13F HOLDINGS REPORT
SPHERA FUNDS MANAGEMENT LTD.
Quarter ended Q4 2024 · Filed February 14, 2025 · Accession 0001496201-25-000001
Total Value
$553.1M
Positions
108
Other Managers
2
Confidential Omitted
No
Holdings (108)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 1,349,181 | $29.7M | 5.38% |
| 2 | BRIDGEBIO PHARMA INC | BBIO | 905,279 | $24.8M | 4.49% |
| 3 | SANOFI | SNYNF | 384,515 | $18.5M | 3.35% |
| 4 | SYNDAX PHARMACEUTICALS INC | SNDX | 1,381,241 | $18.3M | 3.30% |
| 5 | ASTRAZENECA PLC | AZN | 225,060 | $14.7M | 2.67% |
| 6 | AMAZON COM INC | AMZN | 62,607 | $13.7M | 2.48% |
| 7 | NOVA LTD | NVMI | 68,146 | $13.4M | 2.43% |
| 8 | META PLATFORMS INC | META | 21,001 | $12.3M | 2.22% |
| 9 | SAREPTA THERAPEUTICS INC | SRPT | 98,921 | $12.0M | 2.17% |
| 10 | CELLDEX THERAPEUTICS INC NEW | CLDX | 474,103 | $12.0M | 2.17% |
| 11 | ELEDON PHARMACEUTICALS INC | ELDN | 2,551,619 | $10.5M | 1.90% |
| 12 | ELI LILLY & CO | LLY | 13,190 | $10.2M | 1.84% |
| 13 | JOHNSON & JOHNSON | JNJ | 69,831 | $10.1M | 1.83% |
| 14 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 228,776 | $9.6M | 1.74% |
| 15 | MICROSOFT CORP | MSFT | 22,327 | $9.4M | 1.70% |
| 16 | MARVELL TECHNOLOGY INC | MRVL | 78,611 | $8.7M | 1.57% |
| 17 | TOWER SEMICONDUCTOR LTD | TSEM | 166,149 | $8.6M | 1.55% |
| 18 | NOVO-NORDISK A S | NONOF | 98,080 | $8.4M | 1.53% |
| 19 | WIX COM LTD | WIX | 39,253 | $8.4M | 1.52% |
| 20 | ALPHABET INC | GOOG | 43,500 | $8.3M | 1.50% |
| 21 | PHARVARIS N V | PHVS | 388,183 | $7.4M | 1.35% |
| 22 | NICE LTD | NCSYF | 42,500 | $7.2M | 1.30% |
| 23 | CYTOKINETICS INC | CYTK | 153,021 | $7.2M | 1.30% |
| 24 | PRAXIS PRECISION MEDICINES I | PRAX | 91,583 | $7.0M | 1.27% |
| 25 | CHECK POINT SOFTWARE TECH LT | M22465104 | 35,635 | $6.7M | 1.20% |
| 26 | APELLIS PHARMACEUTICALS INC | APLS | 206,251 | $6.6M | 1.19% |
| 27 | IMMATICS N.V | IMTX | 921,111 | $6.5M | 1.18% |
| 28 | PRAXIS PRECISION MEDICINES I | PRAX | 83,000 | $6.4M | 1.15% |
| 29 | ANNEXON INC | ANNX | 1,243,039 | $6.4M | 1.15% |
| 30 | ABBVIE INC | ABBV | 34,256 | $6.1M | 1.10% |
| 31 | MERCK & CO INC | MRK | 59,600 | $5.9M | 1.07% |
| 32 | BIOHAVEN LTD | BHVN | 156,494 | $5.8M | 1.06% |
| 33 | REZOLUTE INC | RZLT | 1,165,895 | $5.7M | 1.03% |
| 34 | JFROG LTD | FROG | 190,381 | $5.6M | 1.01% |
| 35 | DYNE THERAPEUTICS INC | DYN | 236,262 | $5.6M | 1.01% |
| 36 | MERUS N V | N5749R100 | 130,532 | $5.5M | 0.99% |
| 37 | INTELLIA THERAPEUTICS INC | NTLA | 466,080 | $5.4M | 0.98% |
| 38 | ORMAT TECHNOLOGIES INC | ORA | 79,000 | $5.3M | 0.97% |
| 39 | KURA ONCOLOGY INC | KURA | 610,087 | $5.3M | 0.96% |
| 40 | ACADIA PHARMACEUTICALS INC | ACAD | 288,539 | $5.3M | 0.96% |
| 41 | SOLAREDGE TECHNOLOGIES INC | SEDG | 375,000 | $5.1M | 0.92% |
| 42 | ORMAT TECHNOLOGIES INC | ORA | 5,037,000 | $5.0M | 0.91% |
| 43 | NOVARTIS AG | NVSEF | 50,000 | $4.9M | 0.88% |
| 44 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 220,000 | $4.8M | 0.88% |
| 45 | CYBIN INC | HELP | 538,111 | $4.7M | 0.86% |
| 46 | SKYE BIOSCIENCE INC | SKYE | 1,564,628 | $4.4M | 0.80% |
| 47 | GSK PLC | GLAXF | 130,000 | $4.4M | 0.79% |
| 48 | 89BIO INC | 282559103 | 556,532 | $4.4M | 0.79% |
| 49 | VIR BIOTECHNOLOGY INC | VIR | 581,829 | $4.3M | 0.77% |
| 50 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 334,987 | $4.2M | 0.77% |
| 51 | VIKING THERAPEUTICS INC | VKTX | 103,270 | $4.2M | 0.75% |
| 52 | PLIANT THERAPEUTICS INC | PLRX | 297,362 | $3.9M | 0.71% |
| 53 | BROADCOM INC | AVGO | 16,880 | $3.9M | 0.71% |
| 54 | SCHOLAR ROCK HLDG CORP | SRRK | 90,193 | $3.9M | 0.70% |
| 55 | TRAVERE THERAPEUTICS INC | TVTX | 220,700 | $3.8M | 0.70% |
| 56 | ENGENE HOLDINGS INC | ENGNW | 560,000 | $3.7M | 0.67% |
| 57 | SAVARA INC | SVRA | 1,211,533 | $3.7M | 0.67% |
| 58 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 197,550 | $3.7M | 0.67% |
| 59 | JANUX THERAPEUTICS INC | JANX | 68,333 | $3.7M | 0.66% |
| 60 | ALPHA COGNITION INC | ACOG | 620,000 | $3.7M | 0.66% |
| 61 | SPRINGWORKS THERAPEUTICS INC | 85205L107 | 100,000 | $3.6M | 0.65% |
| 62 | BIOGEN INC | BIIB | 22,738 | $3.5M | 0.63% |
| 63 | ENPHASE ENERGY INC | ENPH | 50,198 | $3.4M | 0.62% |
| 64 | ROCKET PHARMACEUTICALS INC | RCKTW | 271,792 | $3.4M | 0.62% |
| 65 | INOZYME PHARMA INC | 45790W108 | 1,191,140 | $3.3M | 0.60% |
| 66 | CAMTEK LTD | CAMT | 36,287 | $2.9M | 0.53% |
| 67 | JASPER THERAPEUTICS INC | JSPRW | 135,720 | $2.9M | 0.52% |
| 68 | CORVUS PHARMACEUTICALS INC | CRVS | 500,491 | $2.7M | 0.48% |
| 69 | CARGO THERAPEUTICS INC | 14179K101 | 179,674 | $2.6M | 0.47% |
| 70 | WORKDAY INC | WDAY | 10,000 | $2.6M | 0.47% |
| 71 | VIGIL NEUROSCIENCE INC | 92673K108 | 1,502,429 | $2.6M | 0.46% |
| 72 | NUTRIEN LTD | NTR | 55,894 | $2.5M | 0.45% |
| 73 | CULLINAN THERAPEUTICS INC | CGEM | 205,000 | $2.5M | 0.45% |
| 74 | PFIZER INC | PFE | 90,000 | $2.4M | 0.43% |
| 75 | VISTAGEN THERAPEUTICS INC | VTGN | 808,550 | $2.4M | 0.43% |
| 76 | CYTOKINETICS INC | CYTK | 50,000 | $2.4M | 0.43% |
| 77 | MINERALYS THERAPEUTICS INC | MLYS | 190,672 | $2.3M | 0.42% |
| 78 | IONIS PHARMACEUTICALS INC | IONS | 63,821 | $2.2M | 0.40% |
| 79 | VENTYX BIOSCIENCES INC | 92332V107 | 1,012,749 | $2.2M | 0.40% |
| 80 | ORIC PHARMACEUTICALS INC | ORIC | 273,213 | $2.2M | 0.40% |
| 81 | CHEMOMAB THERAPEUTICS LTD | CMMB | 1,214,575 | $2.2M | 0.40% |
| 82 | XENON PHARMACEUTICALS INC | XENE | 52,097 | $2.0M | 0.37% |
| 83 | PROMIS NEUROSCIENCES INC | PMN | 1,929,297 | $1.8M | 0.33% |
| 84 | UBER TECHNOLOGIES INC | UBER | 30,000 | $1.8M | 0.33% |
| 85 | LARIMAR THERAPEUTICS INC | LRMR | 455,604 | $1.8M | 0.32% |
| 86 | ZURA BIO LTD | ZURA | 690,718 | $1.7M | 0.31% |
| 87 | SHL TELEMEDICINE LTD | SHMLF | 632,456 | $1.7M | 0.30% |
| 88 | JASPER THERAPEUTICS INC | JSPRW | 77,500 | $1.7M | 0.30% |
| 89 | PERSPECTIVE THERAPEUTICS INC | CATX | 460,247 | $1.5M | 0.27% |
| 90 | JASPER THERAPEUTICS INC | JSPRW | 61,100 | $1.3M | 0.24% |
| 91 | ASTRIA THERAPEUTICS INC | 04635X102 | 139,800 | $1.2M | 0.23% |
| 92 | BRISTOL-MYERS SQUIBB CO | CELG-RI | 20,000 | $1.1M | 0.20% |
| 93 | MERSANA THERAPEUTICS INC | 59045L106 | 690,272 | $987,089 | 0.18% |
| 94 | ALUMIS INC | ALMS | 125,000 | $982,500 | 0.18% |
| 95 | WEREWOLF THERAPEUTICS INC | HOWL | 626,810 | $927,679 | 0.17% |
| 96 | APREA THERAPEUTICS INC | APRE | 270,000 | $888,300 | 0.16% |
| 97 | PERION NETWORK LTD | PERI | 102,612 | $869,124 | 0.16% |
| 98 | ONKURE THERAPEUTICS INC | OKUR | 87,354 | $751,244 | 0.14% |
| 99 | KEZAR LIFE SCIENCES INC | KZR | 108,473 | $728,939 | 0.13% |
| 100 | FATE THERAPEUTICS INC | FATE | 397,177 | $655,342 | 0.12% |
| 101 | ALECTOR INC | ALEC | 324,639 | $613,568 | 0.11% |
| 102 | ELEVATION ONCOLOGY INC | 28623U101 | 1,018,562 | $573,043 | 0.10% |
| 103 | CLIMB BIO INC | CLYM | 251,935 | $453,483 | 0.08% |
| 104 | KYVERNA THERAPEUTICS INC | KYTX | 118,758 | $444,155 | 0.08% |
| 105 | COMPUGEN LTD | CGEN | 177,094 | $270,954 | 0.05% |
| 106 | LAVA THERAPEUTICS NV | N51517105 | 126,328 | $120,138 | 0.02% |
| 107 | APPLIED THERAPEUTICS INC | 03828A101 | 50,000 | $42,810 | 0.01% |
| 108 | IMMATICS N.V | IMTX | 100,000 | $25,150 | 0.00% |