13F HOLDINGS REPORT
SPHERA FUNDS MANAGEMENT LTD.
Quarter ended Q2 2025 · Filed August 14, 2025 · Accession 0001496201-25-000010
Total Value
$426.1M
Positions
111
Other Managers
2
Confidential Omitted
No
Holdings (111)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 1,420,990 | $23.8M | 5.59% |
| 2 | NOVA LTD | NVMI | 75,836 | $20.9M | 4.90% |
| 3 | SPDR SERIES TRUST | 78464A870 | 200,000 | $16.6M | 3.89% |
| 4 | SYNDAX PHARMACEUTICALS INC | SNDX | 1,571,564 | $14.7M | 3.45% |
| 5 | TOWER SEMICONDUCTOR LTD | TSEM | 264,722 | $11.5M | 2.69% |
| 6 | CYTOKINETICS INC | CYTK | 326,718 | $10.8M | 2.53% |
| 7 | SANOFI | SNYNF | 219,515 | $10.6M | 2.49% |
| 8 | BIOGEN INC | BIIB | 82,738 | $10.4M | 2.44% |
| 9 | ASTRAZENECA PLC | AZN | 135,060 | $9.4M | 2.21% |
| 10 | ELI LILLY & CO | LLY | 11,540 | $9.0M | 2.11% |
| 11 | NVIDIA CORPORATION | NVDA | 54,515 | $8.6M | 2.02% |
| 12 | CELLDEX THERAPEUTICS INC NEW | CLDX | 419,540 | $8.5M | 2.00% |
| 13 | NOVO-NORDISK A S | NONOF | 105,677 | $7.3M | 1.71% |
| 14 | AMAZON COM INC | AMZN | 32,441 | $7.1M | 1.67% |
| 15 | CIDARA THERAPEUTICS INC | 171757206 | 138,001 | $6.7M | 1.58% |
| 16 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 180,600 | $6.6M | 1.54% |
| 17 | ORMAT TECHNOLOGIES INC | ORA | 78,000 | $6.5M | 1.53% |
| 18 | MINERALYS THERAPEUTICS INC | MLYS | 480,974 | $6.5M | 1.53% |
| 19 | FORTE BIOSCIENCES INC | FBRX | 495,109 | $6.4M | 1.50% |
| 20 | META PLATFORMS INC | META | 8,526 | $6.3M | 1.48% |
| 21 | JOHNSON & JOHNSON | JNJ | 40,831 | $6.2M | 1.46% |
| 22 | MOONLAKE IMMUNOTHERAPEUTICS | MLTX | 125,000 | $5.9M | 1.38% |
| 23 | MICROSOFT CORP | MSFT | 11,792 | $5.9M | 1.38% |
| 24 | AMICUS THERAPEUTICS INC | FOLD | 990,718 | $5.7M | 1.33% |
| 25 | ORMAT TECHNOLOGIES INC | ORA | 5,037,000 | $5.6M | 1.32% |
| 26 | PHARVARIS N V | PHVS | 309,931 | $5.5M | 1.28% |
| 27 | ELEDON PHARMACEUTICALS INC | ELDN | 1,959,610 | $5.3M | 1.25% |
| 28 | TRAVERE THERAPEUTICS INC | TVTX | 335,333 | $5.0M | 1.16% |
| 29 | ABBVIE INC | ABBV | 25,256 | $4.7M | 1.10% |
| 30 | GSK PLC | GLAXF | 122,000 | $4.7M | 1.10% |
| 31 | PRAXIS PRECISION MEDICINES I | PRAX | 109,757 | $4.6M | 1.08% |
| 32 | NOVARTIS AG | NVSEF | 37,000 | $4.5M | 1.05% |
| 33 | TREVI THERAPEUTICS INC | TRVI | 799,957 | $4.4M | 1.03% |
| 34 | MAZE THERAPEUTICS INC | MAZE | 356,453 | $4.4M | 1.03% |
| 35 | ANNEXON INC | ANNX | 1,764,387 | $4.2M | 0.99% |
| 36 | PRAXIS PRECISION MEDICINES I | PRAX | 100,000 | $4.2M | 0.99% |
| 37 | ISHARES TR | 464287432 | 47,000 | $4.1M | 0.97% |
| 38 | IMMUNOVANT INC | IMVT | 256,743 | $4.1M | 0.96% |
| 39 | ORIC PHARMACEUTICALS INC | ORIC | 394,693 | $4.0M | 0.94% |
| 40 | MERCK & CO INC | MRK | 48,600 | $3.8M | 0.90% |
| 41 | ACADIA PHARMACEUTICALS INC | ACAD | 174,900 | $3.8M | 0.89% |
| 42 | BRIDGEBIO PHARMA INC | BBIO | 87,108 | $3.8M | 0.88% |
| 43 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 100,085 | $3.6M | 0.85% |
| 44 | AVIDITY BIOSCIENCES INC | 05370A108 | 126,000 | $3.6M | 0.84% |
| 45 | ALPHA COGNITION INC | ACOG | 376,649 | $3.5M | 0.82% |
| 46 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 200,000 | $3.4M | 0.79% |
| 47 | REZOLUTE INC | RZLT | 751,447 | $3.4M | 0.79% |
| 48 | CYBIN INC | HELP | 398,309 | $3.3M | 0.78% |
| 49 | APPLIED MATLS INC | 038222105 | 18,000 | $3.3M | 0.77% |
| 50 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 202,996 | $3.2M | 0.75% |
| 51 | IMMATICS N.V | IMTX | 583,105 | $3.1M | 0.74% |
| 52 | SAVARA INC | SVRA | 1,310,233 | $3.0M | 0.70% |
| 53 | UBER TECHNOLOGIES INC | UBER | 30,000 | $2.8M | 0.66% |
| 54 | SAREPTA THERAPEUTICS INC | SRPT | 159,323 | $2.7M | 0.64% |
| 55 | CAMTEK LTD | CAMT | 31,976 | $2.7M | 0.63% |
| 56 | ELBIT SYS LTD | ESLT | 6,000 | $2.7M | 0.63% |
| 57 | PALO ALTO NETWORKS INC | PANW | 13,114 | $2.7M | 0.63% |
| 58 | WIX COM LTD | WIX | 16,931 | $2.7M | 0.63% |
| 59 | AMGEN INC | AMGN | 9,500 | $2.7M | 0.62% |
| 60 | SOLAREDGE TECHNOLOGIES INC | SEDG | 127,966 | $2.6M | 0.61% |
| 61 | ENLIVEN THERAPEUTICS INC | ELVN | 128,515 | $2.6M | 0.60% |
| 62 | SAREPTA THERAPEUTICS INC | SRPT | 150,000 | $2.6M | 0.60% |
| 63 | SKYE BIOSCIENCE INC | SKYE | 538,434 | $2.3M | 0.53% |
| 64 | BRIDGEBIO PHARMA INC | BBIO | 49,900 | $2.2M | 0.51% |
| 65 | DYNE THERAPEUTICS INC | DYN | 221,416 | $2.1M | 0.49% |
| 66 | PFIZER INC | PFE | 86,000 | $2.1M | 0.49% |
| 67 | BIOHAVEN LTD | BHVN | 145,372 | $2.1M | 0.48% |
| 68 | SCHOLAR ROCK HLDG CORP | SRRK | 57,497 | $2.0M | 0.48% |
| 69 | 89BIO INC | 282559103 | 205,675 | $2.0M | 0.47% |
| 70 | STRUCTURE THERAPEUTICS INC | GPCR | 95,931 | $2.0M | 0.47% |
| 71 | JANUX THERAPEUTICS INC | JANX | 85,840 | $2.0M | 0.47% |
| 72 | APELLIS PHARMACEUTICALS INC | APLS | 114,346 | $2.0M | 0.46% |
| 73 | SALESFORCE INC | CRM | 6,800 | $1.9M | 0.44% |
| 74 | ENGENE HOLDINGS INC | ENGNW | 504,409 | $1.8M | 0.43% |
| 75 | CYBERARK SOFTWARE LTD | M2682V108 | 4,000 | $1.6M | 0.38% |
| 76 | MARVELL TECHNOLOGY INC | MRVL | 18,730 | $1.4M | 0.34% |
| 77 | COGENT BIOSCIENCES INC | COGT | 200,000 | $1.4M | 0.34% |
| 78 | ASTRIA THERAPEUTICS INC | 04635X102 | 257,402 | $1.4M | 0.32% |
| 79 | KURA ONCOLOGY INC | KURA | 235,522 | $1.4M | 0.32% |
| 80 | ISHARES BITCOIN TRUST ETF | IBIT | 21,455 | $1.3M | 0.31% |
| 81 | INTELLIA THERAPEUTICS INC | NTLA | 128,780 | $1.2M | 0.28% |
| 82 | VENTYX BIOSCIENCES INC | 92332V107 | 555,814 | $1.2M | 0.28% |
| 83 | ADVANCED MICRO DEVICES INC | AMD | 8,250 | $1.2M | 0.27% |
| 84 | NANO DIMENSION LTD | NNDM | 717,518 | $1.2M | 0.27% |
| 85 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 175,371 | $1.1M | 0.27% |
| 86 | CEVA INC | CEVA | 48,920 | $1.1M | 0.25% |
| 87 | PERSPECTIVE THERAPEUTICS INC | CATX | 310,343 | $1.1M | 0.25% |
| 88 | COGENT BIOSCIENCES INC | COGT | 143,693 | $1.0M | 0.24% |
| 89 | KRYSTAL BIOTECH INC | KRYS | 7,335 | $1.0M | 0.24% |
| 90 | TAYSHA GENE THERAPIES INC | TSHA | 420,000 | $970,200 | 0.23% |
| 91 | PROMIS NEUROSCIENCES INC | PMN | 1,899,297 | $918,880 | 0.22% |
| 92 | VISTAGEN THERAPEUTICS INC | VTGN | 447,939 | $895,878 | 0.21% |
| 93 | CHEMOMAB THERAPEUTICS LTD | CMMB | 738,048 | $856,136 | 0.20% |
| 94 | BRISTOL-MYERS SQUIBB CO | CELG-RI | 17,500 | $810,075 | 0.19% |
| 95 | CORVUS PHARMACEUTICALS INC | CRVS | 183,094 | $732,376 | 0.17% |
| 96 | WEREWOLF THERAPEUTICS INC | HOWL | 626,810 | $683,223 | 0.16% |
| 97 | VERASTEM INC | VSTM | 163,307 | $677,724 | 0.16% |
| 98 | BICARA THERAPEUTICS INC | BCAX | 65,679 | $610,158 | 0.14% |
| 99 | LARIMAR THERAPEUTICS INC | LRMR | 196,635 | $568,275 | 0.13% |
| 100 | SENTINELONE INC | S | 27,000 | $493,560 | 0.12% |
| 101 | APREA THERAPEUTICS INC | APRE | 270,000 | $456,300 | 0.11% |
| 102 | COGNYTE SOFTWARE LTD | CGNT | 45,181 | $417,472 | 0.10% |
| 103 | KEZAR LIFE SCIENCES INC | KZR | 58,539 | $268,109 | 0.06% |
| 104 | CLIMB BIO INC | CLYM | 209,837 | $260,198 | 0.06% |
| 105 | SOLID BIOSCIENCES INC | SLDB | 50,190 | $244,425 | 0.06% |
| 106 | PEPGEN INC | PEPG | 156,467 | $173,678 | 0.04% |
| 107 | ONKURE THERAPEUTICS INC | OKUR | 60,454 | $144,485 | 0.03% |
| 108 | ELEVATION ONCOLOGY INC | 28623U101 | 328,562 | $120,615 | 0.03% |
| 109 | ELEDON PHARMACEUTICALS INC | ELDN | 31,200 | $84,552 | 0.02% |
| 110 | JASPER THERAPEUTICS INC | JSPRW | 14,671 | $81,424 | 0.02% |
| 111 | APPLIED THERAPEUTICS INC | 03828A101 | 50,000 | $15,555 | 0.00% |