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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

SPHERA FUNDS MANAGEMENT LTD.

Quarter ended Q4 2023 · Filed November 14, 2023 · Accession 0001496201-23-000012

Total Value
$549.0M
Positions
83
Other Managers
2
Confidential Omitted
No
View on SEC.gov

Holdings (83)

#IssuerTicker / CUSIPSharesValue% of Filing
1TEVA PHARMACEUTICAL INDS LTD8816242095,013,800$51.1M9.32%
2INVESCO QQQ TRIVZ136,500$48.9M8.91%
3SANOFISNYNF499,515$26.8M4.88%
4ASTRAZENECA PLCAZN285,060$19.3M3.52%
5NICE LTDNCSYF105,000$17.9M3.25%
6ENPHASE ENERGY INCENPH20,900,000$17.3M3.16%
7JOHNSON & JOHNSONJNJ94,831$14.8M2.69%
8MERCK & CO INCMRK123,600$12.7M2.32%
9AMAZON COM INCAMZN95,300$12.1M2.21%
10TOWER SEMICONDUCTOR LTDTSEM469,574$11.5M2.10%
11SYNDAX PHARMACEUTICALS INCSNDX773,061$11.2M2.04%
12MICROSOFT CORPMSFT34,442$10.9M1.98%
13ULTRAGENYX PHARMACEUTICAL INRARE259,135$9.2M1.68%
14BRIDGEBIO PHARMA INCBBIO345,537$9.1M1.66%
15NOVO-NORDISK A SNONOF93,080$8.5M1.54%
16PRAXIS PRECISION MEDICINES IPRAX4,850,317$8.3M1.51%
17ELI LILLY & COLLY14,190$7.6M1.39%
18MADRIGAL PHARMACEUTICALS INCMDGL50,867$7.4M1.35%
19SPRINGWORKS THERAPEUTICS INC85205L107319,911$7.4M1.35%
20IMMATICS N.VIMTX617,173$7.1M1.30%
21SHL TELEMEDICINE LTDSHMLF632,256$7.0M1.27%
22SOLAREDGE TECHNOLOGIES INCSEDG53,500$6.9M1.26%
23CYTOKINETICS INCCYTK233,933$6.9M1.26%
24ABBVIE INCABBV46,000$6.9M1.25%
25PALO ALTO NETWORKS INCPANW28,759$6.7M1.23%
26BIOGEN INCBIIB25,846$6.6M1.21%
27DAY ONE BIOPHARMACEUTICALS IDAWN530,000$6.5M1.18%
28KURA ONCOLOGY INCKURA703,287$6.4M1.17%
29ALNYLAM PHARMACEUTICALS INCALNY36,101$6.4M1.16%
30NICE LTDNCSYF37,482$6.4M1.16%
31POINT BIOPHARMA GLOBAL INC730541109952,642$6.4M1.16%
32TEVA PHARMACEUTICAL INDS LTD881624209600,000$6.1M1.11%
33NOVARTIS AGNVSEF60,000$6.1M1.11%
34SAREPTA THERAPEUTICS INCSRPT50,000$6.1M1.10%
35MERUS N VN5749R100253,333$6.0M1.09%
36DISC MEDICINE INCIRON111,398$5.2M0.95%
37INOZYME PHARMA INC45790W1081,234,907$5.2M0.94%
38ADVANCED MICRO DEVICES INCAMD48,320$5.0M0.90%
39CELLDEX THERAPEUTICS INC NEWCLDX180,000$5.0M0.90%
4089BIO INC282559103319,301$4.9M0.90%
41PTC THERAPEUTICS INCPTCT218,459$4.9M0.89%
42INHIBRX INCINBX256,371$4.7M0.86%
43META PLATFORMS INCMETA15,220$4.6M0.83%
44GRACELL BIOTECHNOLOGIES INC38406L1031,531,497$4.4M0.80%
45ASTRIA THERAPEUTICS INC04635X102580,599$4.3M0.79%
46MINERALYS THERAPEUTICS INCMLYS455,400$4.3M0.79%
47ROCKET PHARMACEUTICALS INCRCKTW209,040$4.3M0.78%
48COGENT BIOSCIENCES INCCOGT420,000$4.1M0.75%
49JASPER THERAPEUTICS INCJSPRW5,687,134$4.0M0.73%
50PROMIS NEUROSCIENCES INCPMN1,834,042$3.7M0.67%
51SPDR SER TR78464A87050,000$3.7M0.67%
52GSK PLCGLAXF100,000$3.6M0.66%
53MIRUM PHARMACEUTICALS INCMIRM114,284$3.6M0.66%
54AMYLYX PHARMACEUTICALS INCAMLX193,650$3.5M0.65%
55FUSION PHARMACEUTICALS INC36118A1001,354,258$3.5M0.64%
56REPLIMUNE GROUP INCREPL185,016$3.2M0.58%
57GILEAD SCIENCES INCGILD40,000$3.0M0.55%
58PFIZER INCPFE90,000$3.0M0.54%
59XENON PHARMACEUTICALS INCXENE82,400$2.8M0.51%
60CELLDEX THERAPEUTICS INC NEWCLDX100,000$2.8M0.50%
61PLIANT THERAPEUTICS INCPLRX156,134$2.7M0.49%
62ICL GROUP LTDICL470,000$2.6M0.48%
63CROWDSTRIKE HLDGS INCCRWD15,000$2.5M0.46%
64KEZAR LIFE SCIENCES INCKZR2,051,676$2.4M0.44%
65MORPHIC HLDG INC61775R10590,000$2.1M0.38%
66ALPINE IMMUNE SCIENCES INC02083G100180,000$2.1M0.38%
67CYTOKINETICS INCCYTK65,000$1.9M0.35%
68GOSSAMER BIO INCGOSS1,932,568$1.6M0.29%
69VERA THERAPEUTICS INCVERA105,000$1.4M0.26%
70WEREWOLF THERAPEUTICS INCHOWL626,810$1.3M0.24%
71XENON PHARMACEUTICALS INCXENE38,959$1.3M0.24%
72RIGEL PHARMACEUTICALS INCRIGL1,228,126$1.3M0.24%
73REZOLUTE INCRZLT996,710$1.3M0.24%
74COMPUGEN LTDCGEN1,319,239$1.2M0.22%
75UNIQURE NVQURE148,734$998,0050.18%
76SELECTA BIOSCIENCES INC816212104752,137$797,2650.15%
77APOGEE THERAPEUTICS INCAPGE30,000$639,0000.12%
78MEDIWOUND LTDMDWD59,553$633,6470.12%
79ELEVATION ONCOLOGY INC28623U101900,000$596,3400.11%
80VISTAGEN THERAPEUTICS INCVTGN100,000$524,0000.10%
81MEDIWOUND LTDMDWD48,980$521,1440.09%
82IMMATICS N.VIMTX100,000$354,0000.06%
83CALLIDITAS THERAPEUTICS AB13124Q10611,863$216,6180.04%