Live Markets
Tuesday, July 28, 2026·George Town, KY·29°·Partly Cloudy
Markets Open · NYSE·Newsletter·Masthead·
VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
Markets · Healthcare

Septerna, Inc. (SEPN)

NGM · Biotechnology

$33.97+0.48 (+1.43%)Quote refreshed

Sources: Yahoo Finance (quote, statistics) · SEC EDGAR (filings, insider trades, 13F holders) · company filings & press wires

Market Cap
$1.53B
P/E (TTM)
EPS
$-0.81
Div Yield
52W Range
$10.62–$38.04
Beta

Company overview

Next earnings: 2026-08-10(13d)

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Peers in Biotechnology

All in industry →

Recent press releases

Septerna, Inc. has not issued a press release in this window.

SEC filings

All filings →

Septerna, Inc. has not filed an SEC document in this window.

Septerna, Inc. has no reported insider trades in the last 90 days.

Institutional holders

All holders →
As of 2025-12-31 · prior 2025-09-30
6,995,858 sh0.0%
6,215,591 sh0.0%
2,715,129 sh+86.6%
4,809,470 sh-2.2%
4,211,659 sh0.0%
3,149,128 sh0.0%
1,720,782 sh-57.1%
1,801,328 sh+23.4%

People at Septerna, Inc.

All people →

Quarterly financials

Full financials →
Revenue trend
03/25
$219.0K
NI -$21.5M
06/25
$119.0K
NI -$24.8M
09/25
$21.5M
NI $8.2M
RevenueNI = Net Income
EPS trend (diluted)
Latest: $0.18
Prior: $-0.56
Revenue sparkline