New Positions
38 managers initiated
Top five by reported value
Kalvista Pharmaceuticals Inc NASDAQ NMS - GLOBAL MARKET:KALV
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
38 new54 added70 reduced22 exited
Total Institutional Holders
162
as of 2025-12-31
Top Holder
VR Adviser, LLC
$108.7M
Largest QoQ Increase
Point72 Asset Management, L.P.
+2,283,766 sh
Largest QoQ Decrease
TUDOR INVESTMENT CORP ET AL
-2,000,000 sh
New Positions(38)
Added To(54)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,427,118 | +1,063,740 | $39.2M | +$22.6M | 78.0% |
| BlackRock, Inc. | 3,754,148 | +628,031 | $60.6M | +$22.6M | 20.1% |
| Kynam Capital Management, LP | 1,810,954 | +1,204,783 | $29.2M | +$21.9M | 198.8% |
| Vestal Point Capital, LP | 1,890,000 | +1,140,000 | $30.5M | +$21.4M | 152.0% |
| MILLENNIUM MANAGEMENT LLC | 2,920,166 | +803,943 | $47.2M | +$21.4M | 38.0% |
| STATE STREET CORP | 1,911,691 | +336,195 | $30.9M | +$11.7M | 21.3% |
| VANGUARD GROUP INC | 2,509,020 | +7,901 | $40.5M | +$10.1M | 0.3% |
| Woodline Partners LP | 1,921,092 | +428 | $31.0M | +$7.6M | 0.0% |
| Parkman Healthcare Partners LLC | 1,768,508 | +33,505 | $28.6M | +$7.4M | 1.9% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,171,755 | +13,298 | $18.9M | +$4.8M | 1.1% |
| MORGAN STANLEY | 700,228 | +135,372 | $11.3M | +$4.4M | 24.0% |
| Blue Owl Capital Holdings LP | 360,000 | +235,000 | $5.8M | +$4.3M | 188.0% |
| Bank of New York Mellon Corp | 695,175 | +98,701 | $11.2M | +$4.0M | 16.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 944,077 | +15,406 | $15.3M | +$3.9M | 1.6% |
| Hennion & Walsh Asset Management, Inc. | 341,819 | +165,236 | $5.5M | +$3.4M | 93.6% |
| Skandinaviska Enskilda Banken AB (publ) | 351,305 | +150,314 | $5.7M | +$3.2M | 74.8% |
| BANK OF AMERICA CORP /DE/ | 389,813 | +25,404 | $6.3M | +$1.9M | 7.0% |
| NORTHERN TRUST CORP | 351,973 | +1,250 | $5.7M | +$1.4M | 0.3% |
| F/M Investments LLC | 236,690 | +37,486 | $3.8M | +$1.4M | 18.8% |
| Boxer Capital Management, LLC | 134,200 | +113,800 | $1.6M | +$1.4M | 557.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,369 | +2,402 | $5.2M | +$1.3M | 0.7% |
| Nuveen, LLC | 107,129 | +27,371 | $1.7M | +$758.7K | 34.3% |
| FMR LLC | 111,807 | +19,439 | $1.8M | +$680.6K | 21.0% |
| Virtus Investment Advisers, Inc. | 40,414 | +31,721 | $652.7K | +$546.8K | 364.9% |
| Invesco Ltd. | 77,864 | +14,621 | $1.3M | +$487.2K | 23.1% |
| WELLS FARGO & COMPANY/MN | 56,014 | +18,770 | $904.6K | +$451.0K | 50.4% |
| Rafferty Asset Management, LLC | 65,593 | +7,803 | $1.1M | +$355.4K | 13.5% |
| Quantinno Capital Management LP | 29,156 | +14,998 | $470.9K | +$298.4K | 105.9% |
| JANE STREET GROUP, LLC | 46,108 | +9,445 | $744.6K | +$298.1K | 25.8% |
| Swiss National Bank | 54,900 | +6,400 | $886.6K | +$295.9K | 13.2% |
| UBS ASSET MANAGEMENT AMERICAS INC | 27,722 | +14,122 | $447.7K | +$282.1K | 103.8% |
| Brevan Howard Capital Management LP | 59,147 | +3,269 | $955.2K | +$274.6K | 5.8% |
| Creative Planning | 44,082 | +6,050 | $711.9K | +$248.7K | 15.9% |
| PROFUND ADVISORS LLC | 24,392 | +11,779 | $393.9K | +$240.3K | 93.4% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,868 | +13,323 | $288.6K | +$233.2K | 293.1% |
| Russell Investments Group, Ltd. | 56,249 | +53 | $908.4K | +$224.0K | 0.1% |
| AlphaQuest LLC | 52,190 | +415 | $842.9K | +$212.2K | 0.8% |
| DEUTSCHE BANK AG\ | 35,091 | +4,836 | $566.7K | +$198.2K | 16.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,410 | +4,024 | $458.8K | +$161.8K | 16.5% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,624 | +1,112 | $347.4K | +$97.5K | 5.4% |
| Truvestments Capital LLC | 4,684 | +3,360 | $75.6K | +$59.5K | 253.8% |
| SEI INVESTMENTS CO | 11,897 | +1 | $192.1K | +$47.2K | 0.0% |
| KLP KAPITALFORVALTNING AS | 6,000 | +800 | $96.9K | +$33.6K | 15.4% |
| NISA INVESTMENT ADVISORS, LLC | 5,076 | +519 | $82.0K | +$26.5K | 11.4% |
| Caitong International Asset Management Co., Ltd | 1,077 | +975 | $17.4K | +$16.2K | 955.9% |
| Mirae Asset Global Investments Co., Ltd. | 2,456 | +510 | $39.7K | +$16.0K | 26.2% |
| QUADRANT CAPITAL GROUP LLC | 1,232 | +455 | $19.9K | +$10.4K | 58.5% |
| Farther Finance Advisors, LLC | 688 | +492 | $11.1K | +$8.7K | 251.0% |
| Smartleaf Asset Management LLC | 575 | +322 | $9.0K | +$5.9K | 127.3% |
| US BANCORP \DE\ | 710 | +63 | $11.5K | +$3.6K | 9.7% |
| Larson Financial Group LLC | 723 | +33 | $11.7K | +$3.3K | 4.8% |
| Sterling Capital Management LLC | 264 | +173 | $4.3K | +$3.2K | 190.1% |
| SG Americas Securities, LLC | 48,030 | +6,410 | $776 | +$269 | 15.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,118 | +3,138 | $374 | +$130 | 15.7% |
Reduced(70)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VR Adviser, LLC | 6,728,985 | 0 | $108.7M | +$26.7M | 0.0% |
| Frazier Life Sciences Management, L.P. | 5,039,867 | 0 | $81.4M | +$20.0M | 0.0% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,768,712 | 0 | $77.0M | +$18.9M | 0.0% |
| Caption Management, LLC | 117,907 | -1,469,715 | $1.9M | -$17.4M | -92.6% |
| TANG CAPITAL MANAGEMENT LLC | 4,573,530 | -468,268 | $73.9M | +$12.5M | -9.3% |
| GOLDMAN SACHS GROUP INC | 835,304 | -964,877 | $13.5M | -$8.4M | -53.6% |
| Capital World Investors | 2,808,583 | -369,004 | $45.4M | +$6.7M | -11.6% |
| EMERALD ADVISERS, LLC | 1,340,495 | -10,759 | $21.6M | +$5.2M | -0.8% |
| Octagon Capital Advisors LP | 1,273,333 | 0 | $20.6M | +$5.1M | 0.0% |
| BARCLAYS PLC | 219,723 | -358,181 | $2.5M | -$4.6M | -62.0% |
| Ikarian Capital, LLC | 35,119 | -364,881 | $567.2K | -$4.3M | -91.2% |
| CITIGROUP INC | 10,771 | -269,885 | $174.0K | -$3.2M | -96.2% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,595 | -279,644 | $2.0M | -$2.9M | -69.0% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 855,461 | -62,514 | $13.8M | +$2.6M | -6.8% |
| Freestone Grove Partners LP | 633,019 | -71,429 | $10.2M | +$1.6M | -10.1% |
| Royal Bank of Canada | 1,231 | -63,214 | $20.0K | -$709.0K | -98.1% |
| PANAGORA ASSET MANAGEMENT INC | 109,391 | -87,944 | $1.8M | -$636.9K | -44.6% |
| DAFNA Capital Management LLC | 356,802 | -65,929 | $5.8M | +$613.5K | -15.6% |
| NAN FUNG TRINITY (HK) LTD | 154,522 | 0 | $2.5M | +$613.5K | 0.0% |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,923 | -50,037 | $257.2K | -$546.2K | -75.8% |
| Schonfeld Strategic Advisors LLC | 305,880 | -140,492 | $4.9M | -$496.8K | -31.5% |
| UBS Group AG | 371,993 | -82,155 | $6.0M | +$476.2K | -18.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 122,379 | -3,673 | $2.0M | +$441.1K | -2.9% |
| RAYMOND JAMES FINANCIAL INC | 129,517 | -19,789 | $2.1M | +$273.2K | -13.3% |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 0 | $646.3K | +$158.9K | 0.0% |
| Magnetar Financial LLC | 10,938 | -15,986 | $176.6K | -$151.3K | -59.4% |
| AQR CAPITAL MANAGEMENT LLC | 24,666 | -19,940 | $398.4K | -$144.9K | -44.7% |
| AMERIPRISE FINANCIAL INC | 34,929 | -520 | $564.1K | +$132.3K | -1.5% |
| EVOKE WEALTH, LLC | 31,841 | -212 | $514.2K | +$123.8K | -0.7% |
| RHUMBLINE ADVISERS | 47,391 | -5,407 | $765.4K | +$122.3K | -10.2% |
| Birchview Capital, LP | 57,000 | -10,000 | $920.5K | +$104.5K | -14.9% |
| Legal & General Group Plc | 23,818 | -136 | $384.7K | +$92.9K | -0.6% |
| MetLife Investment Management, LLC | 21,688 | 0 | $350.3K | +$86.1K | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 21,937 | -1,424 | $354.3K | +$69.1K | -6.1% |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | 0 | $269.9K | +$66.3K | 0.0% |
| JPMORGAN CHASE & CO | 19,454 | -1,305 | $314.2K | +$61.3K | -6.3% |
| INTECH INVESTMENT MANAGEMENT LLC | 12,919 | 0 | $208.6K | +$51.3K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 11,172 | 0 | $180.4K | +$44.4K | 0.0% |
| JANUS HENDERSON GROUP PLC | 10,900 | 0 | $176.3K | +$43.4K | 0.0% |
| ADAR1 Capital Management, LLC | 10,000 | 0 | $161.5K | +$39.7K | 0.0% |
| Choate Investment Advisors | 10,000 | 0 | $161.5K | +$39.7K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,964 | 0 | $160.9K | +$39.6K | 0.0% |
| Tower Research Capital LLC (TRC) | 370 | -2,515 | $6.0K | -$29.2K | -87.2% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,823 | -1,465 | $190.9K | +$29.1K | -11.0% |
| BNP PARIBAS ARBITRAGE, SNC | 4,090 | -3,704 | $66.1K | -$28.9K | -47.5% |
| Rathbones Group Plc | 12,272 | -6,150 | $198.2K | -$26.2K | -33.4% |
| China Universal Asset Management Co., Ltd. | 8,236 | -588 | $133.0K | +$25.5K | -6.7% |
| SRS Capital Advisors, Inc. | 250 | -721 | $4.0K | -$7.8K | -74.3% |
| SHERBROOKE PARK ADVISERS LLC | 11,424 | -4,254 | $184.5K | -$6.5K | -27.1% |
| 1620 INVESTMENT ADVISORS, INC. | 1,590 | 0 | $25.7K | +$6.3K | 0.0% |
| Ameritas Investment Partners, Inc. | 3,186 | -545 | $51.5K | +$6.0K | -14.6% |
| Versant Capital Management, Inc | 1,024 | 0 | $16.5K | +$4.1K | 0.0% |
| Parallel Advisors, LLC | 1,287 | -136 | $20.8K | +$3.5K | -9.6% |
| EverSource Wealth Advisors, LLC | 145 | -316 | $2.3K | -$3.3K | -68.5% |
| GF FUND MANAGEMENT CO. LTD. | 992 | -91 | $16.0K | +$2.8K | -8.4% |
| COMERICA BANK | 519 | 0 | $8.4K | +$2.1K | 0.0% |
| SIGNATUREFD, LLC | 1,583 | -649 | $25.6K | -$1.6K | -29.1% |
| GAMMA Investing LLC | 225 | -194 | $3.6K | -$1.5K | -46.3% |
| TOTH FINANCIAL ADVISORY CORP | 100 | 0 | $1.6K | +$397 | 0.0% |
| ROTHSCHILD INVESTMENT LLC | 70 | -50 | $1.1K | -$331 | -41.7% |
| SBI Securities Co., Ltd. | 119 | -14 | $1.9K | +$302 | -10.5% |
| PNC Financial Services Group, Inc. | 146 | -27 | $2.4K | +$251 | -15.6% |
| True Wealth Design, LLC | 54 | -4 | $873 | +$166 | -6.9% |
| Parkside Financial Bank & Trust | 40 | 0 | $646 | +$158 | 0.0% |
| Optiver Holding B.V. | 149 | -61 | $2.4K | -$152 | -29.0% |
| Sunbelt Securities, Inc. | 9 | -9 | $145 | -$74 | -50.0% |
| CWM, LLC | 659 | -1,163 | $11 | -$11 | -63.8% |
| AMALGAMATED BANK | 1,205 | -138 | $19 | +$3 | -10.3% |
| Daiwa Securities Group Inc. | 154 | 0 | $2 | $0 | 0.0% |
| BESSEMER GROUP INC | 10 | 0 | $0 | $0 | 0.0% |
Sold Out(22)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Sio Capital Management, LLC | 0 | -683,819 | $0 | -$8.3M | — |
| MARSHALL WACE, LLP | 0 | -370,773 | $0 | -$4.5M | — |
| Qube Research & Technologies Ltd | 0 | -325,435 | $0 | -$4.0M | — |
| Jefferies Financial Group Inc. | 0 | -286,875 | $0 | -$3.5M | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | -250,183 | $0 | -$3.0M | — |
| TUDOR INVESTMENT CORP ET AL | 0 | -2,000,000 | $0 | -$2.2M | — |
| SummitTX Capital, L.P. | 0 | -143,561 | $0 | -$1.7M | — |
| Susquehanna Portfolio Strategies, LLC | 0 | -128,011 | $0 | -$1.6M | — |
| Artia Global Partners LP | 0 | -83,110 | $0 | -$1.0M | — |
| STEMPOINT CAPITAL LP | 0 | -56,770 | $0 | -$691.5K | — |
| DIMENSIONAL FUND ADVISORS LP | 0 | -45,444 | $0 | -$553.5K | — |
| HAP Trading, LLC | 0 | -121,219 | $0 | -$456.7K | — |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | -21,421 | $0 | -$260.9K | — |
| D. E. Shaw & Co., Inc. | 0 | -21,100 | $0 | -$257.0K | — |
| AXQ CAPITAL, LP | 0 | -17,213 | $0 | -$209.7K | — |
| DRW Securities, LLC | 0 | -16,775 | $0 | -$196.0K | — |
| Savant Capital, LLC | 0 | -11,568 | $0 | -$140.9K | — |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | -10,686 | $0 | -$130.2K | — |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | -4,662 | $0 | -$56.8K | — |
| BRYN MAWR TRUST Co | 0 | -415 | $0 | -$5.1K | — |
| CIBC Private Wealth Group, LLC | 0 | -160 | $0 | -$1.9K | — |
| CoreCap Advisors, LLC | 0 | -23 | $0 | -$280 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| VR Adviser, LLC | 6,728,985 | $108.7M | 0 | 0.0% |
| Frazier Life Sciences Management, L.P. | 5,039,867 | $81.4M | 0 | 0.0% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,768,712 | $77.0M | 0 | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 4,573,530 | $73.9M | -468,268 | -9.3% |
| BlackRock, Inc. | 3,754,148 | $60.6M | +628,031 | 20.1% |
| MILLENNIUM MANAGEMENT LLC | 2,920,166 | $47.2M | +803,943 | 38.0% |
| Capital World Investors | 2,808,583 | $45.4M | -369,004 | -11.6% |
| VANGUARD GROUP INC | 2,509,020 | $40.5M | +7,901 | 0.3% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,427,118 | $39.2M | +1,063,740 | 78.0% |
| Point72 Asset Management, L.P. | 2,283,766 | $36.9M | +2,283,766 | — |
| Woodline Partners LP | 1,921,092 | $31.0M | +428 | 0.0% |
| STATE STREET CORP | 1,911,691 | $30.9M | +336,195 | 21.3% |
| Vestal Point Capital, LP | 1,890,000 | $30.5M | +1,140,000 | 152.0% |
| Kynam Capital Management, LP | 1,810,954 | $29.2M | +1,204,783 | 198.8% |
| Parkman Healthcare Partners LLC | 1,768,508 | $28.6M | +33,505 | 1.9% |
| EMERALD ADVISERS, LLC | 1,340,495 | $21.6M | -10,759 | -0.8% |
| Octagon Capital Advisors LP | 1,273,333 | $20.6M | 0 | 0.0% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,171,755 | $18.9M | +13,298 | 1.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 944,077 | $15.3M | +15,406 | 1.6% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 855,461 | $13.8M | -62,514 | -6.8% |
New & Closed Positions this quarter
Closed Positions
22 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for KALV against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.