09-30 |
| 22 | Vivo Capital, LLC | 520,505 | $20.8M | 0.70% | 2024-03-31 |
| 23 | TWO SIGMA INVESTMENTS, LP | 519,971 | $20.6M | 0.70% | 2024-03-31 |
| 24 | First Light Asset Management, LLC | 501,243 | $19.9M | 0.67% | 2024-03-31 |
| 25 | JANUS HENDERSON GROUP PLC | 433,021 | $17.1M | 0.58% | 2024-03-31 |
| 26 | D. E. Shaw & Co., Inc. | 428,555 | $17.0M | 0.57% | 2024-03-31 |
| 27 | Candriam S.C.A. | 415,000 | $16.5M | 0.55% | 2024-03-31 |
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 408,542 | $16.2M | 0.55% | 2024-03-31 |
| 29 | Artal Group S.A. | 405,784 | $16.1M | 0.54% | 2024-03-31 |
| 30 | Balyasny Asset Management L.P. | 372,995 | $14.8M | 0.50% | 2024-03-31 |
| 31 | Vestal Point Capital, LP | 350,000 | $13.9M | 0.47% | 2024-03-31 |
| 32 | Nuveen Asset Management, LLC | 342,494 | $13.6M | 0.46% | 2024-03-31 |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 339,142 | $13.4M | 0.45% | 2024-03-31 |
| 34 | NORTHERN TRUST CORP | 316,301 | $12.5M | 0.42% | 2024-03-31 |
| 35 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 310,000 | $12.3M | 0.41% | 2024-03-31 |
| 36 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 267,232 | $10.6M | 0.36% | 2024-03-31 |
| 37 | Nan Fung Group Holdings Ltd | 263,940 | $10.5M | 0.35% | 2024-03-31 |
| 38 | Ikarian Capital, LLC | 261,365 | $10.4M | 0.35% | 2024-03-31 |
| 39 | Invesco Ltd. | 257,475 | $10.2M | 0.34% | 2024-03-31 |
| 40 | Woodline Partners LP | 254,334 | $10.1M | 0.34% | 2024-03-31 |
| 41 | FMR LLC | 238,561 | $9.5M | 0.32% | 2024-03-31 |
| 42 | Rafferty Asset Management, LLC | 234,625 | $9.3M | 0.31% | 2024-03-31 |
| 43 | Integral Health Asset Management, LLC | 230,000 | $9.1M | 0.31% | 2024-03-31 |
| 44 | CITIGROUP INC | 207,488 | $8.2M | 0.27% | 2024-03-31 |
| 45 | Walleye Capital LLC | 206,104 | $8.2M | 0.27% | 2024-03-31 |
| 46 | SILVERARC CAPITAL MANAGEMENT, LLC | 199,020 | $7.9M | 0.26% | 2024-03-31 |
| 47 | GOLDMAN SACHS GROUP INC | 197,857 | $7.8M | 0.26% | 2024-03-31 |
| 48 | BANK OF AMERICA CORP /DE/ | 193,134 | $7.7M | 0.26% | 2024-03-31 |
| 49 | JENNISON ASSOCIATES LLC | 191,974 | $7.6M | 0.25% | 2024-03-31 |
| 50 | Ghost Tree Capital, LLC | 664,132 | $7.6M | 0.89% | 2023-12-31 |
| 51 | DIMENSIONAL FUND ADVISORS LP | 175,617 | $7.0M | 0.23% | 2024-03-31 |
| 52 | UBS Group AG | 153,468 | $6.1M | 0.20% | 2024-03-31 |
| 53 | Qube Research & Technologies Ltd | 150,315 | $6.0M | 0.20% | 2024-03-31 |
| 54 | Bank of New York Mellon Corp | 148,400 | $5.9M | 0.20% | 2024-03-31 |
| 55 | Ensign Peak Advisors, Inc | 140,043 | $5.6M | 0.18% | 2024-03-31 |
| 56 | FEDERATED HERMES, INC. | 138,981 | $5.5M | 0.18% | 2024-03-31 |
| 57 | Atika Capital Management LLC | 138,290 | $5.5M | 0.18% | 2024-03-31 |
| 58 | WELLINGTON MANAGEMENT GROUP LLP | 134,486 | $5.3M | 0.18% | 2024-03-31 |
| 59 | DEUTSCHE BANK AG\ | 128,519 | $5.1M | 0.17% | 2025-06-30 |
| 60 | JANE STREET GROUP, LLC | 121,234 | $4.8M | 0.16% | 2024-03-31 |
| 61 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,000 | $4.8M | 0.16% | 2024-03-31 |
| 62 | Tri Locum Partners LP | 120,687 | $4.8M | 0.16% | 2024-03-31 |
| 63 | TD Asset Management Inc | 118,418 | $4.7M | 0.15% | 2024-03-31 |
| 64 | Exome Asset Management LLC | 117,000 | $4.6M | 0.15% | 2024-03-31 |
| 65 | Trexquant Investment LP | 115,776 | $4.6M | 0.15% | 2024-03-31 |
| 66 | Point72 Asset Management, L.P. | 110,700 | $4.4M | 0.14% | 2024-03-31 |
| 67 | Hillsdale Investment Management Inc. | 102,400 | $4.1M | 0.13% | 2024-03-31 |
| 68 | CITADEL ADVISORS LLC | 98,428 | $3.9M | 0.13% | 2024-03-31 |
| 69 | Rhenman & Partners Asset Management AB | 85,500 | $3.4M | 0.11% | 2024-03-31 |
| 70 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,868 | $3.3M | 0.11% | 2024-03-31 |
| 71 | BAKER BROS. ADVISORS LP | 81,578 | $3.2M | 0.10% | 2024-03-31 |
| 72 | Altium Capital Management LLC | 77,848 | $3.1M | 0.10% | 2024-03-31 |
| 73 | BNP PARIBAS FINANCIAL MARKETS | 77,784 | $3.1M | 0.10% | 2024-03-31 |
| 74 | Raymond James Financial Services Advisors, Inc. | 76,508 | $3.0M | 0.10% | 2024-03-31 |
| 75 | Informed Momentum Co LLC | 74,899 | $3.0M | 0.10% | 2024-03-31 |
| 76 | BOOTHBAY FUND MANAGEMENT, LLC | 67,972 | $2.7M | 0.09% | 2024-03-31 |
| 77 | Swiss National Bank | 63,500 | $2.5M | 0.08% | 2024-03-31 |
| 78 | RHUMBLINE ADVISERS | 54,543 | $2.2M | 0.07% | 2024-03-31 |
| 79 | Cinctive Capital Management LP | 54,071 | $2.1M | 0.07% | 2024-03-31 |
| 80 | Monashee Investment Management LLC | 52,546 | $2.1M | 0.07% | 2024-03-31 |
| 81 | Artia Global Partners LP | 51,714 | $2.0M | 0.06% | 2024-03-31 |
| 82 | Moody Aldrich Partners LLC | 50,798 | $2.0M | 0.06% | 2024-03-31 |
| 83 | TUDOR INVESTMENT CORP ET AL | 50,729 | $2.0M | 0.06% | 2024-03-31 |
| 84 | Jefferies Financial Group Inc. | 100,152 | $1.9M | 0.13% | 2024-03-31 |
| 85 | ALPS ADVISORS INC | 46,222 | $1.8M | 0.06% | 2024-03-31 |
| 86 | VICTORY CAPITAL MANAGEMENT INC | 45,064 | $1.8M | 0.06% | 2024-03-31 |
| 87 | SPHERA FUNDS MANAGEMENT LTD. | 44,841 | $1.8M | 0.06% | 2024-03-31 |
| 88 | Omega Fund Management, LLC | 153,700 | $1.8M | 0.20% | 2023-12-31 |
| 89 | ALLIANCEBERNSTEIN L.P. | 41,290 | $1.6M | 0.05% | 2024-03-31 |
| 90 | AWM Investment Company, Inc. | 40,000 | $1.6M | 0.05% | 2024-03-31 |
| 91 | ClariVest Asset Management LLC | 38,873 | $1.5M | 0.05% | 2024-03-31 |
| 92 | CAPSTONE INVESTMENT ADVISORS, LLC | 38,212 | $1.5M | 0.05% | 2024-03-31 |
| 93 | PROFUND ADVISORS LLC | 36,372 | $1.4M | 0.04% | 2024-03-31 |
| 94 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,823 | $1.3M | 0.04% | 2024-03-31 |
| 95 | STATE OF WISCONSIN INVESTMENT BOARD | 30,133 | $1.2M | 0.04% | 2024-03-31 |
| 96 | Legal & General Group Plc | 27,260 | $1.1M | 0.03% | 2025-03-31 |
| 97 | PRELUDE CAPITAL MANAGEMENT, LLC | 27,100 | $1.1M | 0.03% | 2024-03-31 |
| 98 | Schonfeld Strategic Advisors LLC | 90,937 | $1.0M | 0.12% | 2023-12-31 |
| 99 | Soleus Capital Management, L.P. | 88,073 | $1.0M | 0.11% | 2023-12-31 |
| 100 | CREDIT SUISSE AG/ | 24,465 | $969.8K | 0.03% | 2024-03-31 |
| 101 | Ziegler Capital Management, LLC | 23,982 | $950.6K | 0.03% | 2024-03-31 |
| 102 | Capula Management Ltd | 23,970 | $950.2K | 0.03% | 2024-03-31 |
| 103 | Driehaus Capital Management LLC | 23,566 | $934.2K | 0.03% | 2024-03-31 |
| 104 | Boston Partners | 23,101 | $915.7K | 0.03% | 2024-03-31 |
| 105 | WEXFORD CAPITAL LP | 23,100 | $915.7K | 0.03% | 2024-03-31 |
| 106 | HighVista Strategies LLC | 22,783 | $903.1K | 0.03% | 2024-03-31 |
| 107 | Atom Investors LP | 22,721 | $900.7K | 0.03% | 2024-03-31 |
| 108 | OPPENHEIMER & CO INC | 21,538 | $853.8K | 0.02% | 2024-03-31 |
| 109 | FIRST TRUST ADVISORS LP | 19,836 | $786.3K | 0.02% | 2024-03-31 |
| 110 | MetLife Investment Management, LLC | 19,701 | $780.9K | 0.02% | 2024-03-31 |
| 111 | AMERICAN INTERNATIONAL GROUP, INC. | 18,949 | $751.1K | 0.02% | 2024-03-31 |
| 112 | Jump Financial, LLC | 38,600 | $735.7K | 0.05% | 2024-09-30 |
| 113 | AQR CAPITAL MANAGEMENT LLC | 18,079 | $716.7K | 0.02% | 2024-03-31 |
| 114 | NEW YORK STATE COMMON RETIREMENT FUND | 17,657 | $699.9K | 0.02% | 2025-09-30 |
| 115 | UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 15,425 | $611.4K | 0.02% | 2024-03-31 |
| 116 | OMERS ADMINISTRATION Corp | 15,400 | $610.5K | 0.02% | 2024-03-31 |
| 117 | JPMORGAN CHASE & CO | 14,959 | $593.0K | 0.02% | 2024-12-31 |
| 118 | Scientech Research LLC | 14,742 | $584.4K | 0.01% | 2024-03-31 |
| 119 | BANK OF MONTREAL /CAN/ | 14,500 | $583.6K | 0.01% | 2024-03-31 |
| 120 | MILLENNIUM MANAGEMENT LLC | 14,438 | $572.3K | 0.01% | 2024-03-31 |
| 121 | HighPoint Advisor Group LLC | 15,190 | $570.0K | 0.02% | 2024-03-31 |
| 122 | Connor, Clark & Lunn Investment Management Ltd. | 13,357 | $529.5K | 0.01% | 2024-03-31 |
| 123 | China Universal Asset Management Co., Ltd. | 12,630 | $500.7K | 0.01% | 2024-03-31 |
| 124 | WELLS FARGO & COMPANY/MN | 12,526 | $496.5K | 0.01% | 2024-03-31 |
| 125 | Voya Investment Management LLC | 12,233 | $484.9K | 0.01% | 2024-12-31 |
| 126 | Western Wealth Management, LLC | 12,070 | $478.5K | 0.01% | 2024-03-31 |
| 127 | ProShare Advisors LLC | 11,502 | $455.9K | 0.01% | 2024-03-31 |
| 128 | SEI INVESTMENTS CO | 11,106 | $440.2K | 0.01% | 2024-03-31 |
| 129 | E Fund Management Co., Ltd. | 11,087 | $439.5K | 0.01% | 2024-03-31 |
| 130 | Mesirow Financial Investment Management, Inc. | 10,058 | $398.7K | 0.01% | 2024-03-31 |
| 131 | Entropy Technologies, LP | 9,688 | $384.0K | 0.01% | 2024-03-31 |
| 132 | SUPERSTRING CAPITAL MANAGEMENT LP | 9,038 | $358.3K | 0.01% | 2024-03-31 |
| 133 | Arizona State Retirement System | 8,849 | $350.8K | 0.01% | 2024-03-31 |
| 134 | Gotham Asset Management, LLC | 8,773 | $347.8K | 0.01% | 2024-03-31 |
| 135 | GTS SECURITIES LLC | 8,499 | $336.9K | 0.01% | 2024-03-31 |
| 136 | Zurcher Kantonalbank (Zurich Cantonalbank) | 8,006 | $317.4K | 0.01% | 2024-03-31 |
| 137 | Belvedere Trading LLC | 7,570 | $300.1K | 0.01% | 2024-03-31 |
| 138 | Mirae Asset Global Investments Co., Ltd. | 7,088 | $281.0K | 0.00% | 2024-03-31 |
| 139 | Allspring Global Investments Holdings, LLC | 6,414 | $254.3K | 0.00% | 2024-03-31 |
| 140 | FARALLON CAPITAL MANAGEMENT LLC | 5,900 | $233.9K | 0.00% | 2024-03-31 |
| 141 | Harvest Investment Services, LLC | 5,887 | $233.4K | 0.00% | 2024-03-31 |
| 142 | GLENMEDE TRUST CO NA | 5,780 | $229.1K | 0.00% | 2024-03-31 |
| 143 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 5,459 | $216.4K | 0.00% | 2024-03-31 |
| 144 | VIRTUS ADVISERS, LLC | 4,591 | $182.0K | 0.00% | 2024-03-31 |
| 145 | MOORE CAPITAL MANAGEMENT, LP | 13,744 | $157.4K | 0.01% | 2023-12-31 |
| 146 | Ameritas Investment Partners, Inc. | 3,835 | $152.0K | 0.00% | 2024-03-31 |
| 147 | US BANCORP \DE\ | 3,106 | $123.1K | 0.00% | 2024-03-31 |
| 148 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,028,258 | $120.0K | 4.08% | 2024-03-31 |
| 149 | Metropolitan Life Insurance Co/NY | 2,027 | $80.3K | 0.00% | 2024-03-31 |
| 150 | EntryPoint Capital, LLC | 1,433 | $56.8K | 0.00% | 2024-03-31 |
| 151 | Aquatic Capital Management LLC | 1,200 | $47.6K | 0.00% | 2024-03-31 |
| 152 | Pacer Advisors, Inc. | 1,095 | $43.4K | 0.00% | 2024-03-31 |
| 153 | BIT Capital GmbH | 6,000 | $43.2K | 0.00% | 2024-12-31 |
| 154 | EcoR1 Capital, LLC | 1,000 | $39.6K | 0.00% | 2024-03-31 |
| 155 | Royal Bank of Canada | 861 | $34.0K | 0.00% | 2024-09-30 |
| 156 | GROUP ONE TRADING LLC | 699 | $27.7K | 0.00% | 2024-03-31 |
| 157 | Russell Investments Group, Ltd. | 680 | $27.0K | 0.00% | 2024-03-31 |
| 158 | Dorsey Wright & Associates | 2,273 | $26.0K | 0.00% | 2023-12-31 |
| 159 | OSAIC HOLDINGS, INC. | 651 | $25.8K | 0.00% | 2024-03-31 |
| 160 | Tower Research Capital LLC (TRC) | 605 | $24.0K | 0.00% | 2024-03-31 |
| 161 | TUCKER ASSET MANAGEMENT LLC | 500 | $19.8K | 0.00% | 2024-06-30 |
| 162 | NewEdge Advisors, LLC | 469 | $18.6K | 0.00% | 2024-03-31 |
| 163 | RENAISSANCE TECHNOLOGIES LLC | 244,981 | $9.7K | 0.33% | 2024-03-31 |
| 164 | BFSG, LLC | 175 | $6.9K | 0.00% | 2024-03-31 |
| 165 | ExodusPoint Capital Management, LP | 171,251 | $6.8K | 0.23% | 2024-03-31 |
| 166 | ALGERT GLOBAL LLC | 108,841 | $4.3K | 0.14% | 2024-03-31 |
| 167 | Handelsbanken Fonder AB | 102,000 | $4.0K | 0.13% | 2024-03-31 |
| 168 | PNC Financial Services Group, Inc. | 54 | $2.1K | 0.00% | 2024-03-31 |
| 169 | BARCLAYS PLC | 49,170 | $1.9K | 0.06% | 2024-03-31 |
| 170 | NISA INVESTMENT ADVISORS, LLC | 45 | $1.8K | 0.00% | 2024-03-31 |
| 171 | GAMMA Investing LLC | 43 | $1.7K | 0.00% | 2024-03-31 |
| 172 | SIMPLEX TRADING, LLC | 21,123 | $837 | 0.02% | 2024-03-31 |
| 173 | Farther Finance Advisors, LLC | 20 | $804 | 0.00% | 2024-03-31 |
| 174 | Banque Cantonale Vaudoise | 20,129 | $798 | 0.02% | 2024-03-31 |
| 175 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 18,982 | $752 | 0.02% | 2024-03-31 |
| 176 | CHARTWELL INVESTMENT PARTNERS, LLC | 18,753 | $743 | 0.02% | 2024-03-31 |
| 177 | Riggs Asset Managment Co. Inc. | 16 | $635 | 0.00% | 2024-03-31 |
| 178 | Virtu Financial LLC | 14,813 | $587 | 0.01% | 2024-03-31 |
| 179 | Hikari Power Ltd | 12,445 | $493 | 0.01% | 2024-03-31 |
| 180 | LAZARD ASSET MANAGEMENT LLC | 7,518 | $298 | 0.01% | 2024-06-30 |
| 181 | TEACHER RETIREMENT SYSTEM OF TEXAS | 7,165 | $284 | 0.00% | 2024-03-31 |
| 182 | COMMONWEALTH EQUITY SERVICES, LLC | 6,210 | $246 | 0.00% | 2024-03-31 |
| 183 | PRINCIPAL SECURITIES, INC. | 6 | $238 | 0.00% | 2024-03-31 |
| 184 | Avior Wealth Management, LLC | 6 | $237 | 0.00% | 2024-03-31 |
| 185 | ROTHSCHILD INVESTMENT LLC | 5 | $198 | 0.00% | 2024-06-30 |
| 186 | SG Americas Securities, LLC | 2,686 | $106 | 0.00% | 2024-03-31 |
| 187 | STRS OHIO | 1,900 | $75 | 0.00% | 2024-03-31 |
| 188 | AMALGAMATED BANK | 1,298 | $51 | 0.00% | 2024-03-31 |
| 189 | KBC Group NV | 1,107 | $44 | 0.00% | 2024-03-31 |
| 190 | Daiwa Securities Group Inc. | 238 | $9 | 0.00% | 2024-03-31 |
| 191 | CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | $0 | 0.00% | 2024-03-31 |
| 192 | Covestor Ltd | 4 | $0 | 0.00% | 2024-03-31 |