New Positions
52 managers initiated
Top five by reported value
Janux Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:JANX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
52 new67 added62 reduced40 exited
Total Institutional Holders
180
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$154.4M
Largest QoQ Increase
STATE STREET CORP
+1,962,486 sh
Largest QoQ Decrease
FMR LLC
-5,543,678 sh
New Positions(52)
Added To(67)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 5,350,453 | +649,341 | $73.9M | -$41.1M | 13.8% |
| BlackRock, Inc. | 4,080,200 | +349,206 | $56.3M | -$34.9M | 9.3% |
| VANGUARD GROUP INC | 2,906,386 | +489,282 | $40.1M | -$19.0M | 20.2% |
| ORBIMED ADVISORS LLC | 1,954,426 | +188,326 | $27.0M | -$16.2M | 10.7% |
| Prosight Management, LP | 2,392,523 | +1,527,173 | $33.0M | +$11.9M | 176.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,113,582 | +29,718 | $15.4M | -$11.1M | 2.7% |
| Woodline Partners LP | 1,027,221 | +283 | $14.2M | -$10.9M | 0.0% |
| Caption Management, LLC | 782,500 | +673,800 | $10.8M | +$8.1M | 619.9% |
| Alyeska Investment Group, L.P. | 1,301,089 | +876,244 | $18.0M | +$7.6M | 206.3% |
| STATE STREET CORP | 3,853,951 | +1,962,486 | $53.2M | +$7.0M | 103.8% |
| JANE STREET GROUP, LLC | 624,533 | +531,311 | $8.6M | +$6.3M | 569.9% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,610,186 | +908,582 | $22.2M | +$5.1M | 129.5% |
| TWO SIGMA INVESTMENTS, LP | 471,009 | +367,533 | $6.5M | +$4.0M | 355.2% |
| Walleye Capital LLC | 337,817 | +301,996 | $4.7M | +$3.8M | 843.1% |
| Squarepoint Ops LLC | 390,952 | +324,791 | $5.4M | +$3.8M | 490.9% |
| MORGAN STANLEY | 618,385 | +122,750 | $8.5M | -$3.6M | 24.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 390,506 | +35,962 | $5.4M | -$3.3M | 10.1% |
| CITADEL ADVISORS LLC | 1,235,444 | +405,560 | $17.0M | -$3.2M | 48.9% |
| Trexquant Investment LP | 170,484 | +157,267 | $2.4M | +$2.0M | 1189.9% |
| BANK OF AMERICA CORP /DE/ | 738,330 | +244,878 | $10.2M | -$1.9M | 49.6% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 548,237 | +164,396 | $7.6M | -$1.8M | 42.8% |
| MILLENNIUM MANAGEMENT LLC | 289,808 | +189,163 | $4.0M | +$1.5M | 187.9% |
| UBS Group AG | 590,060 | +199,703 | $8.1M | -$1.4M | 51.1% |
| Bank of New York Mellon Corp | 122,066 | +1,594 | $1.7M | -$1.3M | 1.3% |
| GOLDMAN SACHS GROUP INC | 1,073,656 | +418,548 | $14.8M | -$1.2M | 63.9% |
| Nuveen, LLC | 96,416 | +787 | $1.3M | -$1.0M | 0.8% |
| Swiss National Bank | 77,100 | +2,500 | $1.1M | -$759.2K | 3.4% |
| Rhenman & Partners Asset Management AB | 225,377 | +125,250 | $3.1M | +$663.1K | 125.1% |
| UBS ASSET MANAGEMENT AMERICAS INC | 75,498 | +9,173 | $1.0M | -$579.1K | 13.8% |
| CONGRESS ASSET MANAGEMENT CO /MA | 57,342 | +1,569 | $791.3K | -$571.8K | 2.8% |
| Rafferty Asset Management, LLC | 175,248 | +99,052 | $2.4M | +$556.2K | 130.0% |
| PROFUND ADVISORS LLC | 64,022 | +47,584 | $883.5K | +$481.8K | 289.5% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,320 | +173 | $515.0K | -$392.9K | 0.5% |
| Legal & General Group Plc | 43,467 | +5,551 | $599.8K | -$326.8K | 14.6% |
| Hudson Bay Capital Management LP | 110,000 | +60,000 | $1.5M | +$296.0K | 120.0% |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,487 | +4,967 | $531.1K | -$288.1K | 14.8% |
| Qube Research & Technologies Ltd | 216,005 | +105,156 | $3.0M | +$271.7K | 94.9% |
| SIMPLEX TRADING, LLC | 17,567 | +13,971 | $242.4K | +$242.3K | 388.5% |
| DARK FOREST CAPITAL MANAGEMENT LP | 57,363 | +33,716 | $791.6K | +$213.7K | 142.6% |
| Invesco Ltd. | 28,322 | +3,853 | $390.8K | -$207.2K | 15.7% |
| Quadrature Capital Ltd | 33,002 | +6,141 | $455.4K | -$201.1K | 22.9% |
| CITIGROUP INC | 24,218 | +18,703 | $334.2K | +$199.4K | 339.1% |
| Rock Springs Capital Management LP | 358,798 | +148,432 | $5.0M | -$189.9K | 70.5% |
| Russell Investments Group, Ltd. | 21,062 | +3,560 | $290.7K | -$137.1K | 20.3% |
| Virtus Investment Advisers, Inc. | 17,388 | +12,936 | $240.0K | +$131.1K | 290.6% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,148 | +7,784 | $416.3K | -$127.3K | 34.8% |
| AMERICAN CENTURY COMPANIES INC | 27,691 | +8,738 | $382.1K | -$81.1K | 46.1% |
| SPHERA FUNDS MANAGEMENT LTD. | 157,840 | +72,000 | $2.2M | +$80.3K | 83.9% |
| ProShare Advisors LLC | 10,495 | +1,621 | $144.8K | -$72.0K | 18.3% |
| Raiffeisen Bank International AG | 46,000 | +22,000 | $636.2K | +$67.4K | 91.7% |
| JONES FINANCIAL COMPANIES LLLP | 4,226 | +4,138 | $58.3K | +$56.3K | 4702.3% |
| VICTORY CAPITAL MANAGEMENT INC | 5,953 | +1,090 | $82.2K | -$36.7K | 22.4% |
| Engineers Gate Manager LP | 13,147 | +4,231 | $181.4K | -$36.5K | 47.5% |
| WELLS FARGO & COMPANY/MN | 47,919 | +19,401 | $661.3K | -$35.7K | 68.0% |
| OXFORD ASSET MANAGEMENT LLP | 22,811 | +8,605 | $314.8K | -$32.4K | 60.6% |
| DNB Asset Management AS | 17,274 | +8,355 | $238.4K | +$20.4K | 93.7% |
| Mirae Asset Global Investments Co., Ltd. | 2,923 | +600 | $40.3K | -$16.4K | 25.8% |
| Larson Financial Group LLC | 244 | +216 | $3.4K | +$2.7K | 771.4% |
| AlphaQuest LLC | 12,855 | +5,535 | $177.4K | -$1.5K | 75.6% |
| Rockefeller Capital Management L.P. | 68 | +61 | $938 | +$767 | 871.4% |
| SG Americas Securities, LLC | 79,817 | +50,802 | $1.1K | +$392 | 175.1% |
| ALGERT GLOBAL LLC | 183,367 | +95,150 | $2.5K | +$374 | 107.8% |
| Handelsbanken Fonder AB | 17,800 | +3,800 | $246 | -$96 | 27.1% |
| GAMMA Investing LLC | 16 | +8 | $221 | +$25 | 100.0% |
| AMALGAMATED BANK | 1,347 | +257 | $19 | -$8 | 23.6% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 508 | +137 | $7 | -$2 | 36.9% |
| CWM, LLC | 29 | +25 | $0 | $0 | 625.0% |
Reduced(62)
Sold Out(40)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | $154.4M | 0 | 0.0% |
| JANUS HENDERSON GROUP PLC | 5,350,453 | $73.9M | +649,341 | 13.8% |
| BlackRock, Inc. | 4,080,200 | $56.3M | +349,206 | 9.3% |
| STATE STREET CORP | 3,853,951 | $53.2M | +1,962,486 | 103.8% |
| FMR LLC | 3,512,384 | $48.5M | -5,543,678 | -61.2% |
| VANGUARD GROUP INC | 2,906,386 | $40.1M | +489,282 | 20.2% |
| Prosight Management, LP | 2,392,523 | $33.0M | +1,527,173 | 176.5% |
| ORBIMED ADVISORS LLC | 1,954,426 | $27.0M | +188,326 | 10.7% |
| TCG Crossover Management, LLC | 1,789,617 | $24.7M | +1,789,617 | — |
| WELLINGTON MANAGEMENT GROUP LLP | 1,610,186 | $22.2M | +908,582 | 129.5% |
| Alyeska Investment Group, L.P. | 1,301,089 | $18.0M | +876,244 | 206.3% |
| CITADEL ADVISORS LLC | 1,235,444 | $17.0M | +405,560 | 48.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,113,582 | $15.4M | +29,718 | 2.7% |
| GOLDMAN SACHS GROUP INC | 1,073,656 | $14.8M | +418,548 | 63.9% |
| Woodline Partners LP | 1,027,221 | $14.2M | +283 | 0.0% |
| Logos Global Management LP | 1,000,000 | $13.8M | -435,000 | -30.3% |
| Point72 Asset Management, L.P. | 961,819 | $13.3M | -748,381 | -43.8% |
| READYSTATE ASSET MANAGEMENT LP | 885,895 | $12.2M | -74,484 | -7.8% |
| Balyasny Asset Management LLC | 885,551 | $12.2M | +885,551 | — |
| Caption Management, LLC | 782,500 | $10.8M | +673,800 | 619.9% |
New & Closed Positions this quarter
Closed Positions
40 managers exited
Top five by prior-quarter value
- Paradigm Biocapital Advisors LP$71.4M
- TANG CAPITAL MANAGEMENT LLC$17.1M
- First Turn Management, LLC$15.6M
- BIOIMPACT CAPITAL LLC$15.0M
- abrdn plc$8.4M
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for JANX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.