New Positions
30 managers initiated
Top five by reported value
Tyra Biosciences Inc NASDAQ NMS - GLOBAL MARKET:TYRA
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
30 new43 added62 reduced10 exited
Total Institutional Holders
135
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$320.7M
Largest QoQ Increase
FARALLON CAPITAL MANAGEMENT LLC
+2,066,818 sh
Largest QoQ Decrease
BVF INC/IL
-1,522,129 sh
New Positions(30)
Added To(43)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 3,210,636 | +2,066,818 | $70.3M | +$54.3M | 180.7% |
| JANUS HENDERSON GROUP PLC | 2,935,442 | +60,638 | $77.1M | +$36.9M | 2.1% |
| BlackRock, Inc. | 2,086,423 | +216,949 | $54.9M | +$28.7M | 11.6% |
| VANGUARD GROUP INC | 1,572,785 | +52,600 | $41.3M | +$20.1M | 3.5% |
| Point72 Asset Management, L.P. | 874,192 | +592,160 | $23.0M | +$19.0M | 210.0% |
| Caligan Partners LP | 944,257 | +247,432 | $24.8M | +$15.1M | 35.5% |
| 5AM Venture Management, LLC | 1,029,298 | +90,000 | $27.1M | +$13.9M | 9.6% |
| STATE STREET CORP | 749,463 | +320,991 | $19.7M | +$13.7M | 74.9% |
| MARSHALL WACE, LLP | 711,891 | +109,876 | $18.7M | +$10.3M | 18.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 657,756 | +60,302 | $17.3M | +$8.9M | 10.1% |
| Sio Capital Management, LLC | 526,002 | +11,055 | $13.8M | +$6.6M | 2.1% |
| Eversept Partners, LP | 278,564 | +5,858 | $7.3M | +$3.5M | 2.1% |
| GOLDMAN SACHS GROUP INC | 182,387 | +82,237 | $4.8M | +$3.4M | 82.1% |
| BOOTHBAY FUND MANAGEMENT, LLC | 221,177 | +34,507 | $5.8M | +$3.2M | 18.5% |
| Invesco Ltd. | 129,435 | +113,925 | $3.4M | +$3.2M | 734.5% |
| RAYMOND JAMES FINANCIAL INC | 170,032 | +43,658 | $4.5M | +$2.7M | 34.5% |
| DIMENSIONAL FUND ADVISORS LP | 95,640 | +55,961 | $2.5M | +$2.0M | 141.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 104,305 | +21,434 | $2.7M | +$1.6M | 25.9% |
| Squarepoint Ops LLC | 54,424 | +42,210 | $1.4M | +$1.3M | 345.6% |
| OPPENHEIMER & CO INC | 84,726 | +2,488 | $2.2M | +$1.1M | 3.0% |
| ALPS ADVISORS INC | 43,827 | +19,127 | $1.2M | +$806.7K | 77.4% |
| Bank of New York Mellon Corp | 60,901 | +3,739 | $1.6M | +$801.4K | 6.5% |
| AMERICAN CENTURY COMPANIES INC | 46,227 | +7,815 | $1.2M | +$677.9K | 20.3% |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,023 | +9,375 | $1.0M | +$611.1K | 31.6% |
| WELLS FARGO & COMPANY/MN | 29,049 | +10,579 | $763.7K | +$505.3K | 57.3% |
| AQR CAPITAL MANAGEMENT LLC | 28,631 | +562 | $752.7K | +$360.0K | 2.0% |
| DEUTSCHE BANK AG\ | 16,377 | +894 | $430.6K | +$213.9K | 5.8% |
| BARCLAYS PLC | 61,555 | +4,429 | $589.1K | -$210.1K | 7.8% |
| MetLife Investment Management, LLC | 15,356 | +725 | $403.7K | +$199.0K | 5.0% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,908 | +1,591 | $338.6K | +$180.3K | 14.1% |
| Russell Investments Group, Ltd. | 12,996 | +255 | $341.7K | +$163.4K | 2.0% |
| FMR LLC | 12,563 | +34 | $330.3K | +$155.0K | 0.3% |
| Virtus Investment Advisers, Inc. | 11,756 | +741 | $309.1K | +$155.0K | 6.7% |
| CITIGROUP INC | 3,817 | +2,110 | $100.3K | +$76.5K | 123.6% |
| Mirae Asset Global Investments Co., Ltd. | 2,594 | +534 | $68.2K | +$39.4K | 25.9% |
| Legal & General Group Plc | 2,367 | +175 | $62.2K | +$31.6K | 8.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,595 | +122 | $41.9K | +$21.3K | 8.3% |
| GAMMA Investing LLC | 472 | +161 | $12.4K | +$8.1K | 51.8% |
| Larson Financial Group LLC | 146 | +8 | $3.8K | +$1.9K | 5.8% |
| Farther Finance Advisors, LLC | 60 | +49 | $1.6K | +$1.4K | 445.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,432 | +1,631 | $380 | +$200 | 12.7% |
| CWM, LLC | 1,546 | +17 | $41 | +$20 | 1.1% |
| AMALGAMATED BANK | 814 | +113 | $21 | +$11 | 16.1% |
Reduced(62)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | 0 | $320.7M | +$150.0M | 0.0% |
| Nextech Invest, Ltd. | 4,055,861 | 0 | $106.6M | +$49.9M | 0.0% |
| Alta Partners Management Company, L.P. | 3,823,425 | -256,871 | $100.5M | +$43.4M | -6.3% |
| COMMODORE CAPITAL LP | 3,375,000 | 0 | $88.7M | +$41.5M | 0.0% |
| Canaan Partners XI LLC | 3,374,329 | -233,780 | $88.7M | +$38.2M | -6.5% |
| TCG Crossover Management, LLC | 2,898,103 | 0 | $76.2M | +$35.6M | 0.0% |
| Vestal Point Capital, LP | 2,425,000 | 0 | $63.8M | +$29.8M | 0.0% |
| Balyasny Asset Management LLC | 818,326 | -28,259 | $21.5M | +$9.7M | -3.3% |
| Kynam Capital Management, LP | 1,564,492 | -765,506 | $41.1M | +$8.5M | -32.9% |
| BVF INC/IL | 2,127,665 | -1,522,129 | $55.9M | +$4.9M | -41.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199,426 | -2,161 | $5.2M | +$2.4M | -1.1% |
| NORTHERN TRUST CORP | 200,956 | -7,530 | $5.3M | +$2.4M | -3.6% |
| CITADEL ADVISORS LLC | 12,500 | -122,293 | $328.6K | -$1.6M | -90.7% |
| MORGAN STANLEY | 118,898 | -203,245 | $3.1M | -$1.4M | -63.1% |
| BNP PARIBAS ARBITRAGE, SNC | 120,278 | -8,603 | $3.2M | +$1.4M | -6.7% |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | 0 | $2.2M | +$1.0M | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 114,388 | -29,628 | $3.0M | +$992.5K | -20.6% |
| BANK OF AMERICA CORP /DE/ | 38,310 | -96,009 | $1.0M | -$872.0K | -71.5% |
| JPMORGAN CHASE & CO | 71,175 | -3,054 | $1.9M | +$832.7K | -4.1% |
| UBS Group AG | 58,856 | -288 | $1.5M | +$719.9K | -0.5% |
| Susquehanna Portfolio Strategies, LLC | 48,644 | 0 | $1.3M | +$598.3K | 0.0% |
| PDT Partners, LLC | 42,284 | -1,026 | $1.1M | +$505.7K | -2.4% |
| RHUMBLINE ADVISERS | 38,790 | -1,846 | $1.0M | +$451.3K | -4.5% |
| ALLIANCEBERNSTEIN L.P. | 31,990 | -1,270 | $841.0K | +$375.7K | -3.8% |
| AlphaQuest LLC | 2,139 | -27,921 | $56.2K | -$364.3K | -92.9% |
| XTX Topco Ltd | 30,414 | -3,286 | $799.6K | +$328.1K | -9.8% |
| Auour Investments LLC | 21,020 | 0 | $552.6K | +$258.5K | 0.0% |
| VICTORY CAPITAL MANAGEMENT INC | 18,790 | 0 | $494.0K | +$231.1K | 0.0% |
| AMERIPRISE FINANCIAL INC | 54,625 | -32,482 | $1.4M | +$217.5K | -37.3% |
| Royal Bank of Canada | 742 | -16,148 | $19.0K | -$143.0K | -95.6% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18,542 | -6,420 | $487.5K | +$138.3K | -25.7% |
| BAKER BROS. ADVISORS LP | 10,607 | 0 | $278.9K | +$130.5K | 0.0% |
| Nuveen, LLC | 47,349 | -33,092 | $1.2M | +$119.4K | -41.1% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129,753 | -121,809 | $3.4M | -$108.1K | -48.4% |
| INTECH INVESTMENT MANAGEMENT LLC | 9,801 | -1,601 | $257.7K | +$98.2K | -14.0% |
| China Universal Asset Management Co., Ltd. | 8,697 | -645 | $228.6K | +$97.9K | -6.9% |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 0 | $195.2K | +$91.3K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 6,440 | 0 | $169.3K | +$79.2K | 0.0% |
| TWO SIGMA ADVISERS, LP | 58,900 | -54,300 | $1.5M | -$35.2K | -48.0% |
| Ameritas Investment Partners, Inc. | 1,991 | 0 | $52.3K | +$24.5K | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 107,023 | -92,415 | $2.8M | +$23.5K | -46.3% |
| Sterling Capital Management LLC | 1,488 | -174 | $39.1K | +$15.9K | -10.5% |
| ADVISOR GROUP HOLDINGS, INC. | 1,188 | -4 | $31.2K | +$15.1K | -0.3% |
| GF FUND MANAGEMENT CO. LTD. | 1,048 | -99 | $27.6K | +$11.5K | -8.6% |
| Versant Capital Management, Inc | 819 | 0 | $21.5K | +$10.1K | 0.0% |
| STRS OHIO | 700 | 0 | $18.4K | +$8.6K | 0.0% |
| FEDERATED HERMES, INC. | 1,297 | -858 | $34.1K | +$3.9K | -39.8% |
| Tower Research Capital LLC (TRC) | 331 | -543 | $8.7K | -$3.5K | -62.1% |
| PNC Financial Services Group, Inc. | 208 | 0 | $5.5K | +$2.6K | 0.0% |
| Optiver Holding B.V. | 128 | -240 | $3.4K | -$1.8K | -65.2% |
| True Wealth Design, LLC | 142 | 0 | $3.7K | +$1.7K | 0.0% |
| HighVista Strategies LLC | 35,086 | -30,726 | $922.4K | +$1.7K | -46.7% |
| SRS Capital Advisors, Inc. | 3 | -82 | $79 | -$1.1K | -96.5% |
| NISA INVESTMENT ADVISORS, LLC | 86 | 0 | $2.3K | +$1.1K | 0.0% |
| Clearstead Advisors, LLC | 29 | -96 | $759 | -$990 | -76.8% |
| ROTHSCHILD INVESTMENT LLC | 55 | 0 | $1.4K | +$677 | 0.0% |
| SIGNATUREFD, LLC | 43 | 0 | $1.1K | +$528 | 0.0% |
| EverSource Wealth Advisors, LLC | 42 | -2 | $1.1K | +$489 | -4.5% |
| SBI Securities Co., Ltd. | 4 | -1 | $105 | +$35 | -20.0% |
| Daiwa Securities Group Inc. | 173 | 0 | $5 | +$3 | 0.0% |
| Covestor Ltd | 6 | 0 | $0 | $0 | 0.0% |
| TUDOR INVESTMENT CORP ET AL | 10,761 | 0 | $150.5K | $0 | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Walleye Capital LLC | 0 | -297,808 | $0 | -$4.2M | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -170,100 | $0 | -$2.4M | — |
| AXA Investment Managers S.A. | 0 | -128,789 | $0 | -$1.8M | — |
| Jump Financial, LLC | 0 | -62,000 | $0 | -$867.4K | — |
| JANE STREET GROUP, LLC | 0 | -44,680 | $0 | -$625.1K | — |
| Cubist Systematic Strategies, LLC | 0 | -39,310 | $0 | -$549.9K | — |
| Brevan Howard Capital Management LP | 0 | -31,101 | $0 | -$435.1K | — |
| Trexquant Investment LP | 0 | -15,758 | $0 | -$220.5K | — |
| Rise Advisors, LLC | 0 | -49 | $0 | -$686 | — |
| SG Americas Securities, LLC | 0 | -9,542 | $0 | -$133 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | $320.7M | 0 | 0.0% |
| Nextech Invest, Ltd. | 4,055,861 | $106.6M | 0 | 0.0% |
| Alta Partners Management Company, L.P. | 3,823,425 | $100.5M | -256,871 | -6.3% |
| COMMODORE CAPITAL LP | 3,375,000 | $88.7M | 0 | 0.0% |
| Canaan Partners XI LLC | 3,374,329 | $88.7M | -233,780 | -6.5% |
| JANUS HENDERSON GROUP PLC | 2,935,442 | $77.1M | +60,638 | 2.1% |
| TCG Crossover Management, LLC | 2,898,103 | $76.2M | 0 | 0.0% |
| FARALLON CAPITAL MANAGEMENT LLC | 3,210,636 | $70.3M | +2,066,818 | 180.7% |
| Vestal Point Capital, LP | 2,425,000 | $63.8M | 0 | 0.0% |
| BVF INC/IL | 2,127,665 | $55.9M | -1,522,129 | -41.7% |
| BlackRock, Inc. | 2,086,423 | $54.9M | +216,949 | 11.6% |
| VANGUARD GROUP INC | 1,572,785 | $41.3M | +52,600 | 3.5% |
| Kynam Capital Management, LP | 1,564,492 | $41.1M | -765,506 | -32.9% |
| 5AM Venture Management, LLC | 1,029,298 | $27.1M | +90,000 | 9.6% |
| Caligan Partners LP | 944,257 | $24.8M | +247,432 | 35.5% |
| Point72 Asset Management, L.P. | 874,192 | $23.0M | +592,160 | 210.0% |
| Balyasny Asset Management LLC | 818,326 | $21.5M | -28,259 | -3.3% |
| STATE STREET CORP | 749,463 | $19.7M | +320,991 | 74.9% |
| MARSHALL WACE, LLP | 711,891 | $18.7M | +109,876 | 18.3% |
| Trails Edge Capital Partners, LP | 700,000 | $18.4M | +700,000 | — |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
- Walleye Capital LLC$4.2M
- RENAISSANCE TECHNOLOGIES LLC$2.4M
- AXA Investment Managers S.A.$1.8M
- Jump Financial, LLC$867.4K
- JANE STREET GROUP, LLC$625.1K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for TYRA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.