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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

SPHERA FUNDS MANAGEMENT LTD.

Quarter ended Q2 2023 · Filed May 15, 2023 · Accession 0001496201-23-000006

Total Value
$598.4M
Positions
81
Other Managers
2
Confidential Omitted
No
View on SEC.gov

Holdings (81)

#IssuerTicker / CUSIPSharesValue% of Filing
1ISHARES TR464287655420,900$75.1M12.55%
2SPDR S&P 500 ETF TRSPY75,000$30.7M5.13%
3SANOFISNYNF529,515$28.8M4.82%
4NICE LTDNCSYF115,482$26.4M4.42%
5ASTRAZENECA PLCAZN285,060$19.8M3.31%
6JOHNSON & JOHNSONJNJ119,831$18.6M3.10%
7TEVA PHARMACEUTICAL INDS LTD8816242092,039,500$18.0M3.02%
8TEVA PHARMACEUTICAL INDS LTD8816242092,037,000$18.0M3.01%
9MICROSOFT CORPMSFT54,623$15.7M2.63%
10SYNDAX PHARMACEUTICALS INCSNDX683,061$14.4M2.41%
11MERCK & CO INCMRK120,600$12.8M2.14%
12NOVO-NORDISK A SNONOF71,540$11.4M1.90%
13ENPHASE ENERGY INCENPH10,725,000$11.2M1.87%
14LILLY ELI & COLLY31,690$10.9M1.82%
15NUTRIEN LTDNTR145,466$10.7M1.80%
16INOZYME PHARMA INC45790W1081,781,858$10.2M1.71%
17ABBVIE INCABBV63,000$10.0M1.68%
18BIOGEN INCBIIB33,516$9.3M1.56%
19BRIDGEBIO PHARMA INCBBIO561,983$9.3M1.56%
20AMAZON COM INCAMZN85,680$8.8M1.48%
21INVESCO QQQ TRIVZ26,353$8.5M1.41%
22SPRINGWORKS THERAPEUTICS INC85205L107317,625$8.2M1.37%
23PTC THERAPEUTICS INCPTCT159,100$7.7M1.29%
24ENLIGHT RENEWABLE ENERGY LTDENLT450,864$7.6M1.27%
25KURA ONCOLOGY INCKURA603,287$7.4M1.23%
26ULTRAGENYX PHARMACEUTICAL INRARE183,696$7.4M1.23%
27JASPER THERAPEUTICS INCJSPRW4,044,008$7.3M1.22%
28POINT BIOPHARMA GLOBAL INC730541109952,642$6.9M1.16%
29CAMTEK LTDCAMT239,494$6.8M1.13%
30SAGE THERAPEUTICS INC78667J108155,000$6.5M1.09%
31MERUS N VN5749R100336,993$6.2M1.04%
32SAREPTA THERAPEUTICS INCSRPT44,000$6.1M1.01%
33KEZAR LIFE SCIENCES INCKZR1,888,228$5.9M0.99%
34SELECT SECTOR SPDR TR81369Y70457,700$5.8M0.98%
35BELLUS HEALTH INC NEW07987C204799,860$5.8M0.96%
36PFIZER INCPFE140,000$5.7M0.95%
37IVERIC BIO INC46583P102231,591$5.6M0.94%
38ASTRIA THERAPEUTICS INC04635X102421,018$5.6M0.94%
39NOVARTIS AGNVSEF60,000$5.5M0.92%
40IMMATICS N.VIMTX780,852$5.4M0.90%
41MINERALYS THERAPEUTICS INCMLYS339,000$5.3M0.89%
42ARCELLX INCACLX167,488$5.2M0.86%
43PERION NETWORK LTDPERI130,000$5.1M0.86%
44KINIKSA PHARMACEUTICALS LTDKNSA450,283$4.8M0.81%
45FUSION PHARMACEUTICALS INC36118A1001,283,537$4.8M0.81%
46DISC MEDICINE INCIRON220,013$4.7M0.78%
47MADRIGAL PHARMACEUTICALS INCMDGL19,000$4.6M0.77%
48GRACELL BIOTECHNOLOGIES INC38406L1032,360,580$4.4M0.73%
49TRAVERE THERAPEUTICS INCTVTX187,500$4.2M0.70%
50ROCKET PHARMACEUTICALS INCRCKTW236,000$4.0M0.68%
51PALO ALTO NETWORKS INCPANW20,000$4.0M0.67%
52UNIQURE NVQURE175,400$3.5M0.59%
53VAXCYTE INCPCVX90,000$3.4M0.56%
54BRIDGEBIO PHARMA INCBBIO200,000$3.3M0.55%
55COGENT BIOSCIENCES INCCOGT300,000$3.2M0.54%
56SELECTA BIOSCIENCES INC8162121042,325,000$3.2M0.54%
57MIRUM PHARMACEUTICALS INCMIRM109,336$2.6M0.44%
58DYNE THERAPEUTICS INCDYN219,316$2.5M0.42%
59RIGEL PHARMACEUTICALS INCRIGL1,878,845$2.5M0.41%
60AMGEN INCAMGN10,000$2.4M0.40%
61REZOLUTE INCRZLT1,155,897$2.2M0.37%
62CHINOOK THERAPEUTICS INC16961L10692,200$2.1M0.36%
63WEREWOLF THERAPEUTICS INCHOWL626,810$1.6M0.27%
64ALPINE IMMUNE SCIENCES INC02083G100200,000$1.5M0.26%
65MEDIWOUND LTDMDWD111,127$1.5M0.25%
66CRINETICS PHARMACEUTICALS INCRNX82,747$1.3M0.22%
67KEROS THERAPEUTICS INCKROS30,119$1.3M0.21%
68ALTIMMUNE INCALT300,000$1.3M0.21%
69UNIQURE NVQURE62,000$1.2M0.21%
70ANNEXON INCANNX250,000$962,5000.16%
71PMV PHARMACEUTICALS INCPMVP187,800$895,8060.15%
72REATA PHARMACEUTICALS INC75615P1037,689$699,0840.12%
73INFINITY PHARMACEUTICALS INC45665G3031,476,000$236,1600.04%
74FIVERR INTL LTD33835LAA3250,000$208,2230.03%
75AEGLEA BIOTHERAPEUTICS INC00773J103646,478$187,4790.03%
76OTONOMO TECHNOLOGIES LTDM7571L103391,863$186,4090.03%
77ONCORUS INC68236R103540,258$185,9030.03%
78IMMATICS N.VIMTX100,000$144,0000.02%
79CYCLACEL PHARMACEUTICALS INC23254L603250,000$142,6250.02%
80ARBE ROBOTICS LTDARBEW43,165$137,6960.02%
81MERSANA THERAPEUTICS INC59045L10610,621$43,6520.01%