CUSIP 81734D104
SEPTERNA INC
140 institutions · $1.22B total · 44,142,486 shares · SEPN
| # | Manager | Shares | Value | % of Total | Period |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | $195.0M | 15.84% | 2025-12-31 |
| 2 | TRV GP V, LLC | 6,215,591 | $173.3M | 14.08% | 2025-12-31 |
| 3 | Driehaus Capital Management LLC | 4,809,470 | $134.1M | 10.89% | 2025-12-31 |
| 4 | TRV GP VI, LLC | 4,211,659 | $117.4M | 9.54% | 2025-12-31 |
| 5 | SAMSARA BIOCAPITAL, LLC | 3,149,128 | $87.8M | 7.13% | 2025-12-31 |
| 6 | Siren, L.L.C. | 2,000,000 | $55.8M | 4.53% | 2025-12-31 |
| 7 | BVF INC/IL | 1,720,782 | $48.0M | 3.89% | 2025-12-31 |
| 8 | GOLDMAN SACHS GROUP INC | 1,446,982 | $40.3M | 3.27% | 2025-12-31 |
| 9 | VANGUARD GROUP INC | 1,346,965 | $37.6M | 3.05% | 2025-12-31 |
| 10 | Avoro Capital Advisors LLC | 1,337,500 | $37.3M | 3.02% | 2025-12-31 |
| 11 | ADAR1 Capital Management, LLC | 1,157,611 | $32.3M | 2.62% | 2025-12-31 |
| 12 | BlackRock, Inc. | 1,021,290 | $28.5M | 2.31% | 2025-12-31 |
| 13 | First Light Asset Management, LLC | 620,811 | $17.3M | 1.40% | 2025-12-31 |
| 14 | VR ADVISER, LLC | 610,808 | $17.0M | 1.38% | 2025-12-31 |
| 15 | Casdin Capital, LLC | 553,268 | $15.4M | 1.25% | 2025-12-31 |
| 16 | PRIMECAP MANAGEMENT CO/CA/ | 546,100 | $15.2M | 1.23% | 2025-12-31 |
| 17 | STATE STREET CORP | 540,028 | $15.1M | 1.22% | 2025-12-31 |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 499,514 | $13.9M | 1.13% | 2025-12-31 |
| 19 | PERCEPTIVE ADVISORS LLC | 433,160 | $12.1M | 0.98% | 2025-12-31 |
| 20 | Woodline Partners LP | 385,310 | $10.7M | 0.87% | 2025-12-31 |
| 21 | Soleus Capital Management, L.P. | 383,368 | $10.7M | 0.86% | 2025-12-31 |
| 22 | Catalio Capital Management, LP | 294,360 | $8.2M | 0.66% | 2025-12-31 |
| 23 | Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $6.2M | 0.50% | 2025-12-31 |
| 24 | MARSHALL WACE, LLP | 199,576 | $5.6M | 0.45% | 2025-12-31 |
| 25 | Kalehua Capital Management LLC | 194,544 | $5.4M | 0.44% | 2025-12-31 |
| 26 | Checkpoint Capital L.P. | 283,158 | $5.3M | 0.64% | 2025-09-30 |
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 187,241 | $5.2M | 0.42% | 2025-12-31 |
| 28 | NORTHERN TRUST CORP | 150,584 | $4.2M | 0.34% | 2025-12-31 |
| 29 | Invesco Ltd. | 150,133 | $4.2M | 0.34% | 2025-12-31 |
| 30 | Sio Capital Management, LLC | 189,199 | $3.6M | 0.42% | 2025-09-30 |
| 31 | MILLENNIUM MANAGEMENT LLC | 107,463 | $3.0M | 0.24% | 2025-12-31 |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,400 | $2.8M | 0.22% | 2025-12-31 |
| 33 | TWO SIGMA INVESTMENTS, LP | 92,809 | $2.6M | 0.21% | 2025-12-31 |
| 34 | JANE STREET GROUP, LLC | 80,200 | $2.2M | 0.18% | 2025-12-31 |
| 35 | HighVista Strategies LLC | 78,682 | $2.2M | 0.17% | 2025-12-31 |
| 36 | FEDERATED HERMES, INC. | 75,328 | $2.1M | 0.17% | 2025-12-31 |
| 37 | UBS Group AG | 68,525 | $1.9M | 0.15% | 2025-12-31 |
| 38 | Rangeley Capital, LLC | 65,800 | $1.8M | 0.14% | 2025-12-31 |
| 39 | JACOBS LEVY EQUITY MANAGEMENT, INC | 61,370 | $1.7M | 0.13% | 2025-12-31 |
| 40 | Walleye Capital LLC | 80,341 | $1.5M | 0.18% | 2025-09-30 |
| 41 | JPMORGAN CHASE & CO | 52,464 | $1.5M | 0.11% | 2025-12-31 |
| 42 | AMERICAN CENTURY COMPANIES INC | 50,689 | $1.4M | 0.11% | 2025-12-31 |
| 43 | Longaeva Partners L.P. | 49,902 | $1.4M | 0.11% | 2025-12-31 |
| 44 | Deep Track Capital, LP | 121,716 | $1.3M | 0.27% | 2025-06-30 |
| 45 | Numerai GP LLC | 45,866 | $1.3M | 0.10% | 2025-12-31 |
| 46 | Trexquant Investment LP | 44,005 | $1.2M | 0.09% | 2025-12-31 |
| 47 | CITADEL ADVISORS LLC | 42,179 | $1.2M | 0.09% | 2025-12-31 |
| 48 | BARCLAYS PLC | 38,137 | $1.1M | 0.08% | 2025-12-31 |
| 49 | ExodusPoint Capital Management, LP | 37,867 | $1.1M | 0.08% | 2025-12-31 |
| 50 | MORGAN STANLEY | 37,045 | $1.0M | 0.08% | 2025-12-31 |
| 51 | Bank of New York Mellon Corp | 35,975 | $1.0M | 0.08% | 2025-12-31 |
| 52 | Alyeska Investment Group, L.P. | 35,000 | $975.8K | 0.07% | 2025-12-31 |
| 53 | BANK OF AMERICA CORP /DE/ | 50,448 | $948.9K | 0.11% | 2025-12-31 |
| 54 | RHUMBLINE ADVISERS | 26,419 | $736.6K | 0.05% | 2025-12-31 |
| 55 | Nuveen, LLC | 25,798 | $719.2K | 0.05% | 2025-12-31 |
| 56 | TWO SIGMA ADVISERS, LP | 25,700 | $716.5K | 0.05% | 2025-12-31 |
| 57 | WELLS FARGO & COMPANY/MN | 23,966 | $668.2K | 0.05% | 2025-12-31 |
| 58 | Logos Global Management LP | 23,548 | $656.5K | 0.05% | 2025-12-31 |
| 59 | XTX Topco Ltd | 23,315 | $650.0K | 0.05% | 2025-12-31 |
| 60 | VARCOV Co. | 22,634 | $631.0K | 0.05% | 2025-12-31 |
| 61 | ALLIANCEBERNSTEIN L.P. | 19,600 | $546.4K | 0.04% | 2025-12-31 |
| 62 | TUDOR INVESTMENT CORP ET AL | 18,053 | $503.3K | 0.04% | 2025-12-31 |
| 63 | FRANKLIN RESOURCES INC | 16,692 | $465.4K | 0.03% | 2025-12-31 |
| 64 | DEUTSCHE BANK AG\ | 14,879 | $414.8K | 0.03% | 2025-12-31 |
| 65 | Squarepoint Ops LLC | 14,847 | $413.9K | 0.03% | 2025-12-31 |
| 66 | STRS OHIO | 14,600 | $407.0K | 0.03% | 2025-12-31 |
| 67 | LOS ANGELES CAPITAL MANAGEMENT LLC | 18,550 | $398.6K | 0.04% | 2025-12-31 |
| 68 | Stonepine Capital Management, LLC | 68,084 | $394.2K | 0.15% | 2025-03-31 |
| 69 | AMERIPRISE FINANCIAL INC | 14,090 | $392.8K | 0.03% | 2025-12-31 |
| 70 | MetLife Investment Management, LLC | 13,685 | $381.5K | 0.03% | 2025-12-31 |
| 71 | Verition Fund Management LLC | 20,131 | $378.7K | 0.04% | 2025-09-30 |
| 72 | INTECH INVESTMENT MANAGEMENT LLC | 13,283 | $370.3K | 0.03% | 2025-12-31 |
| 73 | OSAIC HOLDINGS, INC. | 12,494 | $348.3K | 0.02% | 2025-12-31 |
| 74 | Seven Fleet Capital Management LP | 11,445 | $319.1K | 0.02% | 2025-12-31 |
| 75 | UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 28,700 | $303.4K | 0.06% | 2025-06-30 |
| 76 | Dynamic Technology Lab Private Ltd | 10,810 | $301.0K | 0.02% | 2025-12-31 |
| 77 | PharVision Advisers, LLC | 10,739 | $299.4K | 0.02% | 2025-12-31 |
| 78 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 10,594 | $295.4K | 0.02% | 2025-12-31 |
| 79 | Virtus Investment Advisers, LLC | 10,457 | $291.5K | 0.02% | 2025-12-31 |
| 80 | China Universal Asset Management Co., Ltd. | 10,296 | $287.1K | 0.02% | 2025-12-31 |
| 81 | Baader Bank Aktiengesellschaft | 10,000 | $278.8K | 0.02% | 2025-12-31 |
| 82 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,934 | $277.0K | 0.02% | 2025-12-31 |
| 83 | Atom Investors LP | 9,791 | $273.0K | 0.02% | 2025-12-31 |
| 84 | BOOTHBAY FUND MANAGEMENT, LLC | 24,142 | $255.2K | 0.05% | 2025-06-30 |
| 85 | CITIGROUP INC | 9,077 | $253.1K | 0.02% | 2025-12-31 |
| 86 | Graham Capital Management, L.P. | 8,971 | $250.1K | 0.02% | 2025-12-31 |
| 87 | Jump Financial, LLC | 8,399 | $234.2K | 0.01% | 2025-12-31 |
| 88 | BANK OF NOVA SCOTIA | 8,300 | $231.4K | 0.01% | 2025-12-31 |
| 89 | AQR CAPITAL MANAGEMENT LLC | 7,667 | $213.8K | 0.01% | 2025-12-31 |
| 90 | Russell Investments Group, Ltd. | 5,701 | $158.9K | 0.01% | 2025-12-31 |
| 91 | NEW YORK STATE COMMON RETIREMENT FUND | 5,600 | $156.1K | 0.01% | 2025-12-31 |
| 92 | BNP PARIBAS FINANCIAL MARKETS | 5,449 | $151.9K | 0.01% | 2025-12-31 |
| 93 | Police & Firemen's Retirement System of New Jersey | 5,175 | $144.3K | 0.01% | 2025-12-31 |
| 94 | CW Advisors, LLC | 12,589 | $133.1K | 0.02% | 2025-06-30 |
| 95 | Quadrature Capital Ltd | 10,125 | $107.3K | 0.02% | 2025-06-30 |
| 96 | Balyasny Asset Management L.P. | 3,571 | $99.6K | 0.00% | 2025-12-31 |
| 97 | FMR LLC | 3,307 | $92.2K | 0.00% | 2025-12-31 |
| 98 | Mirae Asset Global Investments Co., Ltd. | 2,176 | $60.7K | 0.00% | 2025-12-31 |
| 99 | Tower Research Capital LLC (TRC) | 2,156 | $60.1K | 0.00% | 2025-12-31 |
| 100 | Ameritas Investment Partners, Inc. | 1,944 | $54.2K | 0.00% | 2025-12-31 |
| 101 | Legal & General Group Plc | 1,945 | $54.2K | 0.00% | 2025-12-31 |
| 102 | Caitong International Asset Management Co., Ltd | 1,901 | $53.0K | 0.00% | 2025-12-31 |
| 103 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,316 | $36.7K | 0.00% | 2025-12-31 |
| 104 | Global Retirement Partners, LLC | 1,256 | $35.0K | 0.00% | 2025-12-31 |
| 105 | Sterling Capital Management LLC | 1,232 | $34.3K | 0.00% | 2025-12-31 |
| 106 | SIGNATUREFD, LLC | 989 | $27.6K | 0.00% | 2025-12-31 |
| 107 | GROUP ONE TRADING LLC | 944 | $26.3K | 0.00% | 2025-12-31 |
| 108 | GAMMA Investing LLC | 916 | $25.5K | 0.00% | 2025-12-31 |
| 109 | GF FUND MANAGEMENT CO. LTD. | 878 | $24.5K | 0.00% | 2025-12-31 |
| 110 | Quarry LP | 724 | $20.2K | 0.00% | 2025-12-31 |
| 111 | Royal Bank of Canada | 415 | $12.0K | 0.00% | 2025-12-31 |
| 112 | NISA INVESTMENT ADVISORS, LLC | 341 | $9.5K | 0.00% | 2025-12-31 |
| 113 | Empowered Funds, LLC | 340 | $9.5K | 0.00% | 2025-12-31 |
| 114 | Pinnacle Wealth Planning Services, Inc. | 322 | $9.0K | 0.00% | 2025-12-31 |
| 115 | Versant Capital Management, Inc | 261 | $7.3K | 0.00% | 2025-12-31 |
| 116 | PNC Financial Services Group, Inc. | 198 | $5.5K | 0.00% | 2025-12-31 |
| 117 | US BANCORP \DE\ | 190 | $5.3K | 0.00% | 2025-12-31 |
| 118 | N.E.W. Advisory Services LLC | 180 | $5.0K | 0.00% | 2025-12-31 |
| 119 | RAYMOND JAMES FINANCIAL INC | 222 | $2.3K | 0.00% | 2025-06-30 |
| 120 | COMERICA BANK | 212 | $2.2K | 0.00% | 2025-06-30 |
| 121 | Fortitude Family Office, LLC | 71 | $2.0K | 0.00% | 2025-12-31 |
| 122 | MassMutual Private Wealth & Trust, FSB | 63 | $1.8K | 0.00% | 2025-12-31 |
| 123 | SBI Securities Co., Ltd. | 55 | $1.5K | 0.00% | 2025-12-31 |
| 124 | Cornerstone Financial Management LLC | 52 | $1.4K | 0.00% | 2025-12-31 |
| 125 | EverSource Wealth Advisors, LLC | 41 | $1.1K | 0.00% | 2025-12-31 |
| 126 | ALGERT GLOBAL LLC | 34,944 | $974 | 0.07% | 2025-12-31 |
| 127 | ACADIAN ASSET MANAGEMENT LLC | 30,877 | $858 | 0.06% | 2025-12-31 |
| 128 | ROTHSCHILD INVESTMENT LLC | 30 | $836 | 0.00% | 2025-12-31 |
| 129 | PRICE T ROWE ASSOCIATES INC /MD/ | 25,443 | $710 | 0.05% | 2025-12-31 |
| 130 | Aster Capital Management (DIFC) Ltd | 20 | $558 | 0.00% | 2025-12-31 |
| 131 | GSA CAPITAL PARTNERS LLP | 23,527 | $249 | 0.05% | 2025-06-30 |
| 132 | SIMPLEX TRADING, LLC | 23,525 | $248 | 0.05% | 2025-06-30 |
| 133 | NATIONAL BANK OF CANADA /FI/ | 8 | $150 | 0.00% | 2025-09-30 |
| 134 | Arax Advisory Partners | 3 | $84 | 0.00% | 2025-12-31 |
| 135 | Covestor Ltd | 1,941 | $54 | 0.00% | 2025-12-31 |
| 136 | Farther Finance Advisors, LLC | 1 | $28 | 0.00% | 2025-12-31 |
| 137 | CWM, LLC | 888 | $25 | 0.00% | 2025-12-31 |
| 138 | AMALGAMATED BANK | 672 | $19 | 0.00% | 2025-12-31 |
| 139 | Daiwa Securities Group Inc. | 149 | $4 | 0.00% | 2025-12-31 |
| 140 | CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | $0 | 0.00% | 2025-06-30 |