13F QoQ Ownership Changes
SYRE Institutional Holders
Period 2025-12-31 · prior 2025-09-30 · 32 new · 76 added · 47 reduced · 14 exited
New Positions(32)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | +1,621,620 | $53.1M | +$53.1M | — |
| Point72 Asset Management, L.P. | 662,351 | +662,351 | $21.7M | +$21.7M | — |
| SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | +187,737 | $6.2M | +$6.2M | — |
| Patient Square Capital LP | 150,000 | +150,000 | $4.9M | +$4.9M | — |
| SEVEN GRAND MANAGERS, LLC | 100,000 | +100,000 | $3.3M | +$3.3M | — |
| CITADEL ADVISORS LLC | 88,804 | +88,804 | $2.9M | +$2.9M | — |
| Balyasny Asset Management L.P. | 73,465 | +73,465 | $2.4M | +$2.4M | — |
| ALPS ADVISORS INC | 63,708 | +63,708 | $2.1M | +$2.1M | — |
| AMERIPRISE FINANCIAL INC | 38,256 | +38,256 | $1.3M | +$1.3M | — |
| Cinctive Capital Management LP | 35,935 | +35,935 | $1.2M | +$1.2M | — |
| STEMPOINT CAPITAL LP | 32,377 | +32,377 | $1.1M | +$1.1M | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,911 | +27,911 | $914.4K | +$914.4K | — |
| Voya Investment Management LLC | 27,277 | +27,277 | $893.6K | +$893.6K | — |
| Neo Ivy Capital Management | 18,261 | +18,261 | $598.2K | +$598.2K | — |
| State of New Jersey Common Pension Fund D | 16,698 | +16,698 | $547.0K | +$547.0K | — |
| PSP Research LLC | 15,840 | +15,840 | $518.9K | +$518.9K | — |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | +13,724 | $449.6K | +$449.6K | — |
| TUDOR INVESTMENT CORP ET AL | 10,127 | +10,127 | $331.8K | +$331.8K | — |
| Carlyle Group Inc. | 9,620 | +9,620 | $315.1K | +$315.1K | — |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9,030 | +9,030 | $295.8K | +$295.8K | — |
| CAXTON CORP | 8,919 | +8,919 | $292.2K | +$292.2K | — |
| VARCOV Co. | 8,008 | +8,008 | $262.3K | +$262.3K | — |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,173 | +7,173 | $235.0K | +$235.0K | — |
| MARTINGALE ASSET MANAGEMENT L P | 6,930 | +6,930 | $227.0K | +$227.0K | — |
| Brevan Howard Capital Management LP | 6,198 | +6,198 | $203.0K | +$203.0K | — |
| SEI INVESTMENTS CO | 6,117 | +6,117 | $200.4K | +$200.4K | — |
| Persistent Asset Partners Ltd | 2,246 | +2,246 | $73.6K | +$73.6K | — |
| Remedium Capital Partners, LLC | 1,456,231 | +1,456,231 | $47.7K | +$47.7K | — |
| GROUP ONE TRADING LLC | 400 | +400 | $13.1K | +$13.1K | — |
| Allworth Financial LP | 58 | +58 | $1.9K | +$1.9K | — |
| IFP Advisors, Inc | 48 | +48 | $1.2K | +$1.2K | — |
| SG Americas Securities, LLC | 23,343 | +23,343 | $765 | +$765 | — |
Added To(76)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FMR LLC | 11,638,819 | +2,578,675 | $381.3M | +$229.4M | 28.5% |
| BlackRock, Inc. | 5,522,101 | +1,539,357 | $180.9M | +$114.2M | 38.6% |
| VANGUARD GROUP INC | 4,035,074 | +984,344 | $132.2M | +$81.1M | 32.3% |
| PERCEPTIVE ADVISORS LLC | 3,069,225 | +1,839,780 | $100.5M | +$79.9M | 149.6% |
| RTW INVESTMENTS, LP | 4,171,996 | +550,000 | $136.7M | +$76.0M | 15.2% |
| VR ADVISER, LLC | 3,685,448 | +1,000,000 | $120.7M | +$75.7M | 37.2% |
| Capital International Investors | 3,492,541 | +1,100,000 | $114.4M | +$74.3M | 46.0% |
| Driehaus Capital Management LLC | 2,882,420 | +822,045 | $94.4M | +$59.9M | 39.9% |
| JANUS HENDERSON GROUP PLC | 1,829,009 | +1,816,009 | $59.9M | +$59.7M | 13969.3% |
| Commodore Capital LP | 2,388,245 | +400,161 | $78.2M | +$44.9M | 20.1% |
| STATE STREET CORP | 2,262,839 | +477,633 | $74.1M | +$44.2M | 26.8% |
| TCG Crossover Management, LLC | 1,900,582 | +800,000 | $62.3M | +$43.8M | 72.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,659,140 | +433,987 | $54.4M | +$33.8M | 35.4% |
| Affinity Asset Advisors, LLC | 1,432,591 | +13,292 | $46.9M | +$23.1M | 0.9% |
| FRANKLIN RESOURCES INC | 1,109,274 | +313,999 | $36.3M | +$23.0M | 39.5% |
| Siren, L.L.C. | 818,598 | +450,000 | $26.8M | +$20.6M | 122.1% |
| UBS Group AG | 680,566 | +294,977 | $22.3M | +$15.8M | 76.5% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 710,626 | +96,961 | $23.3M | +$13.0M | 15.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,622 | +149,277 | $18.8M | +$11.7M | 35.1% |
| EMERALD ADVISERS, LLC | 636,109 | +87,397 | $20.8M | +$11.6M | 15.9% |
| NORTHERN TRUST CORP | 561,023 | +118,987 | $18.4M | +$11.0M | 26.9% |
| Caption Management, LLC | 399,900 | +264,700 | $13.1M | +$10.8M | 195.8% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 412,371 | +104,159 | $13.5M | +$8.3M | 33.8% |
| BANK OF AMERICA CORP /DE/ | 419,727 | +74,924 | $13.8M | +$8.0M | 21.7% |
| Candriam S.C.A. | 425,534 | +21,172 | $13.9M | +$7.2M | 5.2% |
| Woodline Partners LP | 265,892 | +134,016 | $8.7M | +$6.5M | 101.6% |
| Invesco Ltd. | 150,934 | +100,232 | $4.9M | +$4.1M | 197.7% |
| Bank of New York Mellon Corp | 192,830 | +56,870 | $6.3M | +$4.0M | 41.8% |
| ARMISTICE CAPITAL, LLC | 196,426 | +40,426 | $6.4M | +$3.8M | 25.9% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | +60,755 | $5.6M | +$3.8M | 55.0% |
| TD Asset Management Inc | 149,822 | +77,454 | $4.9M | +$3.7M | 107.0% |
| DEUTSCHE BANK AG\ | 121,941 | +83,398 | $4.0M | +$3.3M | 216.4% |
| Nuveen, LLC | 150,980 | +54,808 | $4.9M | +$3.3M | 57.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,013 | +57,065 | $4.1M | +$2.9M | 79.3% |
| CITIGROUP INC | 100,058 | +67,162 | $3.3M | +$2.7M | 204.2% |
| F/m Investments LLC | 103,718 | +48,825 | $3.4M | +$2.5M | 88.9% |
| WELLS FARGO & COMPANY/MN | 82,416 | +43,097 | $2.7M | +$2.0M | 109.6% |
| Swiss National Bank | 96,500 | +26,300 | $3.2M | +$2.0M | 37.5% |
| ALLIANCEBERNSTEIN L.P. | 67,500 | +31,270 | $2.2M | +$1.6M | 86.3% |
| RHUMBLINE ADVISERS | 82,956 | +12,042 | $2.7M | +$1.5M | 17.0% |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 62,216 | +22,718 | $2.0M | +$1.4M | 57.5% |
| Susquehanna Portfolio Strategies, LLC | 53,101 | +31,362 | $1.7M | +$1.4M | 144.3% |
| Legal & General Group Plc | 56,448 | +9,607 | $1.8M | +$1.1M | 20.5% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,038 | +14,835 | $1.6M | +$1.0M | 44.7% |
| MetLife Investment Management, LLC | 38,011 | +8,093 | $1.2M | +$743.8K | 27.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,144 | +8,696 | $1.1M | +$706.5K | 32.9% |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 24,950 | +6,450 | $817.4K | +$507.3K | 34.9% |
| PROFUND ADVISORS LLC | 20,593 | +7,370 | $674.6K | +$453.0K | 55.7% |
| BARCLAYS PLC | 216,646 | +48,316 | $3.2M | +$422.0K | 28.7% |
| Waverly Advisors, LLC | 25,954 | +1 | $850.3K | +$415.3K | 0.0% |
| Optimize Financial Inc | 25,331 | +364 | $829.8K | +$411.4K | 1.4% |
| Police & Firemen's Retirement System of New Jersey | 18,360 | +4,551 | $601.5K | +$370.0K | 33.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,165 | +2,600 | $627.8K | +$350.2K | 15.7% |
| ProShare Advisors LLC | 15,989 | +5,311 | $523.8K | +$344.8K | 49.7% |
| AQR CAPITAL MANAGEMENT LLC | 17,820 | +773 | $583.8K | +$298.1K | 4.5% |
| Arizona State Retirement System | 13,797 | +3,104 | $452.0K | +$272.8K | 29.0% |
| China Universal Asset Management Co., Ltd. | 12,644 | +2,057 | $414.2K | +$236.8K | 19.4% |
| KLP KAPITALFORVALTNING AS | 10,400 | +2,600 | $340.7K | +$210.0K | 33.3% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,164 | +290 | $365.7K | +$183.5K | 2.7% |
| Virtus Investment Advisers, LLC | 7,913 | +1,488 | $259.2K | +$151.5K | 23.1% |
| Ameritas Investment Partners, Inc. | 5,593 | +1,427 | $183.2K | +$113.4K | 34.3% |
| Russell Investments Group, Ltd. | 5,554 | +1,320 | $181.9K | +$111.0K | 31.2% |
| Mirae Asset Global Investments Co., Ltd. | 3,770 | +1,435 | $123.5K | +$84.4K | 61.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,601,882 | +981,262 | $52.5K | +$42.1K | 158.1% |
| Sterling Capital Management LLC | 1,610 | +396 | $52.7K | +$32.4K | 32.6% |
| GF FUND MANAGEMENT CO. LTD. | 1,523 | +224 | $49.9K | +$28.1K | 17.2% |
| Rockefeller Capital Management L.P. | 549 | +148 | $18.0K | +$11.3K | 36.9% |
| GAMMA Investing LLC | 330 | +122 | $10.8K | +$7.3K | 58.6% |
| OSAIC HOLDINGS, INC. | 367 | +53 | $12.0K | +$6.9K | 16.9% |
| Larson Financial Group LLC | 144 | +132 | $4.7K | +$4.5K | 1100.0% |
| ROTHSCHILD INVESTMENT LLC | 82 | +2 | $2.7K | +$1.3K | 2.5% |
| Farther Finance Advisors, LLC | 37 | +27 | $1.2K | +$1.0K | 270.0% |
| AMALGAMATED BANK | 2,165 | +786 | $71 | +$48 | 57.0% |
| CWM, LLC | 1,970 | +10 | $65 | +$32 | 0.5% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 656 | +321 | $21 | +$15 | 95.8% |
| Daiwa Securities Group Inc. | 258 | +52 | $8 | +$5 | 25.2% |
Reduced(47)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 4,018,101 | 0 | $131.6M | +$64.3M | 0.0% |
| Paradigm Biocapital Advisors LP | 1,467,266 | 0 | $48.1M | +$23.5M | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,549,284 | -91,028 | $50.8M | +$23.3M | -5.5% |
| BAKER BROS. ADVISORS LP | 1,000,000 | 0 | $32.8M | +$16.0M | 0.0% |
| Pictet Asset Management Holding SA | 913,960 | -122,258 | $29.9M | +$12.6M | -11.8% |
| Polar Capital Holdings Plc | 740,326 | -48,462 | $24.3M | +$11.0M | -6.1% |
| BRAIDWELL LP | 1,634,615 | -943,789 | $53.5M | +$10.3M | -36.6% |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | -1,307,800 | $62.0M | +$8.4M | -40.9% |
| Blackstone Inc. | 500,998 | 0 | $16.4M | +$8.0M | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 11,844 | -304,065 | $388.0K | -$4.9M | -96.3% |
| MILLENNIUM MANAGEMENT LLC | 76,194 | -332,005 | $2.5M | -$4.3M | -81.3% |
| GOLDMAN SACHS GROUP INC | 275,065 | -54,468 | $9.0M | +$3.5M | -16.5% |
| Capital World Investors | 200,172 | 0 | $6.6M | +$3.2M | 0.0% |
| JPMORGAN CHASE & CO | 62,951 | -213,033 | $2.1M | -$2.6M | -77.2% |
| HighVista Strategies LLC | 188,206 | -27,540 | $6.2M | +$2.5M | -12.8% |
| MERCER GLOBAL ADVISORS INC /ADV | 106,316 | -348 | $3.5M | +$1.7M | -0.3% |
| B Group, Inc. | 100,000 | 0 | $3.3M | +$1.6M | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 77,290 | -6,926 | $2.5M | +$1.1M | -8.2% |
| AlphaQuest LLC | 3,538 | -62,625 | $115.9K | -$993.0K | -94.7% |
| Rafferty Asset Management, LLC | 53,410 | -6,257 | $1.7M | +$749.7K | -10.5% |
| Parkman Healthcare Partners LLC | 124,485 | -76,268 | $4.1M | +$713.5K | -38.0% |
| VICTORY CAPITAL MANAGEMENT INC | 146,079 | -180,002 | $4.8M | -$679.6K | -55.2% |
| ADAR1 Capital Management, LLC | 34,051 | 0 | $1.1M | +$544.8K | 0.0% |
| MORGAN STANLEY | 182,734 | -151,988 | $6.0M | +$376.4K | -45.4% |
| Assenagon Asset Management S.A. | 22,136 | 0 | $725.2K | +$354.2K | 0.0% |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,252 | -6,294 | $892.8K | +$330.5K | -18.8% |
| Global Endowment Management, LP | 18,184 | 0 | $596.0K | +$291.2K | 0.0% |
| INTECH INVESTMENT MANAGEMENT LLC | 18,274 | -2,086 | $598.7K | +$257.4K | -10.2% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 61,574 | -46,164 | $2.0M | +$200.4K | -42.8% |
| Royal Bank of Canada | 1,988 | -8,658 | $65.0K | -$96.0K | -81.3% |
| ExodusPoint Capital Management, LP | 37,871 | -30,692 | $1.2M | +$91.5K | -44.8% |
| Tower Research Capital LLC (TRC) | 425 | -4,171 | $13.9K | -$63.1K | -90.8% |
| NISA INVESTMENT ADVISORS, LLC | 705 | 0 | $23.1K | +$11.3K | 0.0% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,882 | -5,290 | $312.5K | +$8.0K | -29.1% |
| SBI Securities Co., Ltd. | 5 | -118 | $164 | -$5.7K | -95.9% |
| MEEDER ASSET MANAGEMENT INC | 181 | -35 | $5.9K | +$2.3K | -16.2% |
| PNC Financial Services Group, Inc. | 86 | 0 | $2.8K | +$1.4K | 0.0% |
| SIGNATUREFD, LLC | 70 | 0 | $2.3K | +$1.1K | 0.0% |
| EverSource Wealth Advisors, LLC | 65 | 0 | $2.1K | +$1.0K | 0.0% |
| Parkside Financial Bank & Trust | 35 | 0 | $1.1K | +$560 | 0.0% |
| Optiver Holding B.V. | 240 | -260 | $7.9K | -$518 | -52.0% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 0 | $845 | +$413 | 0.0% |
| US BANCORP \DE\ | 10 | 0 | $328 | +$160 | 0.0% |
| COMERICA BANK | 5 | 0 | $164 | +$80 | 0.0% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,589 | 0 | $52 | +$25 | 0.0% |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | $0 | $0 | — |
| Covestor Ltd | 6 | 0 | $0 | $0 | 0.0% |
Sold Out(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 0 | -1,388,854 | $0 | -$23.3M | — |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | -264,317 | $0 | -$4.4M | — |
| JANE STREET GROUP, LLC | 0 | -96,057 | $0 | -$1.6M | — |
| Schonfeld Strategic Advisors LLC | 0 | -81,474 | $0 | -$1.4M | — |
| Opaleye Management Inc. | 0 | -65,000 | $0 | -$1.1M | — |
| Verition Fund Management LLC | 0 | -48,496 | $0 | -$812.8K | — |
| DLD Asset Management, LP | 0 | -30,000 | $0 | -$502.8K | — |
| Jump Financial, LLC | 0 | -27,100 | $0 | -$454.2K | — |
| Squarepoint Ops LLC | 0 | -20,232 | $0 | -$339.1K | — |
| Quadrature Capital Ltd | 0 | -19,366 | $0 | -$324.8K | — |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | -14,733 | $0 | -$246.9K | — |
| DRW Securities, LLC | 0 | -11,475 | $0 | -$190.2K | — |
| HUNTINGTON NATIONAL BANK | 0 | -1,470 | $0 | -$24.6K | — |
| Arax Advisory Partners | 0 | -121 | $0 | -$2.0K | — |