New Positions
43 managers initiated
Top five by reported value
- Longaeva Partners L.P.$15.6M
- MAK CAPITAL ONE LLC$14.9M
- Palo Alto Investors LP$12.0M
- D. E. Shaw & Co., Inc.$5.3M
- Ishara Investments LP$3.8M
Annexon Inc NASDAQ NMS - GLOBAL MARKET:ANNX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
43 new69 added54 reduced20 exited
Total Institutional Holders
166
as of 2025-12-31
Top Holder
FMR LLC
$51.3M
Largest QoQ Increase
ADAGE CAPITAL PARTNERS GP, L.L.C.
+4,000,000 sh
Largest QoQ Decrease
Candriam S.C.A.
-2,534,230 sh
New Positions(43)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Longaeva Partners L.P. | 3,100,000 | +3,100,000 | $15.6M | +$15.6M | — |
| MAK CAPITAL ONE LLC | 2,958,527 | +2,958,527 | $14.9M | +$14.9M | — |
| Palo Alto Investors LP | 2,384,192 | +2,384,192 | $12.0M | +$12.0M | — |
| D. E. Shaw & Co., Inc. | 1,046,221 | +1,046,221 | $5.3M | +$5.3M | — |
| Ishara Investments LP | 750,000 | +750,000 | $3.8M | +$3.8M | — |
| DIADEMA PARTNERS LP | 659,100 | +659,100 | $3.3M | +$3.3M | — |
| MARSHALL WACE, LLP | 520,998 | +520,998 | $2.6M | +$2.6M | — |
| Caption Management, LLC | 489,191 | +489,191 | $2.5M | +$2.5M | — |
| WELLINGTON MANAGEMENT GROUP LLP | 398,077 | +398,077 | $2.0M | +$2.0M | — |
| DAFNA Capital Management LLC | 272,812 | +272,812 | $1.4M | +$1.4M | — |
| Ikarian Capital, LLC | 230,244 | +230,244 | $1.2M | +$1.2M | — |
| Rafferty Asset Management, LLC | 141,644 | +141,644 | $711.1K | +$711.1K | — |
| Jump Financial, LLC | 122,858 | +122,858 | $616.7K | +$616.7K | — |
| Persistent Asset Partners Ltd | 93,657 | +93,657 | $470.2K | +$470.2K | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,069 | +64,069 | $321.6K | +$321.6K | — |
| SEI INVESTMENTS CO | 58,259 | +58,259 | $292.5K | +$292.5K | — |
| WINTON GROUP Ltd | 53,400 | +53,400 | $268.1K | +$268.1K | — |
| PROFUND ADVISORS LLC | 53,008 | +53,008 | $266.1K | +$266.1K | — |
| Quadrature Capital Ltd | 48,573 | +48,573 | $243.8K | +$243.8K | — |
| ADAR1 Capital Management, LLC | 48,000 | +48,000 | $241.0K | +$241.0K | — |
| Pale Fire Capital SE | 38,600 | +38,600 | $193.8K | +$193.8K | — |
| Landing Point Financial Group, LLC | 34,900 | +34,900 | $175.2K | +$175.2K | — |
| CAPTRUST FINANCIAL ADVISORS | 31,585 | +31,585 | $158.6K | +$158.6K | — |
| Mariner, LLC | 31,335 | +31,335 | $157.4K | +$157.4K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 17,600 | +17,600 | $88.4K | +$88.4K | — |
| Scientech Research LLC | 17,216 | +17,216 | $86.4K | +$86.4K | — |
| Caitong International Asset Management Co., Ltd | 16,415 | +16,415 | $82.4K | +$82.4K | — |
| Cerity Partners LLC | 14,801 | +14,801 | $74.3K | +$74.3K | — |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,000 | +12,000 | $60.2K | +$60.2K | — |
| MERCER GLOBAL ADVISORS INC /ADV | 10,386 | +10,386 | $52.1K | +$52.1K | — |
| SIMPLEX TRADING, LLC | 10,268 | +10,268 | $51.5K | +$51.5K | — |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,016 | +10,016 | $50.3K | +$50.3K | — |
| JONES FINANCIAL COMPANIES LLLP | 2,987 | +2,987 | $15.0K | +$15.0K | — |
| Larson Financial Group LLC | 2,000 | +2,000 | $10.0K | +$10.0K | — |
| IFP Advisors, Inc | 897 | +897 | $3.8K | +$3.8K | — |
| FEDERATED HERMES, INC. | 753 | +753 | $3.8K | +$3.8K | — |
| Allworth Financial LP | 416 | +416 | $2.1K | +$2.1K | — |
| Rockefeller Capital Management L.P. | 334 | +334 | $1.7K | +$1.7K | — |
| ASSETMARK, INC | 333 | +333 | $1.7K | +$1.7K | — |
| Prestige Wealth Management Group LLC | 185 | +185 | $444 | +$444 | — |
| MAI Capital Management | 63 | +63 | $317 | +$317 | — |
| MOUNT VERNON ASSOCIATES INC /MD/ | 10,500 | +10,500 | $53 | +$53 | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 4 | +4 | $20 | +$20 | — |
Added To(69)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Redmile Group, LLC | 10,050,644 | +3,750,000 | $50.5M | +$31.2M | 59.5% |
| BVF INC/IL | 9,128,080 | +2,128,080 | $45.8M | +$24.5M | 30.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,500,000 | +4,000,000 | $27.6M | +$23.0M | 266.7% |
| VANGUARD GROUP INC | 7,753,387 | +1,918,275 | $38.9M | +$21.1M | 32.9% |
| BlackRock, Inc. | 8,960,434 | +1,061,426 | $45.0M | +$20.9M | 13.4% |
| STATE STREET CORP | 4,652,185 | +2,601,877 | $23.4M | +$17.1M | 126.9% |
| AMERIPRISE FINANCIAL INC | 4,348,782 | +2,156,428 | $21.8M | +$15.1M | 98.4% |
| Balyasny Asset Management LLC | 3,299,256 | +2,001,996 | $16.6M | +$12.6M | 154.3% |
| Nuveen, LLC | 2,915,324 | +2,232,766 | $14.6M | +$12.6M | 327.1% |
| Woodline Partners LP | 4,000,074 | +1,361,799 | $20.1M | +$12.0M | 51.6% |
| Qube Research & Technologies Ltd | 2,381,479 | +1,808,835 | $12.0M | +$10.2M | 315.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,902,896 | +465,952 | $14.6M | +$7.1M | 19.1% |
| MILLENNIUM MANAGEMENT LLC | 2,836,857 | +14,034 | $14.2M | +$5.6M | 0.5% |
| Invesco Ltd. | 972,449 | +770,504 | $4.9M | +$4.3M | 381.5% |
| BANK OF AMERICA CORP /DE/ | 1,605,581 | +311,279 | $8.1M | +$4.1M | 24.0% |
| Russell Investments Group, Ltd. | 683,016 | +664,796 | $3.4M | +$3.4M | 3648.7% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 683,879 | +661,290 | $3.4M | +$3.4M | 2927.5% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,057,060 | +266,810 | $5.3M | +$2.9M | 33.8% |
| JANE STREET GROUP, LLC | 577,036 | +345,442 | $2.9M | +$2.2M | 149.2% |
| AQR CAPITAL MANAGEMENT LLC | 776,307 | +202,184 | $3.9M | +$2.1M | 35.2% |
| Schonfeld Strategic Advisors LLC | 522,846 | +310,627 | $2.6M | +$2.0M | 146.4% |
| Parkman Healthcare Partners LLC | 601,202 | +195,249 | $3.0M | +$1.8M | 48.1% |
| RENAISSANCE TECHNOLOGIES LLC | 802,600 | +49,021 | $4.0M | +$1.7M | 6.5% |
| WELLS FARGO & COMPANY/MN | 573,748 | +164,271 | $2.9M | +$1.6M | 40.1% |
| Cinctive Capital Management LP | 358,986 | +293,520 | $1.8M | +$1.6M | 448.4% |
| Point72 Asset Management, L.P. | 371,190 | +281,141 | $1.9M | +$1.6M | 312.2% |
| NORTHERN TRUST CORP | 792,000 | +4,292 | $4.0M | +$1.6M | 0.5% |
| SummitTX Capital, L.P. | 438,497 | +196,506 | $2.2M | +$1.5M | 81.2% |
| Hennion & Walsh Asset Management, Inc. | 534,986 | +59,057 | $2.7M | +$1.2M | 12.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 354,308 | +171,658 | $1.8M | +$1.2M | 94.0% |
| CITADEL ADVISORS LLC | 380,894 | +135,794 | $1.9M | +$1.2M | 55.4% |
| Bank of New York Mellon Corp | 361,677 | +53,489 | $1.8M | +$875.6K | 17.4% |
| UBS Group AG | 377,104 | +30,965 | $1.9M | +$837.3K | 8.9% |
| TWO SIGMA INVESTMENTS, LP | 332,038 | +52,904 | $1.7M | +$815.5K | 18.9% |
| XTX Topco Ltd | 243,313 | +95,473 | $1.2M | +$770.5K | 64.6% |
| Susquehanna Portfolio Strategies, LLC | 356,619 | +2,875 | $1.8M | +$711.3K | 0.8% |
| AMERICAN CENTURY COMPANIES INC | 251,158 | +14,422 | $1.3M | +$538.8K | 6.1% |
| IEQ CAPITAL, LLC | 182,982 | +32,660 | $918.6K | +$460.1K | 21.7% |
| DNB Asset Management AS | 118,324 | +33,801 | $594.0K | +$336.2K | 40.0% |
| Brevan Howard Capital Management LP | 123,753 | +29,199 | $621.2K | +$332.9K | 30.9% |
| BNP PARIBAS ARBITRAGE, SNC | 61,572 | +41,833 | $309.1K | +$248.9K | 211.9% |
| EntryPoint Capital, LLC | 42,774 | +22,803 | $214.7K | +$153.8K | 114.2% |
| Virtus Investment Advisers, Inc. | 53,527 | +11,540 | $268.7K | +$140.6K | 27.5% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,763 | +9,784 | $275.1K | +$137.9K | 21.8% |
| INTECH INVESTMENT MANAGEMENT LLC | 42,524 | +15,848 | $213.5K | +$132.1K | 59.4% |
| JPMORGAN CHASE & CO | 53,729 | +6,843 | $269.7K | +$126.7K | 14.6% |
| CITIGROUP INC | 23,640 | +16,812 | $118.7K | +$97.8K | 246.2% |
| China Universal Asset Management Co., Ltd. | 36,084 | +823 | $181.1K | +$73.6K | 2.3% |
| Creative Planning | 24,004 | +8,553 | $120.5K | +$73.4K | 55.4% |
| RAYMOND JAMES FINANCIAL INC | 24,869 | +4,869 | $124.8K | +$63.8K | 24.3% |
| ProShare Advisors LLC | 24,698 | +4,410 | $124.0K | +$62.1K | 21.7% |
| AXQ CAPITAL, LP | 29,108 | +1,241 | $146.1K | +$61.1K | 4.5% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 19,553 | +2,348 | $99.7K | +$46.9K | 13.6% |
| VICTORY CAPITAL MANAGEMENT INC | 14,757 | +3,736 | $74.1K | +$40.5K | 33.9% |
| CI Private Wealth, LLC | 19,693 | +28 | $98.9K | +$38.9K | 0.1% |
| BARCLAYS PLC | 177,628 | +29,698 | $426.3K | -$24.9K | 20.1% |
| Mirae Asset Global Investments Co., Ltd. | 7,033 | +2,785 | $35.3K | +$22.4K | 65.6% |
| Legal & General Group Plc | 9,307 | +831 | $46.7K | +$20.9K | 9.8% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,163 | +168 | $30.9K | +$12.7K | 2.8% |
| GF FUND MANAGEMENT CO. LTD. | 2,843 | +479 | $14.3K | +$7.1K | 20.3% |
| ACADIAN ASSET MANAGEMENT LLC | 861,245 | +328,882 | $4.3K | +$2.7K | 61.8% |
| PNC Financial Services Group, Inc. | 1,132 | +9 | $5.7K | +$2.3K | 0.8% |
| EverSource Wealth Advisors, LLC | 539 | +243 | $2.7K | +$1.8K | 82.1% |
| Farther Finance Advisors, LLC | 309 | +308 | $1.6K | +$1.5K | 30800.0% |
| True Wealth Design, LLC | 211 | +156 | $1.1K | +$892 | 283.6% |
| ROTHSCHILD INVESTMENT LLC | 236 | +71 | $1.2K | +$682 | 43.0% |
| Sunbelt Securities, Inc. | 110 | +23 | $552 | +$287 | 26.4% |
| SG Americas Securities, LLC | 28,071 | +17,074 | $141 | +$107 | 155.3% |
| CWM, LLC | 30,297 | +6,809 | $152 | +$80 | 29.0% |
Reduced(54)
Sold Out(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Candriam S.C.A. | 0 | -2,534,230 | $0 | -$7.7M | — |
| Rhenman & Partners Asset Management AB | 0 | -823,000 | $0 | -$2.5M | — |
| Point72 Europe (London) LLP | 0 | -302,861 | $0 | -$923.7K | — |
| ExodusPoint Capital Management, LP | 0 | -243,755 | $0 | -$743.5K | — |
| ALPS ADVISORS INC | 0 | -47,879 | $0 | -$146.0K | — |
| Atom Investors LP | 0 | -30,453 | $0 | -$92.9K | — |
| Forefront Wealth Partners, LLC | 0 | -27,027 | $0 | -$82.4K | — |
| HSBC HOLDINGS PLC | 0 | -25,721 | $0 | -$78.1K | — |
| TWO SIGMA ADVISERS, LP | 0 | -23,800 | $0 | -$72.6K | — |
| Cubist Systematic Strategies, LLC | 0 | -22,771 | $0 | -$69.5K | — |
| MATAURO, LLC | 0 | -20,572 | $0 | -$62.7K | — |
| Savant Capital, LLC | 0 | -13,095 | $0 | -$39.9K | — |
| 49 WEALTH MANAGEMENT, LLC | 0 | -12,083 | $0 | -$36.9K | — |
| PRUDENTIAL FINANCIAL INC | 0 | -11,670 | $0 | -$35.6K | — |
| CIBC Bancorp USA Inc. | 0 | -10,208 | $0 | -$31.1K | — |
| Clearstead Advisors, LLC | 0 | -355 | $0 | -$1.1K | — |
| BRYN MAWR TRUST Co | 0 | -296 | $0 | -$903 | — |
| PARK AVENUE SECURITIES LLC | 0 | -113,068 | $0 | -$345 | — |
| HRT FINANCIAL LP | 0 | -84,582 | $0 | -$257 | — |
| Advisory Services Network, LLC | 0 | -23 | $0 | -$70 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FMR LLC | 10,222,470 | $51.3M | -858,693 | -7.7% |
| Redmile Group, LLC | 10,050,644 | $50.5M | +3,750,000 | 59.5% |
| BVF INC/IL | 9,128,080 | $45.8M | +2,128,080 | 30.4% |
| BlackRock, Inc. | 8,960,434 | $45.0M | +1,061,426 | 13.4% |
| VANGUARD GROUP INC | 7,753,387 | $38.9M | +1,918,275 | 32.9% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,500,000 | $27.6M | +4,000,000 | 266.7% |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | $26.4M | 0 | 0.0% |
| Bellevue Group AG | 5,157,290 | $25.9M | 0 | 0.0% |
| STATE STREET CORP | 4,652,185 | $23.4M | +2,601,877 | 126.9% |
| AMERIPRISE FINANCIAL INC | 4,348,782 | $21.8M | +2,156,428 | 98.4% |
| Woodline Partners LP | 4,000,074 | $20.1M | +1,361,799 | 51.6% |
| Balyasny Asset Management LLC | 3,299,256 | $16.6M | +2,001,996 | 154.3% |
| Longaeva Partners L.P. | 3,100,000 | $15.6M | +3,100,000 | — |
| MAK CAPITAL ONE LLC | 2,958,527 | $14.9M | +2,958,527 | — |
| Nuveen, LLC | 2,915,324 | $14.6M | +2,232,766 | 327.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,902,896 | $14.6M | +465,952 | 19.1% |
| MORGAN STANLEY | 2,856,143 | $14.3M | -173,705 | -5.7% |
| MILLENNIUM MANAGEMENT LLC | 2,836,857 | $14.2M | +14,034 | 0.5% |
| Opaleye Management Inc. | 2,600,000 | $13.1M | 0 | 0.0% |
| Palo Alto Investors LP | 2,384,192 | $12.0M | +2,384,192 | — |
New & Closed Positions this quarter
Closed Positions
20 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ANNX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.