| PERCEPTIVE ADVISORS LLC | 12,050,000 | +12,050,000 | $28.3M | +$28.3M | — |
| Commodore Capital LP | 11,445,000 | +11,445,000 | $26.9M | +$26.9M | — |
| JANUS HENDERSON GROUP PLC | 10,540,334 | +10,540,334 | $24.8M | +$24.8M | — |
| Point72 Asset Management, L.P. | 10,495,252 | +10,495,252 | $24.7M | +$24.7M | — |
| Octagon Capital Advisors LP | 9,567,898 | +9,567,898 | $22.5M | +$22.5M | — |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | +7,124,116 | $16.7M | +$16.7M | — |
| AMERIPRISE FINANCIAL INC | 6,911,237 | +6,911,237 | $16.2M | +$16.2M | — |
| Eversept Partners, LP | 5,391,548 | +5,391,548 | $12.7M | +$12.7M | — |
| FRANKLIN RESOURCES INC | 5,092,562 | +5,092,562 | $12.0M | +$12.0M | — |
| Boxer Capital Management, LLC | 4,799,875 | +4,799,875 | $11.3M | +$11.3M | — |
| Squadron Capital Management LLC | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| B Group, Inc. | 4,500,000 | +4,500,000 | $10.6M | +$10.6M | — |
| STEMPOINT CAPITAL LP | 4,192,375 | +4,192,375 | $9.9M | +$9.9M | — |
| RENAISSANCE TECHNOLOGIES LLC | 2,382,500 | +2,382,500 | $5.6M | +$5.6M | — |
| Vivo Capital, LLC | 2,293,578 | +2,293,578 | $5.4M | +$5.4M | — |
| VANGUARD GROUP INC | 2,115,622 | +2,115,622 | $5.0M | +$5.0M | — |
| ADAR1 Capital Management, LLC | 2,004,845 | +2,004,845 | $4.7M | +$4.7M | — |
| Artia Global Partners LP | 1,992,367 | +1,992,367 | $4.7M | +$4.7M | — |
| BlackRock, Inc. | 1,879,319 | +1,879,319 | $4.4M | +$4.4M | — |
| ORBIMED ADVISORS LLC | 1,871,420 | +1,871,420 | $4.4M | +$4.4M | — |
| CITADEL ADVISORS LLC | 1,701,411 | +1,701,411 | $4.0M | +$4.0M | — |
| HighVista Strategies LLC | 1,300,031 | +1,300,031 | $3.1M | +$3.1M | — |
| Exome Asset Management LLC | 758,203 | +758,203 | $1.8M | +$1.8M | — |
| PLATINUM INVESTMENT MANAGEMENT LTD | 664,087 | +664,087 | $1.6M | +$1.6M | — |
| Hudson Bay Capital Management LP | 656,460 | +656,460 | $1.5M | +$1.5M | — |
| STATE STREET CORP | 643,997 | +643,997 | $1.5M | +$1.5M | — |
| GOLDMAN SACHS GROUP INC | 557,565 | +557,565 | $1.3M | +$1.3M | — |
| Persistent Asset Partners Ltd | 416,035 | +416,035 | $977.7K | +$977.7K | — |
| Resolute Capital Asset Partners LLC | 400,000 | +400,000 | $940.0K | +$940.0K | — |
| SUPERSTRING CAPITAL MANAGEMENT LP | 367,103 | +367,103 | $862.7K | +$862.7K | — |
| JANE STREET GROUP, LLC | 343,686 | +343,686 | $807.7K | +$807.7K | — |
| Seven Fleet Capital Management LP | 327,500 | +327,500 | $769.6K | +$769.6K | — |
| Balyasny Asset Management L.P. | 325,367 | +325,367 | $764.6K | +$764.6K | — |
| Squarepoint Ops LLC | 322,090 | +322,090 | $756.9K | +$756.9K | — |
| Creek Drive Management Group LLC | 307,500 | +307,500 | $722.6K | +$722.6K | — |
| BIT Capital GmbH | 305,000 | +305,000 | $716.8K | +$716.8K | — |
| MILLENNIUM MANAGEMENT LLC | 294,486 | +294,486 | $692.0K | +$692.0K | — |
| NORTHERN TRUST CORP | 283,147 | +283,147 | $665.4K | +$665.4K | — |
| Ikarian Capital, LLC | 274,978 | +274,978 | $646.2K | +$646.2K | — |
| Quadrature Capital Ltd | 240,586 | +240,586 | $565.4K | +$565.4K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,659 | +212,659 | $499.7K | +$499.7K | — |
| Scientech Research LLC | 211,441 | +211,441 | $496.9K | +$496.9K | — |
| TD Asset Management Inc | 204,448 | +204,448 | $480.5K | +$480.5K | — |
| SPHERA FUNDS MANAGEMENT LTD. | 184,100 | +184,100 | $432.6K | +$432.6K | — |
| DIADEMA PARTNERS LP | 166,049 | +166,049 | $390.2K | +$390.2K | — |
| ACT CAPITAL MANAGEMENT, LLC | 150,000 | +150,000 | $352.5K | +$352.5K | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,648 | +132,648 | $311.7K | +$311.7K | — |
| OMERS ADMINISTRATION Corp | 108,000 | +108,000 | $253.8K | +$253.8K | — |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 106,636 | +106,636 | $251.7K | +$251.7K | — |
| SILVERARC CAPITAL MANAGEMENT, LLC | 102,108 | +102,108 | $240.0K | +$240.0K | — |
| Pale Fire Capital SE | 70,710 | +70,710 | $166.2K | +$166.2K | — |
| Jefferies Financial Group Inc. | 46,761 | +46,761 | $109.9K | +$109.9K | — |
| VIRTUS ADVISERS, LLC | 46,000 | +46,000 | $108.1K | +$108.1K | — |
| Lighthouse Investment Partners, LLC | 39,480 | +39,480 | $92.8K | +$92.8K | — |
| Total Clarity Wealth Management, Inc. | 29,935 | +29,935 | $70.3K | +$70.3K | — |
| Caitong International Asset Management Co., Ltd | 29,388 | +29,388 | $69.1K | +$69.1K | — |
| TWO SIGMA INVESTMENTS, LP | 27,640 | +27,640 | $65.0K | +$65.0K | — |
| Vontobel Holding Ltd. | 20,000 | +20,000 | $47.0K | +$47.0K | — |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,650 | +16,650 | $39.1K | +$39.1K | — |
| VICTORY CAPITAL MANAGEMENT INC | 16,072 | +16,072 | $37.8K | +$37.8K | — |
| LPL Financial LLC | 15,154 | +15,154 | $35.6K | +$35.6K | — |
| WINTON GROUP Ltd | 14,891 | +14,891 | $35.0K | +$35.0K | — |
| BARCLAYS PLC | 14,780 | +14,780 | $34.7K | +$34.7K | — |
| Atom Investors LP | 14,041 | +14,041 | $33.0K | +$33.0K | — |
| Bank of New York Mellon Corp | 12,912 | +12,912 | $30.3K | +$30.3K | — |
| Schonfeld Strategic Advisors LLC | 11,231 | +11,231 | $26.4K | +$26.4K | — |
| Cetera Investment Advisers | 10,512 | +10,512 | $24.7K | +$24.7K | — |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,577,856 | +1,577,856 | $3.7K | +$3.7K | — |
| OSAIC HOLDINGS, INC. | 66 | +66 | $155 | +$155 | — |
| Virtu Financial LLC | 11,870 | +11,870 | $28 | +$28 | — |
| FMR LLC | 10 | +10 | $24 | +$24 | — |
| FNY Investment Advisers, LLC | 9,951 | +9,951 | $23 | +$23 | — |
| Avion Wealth | 500 | +500 | $1 | +$1 | — |