New Positions
74 managers initiated
Top five by reported value
Palisade Bio Inc NASDAQ NMS - GLOBAL MARKET:PALI
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
74 new7 added4 reduced1 exited
Total Institutional Holders
85
as of 2025-12-31
Top Holder
PERCEPTIVE ADVISORS LLC
$28.3M
Largest QoQ Increase
PERCEPTIVE ADVISORS LLC
+12,050,000 sh
Largest QoQ Decrease
TWO SIGMA SECURITIES, LLC
-29,406 sh
New Positions(74)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 12,050,000 | +12,050,000 | $28.3M | +$28.3M | — |
| COMMODORE CAPITAL LP | 11,445,000 | +11,445,000 | $26.9M | +$26.9M | — |
| JANUS HENDERSON GROUP PLC | 10,540,334 | +10,540,334 | $24.8M | +$24.8M | — |
| Point72 Asset Management, L.P. | 10,495,252 | +10,495,252 | $24.7M | +$24.7M | — |
| Octagon Capital Advisors LP | 9,567,898 | +9,567,898 | $22.5M | +$22.5M | — |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | +7,124,116 | $16.7M | +$16.7M | — |
| AMERIPRISE FINANCIAL INC | 6,911,237 | +6,911,237 | $16.2M | +$16.2M | — |
| Eversept Partners, LP | 5,391,548 | +5,391,548 | $12.7M | +$12.7M | — |
| FRANKLIN RESOURCES INC | 5,092,562 | +5,092,562 | $12.0M | +$12.0M | — |
| Boxer Capital Management, LLC | 4,799,875 | +4,799,875 | $11.3M | +$11.3M | — |
| Squadron Capital Management LLC | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| B Group, Inc. | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| STEMPOINT CAPITAL LP | 4,192,375 | +4,192,375 | $9.9M | +$9.9M | — |
| RENAISSANCE TECHNOLOGIES LLC | 2,382,500 | +2,382,500 | $5.6M | +$5.6M | — |
| Vivo Capital, LLC | 2,293,578 | +2,293,578 | $5.4M | +$5.4M | — |
| VANGUARD GROUP INC | 2,115,622 | +2,115,622 | $5.0M | +$5.0M | — |
| ADAR1 Capital Management, LLC | 2,004,845 | +2,004,845 | $4.7M | +$4.7M | — |
| Artia Global Partners LP | 1,992,367 | +1,992,367 | $4.7M | +$4.7M | — |
| BlackRock, Inc. | 1,879,319 | +1,879,319 | $4.4M | +$4.4M | — |
| ORBIMED ADVISORS LLC | 1,871,420 | +1,871,420 | $4.4M | +$4.4M | — |
| CITADEL ADVISORS LLC | 1,701,411 | +1,701,411 | $4.0M | +$4.0M | — |
| HighVista Strategies LLC | 1,300,031 | +1,300,031 | $3.1M | +$3.1M | — |
| Exome Asset Management LLC | 758,203 | +758,203 | $1.8M | +$1.8M | — |
| PLATINUM INVESTMENT MANAGEMENT LTD | 664,087 | +664,087 | $1.6M | +$1.6M | — |
| Hudson Bay Capital Management LP | 656,460 | +656,460 | $1.5M | +$1.5M | — |
| STATE STREET CORP | 643,997 | +643,997 | $1.5M | +$1.5M | — |
| GOLDMAN SACHS GROUP INC | 557,565 | +557,565 | $1.3M | +$1.3M | — |
| Persistent Asset Partners Ltd | 416,035 | +416,035 | $977.7K | +$977.7K | — |
| Resolute Capital Asset Partners LLC | 400,000 | +400,000 | $940.0K | +$940.0K | — |
| SUPERSTRING CAPITAL MANAGEMENT LP | 367,103 | +367,103 | $862.7K | +$862.7K | — |
| JANE STREET GROUP, LLC | 343,686 | +343,686 | $807.7K | +$807.7K | — |
| Seven Fleet Capital Management LP | 327,500 | +327,500 | $769.6K | +$769.6K | — |
| Balyasny Asset Management LLC | 325,367 | +325,367 | $764.6K | +$764.6K | — |
| Squarepoint Ops LLC | 322,090 | +322,090 | $756.9K | +$756.9K | — |
| Creek Drive Management Group LLC | 307,500 | +307,500 | $722.6K | +$722.6K | — |
| BIT Capital GmbH | 305,000 | +305,000 | $716.8K | +$716.8K | — |
| MILLENNIUM MANAGEMENT LLC | 294,486 | +294,486 | $692.0K | +$692.0K | — |
| NORTHERN TRUST CORP | 283,147 | +283,147 | $665.4K | +$665.4K | — |
| Ikarian Capital, LLC | 274,978 | +274,978 | $646.2K | +$646.2K | — |
| Quadrature Capital Ltd | 240,586 | +240,586 | $565.4K | +$565.4K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,659 | +212,659 | $499.7K | +$499.7K | — |
| Scientech Research LLC | 211,441 | +211,441 | $496.9K | +$496.9K | — |
| TD Asset Management Inc | 204,448 | +204,448 | $480.5K | +$480.5K | — |
| SPHERA FUNDS MANAGEMENT LTD. | 184,100 | +184,100 | $432.6K | +$432.6K | — |
| DIADEMA PARTNERS LP | 166,049 | +166,049 | $390.2K | +$390.2K | — |
| ACT CAPITAL MANAGEMENT, LLC | 150,000 | +150,000 | $352.5K | +$352.5K | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,648 | +132,648 | $311.7K | +$311.7K | — |
| OMERS ADMINISTRATION Corp | 108,000 | +108,000 | $253.8K | +$253.8K | — |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 106,636 | +106,636 | $251.7K | +$251.7K | — |
| SILVERARC CAPITAL MANAGEMENT, LLC | 102,108 | +102,108 | $240.0K | +$240.0K | — |
| Pale Fire Capital SE | 70,710 | +70,710 | $166.2K | +$166.2K | — |
| Jefferies Financial Group Inc. | 46,761 | +46,761 | $109.9K | +$109.9K | — |
| Virtus ETF Advisers LLC | 46,000 | +46,000 | $108.1K | +$108.1K | — |
| Lighthouse Investment Partners, LLC | 39,480 | +39,480 | $92.8K | +$92.8K | — |
| Total Clarity Wealth Management, Inc. | 29,935 | +29,935 | $70.3K | +$70.3K | — |
| Caitong International Asset Management Co., Ltd | 29,388 | +29,388 | $69.1K | +$69.1K | — |
| TWO SIGMA INVESTMENTS, LP | 27,640 | +27,640 | $65.0K | +$65.0K | — |
| Vontobel Holding Ltd. | 20,000 | +20,000 | $47.0K | +$47.0K | — |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,650 | +16,650 | $39.1K | +$39.1K | — |
| VICTORY CAPITAL MANAGEMENT INC | 16,072 | +16,072 | $37.8K | +$37.8K | — |
| LPL Financial LLC | 15,154 | +15,154 | $35.6K | +$35.6K | — |
| WINTON GROUP Ltd | 14,891 | +14,891 | $35.0K | +$35.0K | — |
| BARCLAYS PLC | 14,780 | +14,780 | $34.7K | +$34.7K | — |
| Atom Investors LP | 14,041 | +14,041 | $33.0K | +$33.0K | — |
| Bank of New York Mellon Corp | 12,912 | +12,912 | $30.3K | +$30.3K | — |
| Schonfeld Strategic Advisors LLC | 11,231 | +11,231 | $26.4K | +$26.4K | — |
| Cetera Investment Advisers | 10,512 | +10,512 | $24.7K | +$24.7K | — |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,577,856 | +1,577,856 | $3.7K | +$3.7K | — |
| ADVISOR GROUP HOLDINGS, INC. | 66 | +66 | $155 | +$155 | — |
| Virtu Financial LLC | 11,870 | +11,870 | $28 | +$28 | — |
| FMR LLC | 10 | +10 | $24 | +$24 | — |
| FNY Investment Advisers, LLC | 9,951 | +9,951 | $23 | +$23 | — |
| Avion Wealth | 500 | +500 | $1 | +$1 | — |
Added To(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MORGAN STANLEY | 4,142,446 | +4,133,828 | $9.7M | +$9.7M | 47967.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,565,452 | +1,538,832 | $3.7M | +$3.7M | 5780.7% |
| UBS Group AG | 247,754 | +228,341 | $582.2K | +$565.5K | 1176.2% |
| BANK OF AMERICA CORP /DE/ | 70,097 | +70,011 | $164.7K | +$164.7K | 81408.1% |
| CITIGROUP INC | 52,281 | +49,934 | $122.9K | +$120.8K | 2127.6% |
| XTX Topco Ltd | 21,669 | +7,584 | $50.9K | +$38.8K | 53.8% |
| Newbridge Financial Services Group, Inc. | 15,000 | +2,000 | $35.3K | +$24.1K | 15.4% |
Reduced(4)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Tower Research Capital LLC (TRC) | 1,025 | -4,371 | $2.4K | -$2.2K | -81.0% |
| Rockefeller Capital Management L.P. | 500 | 0 | $1.2K | +$745 | 0.0% |
| Federation des caisses Desjardins du Quebec | 100 | 0 | $235 | +$149 | 0.0% |
| WELLS FARGO & COMPANY/MN | 21 | 0 | $49 | +$31 | 0.0% |
Sold Out(1)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TWO SIGMA SECURITIES, LLC | 0 | -29,406 | $0 | -$25.3K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 12,050,000 | $28.3M | +12,050,000 | — |
| COMMODORE CAPITAL LP | 11,445,000 | $26.9M | +11,445,000 | — |
| JANUS HENDERSON GROUP PLC | 10,540,334 | $24.8M | +10,540,334 | — |
| Point72 Asset Management, L.P. | 10,495,252 | $24.7M | +10,495,252 | — |
| Octagon Capital Advisors LP | 9,567,898 | $22.5M | +9,567,898 | — |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | $16.7M | +7,124,116 | — |
| AMERIPRISE FINANCIAL INC | 6,911,237 | $16.2M | +6,911,237 | — |
| Eversept Partners, LP | 5,391,548 | $12.7M | +5,391,548 | — |
| FRANKLIN RESOURCES INC | 5,092,562 | $12.0M | +5,092,562 | — |
| Boxer Capital Management, LLC | 4,799,875 | $11.3M | +4,799,875 | — |
| B Group, Inc. | 4,500,000 | $10.6M | +4,500,000 | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | $10.6M | +4,500,000 | — |
| Squadron Capital Management LLC | 4,500,000 | $10.6M | +4,500,000 | — |
| STEMPOINT CAPITAL LP | 4,192,375 | $9.9M | +4,192,375 | — |
| MORGAN STANLEY | 4,142,446 | $9.7M | +4,133,828 | 47967.4% |
| RENAISSANCE TECHNOLOGIES LLC | 2,382,500 | $5.6M | +2,382,500 | — |
| Vivo Capital, LLC | 2,293,578 | $5.4M | +2,293,578 | — |
| VANGUARD GROUP INC | 2,115,622 | $5.0M | +2,115,622 | — |
| ADAR1 Capital Management, LLC | 2,004,845 | $4.7M | +2,004,845 | — |
| Artia Global Partners LP | 1,992,367 | $4.7M | +1,992,367 | — |
New & Closed Positions this quarter
Closed Positions
1 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PALI against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.