New Positions
30 managers initiated
Top five by reported value
Tectonic Therapeutic Inc NASDAQ NMS - GLOBAL MARKET:TECX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
30 new36 added43 reduced23 exited
Total Institutional Holders
108
as of 2025-12-31
Top Holder
FMR LLC
$58.6M
Largest QoQ Increase
BAKER BROS. ADVISORS LP
+803,400 sh
Largest QoQ Decrease
TFG Asset Management GP Ltd
-243,728 sh
New Positions(30)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 574,600 | +574,600 | $12.0M | +$12.0M | — |
| Vestal Point Capital, LP | 328,000 | +328,000 | $6.8M | +$6.8M | — |
| PERCEPTIVE ADVISORS LLC | 250,000 | +250,000 | $5.2M | +$5.2M | — |
| Opaleye Management Inc. | 214,747 | +214,747 | $4.5M | +$4.5M | — |
| D. E. Shaw & Co., Inc. | 120,250 | +120,250 | $2.5M | +$2.5M | — |
| KOTLER KEVIN | 80,000 | +80,000 | $1.7M | +$1.7M | — |
| PFM Health Sciences, LP | 42,724 | +42,724 | $891.2K | +$891.2K | — |
| Jump Financial, LLC | 39,500 | +39,500 | $824.0K | +$824.0K | — |
| Schonfeld Strategic Advisors LLC | 39,109 | +39,109 | $815.8K | +$815.8K | — |
| BIT Capital GmbH | 30,000 | +30,000 | $625.8K | +$625.8K | — |
| Aquatic Capital Management LLC | 22,262 | +22,262 | $464.4K | +$464.4K | — |
| ALPS ADVISORS INC | 15,369 | +15,369 | $320.6K | +$320.6K | — |
| SEI INVESTMENTS CO | 15,251 | +15,251 | $318.1K | +$318.1K | — |
| Palumbo Wealth Management LLC | 13,046 | +13,046 | $272.1K | +$272.1K | — |
| Marex Group plc | 12,501 | +12,501 | $260.8K | +$260.8K | — |
| DIMENSIONAL FUND ADVISORS LP | 10,075 | +10,075 | $210.2K | +$210.2K | — |
| DEUTSCHE BANK AG\ | 7,589 | +7,589 | $158.3K | +$158.3K | — |
| AlphaCentric Advisors LLC | 6,476 | +6,476 | $135.1K | +$135.1K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 6,300 | +6,300 | $131.4K | +$131.4K | — |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,410 | +6,410 | $112.8K | +$112.8K | — |
| NISA INVESTMENT ADVISORS, LLC | 5,000 | +5,000 | $104.3K | +$104.3K | — |
| HighMark Wealth Management LLC | 587 | +587 | $12.2K | +$12.2K | — |
| Farther Finance Advisors, LLC | 373 | +373 | $7.8K | +$7.8K | — |
| UBS ASSET MANAGEMENT AMERICAS INC | 173 | +173 | $3.6K | +$3.6K | — |
| GSA CAPITAL PARTNERS LLP | 63,276 | +63,276 | $1.3K | +$1.3K | — |
| Allworth Financial LP | 62 | +62 | $1.3K | +$1.3K | — |
| OPTIMA CAPITAL LLC | 31 | +31 | $647 | +$647 | — |
| True Wealth Design, LLC | 5 | +5 | $105 | +$105 | — |
| Sunbelt Securities, Inc. | 5 | +5 | $104 | +$104 | — |
| EverSource Wealth Advisors, LLC | 2 | +2 | $42 | +$42 | — |
Added To(36)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| abrdn plc | 1,141,824 | +785,648 | $23.8M | +$18.2M | 220.6% |
| BAKER BROS. ADVISORS LP | 903,400 | +803,400 | $18.8M | +$17.3M | 803.4% |
| FMR LLC | 2,807,442 | +661 | $58.6M | +$14.5M | 0.0% |
| BRAIDWELL LP | 927,524 | +190,657 | $19.3M | +$7.8M | 25.9% |
| BlackRock, Inc. | 854,363 | +26,510 | $17.8M | +$4.8M | 3.2% |
| 5AM Venture Management, LLC | 606,660 | +95,000 | $12.7M | +$4.6M | 18.6% |
| Point72 Asset Management, L.P. | 492,332 | +70,577 | $10.3M | +$3.7M | 16.7% |
| VANGUARD GROUP INC | 599,898 | +30,418 | $12.5M | +$3.6M | 5.3% |
| CITADEL ADVISORS LLC | 385,217 | +86,829 | $8.0M | +$3.4M | 29.1% |
| Squarepoint Ops LLC | 199,646 | +134,211 | $4.2M | +$3.1M | 205.1% |
| MILLENNIUM MANAGEMENT LLC | 300,820 | +62,650 | $6.3M | +$2.5M | 26.3% |
| ExodusPoint Capital Management, LP | 111,188 | +98,171 | $2.3M | +$2.1M | 754.2% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 238,913 | +44,513 | $5.0M | +$1.9M | 22.9% |
| STATE STREET CORP | 209,125 | +43,594 | $4.4M | +$1.8M | 26.3% |
| Pale Fire Capital SE | 261,026 | +1,300 | $5.4M | +$1.4M | 0.5% |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,225 | +449 | $4.4M | +$1.1M | 0.2% |
| WELLS FARGO & COMPANY/MN | 120,411 | +17,938 | $2.5M | +$904.0K | 17.5% |
| Connor, Clark & Lunn Investment Management Ltd. | 71,657 | +27,772 | $1.5M | +$806.2K | 63.3% |
| DIADEMA PARTNERS LP | 100,600 | +600 | $2.1M | +$529.5K | 0.6% |
| RAYMOND JAMES FINANCIAL INC | 54,601 | +2,670 | $1.1M | +$324.2K | 5.1% |
| AlphaQuest LLC | 18,187 | +10,888 | $379.4K | +$264.9K | 149.2% |
| MARSHALL WACE, LLP | 30,918 | +5,842 | $644.9K | +$251.5K | 23.3% |
| Virtus Investment Advisers, Inc. | 13,462 | +8,391 | $280.8K | +$201.3K | 165.5% |
| WELLINGTON MANAGEMENT GROUP LLP | 37,379 | +17 | $779.7K | +$193.5K | 0.0% |
| SIMPLEX TRADING, LLC | 9,142 | +8,374 | $190.7K | +$190.7K | 1090.4% |
| MONIMUS CAPITAL MANAGEMENT, LP | 26,594 | +2,700 | $554.8K | +$179.9K | 11.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,461 | +103 | $677.1K | +$169.4K | 0.3% |
| BARCLAYS PLC | 21,891 | +3,915 | $435.0K | +$152.9K | 21.8% |
| Clearstead Advisors, LLC | 6,500 | +5,000 | $135.6K | +$112.1K | 333.3% |
| BANK OF AMERICA CORP /DE/ | 9,225 | +2,860 | $192.4K | +$92.6K | 44.9% |
| BNP PARIBAS ARBITRAGE, SNC | 2,819 | +397 | $58.8K | +$20.8K | 16.4% |
| GROUP ONE TRADING, L.P. | 541 | +368 | $11.3K | +$8.6K | 212.7% |
| Mirae Asset Global Investments Co., Ltd. | 909 | +186 | $19.0K | +$7.6K | 25.7% |
| Russell Investments Group, Ltd. | 929 | +19 | $19.4K | +$5.1K | 2.1% |
| GAMMA Investing LLC | 29 | +21 | $605 | +$479 | 262.5% |
| CWM, LLC | 466 | +82 | $10 | +$4 | 21.4% |
Reduced(43)
Sold Out(23)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FMR LLC | 2,807,442 | $58.6M | +661 | 0.0% |
| abrdn plc | 1,141,824 | $23.8M | +785,648 | 220.6% |
| BRAIDWELL LP | 927,524 | $19.3M | +190,657 | 25.9% |
| BAKER BROS. ADVISORS LP | 903,400 | $18.8M | +803,400 | 803.4% |
| BlackRock, Inc. | 854,363 | $17.8M | +26,510 | 3.2% |
| 5AM Venture Management, LLC | 606,660 | $12.7M | +95,000 | 18.6% |
| VANGUARD GROUP INC | 599,898 | $12.5M | +30,418 | 5.3% |
| ORBIMED ADVISORS LLC | 574,600 | $12.0M | +574,600 | — |
| Point72 Asset Management, L.P. | 492,332 | $10.3M | +70,577 | 16.7% |
| FARALLON CAPITAL MANAGEMENT LLC | 640,000 | $10.0M | 0 | 0.0% |
| CITADEL ADVISORS LLC | 385,217 | $8.0M | +86,829 | 29.1% |
| Vestal Point Capital, LP | 328,000 | $6.8M | +328,000 | — |
| MILLENNIUM MANAGEMENT LLC | 300,820 | $6.3M | +62,650 | 26.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 263,560 | $5.5M | -5,793 | -2.1% |
| Pale Fire Capital SE | 261,026 | $5.4M | +1,300 | 0.5% |
| PERCEPTIVE ADVISORS LLC | 250,000 | $5.2M | +250,000 | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 238,913 | $5.0M | +44,513 | 22.9% |
| Prosight Management, LP | 235,000 | $4.9M | -144,254 | -38.0% |
| Opaleye Management Inc. | 214,747 | $4.5M | +214,747 | — |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,225 | $4.4M | +449 | 0.2% |
New & Closed Positions this quarter
Closed Positions
23 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for TECX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.