13F HOLDINGS REPORT
SPHERA FUNDS MANAGEMENT LTD.
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001496201-25-000017
Total Value
$474.1M
Positions
115
Other Managers
2
Confidential Omitted
No
Holdings (115)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 1,307,025 | $26.4M | 5.57% |
| 2 | NICE LTD | NCSYF | 157,400 | $22.8M | 4.81% |
| 3 | TOWER SEMICONDUCTOR LTD | TSEM | 311,802 | $22.5M | 4.76% |
| 4 | MERUS N V | N5749R100 | 150,000 | $14.1M | 2.98% |
| 5 | NOVA LTD | NVMI | 43,896 | $14.0M | 2.96% |
| 6 | INVESCO QQQ TR | IVZ | 22,960 | $13.8M | 2.91% |
| 7 | BIOGEN INC | BIIB | 82,738 | $11.6M | 2.44% |
| 8 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 352,558 | $10.6M | 2.24% |
| 9 | ASTRAZENECA PLC | AZN | 135,060 | $10.4M | 2.19% |
| 10 | SANOFI SA | SNYNF | 219,515 | $10.4M | 2.19% |
| 11 | CIDARA THERAPEUTICS INC | 171757206 | 100,000 | $9.6M | 2.02% |
| 12 | CYTOKINETICS INC | CYTK | 161,517 | $8.9M | 1.87% |
| 13 | MINERALYS THERAPEUTICS INC | MLYS | 219,910 | $8.3M | 1.76% |
| 14 | AMICUS THERAPEUTICS INC | FOLD | 991,142 | $7.8M | 1.65% |
| 15 | ELI LILLY & CO | LLY | 10,040 | $7.7M | 1.62% |
| 16 | JOHNSON & JOHNSON | JNJ | 40,831 | $7.6M | 1.60% |
| 17 | CIDARA THERAPEUTICS INC | 171757206 | 75,743 | $7.3M | 1.53% |
| 18 | FORTE BIOSCIENCES INC | FBRX | 474,309 | $7.1M | 1.50% |
| 19 | BRIDGEBIO PHARMA INC | BBIO | 130,000 | $6.8M | 1.42% |
| 20 | SYNDAX PHARMACEUTICALS INC | SNDX | 387,716 | $6.0M | 1.26% |
| 21 | TREVI THERAPEUTICS INC | TRVI | 643,957 | $5.9M | 1.24% |
| 22 | NOVO-NORDISK A S | NONOF | 105,677 | $5.9M | 1.24% |
| 23 | ABBVIE INC | ABBV | 25,256 | $5.8M | 1.23% |
| 24 | CELLEBRITE DI LTD | CLBT | 298,948 | $5.5M | 1.17% |
| 25 | ANNEXON INC | ANNX | 1,794,387 | $5.5M | 1.15% |
| 26 | DYNE THERAPEUTICS INC | DYN | 426,518 | $5.4M | 1.14% |
| 27 | CELLDEX THERAPEUTICS INC NEW | CLDX | 207,764 | $5.4M | 1.13% |
| 28 | SOLAREDGE TECHNOLOGIES INC | SEDG | 4,000,000 | $5.3M | 1.12% |
| 29 | GSK PLC | GLAXF | 122,000 | $5.3M | 1.11% |
| 30 | SOLAREDGE TECHNOLOGIES INC | SEDG | 140,966 | $5.2M | 1.10% |
| 31 | ORIC PHARMACEUTICALS INC | ORIC | 431,693 | $5.2M | 1.09% |
| 32 | IMMATICS N.V | IMTX | 583,105 | $5.0M | 1.05% |
| 33 | STRUCTURE THERAPEUTICS INC | GPCR | 173,931 | $4.9M | 1.03% |
| 34 | SAVARA INC | SVRA | 1,350,333 | $4.8M | 1.02% |
| 35 | NOVARTIS AG | NVSEF | 37,000 | $4.7M | 1.00% |
| 36 | RAPPORT THERAPEUTICS INC | RAPP | 157,533 | $4.7M | 0.99% |
| 37 | UNIQURE NV | QURE | 75,000 | $4.4M | 0.92% |
| 38 | VARONIS SYS INC | VRNS | 73,900 | $4.2M | 0.90% |
| 39 | ISHARES TR | 464287432 | 47,000 | $4.2M | 0.89% |
| 40 | IMMUNOVANT INC | IMVT | 256,743 | $4.1M | 0.87% |
| 41 | MERCK & CO INC | MRK | 48,600 | $4.1M | 0.86% |
| 42 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 200,000 | $4.0M | 0.85% |
| 43 | MAZE THERAPEUTICS INC | MAZE | 154,343 | $4.0M | 0.84% |
| 44 | ENGENE HOLDINGS INC | ENGNW | 504,409 | $3.4M | 0.73% |
| 45 | ELBIT SYS LTD | ESLT | 6,740 | $3.4M | 0.72% |
| 46 | REZOLUTE INC | RZLT | 363,947 | $3.4M | 0.72% |
| 47 | ENLIVEN THERAPEUTICS INC | ELVN | 166,765 | $3.4M | 0.72% |
| 48 | MEDIWOUND LTD | MDWD | 185,270 | $3.3M | 0.70% |
| 49 | ELEDON PHARMACEUTICALS INC | ELDN | 1,280,233 | $3.3M | 0.70% |
| 50 | ACADIA PHARMACEUTICALS INC | ACAD | 148,900 | $3.2M | 0.67% |
| 51 | PRAXIS PRECISION MEDICINES I | PRAX | 57,901 | $3.1M | 0.65% |
| 52 | CAMTEK LTD | CAMT | 29,048 | $3.1M | 0.64% |
| 53 | AMAZON COM INC | AMZN | 13,760 | $3.0M | 0.64% |
| 54 | CORVUS PHARMACEUTICALS INC | CRVS | 407,709 | $3.0M | 0.63% |
| 55 | PHARVARIS N V | PHVS | 119,406 | $3.0M | 0.63% |
| 56 | SAREPTA THERAPEUTICS INC | SRPT | 150,000 | $2.9M | 0.61% |
| 57 | META PLATFORMS INC | META | 3,924 | $2.9M | 0.61% |
| 58 | SOLENO THERAPEUTICS INC | SLNO | 41,606 | $2.8M | 0.59% |
| 59 | REVOLUTION MEDICINES INC | RVMDW | 60,000 | $2.8M | 0.59% |
| 60 | ORMAT TECHNOLOGIES INC | ORA | 29,000 | $2.8M | 0.59% |
| 61 | IDEAYA BIOSCIENCES INC | IDYA | 100,000 | $2.7M | 0.57% |
| 62 | AMGEN INC | AMGN | 9,500 | $2.7M | 0.57% |
| 63 | PRAXIS PRECISION MEDICINES I | PRAX | 50,000 | $2.6M | 0.56% |
| 64 | ADVANCED MICRO DEVICES INC | AMD | 15,470 | $2.5M | 0.53% |
| 65 | TRAVERE THERAPEUTICS INC | TVTX | 101,800 | $2.4M | 0.51% |
| 66 | ROIVANT SCIENCES LTD | ROIV | 151,600 | $2.3M | 0.48% |
| 67 | ALPHA COGNITION INC | ACOG | 338,752 | $2.2M | 0.47% |
| 68 | PFIZER INC | PFE | 86,000 | $2.2M | 0.46% |
| 69 | CYBIN INC | HELP | 370,376 | $2.2M | 0.46% |
| 70 | KURA ONCOLOGY INC | KURA | 245,522 | $2.2M | 0.46% |
| 71 | BROADCOM INC | AVGO | 6,555 | $2.2M | 0.46% |
| 72 | CEVA INC | CEVA | 81,085 | $2.1M | 0.45% |
| 73 | BRIDGEBIO PHARMA INC | BBIO | 40,746 | $2.1M | 0.45% |
| 74 | JANUX THERAPEUTICS INC | JANX | 85,840 | $2.1M | 0.44% |
| 75 | SKYE BIOSCIENCE INC | SKYE | 478,928 | $1.9M | 0.40% |
| 76 | ASTRIA THERAPEUTICS INC | 04635X102 | 251,225 | $1.8M | 0.39% |
| 77 | TECTONIC THERAPEUTIC INC | TECX | 115,908 | $1.8M | 0.38% |
| 78 | VAXCYTE INC | PCVX | 50,000 | $1.8M | 0.38% |
| 79 | PERSPECTIVE THERAPEUTICS INC | CATX | 510,343 | $1.8M | 0.37% |
| 80 | IMMUNOME INC | IMNM | 147,200 | $1.7M | 0.36% |
| 81 | MILESTONE PHARMACEUTICALS IN | MIST | 820,000 | $1.6M | 0.35% |
| 82 | JASPER THERAPEUTICS INC | JSPRW | 629,470 | $1.5M | 0.32% |
| 83 | UNIQURE NV | QURE | 24,900 | $1.5M | 0.31% |
| 84 | APELLIS PHARMACEUTICALS INC | APLS | 63,660 | $1.4M | 0.30% |
| 85 | COGENT BIOSCIENCES INC | COGT | 98,526 | $1.4M | 0.30% |
| 86 | STRUCTURE THERAPEUTICS INC | GPCR | 50,000 | $1.4M | 0.30% |
| 87 | ISHARES BITCOIN TRUST ETF | IBIT | 21,455 | $1.4M | 0.29% |
| 88 | VENTYX BIOSCIENCES INC | 92332V107 | 440,114 | $1.4M | 0.29% |
| 89 | BIOHAVEN LTD | BHVN | 91,155 | $1.4M | 0.29% |
| 90 | BICARA THERAPEUTICS INC | BCAX | 85,747 | $1.4M | 0.29% |
| 91 | TAYSHA GENE THERAPIES INC | TSHA | 408,146 | $1.3M | 0.28% |
| 92 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 175,371 | $1.2M | 0.26% |
| 93 | WEREWOLF THERAPEUTICS INC | HOWL | 626,810 | $1.2M | 0.26% |
| 94 | TREVI THERAPEUTICS INC | TRVI | 129,200 | $1.2M | 0.25% |
| 95 | SAB BIOTHERAPEUTICS INC | SABSW | 566,395 | $1.1M | 0.24% |
| 96 | ENPHASE ENERGY INC | ENPH | 26,700 | $944,913 | 0.20% |
| 97 | VOYAGER THERAPEUTICS INC | VYGR | 199,761 | $932,884 | 0.20% |
| 98 | CLIMB BIO INC | CLYM | 434,837 | $874,022 | 0.18% |
| 99 | LARIMAR THERAPEUTICS INC | LRMR | 260,385 | $841,044 | 0.18% |
| 100 | PEPGEN INC | PEPG | 171,467 | $792,178 | 0.17% |
| 101 | BRISTOL-MYERS SQUIBB CO | CELG-RI | 17,500 | $789,250 | 0.17% |
| 102 | VERASTEM INC | VSTM | 78,307 | $691,451 | 0.15% |
| 103 | ROIVANT SCIENCES LTD | ROIV | 42,571 | $644,099 | 0.14% |
| 104 | 89BIO INC | 282559103 | 39,675 | $583,223 | 0.12% |
| 105 | ELEDON PHARMACEUTICALS INC | ELDN | 200,000 | $518,000 | 0.11% |
| 106 | MOONLAKE IMMUNOTHERAPEUTICS | MLTX | 71,010 | $509,142 | 0.11% |
| 107 | CHEMOMAB THERAPEUTICS LTD | CMMB | 179,425 | $471,888 | 0.10% |
| 108 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 12,496 | $430,987 | 0.09% |
| 109 | APREA THERAPEUTICS INC | APRE | 270,000 | $398,250 | 0.08% |
| 110 | WAVE LIFE SCIENCES LTD | WVE | 50,000 | $366,000 | 0.08% |
| 111 | ONKURE THERAPEUTICS INC | OKUR | 60,454 | $166,249 | 0.04% |
| 112 | DESIGN THERAPEUTICS INC | DSGN | 21,918 | $165,043 | 0.03% |
| 113 | PROMIS NEUROSCIENCES INC | PMN | 295,187 | $125,454 | 0.03% |
| 114 | MOONLAKE IMMUNOTHERAPEUTICS | MLTX | 10,000 | $71,700 | 0.02% |
| 115 | APPLIED THERAPEUTICS INC | 03828A101 | 50,000 | $30,245 | 0.01% |