New Positions
14 managers initiated
Top five by reported value
Silence Therapeutics plc PNK:SLNCF
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
14 new15 added29 reduced12 exited
Total Institutional Holders
58
as of 2025-12-31
Top Holder
TCG Crossover Management, LLC
$18.4M
Largest QoQ Increase
GREAT POINT PARTNERS LLC
+808,032 sh
Largest QoQ Decrease
Lombard Odier Asset Management (USA) Corp
-1,589,047 sh
New Positions(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 808,032 | +808,032 | $4.9M | +$4.9M | — |
| TFG Asset Management GP Ltd | 365,369 | +365,369 | $2.2M | +$2.2M | — |
| Ishara Investments LP | 240,000 | +240,000 | $1.5M | +$1.5M | — |
| Seven Fleet Capital Management LP | 147,600 | +147,600 | $897.4K | +$897.4K | — |
| Point72 Asset Management, L.P. | 114,070 | +114,070 | $693.5K | +$693.5K | — |
| Opaleye Management Inc. | 78,926 | +78,926 | $479.9K | +$479.9K | — |
| Quadrature Capital Ltd | 54,380 | +54,380 | $330.6K | +$330.6K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,866 | +41,866 | $254.5K | +$254.5K | — |
| Qube Research & Technologies Ltd | 34,962 | +34,962 | $212.6K | +$212.6K | — |
| JANE STREET GROUP, LLC | 29,168 | +29,168 | $177.3K | +$177.3K | — |
| RAYMOND JAMES FINANCIAL INC | 25,000 | +25,000 | $152.0K | +$152.0K | — |
| XTX Topco Ltd | 11,718 | +11,718 | $71.2K | +$71.2K | — |
| Global Retirement Partners, LLC | 1,000 | +1,000 | $6.1K | +$6.1K | — |
| SageView Advisory Group, LLC | 11 | +11 | $67 | +$67 | — |
Added To(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 1,542,427 | +500,000 | $9.4M | +$4.0M | 48.0% |
| MILLENNIUM MANAGEMENT LLC | 659,592 | +361,080 | $4.0M | +$2.5M | 121.0% |
| CITADEL ADVISORS LLC | 258,861 | +237,356 | $1.6M | +$1.5M | 1103.7% |
| MARSHALL WACE, LLP | 155,680 | +72,461 | $946.5K | +$514.6K | 87.1% |
| BANK OF MONTREAL /CAN/ | 160,474 | +6,692 | $975.7K | +$177.6K | 4.3% |
| BlackRock, Inc. | 73,153 | +11,321 | $444.8K | +$123.9K | 18.3% |
| BNP PARIBAS ARBITRAGE, SNC | 12,027 | +11,427 | $73.1K | +$70.0K | 1904.5% |
| RHUMBLINE ADVISERS | 12,999 | +7,134 | $79.0K | +$48.6K | 121.6% |
| ADAR1 Capital Management, LLC | 23,643 | +5,000 | $143.7K | +$47.0K | 26.8% |
| China Universal Asset Management Co., Ltd. | 13,653 | +5,421 | $83.0K | +$40.3K | 65.8% |
| SIMPLEX TRADING, LLC | 3,991 | +3,340 | $24.3K | +$24.3K | 513.0% |
| GAMMA Investing LLC | 10,112 | +197 | $61.5K | +$10.0K | 2.0% |
| JPMORGAN CHASE & CO | 7,942 | +176 | $48.3K | +$8.0K | 2.3% |
| Mirae Asset Global Investments Co., Ltd. | 2,282 | +466 | $13.9K | +$4.5K | 25.7% |
| Tower Research Capital LLC (TRC) | 2,448 | +1 | $14.9K | +$2.2K | 0.0% |
Reduced(29)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Lombard Odier Asset Management (USA) Corp | 255,901 | -1,589,047 | $1.2M | -$6.0M | -86.1% |
| MORGAN STANLEY | 324,630 | -883,094 | $2.0M | -$4.3M | -73.1% |
| TCG Crossover Management, LLC | 3,033,560 | 0 | $18.4M | +$2.7M | 0.0% |
| Siren, L.L.C. | 2,911,438 | 0 | $17.7M | +$2.6M | 0.0% |
| Redmile Group, LLC | 2,164,777 | 0 | $13.2M | +$1.9M | 0.0% |
| Vivo Capital, LLC | 1,105,454 | 0 | $6.7M | +$983.9K | 0.0% |
| Nextech Invest, Ltd. | 952,400 | 0 | $5.8M | +$847.6K | 0.0% |
| Ikarian Capital, LLC | 865,784 | -35,000 | $1.7M | +$425.4K | -3.9% |
| 5AM Venture Management, LLC | 476,200 | 0 | $2.9M | +$423.8K | 0.0% |
| UBS Group AG | 207,513 | -99,850 | $1.3M | -$333.5K | -32.5% |
| ADVISOR GROUP HOLDINGS, INC. | 3 | -62,168 | $18 | -$298.9K | -100.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | -70,549 | $1.3M | -$180.1K | -25.2% |
| M28 Capital Management LP | 185,100 | 0 | $1.1M | +$164.7K | 0.0% |
| TWO SIGMA ADVISERS, LP | 15,900 | -26,700 | $96.7K | -$124.4K | -62.7% |
| TWO SIGMA INVESTMENTS, LP | 39,344 | -23,903 | $239.2K | -$89.0K | -37.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | 0 | $179.6K | +$26.3K | 0.0% |
| Royal Bank of Canada | 16 | -6,709 | $0 | -$26.0K | -99.8% |
| GOLDMAN SACHS GROUP INC | 18,114 | -4,530 | $110.1K | -$7.4K | -20.0% |
| BARCLAYS PLC | 7,035 | -101 | $40.8K | +$3.8K | -1.4% |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 0 | $15.2K | +$1.4K | 0.0% |
| Parallel Advisors, LLC | 1,300 | 0 | $7.9K | +$1.2K | 0.0% |
| CITIGROUP INC | 1,621 | -152 | $9.9K | +$654 | -8.6% |
| GF FUND MANAGEMENT CO. LTD. | 922 | -56 | $5.6K | +$530 | -5.7% |
| BANK OF AMERICA CORP /DE/ | 2,966 | -565 | $18.0K | -$293 | -16.0% |
| Steward Partners Investment Advisory, LLC | 100 | 0 | $608 | +$89 | 0.0% |
| SG Americas Securities, LLC | 256,340 | -51,949 | $1.6K | -$41 | -16.9% |
| Rockefeller Capital Management L.P. | 45 | 0 | $274 | +$40 | 0.0% |
| SBI Securities Co., Ltd. | 28 | -1 | $170 | +$19 | -3.4% |
| CANTOR FITZGERALD, L. P. | 801,306 | 0 | $4.2M | $0 | 0.0% |
Sold Out(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | -970,130 | $0 | -$5.0M | — |
| HSBC HOLDINGS PLC | 0 | -172,873 | $0 | -$909.3K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -24,066 | $0 | -$457.3K | — |
| Woodline Partners LP | 0 | -62,459 | $0 | -$324.2K | — |
| Massar Capital Management, LP | 0 | -19,863 | $0 | -$115.2K | — |
| Virtus Investment Advisers, Inc. | 0 | -20,374 | $0 | -$105.7K | — |
| EHP Funds Inc. | 0 | -10,673 | $0 | -$55.4K | — |
| WEXFORD CAPITAL LP | 0 | -7,708 | $0 | -$40.0K | — |
| PRINCIPAL SECURITIES, INC. | 0 | -17 | $0 | -$88 | — |
| HRT FINANCIAL LP | 0 | -10,887 | $0 | -$56 | — |
| Cambridge Investment Research Advisors, Inc. | 0 | -10,194 | $0 | -$53 | — |
| ACADIAN ASSET MANAGEMENT LLC | 0 | -4,218 | $0 | -$21 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| TCG Crossover Management, LLC | 3,033,560 | $18.4M | 0 | 0.0% |
| Siren, L.L.C. | 2,911,438 | $17.7M | 0 | 0.0% |
| Redmile Group, LLC | 2,164,777 | $13.2M | 0 | 0.0% |
| Nantahala Capital Management, LLC | 1,542,427 | $9.4M | +500,000 | 48.0% |
| Vivo Capital, LLC | 1,105,454 | $6.7M | 0 | 0.0% |
| Nextech Invest, Ltd. | 952,400 | $5.8M | 0 | 0.0% |
| GREAT POINT PARTNERS LLC | 808,032 | $4.9M | +808,032 | — |
| CANTOR FITZGERALD, L. P. | 801,306 | $4.2M | 0 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 659,592 | $4.0M | +361,080 | 121.0% |
| 5AM Venture Management, LLC | 476,200 | $2.9M | 0 | 0.0% |
| TFG Asset Management GP Ltd | 365,369 | $2.2M | +365,369 | — |
| MORGAN STANLEY | 324,630 | $2.0M | -883,094 | -73.1% |
| Ikarian Capital, LLC | 865,784 | $1.7M | -35,000 | -3.9% |
| CITADEL ADVISORS LLC | 258,861 | $1.6M | +237,356 | 1103.7% |
| Ishara Investments LP | 240,000 | $1.5M | +240,000 | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | $1.3M | -70,549 | -25.2% |
| UBS Group AG | 207,513 | $1.3M | -99,850 | -32.5% |
| Lombard Odier Asset Management (USA) Corp | 255,901 | $1.2M | -1,589,047 | -86.1% |
| M28 Capital Management LP | 185,100 | $1.1M | 0 | 0.0% |
| BANK OF MONTREAL /CAN/ | 160,474 | $975.7K | +6,692 | 4.3% |
New & Closed Positions this quarter
Closed Positions
12 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for SLNCF against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.