13F HOLDINGS REPORT
SPHERA FUNDS MANAGEMENT LTD.
Quarter ended Q1 2025 · Filed May 15, 2025 · Accession 0001496201-25-000007
Total Value
$434.3M
Positions
116
Other Managers
2
Confidential Omitted
No
Holdings (116)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | ISHARES TR | 464287432 | 255,100 | $23.2M | 5.35% |
| 2 | SYNDAX PHARMACEUTICALS INC | SNDX | 1,663,974 | $20.4M | 4.71% |
| 3 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 1,252,181 | $19.2M | 4.43% |
| 4 | SANOFI | SNYNF | 304,515 | $16.9M | 3.89% |
| 5 | NOVA LTD | NVMI | 90,697 | $16.7M | 3.85% |
| 6 | ASTRAZENECA PLC | AZN | 175,060 | $12.9M | 2.96% |
| 7 | BRIDGEBIO PHARMA INC | BBIO | 366,608 | $12.7M | 2.92% |
| 8 | SAREPTA THERAPEUTICS INC | SRPT | 157,931 | $10.1M | 2.32% |
| 9 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 267,385 | $9.7M | 2.23% |
| 10 | ELI LILLY & CO | LLY | 11,690 | $9.7M | 2.22% |
| 11 | CELLDEX THERAPEUTICS INC NEW | CLDX | 507,829 | $9.2M | 2.12% |
| 12 | JOHNSON & JOHNSON | JNJ | 52,831 | $8.8M | 2.02% |
| 13 | NOVO-NORDISK A S | NONOF | 118,080 | $8.2M | 1.89% |
| 14 | ELEDON PHARMACEUTICALS INC | ELDN | 2,307,119 | $7.8M | 1.80% |
| 15 | MINERALYS THERAPEUTICS INC | MLYS | 465,526 | $7.4M | 1.70% |
| 16 | AMAZON COM INC | AMZN | 36,607 | $7.0M | 1.60% |
| 17 | ABBVIE INC | ABBV | 30,256 | $6.3M | 1.46% |
| 18 | PHARVARIS N V | PHVS | 383,856 | $6.0M | 1.39% |
| 19 | ORMAT TECHNOLOGIES INC | ORA | 84,000 | $5.9M | 1.37% |
| 20 | CYTOKINETICS INC | CYTK | 144,961 | $5.8M | 1.34% |
| 21 | META PLATFORMS INC | META | 9,962 | $5.7M | 1.32% |
| 22 | NOVARTIS AG | NVSEF | 50,000 | $5.6M | 1.28% |
| 23 | MERCK & CO INC | MRK | 59,600 | $5.3M | 1.23% |
| 24 | PRAXIS PRECISION MEDICINES I | PRAX | 140,660 | $5.3M | 1.23% |
| 25 | ORMAT TECHNOLOGIES INC | ORA | 5,037,000 | $5.2M | 1.20% |
| 26 | NICE LTD | NCSYF | 33,303 | $5.1M | 1.18% |
| 27 | GSK PLC | GLAXF | 130,000 | $5.0M | 1.16% |
| 28 | SOLAREDGE TECHNOLOGIES INC | SEDG | 309,216 | $5.0M | 1.15% |
| 29 | TEVA PHARMACEUTICAL INDS LTD | 881624209 | 320,000 | $4.9M | 1.13% |
| 30 | 89BIO INC | 282559103 | 618,343 | $4.5M | 1.04% |
| 31 | MERUS N V | N5749R100 | 106,532 | $4.5M | 1.03% |
| 32 | IMMATICS N.V | IMTX | 921,111 | $4.2M | 0.96% |
| 33 | APELLIS PHARMACEUTICALS INC | APLS | 181,346 | $4.0M | 0.91% |
| 34 | MAZE THERAPEUTICS INC | MAZE | 355,554 | $3.9M | 0.90% |
| 35 | PRAXIS PRECISION MEDICINES I | PRAX | 100,000 | $3.8M | 0.87% |
| 36 | TRAVERE THERAPEUTICS INC | TVTX | 200,000 | $3.6M | 0.83% |
| 37 | SAVARA INC | SVRA | 1,284,151 | $3.6M | 0.82% |
| 38 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 277,550 | $3.5M | 0.81% |
| 39 | DYNE THERAPEUTICS INC | DYN | 329,262 | $3.4M | 0.79% |
| 40 | ANNEXON INC | ANNX | 1,764,387 | $3.4M | 0.78% |
| 41 | JANUX THERAPEUTICS INC | JANX | 125,840 | $3.4M | 0.78% |
| 42 | CYBIN INC | HELP | 527,222 | $3.3M | 0.77% |
| 43 | IMMUNOVANT INC | IMVT | 194,638 | $3.3M | 0.77% |
| 44 | NVIDIA CORPORATION | NVDA | 29,605 | $3.2M | 0.74% |
| 45 | REZOLUTE INC | RZLT | 1,081,447 | $3.1M | 0.72% |
| 46 | AVIDITY BIOSCIENCES INC | 05370A108 | 106,000 | $3.1M | 0.72% |
| 47 | AMGEN INC | AMGN | 10,000 | $3.1M | 0.72% |
| 48 | BIOGEN INC | BIIB | 22,738 | $3.1M | 0.72% |
| 49 | ALPHA COGNITION INC | ACOG | 596,992 | $3.0M | 0.70% |
| 50 | VIGIL NEUROSCIENCE INC | 92673K108 | 1,604,429 | $2.9M | 0.66% |
| 51 | INTELLIA THERAPEUTICS INC | NTLA | 381,080 | $2.7M | 0.62% |
| 52 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 334,987 | $2.7M | 0.61% |
| 53 | APPLIED MATLS INC | 038222105 | 18,000 | $2.6M | 0.60% |
| 54 | SCHOLAR ROCK HLDG CORP | SRRK | 78,193 | $2.5M | 0.58% |
| 55 | SALESFORCE INC | CRM | 9,100 | $2.4M | 0.56% |
| 56 | BIOHAVEN LTD | BHVN | 99,784 | $2.4M | 0.55% |
| 57 | ENGENE HOLDINGS INC | ENGNW | 528,365 | $2.4M | 0.55% |
| 58 | SKYE BIOSCIENCE INC | SKYE | 1,476,353 | $2.3M | 0.54% |
| 59 | WORKDAY INC | WDAY | 10,000 | $2.3M | 0.54% |
| 60 | SPRINGWORKS THERAPEUTICS INC | 85205L107 | 52,009 | $2.3M | 0.53% |
| 61 | PFIZER INC | PFE | 90,000 | $2.3M | 0.53% |
| 62 | KURA ONCOLOGY INC | KURA | 343,522 | $2.3M | 0.52% |
| 63 | ENLIVEN THERAPEUTICS INC | ELVN | 111,743 | $2.2M | 0.51% |
| 64 | TOWER SEMICONDUCTOR LTD | TSEM | 61,549 | $2.2M | 0.51% |
| 65 | UBER TECHNOLOGIES INC | UBER | 30,000 | $2.2M | 0.50% |
| 66 | ALPHABET INC | GOOG | 13,500 | $2.1M | 0.49% |
| 67 | VIKING THERAPEUTICS INC | VKTX | 83,270 | $2.0M | 0.46% |
| 68 | COGENT BIOSCIENCES INC | COGT | 335,024 | $2.0M | 0.46% |
| 69 | VISTAGEN THERAPEUTICS INC | VTGN | 790,550 | $2.0M | 0.46% |
| 70 | BROADCOM INC | AVGO | 11,695 | $2.0M | 0.45% |
| 71 | IONIS PHARMACEUTICALS INC | IONS | 63,821 | $1.9M | 0.44% |
| 72 | NIKE INC | NKE | 30,050 | $1.9M | 0.44% |
| 73 | CHECK POINT SOFTWARE TECH LT | M22465104 | 8,334 | $1.9M | 0.44% |
| 74 | ROCKET PHARMACEUTICALS INC | RCKTW | 271,792 | $1.8M | 0.42% |
| 75 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 50,000 | $1.8M | 0.42% |
| 76 | MICROSOFT CORP | MSFT | 4,592 | $1.7M | 0.40% |
| 77 | NUTRIEN LTD | NTR | 30,894 | $1.5M | 0.35% |
| 78 | STRUCTURE THERAPEUTICS INC | GPCR | 84,000 | $1.5M | 0.33% |
| 79 | WIX COM LTD | WIX | 8,800 | $1.4M | 0.33% |
| 80 | JFROG LTD | FROG | 42,871 | $1.4M | 0.32% |
| 81 | CAMTEK LTD | CAMT | 23,086 | $1.4M | 0.31% |
| 82 | PROMIS NEUROSCIENCES INC | PMN | 1,929,297 | $1.3M | 0.31% |
| 83 | SHL TELEMEDICINE LTD | SHMLF | 632,456 | $1.3M | 0.30% |
| 84 | ORIC PHARMACEUTICALS INC | ORIC | 234,834 | $1.3M | 0.30% |
| 85 | CEVA INC | CEVA | 48,920 | $1.3M | 0.29% |
| 86 | BRISTOL-MYERS SQUIBB CO | CELG-RI | 20,000 | $1.2M | 0.28% |
| 87 | VENTYX BIOSCIENCES INC | 92332V107 | 1,012,749 | $1.2M | 0.27% |
| 88 | NANO DIMENSION LTD | NNDM | 717,518 | $1.1M | 0.26% |
| 89 | INOZYME PHARMA INC | 45790W108 | 1,191,140 | $1.1M | 0.25% |
| 90 | OUTLOOK THERAPEUTICS INC | OTLK | 857,142 | $1.0M | 0.24% |
| 91 | ASTRIA THERAPEUTICS INC | 04635X102 | 189,800 | $1.0M | 0.23% |
| 92 | CHEMOMAB THERAPEUTICS LTD | CMMB | 900,428 | $981,467 | 0.23% |
| 93 | PERSPECTIVE THERAPEUTICS INC | CATX | 460,247 | $980,326 | 0.23% |
| 94 | MARVELL TECHNOLOGY INC | MRVL | 15,070 | $927,860 | 0.21% |
| 95 | ARVINAS INC | ARVN | 125,000 | $877,500 | 0.20% |
| 96 | XENON PHARMACEUTICALS INC | XENE | 26,097 | $875,554 | 0.20% |
| 97 | PERION NETWORK LTD | PERI | 102,612 | $835,262 | 0.19% |
| 98 | REGULUS THERAPEUTICS INC | 75915K309 | 452,845 | $792,479 | 0.18% |
| 99 | LARIMAR THERAPEUTICS INC | LRMR | 366,304 | $787,554 | 0.18% |
| 100 | CORVUS PHARMACEUTICALS INC | CRVS | 205,859 | $654,632 | 0.15% |
| 101 | WEREWOLF THERAPEUTICS INC | HOWL | 626,810 | $609,385 | 0.14% |
| 102 | VIR BIOTECHNOLOGY INC | VIR | 90,855 | $588,740 | 0.14% |
| 103 | APREA THERAPEUTICS INC | APRE | 270,000 | $550,800 | 0.13% |
| 104 | ZURA BIO LTD | ZURA | 421,229 | $543,385 | 0.13% |
| 105 | KEZAR LIFE SCIENCES INC | KZR | 108,473 | $529,348 | 0.12% |
| 106 | JASPER THERAPEUTICS INC | JSPRW | 122,017 | $524,673 | 0.12% |
| 107 | ISHARES BITCOIN TRUST ETF | IBIT | 8,150 | $381,502 | 0.09% |
| 108 | CIDARA THERAPEUTICS INC | 171757206 | 17,128 | $368,937 | 0.08% |
| 109 | ONKURE THERAPEUTICS INC | OKUR | 80,454 | $345,952 | 0.08% |
| 110 | FATE THERAPEUTICS INC | FATE | 397,177 | $313,810 | 0.07% |
| 111 | CLIMB BIO INC | CLYM | 241,935 | $295,161 | 0.07% |
| 112 | ALECTOR INC | ALEC | 109,208 | $134,326 | 0.03% |
| 113 | ELEVATION ONCOLOGY INC | 28623U101 | 358,562 | $92,903 | 0.02% |
| 114 | LAVA THERAPEUTICS NV | N51517105 | 48,420 | $61,493 | 0.01% |
| 115 | APPLIED THERAPEUTICS INC | 03828A101 | 50,000 | $24,445 | 0.01% |
| 116 | IMMATICS N.V | IMTX | 100,000 | $1,580 | 0.00% |