New Positions
46 managers initiated
Top five by reported value
Oruka Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:ORKA
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
46 new51 added44 reduced9 exited
Total Institutional Holders
141
as of 2025-12-31
Top Holder
FMR LLC
$220.1M
Largest QoQ Increase
Paradigm Biocapital Advisors LP
+1,710,316 sh
Largest QoQ Decrease
BRAIDWELL LP
-1,297,555 sh
New Positions(46)
Added To(51)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FMR LLC | 7,261,384 | +3,763 | $220.1M | +$80.5M | 0.1% |
| BlackRock, Inc. | 3,539,415 | +1,334,864 | $107.3M | +$64.9M | 60.5% |
| VANGUARD GROUP INC | 2,453,530 | +676,865 | $74.4M | +$40.2M | 38.1% |
| STATE STREET CORP | 1,383,847 | +731,819 | $41.9M | +$29.4M | 112.2% |
| RTW INVESTMENTS, LP | 2,058,148 | +112,499 | $62.4M | +$25.0M | 5.8% |
| PERCEPTIVE ADVISORS LLC | 1,476,501 | +208,480 | $44.8M | +$20.4M | 16.4% |
| Blackstone Inc. | 1,165,408 | +315,008 | $35.3M | +$19.0M | 37.0% |
| CITADEL ADVISORS LLC | 726,118 | +396,732 | $22.0M | +$15.7M | 120.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 942,507 | +252,535 | $28.6M | +$15.3M | 36.6% |
| UBS Group AG | 271,013 | +184,453 | $8.2M | +$6.5M | 213.1% |
| Woodline Partners LP | 574,553 | +223 | $17.4M | +$6.4M | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,496 | +82,570 | $10.0M | +$5.2M | 33.4% |
| Candriam S.C.A. | 400,509 | +33,515 | $12.1M | +$5.1M | 9.1% |
| NORTHERN TRUST CORP | 280,904 | +61,195 | $8.5M | +$4.3M | 27.9% |
| Invesco Ltd. | 143,121 | +126,803 | $4.3M | +$4.0M | 777.1% |
| DEUTSCHE BANK AG\ | 119,329 | +97,210 | $3.6M | +$3.2M | 439.5% |
| BANK OF AMERICA CORP /DE/ | 139,272 | +60,277 | $4.2M | +$2.7M | 76.3% |
| GOLDMAN SACHS GROUP INC | 92,995 | +73,220 | $2.8M | +$2.4M | 370.3% |
| Bank of New York Mellon Corp | 114,173 | +43,541 | $3.5M | +$2.1M | 61.6% |
| Nuveen, LLC | 86,347 | +51,034 | $2.6M | +$1.9M | 144.5% |
| TD Asset Management Inc | 79,896 | +34,020 | $2.4M | +$1.5M | 74.2% |
| AMERICAN CENTURY COMPANIES INC | 57,080 | +22,969 | $1.7M | +$1.1M | 67.3% |
| Rafferty Asset Management, LLC | 38,485 | +25,698 | $1.2M | +$920.6K | 201.0% |
| WELLS FARGO & COMPANY/MN | 43,261 | +22,405 | $1.3M | +$910.2K | 107.4% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,358 | +9,450 | $1.8M | +$802.5K | 18.2% |
| RHUMBLINE ADVISERS | 41,017 | +10,690 | $1.2M | +$660.0K | 35.2% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,658 | +19,960 | $656.5K | +$623.8K | 1175.5% |
| KENNEDY CAPITAL MANAGEMENT LLC | 48,686 | +420 | $1.5M | +$547.5K | 0.9% |
| Legal & General Group Plc | 18,744 | +16,267 | $568.1K | +$520.5K | 656.7% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,152 | +7,009 | $608.1K | +$355.4K | 53.3% |
| JPMORGAN CHASE & CO | 20,417 | +5,938 | $618.8K | +$340.4K | 41.0% |
| MetLife Investment Management, LLC | 21,362 | +4,849 | $647.5K | +$329.9K | 29.4% |
| AlphaQuest LLC | 14,901 | +4,140 | $451.6K | +$244.7K | 38.5% |
| CITIGROUP INC | 9,828 | +6,457 | $297.9K | +$233.1K | 191.5% |
| INTECH INVESTMENT MANAGEMENT LLC | 14,813 | +2,307 | $449.0K | +$208.5K | 18.4% |
| Police & Firemen's Retirement System of New Jersey | 10,207 | +2,849 | $309.4K | +$167.9K | 38.7% |
| China Universal Asset Management Co., Ltd. | 7,888 | +1,323 | $239.1K | +$112.8K | 20.1% |
| US BANCORP \DE\ | 2,925 | +2,747 | $88.7K | +$85.2K | 1543.3% |
| BNP PARIBAS ARBITRAGE, SNC | 5,892 | +145 | $178.6K | +$68.1K | 2.5% |
| Russell Investments Group, Ltd. | 3,041 | +788 | $92.2K | +$48.8K | 35.0% |
| Mirae Asset Global Investments Co., Ltd. | 2,352 | +904 | $71.3K | +$43.4K | 62.4% |
| Ameritas Investment Partners, Inc. | 3,132 | +355 | $94.9K | +$41.5K | 12.8% |
| Sterling Capital Management LLC | 2,224 | +347 | $67.4K | +$31.3K | 18.5% |
| GF FUND MANAGEMENT CO. LTD. | 950 | +144 | $28.8K | +$13.3K | 17.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 649,346 | +22,540 | $19.7K | +$7.6K | 3.6% |
| GROUP ONE TRADING, L.P. | 200 | +100 | $6.1K | +$4.1K | 100.0% |
| J.Safra Asset Management Corp | 155 | +107 | $4.7K | +$4.0K | 222.9% |
| Larson Financial Group LLC | 13 | +2 | $394 | +$182 | 18.2% |
| ADVISOR GROUP HOLDINGS, INC. | 4 | +3 | $121 | +$102 | 300.0% |
| AMALGAMATED BANK | 1,212 | +283 | $37 | +$19 | 30.5% |
| CWM, LLC | 586 | +192 | $18 | +$10 | 48.7% |
Reduced(44)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VR Adviser, LLC | 4,148,428 | 0 | $125.7M | +$46.0M | 0.0% |
| Fairmount Funds Management LLC | 3,705,262 | 0 | $112.3M | +$41.1M | 0.0% |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | 0 | $80.8M | +$29.5M | 0.0% |
| BRAIDWELL LP | 84,795 | -1,297,555 | $2.6M | -$24.0M | -93.9% |
| COMMODORE CAPITAL LP | 1,753,054 | 0 | $53.1M | +$19.4M | 0.0% |
| Avoro Capital Advisors LLC | 1,333,340 | 0 | $40.4M | +$14.8M | 0.0% |
| Deep Track Capital, LP | 2,161,510 | -493,271 | $65.5M | +$14.5M | -18.6% |
| Polar Capital Holdings Plc | 978,288 | -54,019 | $29.7M | +$9.8M | -5.2% |
| FRANKLIN RESOURCES INC | 938,421 | -127,361 | $28.4M | +$7.9M | -11.9% |
| Avidity Partners Management LP | 660,424 | 0 | $20.0M | +$7.3M | 0.0% |
| MERCER GLOBAL ADVISORS INC /ADV | 745,277 | -107,134 | $22.6M | +$6.2M | -12.6% |
| Cormorant Asset Management, LP | 533,340 | 0 | $16.2M | +$5.9M | 0.0% |
| Affinity Asset Advisors, LLC | 802,342 | -156,838 | $24.3M | +$5.9M | -16.4% |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | 0 | $13.0M | +$4.8M | 0.0% |
| Cable Car Capital, LP | 400,000 | -100,000 | $12.1M | +$2.5M | -20.0% |
| GREAT POINT PARTNERS LLC | 183,330 | 0 | $5.6M | +$2.0M | 0.0% |
| Point72 Asset Management, L.P. | 600,000 | -437,002 | $18.2M | -$1.8M | -42.1% |
| MORGAN STANLEY | 122,198 | -12,635 | $3.7M | +$1.1M | -9.4% |
| Resolute Capital Asset Partners LLC | 12,500 | -62,500 | $378.9K | -$1.1M | -83.3% |
| Palo Alto Investors LP | 59,985 | 0 | $1.8M | +$1.0M | 0.0% |
| abrdn plc | 75,680 | 0 | $2.3M | +$838.5K | 0.0% |
| B Group, Inc. | 75,000 | 0 | $2.3M | +$831.0K | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 84,716 | -6,378 | $2.6M | +$816.0K | -7.0% |
| BARCLAYS PLC | 91,164 | -4,166 | $1.0M | -$811.2K | -4.4% |
| D. E. Shaw & Co., Inc. | 76,415 | -19,002 | $2.3M | +$481.3K | -19.9% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,565 | -44,935 | $1.2M | -$414.6K | -52.5% |
| Financial Enhancement Group LLC | 31,293 | -1,526 | $1.1M | +$336.2K | -4.6% |
| TWO SIGMA INVESTMENTS, LP | 28,566 | 0 | $865.8K | +$316.5K | 0.0% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,184 | 0 | $849.8K | +$286.9K | 0.0% |
| ADAR1 Capital Management, LLC | 20,840 | 0 | $631.7K | +$230.9K | 0.0% |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 15,406 | 0 | $467.0K | +$170.7K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,600 | 0 | $260.7K | +$95.3K | 0.0% |
| ALTFEST L J & CO INC | 10,857 | -2,440 | $329.1K | +$73.4K | -18.4% |
| Tower Research Capital LLC (TRC) | 495 | -1,723 | $15.0K | -$27.6K | -77.7% |
| Stone House Investment Management, LLC | 1,000 | 0 | $30.3K | +$11.1K | 0.0% |
| Royal Bank of Canada | 1,139 | -1,375 | $34.0K | +$7.0K | -54.7% |
| PNC Financial Services Group, Inc. | 1,450 | -564 | $44.0K | +$5.2K | -28.0% |
| Activest Wealth Management | 166 | 0 | $5.0K | +$1.8K | 0.0% |
| True Wealth Design, LLC | 26 | 0 | $789 | +$289 | 0.0% |
| Parallel Advisors, LLC | 20 | 0 | $606 | +$221 | 0.0% |
| EverSource Wealth Advisors, LLC | 16 | 0 | $485 | +$177 | 0.0% |
| Farther Finance Advisors, LLC | 10 | 0 | $303 | +$111 | 0.0% |
| CIBC Private Wealth Group, LLC | 1 | 0 | $30 | +$11 | 0.0% |
| Daiwa Securities Group Inc. | 116 | 0 | $4 | +$2 | 0.0% |
Sold Out(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 0 | -64,991 | $0 | -$1.2M | — |
| TORONTO DOMINION BANK | 0 | -58,332 | $0 | -$1.1M | — |
| JANE STREET GROUP, LLC | 0 | -56,200 | $0 | -$1.1M | — |
| Caption Management, LLC | 0 | -13,300 | $0 | -$255.8K | — |
| SRS Capital Advisors, Inc. | 0 | -72 | $0 | -$1.4K | — |
| Rise Advisors, LLC | 0 | -36 | $0 | -$692 | — |
| NATIONAL BANK OF CANADA /FI/ | 0 | -8 | $0 | -$153 | — |
| SBI Securities Co., Ltd. | 0 | -6 | $0 | -$115 | — |
| SIMPLEX TRADING, LLC | 0 | -729 | $0 | -$14 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FMR LLC | 7,261,384 | $220.1M | +3,763 | 0.1% |
| VR Adviser, LLC | 4,148,428 | $125.7M | 0 | 0.0% |
| Fairmount Funds Management LLC | 3,705,262 | $112.3M | 0 | 0.0% |
| BlackRock, Inc. | 3,539,415 | $107.3M | +1,334,864 | 60.5% |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | $80.8M | 0 | 0.0% |
| VANGUARD GROUP INC | 2,453,530 | $74.4M | +676,865 | 38.1% |
| Deep Track Capital, LP | 2,161,510 | $65.5M | -493,271 | -18.6% |
| RTW INVESTMENTS, LP | 2,058,148 | $62.4M | +112,499 | 5.8% |
| COMMODORE CAPITAL LP | 1,753,054 | $53.1M | 0 | 0.0% |
| Paradigm Biocapital Advisors LP | 1,710,316 | $51.8M | +1,710,316 | — |
| PERCEPTIVE ADVISORS LLC | 1,476,501 | $44.8M | +208,480 | 16.4% |
| STATE STREET CORP | 1,383,847 | $41.9M | +731,819 | 112.2% |
| Avoro Capital Advisors LLC | 1,333,340 | $40.4M | 0 | 0.0% |
| Blackstone Inc. | 1,165,408 | $35.3M | +315,008 | 37.0% |
| Polar Capital Holdings Plc | 978,288 | $29.7M | -54,019 | -5.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 942,507 | $28.6M | +252,535 | 36.6% |
| FRANKLIN RESOURCES INC | 938,421 | $28.4M | -127,361 | -11.9% |
| Affinity Asset Advisors, LLC | 802,342 | $24.3M | -156,838 | -16.4% |
| MERCER GLOBAL ADVISORS INC /ADV | 745,277 | $22.6M | -107,134 | -12.6% |
| CITADEL ADVISORS LLC | 726,118 | $22.0M | +396,732 | 120.4% |
New & Closed Positions this quarter
Closed Positions
9 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ORKA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.