New Positions
21 managers initiated
Top five by reported value
SAB Biotherapeutics, Inc. NCM:SABSW
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
21 new11 added16 reduced7 exited
Total Institutional Holders
48
as of 2025-12-31
Top Holder
Vivo Capital, LLC
$42.7M
Largest QoQ Increase
Spruce Street Capital LP
+2,198,502 sh
Largest QoQ Decrease
BVF INC/IL
-932,697 sh
New Positions(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Spruce Street Capital LP | 2,198,502 | +2,198,502 | $8.2M | +$8.2M | — |
| Blackstone Inc. | 2,143,585 | +2,143,585 | $8.0M | +$8.0M | — |
| PERCEPTIVE ADVISORS LLC | 803,210 | +803,210 | $3.0M | +$3.0M | — |
| Propel Bio Management, LLC | 652,881 | +652,881 | $2.4M | +$2.4M | — |
| Jefferies Financial Group Inc. | 580,328 | +580,328 | $2.2M | +$2.2M | — |
| Balyasny Asset Management LLC | 475,439 | +475,439 | $1.8M | +$1.8M | — |
| MILLENNIUM MANAGEMENT LLC | 324,090 | +324,090 | $1.2M | +$1.2M | — |
| AMERIPRISE FINANCIAL INC | 283,645 | +283,645 | $1.1M | +$1.1M | — |
| MARSHALL WACE, LLP | 236,460 | +236,460 | $884.4K | +$884.4K | — |
| Simplify Asset Management Inc. | 208,227 | +208,227 | $778.8K | +$778.8K | — |
| STEMPOINT CAPITAL LP | 146,558 | +146,558 | $548.1K | +$548.1K | — |
| ExodusPoint Capital Management, LP | 86,113 | +86,113 | $322.1K | +$322.1K | — |
| OMERS ADMINISTRATION Corp | 42,000 | +42,000 | $157.1K | +$157.1K | — |
| Qube Research & Technologies Ltd | 31,147 | +31,147 | $116.5K | +$116.5K | — |
| Verition Fund Management LLC | 26,867 | +26,867 | $100.5K | +$100.5K | — |
| Persistent Asset Partners Ltd | 19,790 | +19,790 | $74.0K | +$74.0K | — |
| Focus Partners Wealth | 19,201 | +19,201 | $71.8K | +$71.8K | — |
| CITADEL ADVISORS LLC | 17,650 | +17,650 | $66.0K | +$66.0K | — |
| FIFTH LANE CAPITAL, LP | 15,000 | +15,000 | $56.1K | +$56.1K | — |
| STATE STREET CORP | 13,122 | +13,122 | $49.1K | +$49.1K | — |
| State of Wyoming | 8,971 | +8,971 | $33.6K | +$33.6K | — |
Added To(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 1,847,136 | +1,481,383 | $6.9M | +$6.2M | 405.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 119,517 | +33,799 | $447.0K | +$274.7K | 39.4% |
| GOLDMAN SACHS GROUP INC | 51,348 | +40,127 | $192.0K | +$169.5K | 357.6% |
| CITIGROUP INC | 29,974 | +29,142 | $112.1K | +$110.4K | 3502.6% |
| ADAR1 Capital Management, LLC | 26,344 | +11,344 | $98.5K | +$68.4K | 75.6% |
| BlackRock, Inc. | 17,239 | +10,900 | $64.5K | +$51.7K | 171.9% |
| BANK OF AMERICA CORP /DE/ | 10,613 | +10,539 | $39.7K | +$39.5K | 14241.9% |
| NORTHERN TRUST CORP | 16,412 | +5,025 | $61.4K | +$38.5K | 44.1% |
| MORGAN STANLEY | 4,262 | +4,094 | $15.9K | +$15.6K | 2436.9% |
| ADVISOR GROUP HOLDINGS, INC. | 5,024 | +200 | $18.8K | +$8.8K | 4.1% |
| JPMORGAN CHASE & CO | 1,990 | +1,903 | $7.4K | +$7.3K | 2187.3% |
Reduced(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Vivo Capital, LLC | 11,420,000 | 0 | $42.7M | +$19.8M | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 4,401,500 | 0 | $16.5M | +$7.6M | 0.0% |
| COMMODORE CAPITAL LP | 4,401,500 | 0 | $16.5M | +$7.6M | 0.0% |
| Woodline Partners LP | 2,850,881 | 0 | $10.7M | +$4.9M | 0.0% |
| Sessa Capital IM, L.P. | 2,198,457 | 0 | $8.2M | +$3.8M | 0.0% |
| HB Wealth Management, LLC | 307,500 | 0 | $1.2M | +$532.0K | 0.0% |
| AWM Investment Company, Inc. | 200,000 | 0 | $748.0K | +$346.0K | 0.0% |
| Pathstone Holdings, LLC | 50,650 | 0 | $189.4K | +$87.6K | 0.0% |
| Kestra Advisory Services, LLC | 11,550 | -380 | $43.2K | +$19.2K | -3.2% |
| CAXTON CORP | 10,527 | -408 | $39.4K | +$17.4K | -3.7% |
| UBS Group AG | 7,398 | -5,823 | $27.7K | +$1.1K | -44.0% |
| MAI Capital Management | 217 | 0 | $812 | +$375 | 0.0% |
| GS Investments, Inc. | 200 | 0 | $748 | +$346 | 0.0% |
| HARBOUR INVESTMENTS, INC. | 50 | 0 | $187 | +$86 | 0.0% |
| SBI Securities Co., Ltd. | 50 | -2 | $187 | +$82 | -3.8% |
| First PREMIER Bank | 18,986 | 0 | $71 | +$33 | 0.0% |
Sold Out(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BVF INC/IL | 0 | -932,697 | $0 | -$1.9M | — |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | -566,395 | $0 | -$1.1M | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -80,840 | $0 | -$162.5K | — |
| Kovitz Investment Group Partners, LLC | 0 | -19,201 | $0 | -$38.6K | — |
| DIMENSIONAL FUND ADVISORS LP | 0 | -15,781 | $0 | -$31.7K | — |
| Tower Research Capital LLC (TRC) | 0 | -1,560 | $0 | -$3.1K | — |
| Virtu Financial LLC | 0 | -19,982 | $0 | -$40 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Vivo Capital, LLC | 11,420,000 | $42.7M | 0 | 0.0% |
| COMMODORE CAPITAL LP | 4,401,500 | $16.5M | 0 | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 4,401,500 | $16.5M | 0 | 0.0% |
| Woodline Partners LP | 2,850,881 | $10.7M | 0 | 0.0% |
| Spruce Street Capital LP | 2,198,502 | $8.2M | +2,198,502 | — |
| Sessa Capital IM, L.P. | 2,198,457 | $8.2M | 0 | 0.0% |
| Blackstone Inc. | 2,143,585 | $8.0M | +2,143,585 | — |
| VANGUARD GROUP INC | 1,847,136 | $6.9M | +1,481,383 | 405.0% |
| PERCEPTIVE ADVISORS LLC | 803,210 | $3.0M | +803,210 | — |
| Propel Bio Management, LLC | 652,881 | $2.4M | +652,881 | — |
| Jefferies Financial Group Inc. | 580,328 | $2.2M | +580,328 | — |
| Balyasny Asset Management LLC | 475,439 | $1.8M | +475,439 | — |
| MILLENNIUM MANAGEMENT LLC | 324,090 | $1.2M | +324,090 | — |
| HB Wealth Management, LLC | 307,500 | $1.2M | 0 | 0.0% |
| AMERIPRISE FINANCIAL INC | 283,645 | $1.1M | +283,645 | — |
| MARSHALL WACE, LLP | 236,460 | $884.4K | +236,460 | — |
| Simplify Asset Management Inc. | 208,227 | $778.8K | +208,227 | — |
| AWM Investment Company, Inc. | 200,000 | $748.0K | 0 | 0.0% |
| STEMPOINT CAPITAL LP | 146,558 | $548.1K | +146,558 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 119,517 | $447.0K | +33,799 | 39.4% |
New & Closed Positions this quarter
Closed Positions
7 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for SABSW against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.