New Positions
60 managers initiated
Top five by reported value
Compass Therapeutics Inc. NASDAQ NMS - GLOBAL MARKET:CMPX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
60 new58 added52 reduced11 exited
Total Institutional Holders
170
as of 2025-12-31
Top Holder
TANG CAPITAL MANAGEMENT LLC
$90.2M
Largest QoQ Increase
DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)
+3,606,000 sh
Largest QoQ Decrease
BIOIMPACT CAPITAL LLC
-5,075,970 sh
New Positions(60)
Added To(58)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,182,379 | +81,220 | $76.2M | +$26.8M | 0.6% |
| BVF INC/IL | 7,764,842 | +3,014,842 | $41.7M | +$25.1M | 63.5% |
| BlackRock, Inc. | 9,388,624 | +2,017,877 | $50.4M | +$24.6M | 27.4% |
| VANGUARD GROUP INC | 8,048,374 | +985,575 | $43.2M | +$18.5M | 13.9% |
| STATE STREET CORP | 4,890,525 | +1,784,012 | $26.3M | +$15.4M | 57.4% |
| Sofinnova Investments, Inc. | 3,365,446 | +1,336,560 | $18.1M | +$11.0M | 65.9% |
| Blue Owl Capital Holdings LP | 3,466,525 | +875,000 | $18.6M | +$9.5M | 33.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,502,526 | +558,057 | $18.8M | +$8.5M | 18.9% |
| Birchview Capital, LP | 1,592,938 | +720,000 | $8.6M | +$5.5M | 82.5% |
| GOLDMAN SACHS GROUP INC | 1,517,415 | +477,744 | $8.1M | +$4.5M | 46.0% |
| ACUTA CAPITAL PARTNERS, LLC | 1,093,300 | +253,210 | $5.9M | +$2.9M | 30.1% |
| NORTHERN TRUST CORP | 972,935 | +111,000 | $5.2M | +$2.2M | 12.9% |
| CITIGROUP INC | 261,876 | +251,225 | $1.4M | +$1.4M | 2358.7% |
| MORGAN STANLEY | 365,245 | +178,293 | $2.0M | +$1.3M | 95.4% |
| DIMENSIONAL FUND ADVISORS LP | 341,596 | +166,040 | $1.8M | +$1.2M | 94.6% |
| BANK OF AMERICA CORP /DE/ | 266,434 | +192,633 | $1.4M | +$1.2M | 261.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,157 | +74,907 | $2.2M | +$1.0M | 22.3% |
| Bank of New York Mellon Corp | 312,480 | +89,304 | $1.7M | +$896.9K | 40.0% |
| STATE OF WISCONSIN INVESTMENT BOARD | 185,423 | +144,023 | $995.7K | +$850.8K | 347.9% |
| Nuveen, LLC | 288,924 | +29,713 | $1.6M | +$644.3K | 11.5% |
| AQR CAPITAL MANAGEMENT LLC | 155,218 | +96,070 | $833.5K | +$626.5K | 162.4% |
| ADAR1 Capital Management, LLC | 139,000 | +89,000 | $746.4K | +$571.4K | 178.0% |
| Rafferty Asset Management, LLC | 151,743 | +80,784 | $814.9K | +$566.5K | 113.8% |
| XTX Topco Ltd | 115,634 | +98,684 | $621.0K | +$561.6K | 582.2% |
| WELLS FARGO & COMPANY/MN | 144,798 | +76,625 | $777.6K | +$539.0K | 112.4% |
| ALPS ADVISORS INC | 146,040 | +63,033 | $784.2K | +$493.7K | 75.9% |
| Brevan Howard Capital Management LP | 118,528 | +72,651 | $636.5K | +$475.9K | 158.4% |
| Squarepoint Ops LLC | 126,192 | +38,339 | $677.7K | +$370.2K | 43.6% |
| Creative Planning | 108,144 | +47,217 | $580.7K | +$367.5K | 77.5% |
| DEUTSCHE BANK AG\ | 109,273 | +13,488 | $586.8K | +$251.5K | 14.1% |
| PROFUND ADVISORS LLC | 57,246 | +40,778 | $307.4K | +$249.8K | 247.6% |
| JANE STREET GROUP, LLC | 70,063 | +25,584 | $376.2K | +$220.6K | 57.5% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,576 | +19,726 | $373.7K | +$198.1K | 39.6% |
| MetLife Investment Management, LLC | 73,985 | +15,638 | $397.3K | +$193.1K | 26.8% |
| BARCLAYS PLC | 241,721 | +19,303 | $628.5K | -$150.0K | 8.7% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,742 | +13,782 | $240.3K | +$131.9K | 44.5% |
| Invesco Ltd. | 63,901 | +3,245 | $343.1K | +$130.9K | 5.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,325 | +7,164 | $216.5K | +$100.5K | 21.6% |
| Police & Firemen's Retirement System of New Jersey | 35,503 | +7,172 | $190.7K | +$91.5K | 25.3% |
| LPL Financial LLC | 44,470 | +2,000 | $238.8K | +$90.2K | 4.7% |
| ProShare Advisors LLC | 23,972 | +6,968 | $128.7K | +$69.2K | 41.0% |
| Voya Investment Management LLC | 22,629 | +5,415 | $121.5K | +$61.3K | 31.4% |
| WELCH & FORBES LLC | 19,000 | +4,000 | $102.0K | +$49.5K | 26.7% |
| SIMPLEX TRADING, LLC | 8,912 | +4,819 | $47.9K | +$47.8K | 117.7% |
| Focus Partners Wealth | 18,595 | +2,790 | $99.9K | +$43.9K | 17.6% |
| CAPTRUST FINANCIAL ADVISORS | 20,846 | +322 | $111.9K | +$40.1K | 1.6% |
| Russell Investments Group, Ltd. | 11,558 | +3,773 | $62.1K | +$34.8K | 48.5% |
| Legal & General Group Plc | 12,753 | +3,110 | $68.5K | +$34.8K | 32.3% |
| VICTORY CAPITAL MANAGEMENT INC | 14,311 | +1,659 | $76.8K | +$32.6K | 13.1% |
| Ameritas Investment Partners, Inc. | 10,621 | +3,085 | $57.0K | +$30.7K | 40.9% |
| Sequoia Financial Advisors, LLC | 15,894 | +141 | $85.4K | +$30.2K | 0.9% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,056 | +662 | $43.3K | +$17.4K | 8.9% |
| Sterling Capital Management LLC | 3,827 | +492 | $20.6K | +$8.9K | 14.8% |
| Farther Finance Advisors, LLC | 680 | +292 | $3.7K | +$2.3K | 75.3% |
| ROTHSCHILD INVESTMENT LLC | 164 | +44 | $881 | +$461 | 36.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,488 | +13,900 | $379 | +$180 | 24.6% |
| AMALGAMATED BANK | 4,111 | +1,034 | $22 | +$11 | 33.6% |
| CWM, LLC | 3,059 | +1,168 | $16 | +$9 | 61.8% |
Reduced(52)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 16,790,809 | -21,154 | $90.2M | +$31.3M | -0.1% |
| ORBIMED ADVISORS LLC | 15,219,994 | 0 | $81.7M | +$28.5M | 0.0% |
| Vivo Capital, LLC | 9,545,466 | 0 | $51.3M | +$17.9M | 0.0% |
| ENAVATE SCIENCES GP, LLC | 7,788,150 | 0 | $41.8M | +$14.6M | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,436,500 | -750,000 | $23.8M | +$5.7M | -14.5% |
| Rock Springs Capital Management LP | 3,927,202 | -547,500 | $21.1M | +$5.4M | -12.2% |
| MILLENNIUM MANAGEMENT LLC | 3,109,286 | -128,286 | $16.7M | +$5.4M | -4.0% |
| RTW INVESTMENTS, LP | 2,500,000 | 0 | $13.4M | +$4.7M | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,051,343 | -1,782,645 | $5.6M | -$4.3M | -62.9% |
| JPMORGAN CHASE & CO | 870,014 | -1,129,264 | $4.7M | -$2.3M | -56.5% |
| Blackstone Inc. | 6,126,182 | -3,713,926 | $32.9M | -$1.5M | -37.7% |
| Balyasny Asset Management LLC | 1,593,275 | -1,233,087 | $8.6M | -$1.3M | -43.6% |
| Burkehill Global Management, LP | 700,000 | 0 | $3.8M | +$1.3M | 0.0% |
| Logos Global Management LP | 1,150,000 | -900,000 | $6.2M | -$999.5K | -43.9% |
| Monashee Investment Management LLC | 1,000,000 | -250,000 | $5.4M | +$995.0K | -20.0% |
| Schonfeld Strategic Advisors LLC | 452,442 | -23,849 | $2.4M | +$762.6K | -5.0% |
| FMR LLC | 2,579,711 | -1,557,851 | $13.9M | -$628.4K | -37.6% |
| WELLINGTON MANAGEMENT GROUP LLP | 316,849 | -1,275 | $1.7M | +$588.0K | -0.4% |
| Royal Bank of Canada | 3,821 | -156,880 | $21.0K | -$390.0K | -97.6% |
| CITADEL ADVISORS LLC | 105,682 | -127,589 | $567.5K | -$248.9K | -54.7% |
| RHUMBLINE ADVISERS | 134,605 | -4,708 | $722.8K | +$235.2K | -3.4% |
| UBS Group AG | 167,856 | -30,415 | $901.4K | +$207.4K | -15.3% |
| Quadrature Capital Ltd | 12,293 | -35,134 | $66.0K | -$100.0K | -74.1% |
| ALLIANCEBERNSTEIN L.P. | 83,940 | -20,220 | $450.8K | +$86.2K | -19.4% |
| INTECH INVESTMENT MANAGEMENT LLC | 38,936 | 0 | $209.1K | +$72.8K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,407 | 0 | $163.3K | +$56.9K | 0.0% |
| Simplicity Wealth,LLC | 33,869 | -3,165 | $181.9K | +$52.3K | -8.5% |
| Walleye Trading LLC | 25,000 | 0 | $134.3K | +$46.8K | 0.0% |
| Atom Investors LP | 77,281 | -29,393 | $415.0K | +$41.6K | -27.6% |
| Independent Advisor Alliance | 17,894 | 0 | $96.1K | +$33.5K | 0.0% |
| CAXTON CORP | 29,495 | -24,008 | $158.4K | -$28.9K | -44.9% |
| North Star Investment Management Corp. | 12,500 | 0 | $67.1K | +$23.4K | 0.0% |
| Stonebrook Private Inc. | 10,230 | 0 | $54.9K | +$19.1K | 0.0% |
| PNC Financial Services Group, Inc. | 413 | -5,409 | $2.2K | -$18.2K | -92.9% |
| BNP PARIBAS ARBITRAGE, SNC | 15,645 | -3,878 | $84.0K | +$15.7K | -19.9% |
| Tower Research Capital LLC (TRC) | 1,698 | -4,341 | $9.1K | -$12.0K | -71.9% |
| CM Management, LLC | 100,000 | -50,000 | $537.0K | +$12.0K | -33.3% |
| MCF Advisors LLC | 5,540 | 0 | $29.8K | +$10.4K | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 5,248 | 0 | $28.2K | +$9.8K | 0.0% |
| Fortitude Family Office, LLC | 4,591 | -387 | $24.7K | +$7.2K | -7.8% |
| EverSource Wealth Advisors, LLC | 4,370 | -1,859 | $23.5K | +$1.7K | -29.8% |
| QUADRANT CAPITAL GROUP LLC | 405 | 0 | $2.2K | +$757 | 0.0% |
| SRS Capital Advisors, Inc. | 18 | -207 | $97 | -$690 | -92.0% |
| SIG BROKERAGE, LP | 17,076 | -9,289 | $91.7K | -$580 | -35.2% |
| Marshall & Sterling Wealth Advisors Inc. | 200 | 0 | $1.1K | +$374 | 0.0% |
| Optiver Holding B.V. | 1,096 | -546 | $5.9K | +$139 | -33.3% |
| SBI Securities Co., Ltd. | 237 | -93 | $1.3K | +$118 | -28.2% |
| SG Americas Securities, LLC | 106,533 | -42,780 | $572 | +$49 | -28.6% |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 0 | $72 | +$25 | 0.0% |
| Sunbelt Securities, Inc. | 8 | 0 | $43 | +$15 | 0.0% |
| BESSEMER GROUP INC | 526 | 0 | $3 | +$1 | 0.0% |
| CANTOR FITZGERALD, L. P. | 80,000 | 0 | $280.0K | $0 | 0.0% |
Sold Out(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BIOIMPACT CAPITAL LLC | 0 | -5,075,970 | $0 | -$17.8M | — |
| Caption Management, LLC | 0 | -1,154,170 | $0 | -$4.0M | — |
| DAFNA Capital Management LLC | 0 | -946,661 | $0 | -$3.3M | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -79,000 | $0 | -$276.5K | — |
| STRS OHIO | 0 | -17,900 | $0 | -$62.6K | — |
| Strategic Wealth Partners, Ltd. | 0 | -12,100 | $0 | -$42.4K | — |
| CIBC Bancorp USA Inc. | 0 | -10,600 | $0 | -$37.1K | — |
| ACT Advisors, LLC. | 0 | -10,376 | $0 | -$36.3K | — |
| Apollon Wealth Management, LLC | 0 | -10,015 | $0 | -$35.1K | — |
| Virtu Financial LLC | 0 | -12,681 | $0 | -$44 | — |
| Clearstead Advisors, LLC | 0 | -4 | $0 | -$14 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 16,790,809 | $90.2M | -21,154 | -0.1% |
| ORBIMED ADVISORS LLC | 15,219,994 | $81.7M | 0 | 0.0% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,182,379 | $76.2M | +81,220 | 0.6% |
| Vivo Capital, LLC | 9,545,466 | $51.3M | 0 | 0.0% |
| BlackRock, Inc. | 9,388,624 | $50.4M | +2,017,877 | 27.4% |
| VANGUARD GROUP INC | 8,048,374 | $43.2M | +985,575 | 13.9% |
| ENAVATE SCIENCES GP, LLC | 7,788,150 | $41.8M | 0 | 0.0% |
| BVF INC/IL | 7,764,842 | $41.7M | +3,014,842 | 63.5% |
| Blackstone Inc. | 6,126,182 | $32.9M | -3,713,926 | -37.7% |
| STATE STREET CORP | 4,890,525 | $26.3M | +1,784,012 | 57.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,436,500 | $23.8M | -750,000 | -14.5% |
| Rock Springs Capital Management LP | 3,927,202 | $21.1M | -547,500 | -12.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 3,606,000 | $19.4M | +3,606,000 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 3,502,526 | $18.8M | +558,057 | 18.9% |
| Blue Owl Capital Holdings LP | 3,466,525 | $18.6M | +875,000 | 33.8% |
| Sofinnova Investments, Inc. | 3,365,446 | $18.1M | +1,336,560 | 65.9% |
| MILLENNIUM MANAGEMENT LLC | 3,109,286 | $16.7M | -128,286 | -4.0% |
| BRAIDWELL LP | 2,786,778 | $15.0M | +2,786,778 | — |
| FMR LLC | 2,579,711 | $13.9M | -1,557,851 | -37.6% |
| Palo Alto Investors LP | 2,532,419 | $13.6M | +2,532,419 | — |
New & Closed Positions this quarter
Closed Positions
11 managers exited
Top five by prior-quarter value
- BIOIMPACT CAPITAL LLC$17.8M
- Caption Management, LLC$4.0M
- DAFNA Capital Management LLC$3.3M
- RENAISSANCE TECHNOLOGIES LLC$276.5K
- STRS OHIO$62.6K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for CMPX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.