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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

SPHERA FUNDS MANAGEMENT LTD.

Quarter ended Q1 2023 · Filed February 14, 2023 · Accession 0001496201-23-000003

Total Value
$465.9M
Positions
64
Other Managers
2
Confidential Omitted
No
View on SEC.gov

Holdings (64)

#IssuerTicker / CUSIPSharesValue% of Filing
1INVESCO QQQ TRIVZ231,000$61.5M13.20%
2INVESCO QQQ TRIVZ210,000$55.9M12.00%
3ASTRAZENECA PLCAZN400,060$27.1M5.82%
4SANOFISNYNF559,515$27.1M5.82%
5TEVA PHARMACEUTICAL INDS LTD8816249092,222,300$20.3M4.35%
6JOHNSON & JOHNSONJNJ109,831$19.4M4.16%
7SYNDAX PHARMACEUTICALS INCSNDX710,561$18.1M3.88%
8MERCK & CO INCMRK120,600$13.4M2.87%
9CRINETICS PHARMACEUTICALS INCRNX671,644$12.3M2.64%
10ALBIREO PHARMA INC01345P106463,828$10.0M2.15%
11ABBVIE INCABBV60,000$9.7M2.08%
12NOVO-NORDISK A SNONOF71,540$9.7M2.08%
13LILLY ELI & COLLY25,690$9.4M2.02%
14KEZAR LIFE SCIENCES INCKZR1,305,183$9.2M1.97%
15ULTRAGENYX PHARMACEUTICAL INRARE183,696$8.5M1.83%
16SPRINGWORKS THERAPEUTICS INC85205L107316,625$8.2M1.77%
17KEROS THERAPEUTICS INCKROS158,757$7.6M1.64%
18ARCELLX INCACLX237,488$7.4M1.58%
19ASTRIA THERAPEUTICS INC04635X102469,340$7.0M1.50%
20TOWER SEMICONDUCTOR LTDTSEM161,600$7.0M1.50%
21POINT BIOPHARMA GLOBAL INC730541109952,642$6.9M1.49%
22KURA ONCOLOGY INCKURA558,287$6.9M1.49%
23IMMATICS N.VIMTX780,852$6.8M1.46%
24CINCOR PHARMA INC17240Y109529,640$6.5M1.40%
25FIVE9 INCFIVN95,000$6.4M1.38%
26ALTIMMUNE INCALT380,298$6.3M1.34%
27CONCERT PHARMACEUTICALS INC2060221051,002,783$5.9M1.26%
28SPDR SER TR78464A87070,000$5.8M1.25%
29GENERAC HLDGS INCGNRC50,000$5.0M1.08%
30MERUS N VN5749R100316,993$4.9M1.05%
31KINIKSA PHARMACEUTICALS LTDKNSA307,283$4.6M0.99%
32LEONARDO DRS INCDRS335,557$4.3M0.92%
33IVERIC BIO INC46583P102195,591$4.2M0.90%
34BELLUS HEALTH INC NEW07987C204489,860$4.0M0.86%
35FIVERR INTL LTD33835LAA34,951,000$4.0M0.86%
36RIGEL PHARMACEUTICALS INCRIGL2,278,845$3.4M0.73%
37CHINOOK THERAPEUTICS INC16961L106127,200$3.3M0.72%
38APELLIS PHARMACEUTICALS INCAPLS60,000$3.1M0.67%
39CAMTEK LTDCAMT110,000$2.4M0.52%
40REZOLUTE INCRZLT1,155,897$2.4M0.51%
4189BIO INC282559103180,600$2.3M0.49%
42BIOGEN INCBIIB7,516$2.1M0.45%
43STOKE THERAPEUTICS INCSTOK188,640$1.7M0.37%
44INOZYME PHARMA INC45790W1081,625,058$1.7M0.37%
45PMV PHARMACEUTICALS INCPMVP187,800$1.6M0.35%
46BIOATLA INCBCAB186,600$1.5M0.33%
47ALPINE IMMUNE SCIENCES INC02083G100200,000$1.5M0.32%
48WEREWOLF THERAPEUTICS INCHOWL626,810$1.3M0.28%
49MEDIWOUND LTDMDWD75,413$1.0M0.22%
50AUTOLUS THERAPEUTICS PLCAUTL500,000$950,0000.20%
51APPLIED MATLS INC0382221058,499$827,5580.18%
52INFINITY PHARMACEUTICALS INC45665G3031,476,000$819,1800.18%
53NICE SYS INC65366HAB9250,000$576,5500.12%
54TABOOLA.COM LTDTBLAW120,000$369,6000.08%
55MAGIC SOFTWARE ENTERPRISES LRMTHF21,981$352,1990.08%
56IMMATICS N.VIMTX100,000$251,0000.05%
57AEGLEA BIOTHERAPEUTICS INC00773J103440,837$198,3330.04%
58CYCLACEL PHARMACEUTICALS INC23254L603250,000$166,7500.04%
59OTONOMO TECHNOLOGIES LTDM7571L103391,863$159,4880.03%
60ARBE ROBOTICS LTDARBEW43,165$147,1930.03%
61ONCORUS INC68236R103540,258$136,8470.03%
62DYNE THERAPEUTICS INCDYN7,149$82,8570.02%
6389BIO INC2825599033,600$45,8280.01%
64OUTBRAIN INCTEAD12,148$43,9760.01%