New Positions
9 managers initiated
Top five by reported value
- Ishara Investments LP$1.8M
- MARSHALL WACE, LLP$334.5K
- OPAL CAPITAL LLC$173.4K
- Point72 Asset Management, L.P.$135.4K
- Sivia Capital Partners, LLC$27.0K
Zentalis Pharmaceuticals Inc NASDAQ NMS - GLOBAL MARKET:ZNTL
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
9 new28 added49 reduced24 exited
Total Institutional Holders
86
as of 2025-12-31
Top Holder
5AM Venture Management, LLC
$5.3M
Largest QoQ Increase
5AM Venture Management, LLC
+3,457,913 sh
Largest QoQ Decrease
Matrix Capital Management Company, LP
-13,959,973 sh
New Positions(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Ishara Investments LP | 1,320,000 | +1,320,000 | $1.8M | +$1.8M | — |
| MARSHALL WACE, LLP | 247,788 | +247,788 | $334.5K | +$334.5K | — |
| OPAL CAPITAL LLC | 72,251 | +72,251 | $173.4K | +$173.4K | — |
| Point72 Asset Management, L.P. | 100,290 | +100,290 | $135.4K | +$135.4K | — |
| Sivia Capital Partners, LLC | 20,000 | +20,000 | $27.0K | +$27.0K | — |
| AMERICAN CENTURY COMPANIES INC | 12,880 | +12,880 | $17.4K | +$17.4K | — |
| Shay Capital LLC | 10,662 | +10,662 | $14.4K | +$14.4K | — |
| IFP Advisors, Inc | 24 | +24 | $36 | +$36 | — |
| Inspire Investing, LLC | 16 | +16 | $22 | +$22 | — |
Added To(28)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 3,947,913 | +3,457,913 | $5.3M | +$4.6M | 705.7% |
| Opaleye Management Inc. | 1,400,906 | +1,084,356 | $1.9M | +$1.4M | 342.6% |
| Connor, Clark & Lunn Investment Management Ltd. | 787,055 | +406,233 | $1.1M | +$487.5K | 106.7% |
| RENAISSANCE TECHNOLOGIES LLC | 2,883,745 | +558,390 | $3.9M | +$381.8K | 24.0% |
| BNP PARIBAS ARBITRAGE, SNC | 419,367 | +260,432 | $566.1K | +$326.2K | 163.9% |
| Anfield Capital Management, LLC | 242,605 | +171,228 | $327.5K | +$219.7K | 239.9% |
| TWO SIGMA ADVISERS, LP | 1,483,500 | +22,300 | $2.0M | -$203.7K | 1.5% |
| BlackRock, Inc. | 1,249,968 | +464 | $1.7M | -$199.3K | 0.0% |
| Almitas Capital LLC | 610,073 | +152,751 | $823.6K | +$133.0K | 33.4% |
| D. E. Shaw & Co., Inc. | 1,660,378 | +251,575 | $2.2M | +$114.2K | 17.9% |
| Squarepoint Ops LLC | 107,734 | +86,412 | $145.4K | +$113.2K | 405.3% |
| UBS Group AG | 674,598 | +141,920 | $910.7K | +$106.4K | 26.6% |
| RBF Capital, LLC | 160,000 | +80,000 | $216.0K | +$95.2K | 100.0% |
| Quadrature Capital Ltd | 137,568 | +76,917 | $185.7K | +$93.5K | 126.8% |
| COMMONWEALTH EQUITY SERVICES, LLC | 61,412 | +425 | $82.9K | +$82.8K | 0.7% |
| TWO SIGMA INVESTMENTS, LP | 1,471,414 | +108,067 | $2.0M | -$72.2K | 7.9% |
| Stonepine Capital Management, LLC | 463,700 | +9,900 | $626.0K | -$59.2K | 2.2% |
| 49 WEALTH MANAGEMENT, LLC | 70,911 | +42,719 | $95.7K | +$53.2K | 151.5% |
| XTX Topco Ltd | 576,707 | +28,078 | $778.6K | -$49.9K | 5.1% |
| ADAR1 Capital Management, LLC | 80,000 | +30,000 | $108.0K | +$32.5K | 60.0% |
| FMR LLC | 243,308 | +40,003 | $328.5K | +$21.5K | 19.7% |
| BARR E S & CO | 57,500 | +17,500 | $77.6K | +$17.2K | 43.8% |
| Quarry LP | 132,000 | +23,250 | $178.2K | +$14.0K | 21.4% |
| Invesco Ltd. | 188,582 | +14,961 | $254.6K | -$7.6K | 8.6% |
| Royal Bank of Canada | 12,740 | +3,994 | $17.0K | +$5.0K | 45.7% |
| PRUDENTIAL FINANCIAL INC | 24,550 | +2,950 | $33.1K | +$527 | 13.7% |
| ACADIAN ASSET MANAGEMENT LLC | 2,849,294 | +4,142 | $3.8K | -$452 | 0.1% |
| GSA CAPITAL PARTNERS LLP | 1,169,573 | +91,917 | $1.6K | -$48 | 8.5% |
Reduced(49)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MORGAN STANLEY | 803,654 | -604,175 | $1.1M | -$1.0M | -42.9% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 124,525 | -576,051 | $168.1K | -$889.8K | -82.2% |
| JPMORGAN CHASE & CO | 185,007 | -538,068 | $249.8K | -$842.1K | -74.4% |
| CITADEL ADVISORS LLC | 1,964,255 | -146,035 | $2.7M | -$534.8K | -6.9% |
| VANGUARD GROUP INC | 2,855,590 | -48,810 | $3.9M | -$530.6K | -1.7% |
| BANK OF AMERICA CORP /DE/ | 1,367,254 | -181,527 | $1.8M | -$492.9K | -11.7% |
| MILLENNIUM MANAGEMENT LLC | 673,129 | -229,392 | $908.7K | -$454.1K | -25.4% |
| GOLDMAN SACHS GROUP INC | 118,212 | -226,943 | $159.6K | -$361.6K | -65.8% |
| JANE STREET GROUP, LLC | 473,175 | -172,448 | $638.8K | -$336.1K | -26.7% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,343 | -201,166 | $14.0K | -$305.4K | -95.1% |
| Peapod Lane Capital LLC | 448,861 | -116,510 | $606.0K | -$247.9K | -20.6% |
| BARCLAYS PLC | 1 | -161,469 | $1 | -$243.8K | -100.0% |
| Decheng Capital LLC | 1,323,327 | 0 | $1.8M | -$211.7K | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 957,420 | -5,200 | $1.3M | -$161.0K | -0.5% |
| Pfizer Inc | 953,834 | 0 | $1.3M | -$152.6K | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 96,263 | -88,769 | $129.9K | -$149.4K | -48.0% |
| Graham Capital Management, L.P. | 90,910 | -61,237 | $122.7K | -$107.0K | -40.2% |
| AQR CAPITAL MANAGEMENT LLC | 45,995 | -60,970 | $62.1K | -$99.4K | -57.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 589,105 | -117 | $795.7K | -$94.5K | -0.0% |
| Woodline Partners LP | 530,582 | 0 | $716.3K | -$84.9K | 0.0% |
| Qube Research & Technologies Ltd | 17,471 | -39,168 | $23.6K | -$61.9K | -69.2% |
| STATE STREET CORP | 271,790 | 0 | $366.9K | -$43.5K | 0.0% |
| Creative Planning | 260,000 | 0 | $351.0K | -$41.6K | 0.0% |
| IEQ CAPITAL, LLC | 12,229 | -21,924 | $16.5K | -$35.1K | -64.2% |
| Walleye Capital LLC | 110,448 | -10,000 | $149.1K | -$32.8K | -8.3% |
| PANAGORA ASSET MANAGEMENT INC | 86,640 | -11,258 | $117.0K | -$30.9K | -11.5% |
| SEI INVESTMENTS CO | 167,100 | 0 | $225.6K | -$26.7K | 0.0% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 130,407 | -35,883 | $232.1K | -$25.6K | -21.6% |
| NORTHERN TRUST CORP | 92,871 | -1,248 | $125.4K | -$16.7K | -1.3% |
| Carson Advisory Inc. | 23,470 | -8,600 | $31.7K | -$16.7K | -26.8% |
| FEDERATED HERMES, INC. | 34,574 | -6,545 | $46.7K | -$15.4K | -15.9% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,300 | 0 | $104.4K | -$12.4K | 0.0% |
| HIGHLINE WEALTH PARTNERS LLC | 5,000 | -7,000 | $6.8K | -$11.4K | -58.3% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 51,061 | 0 | $68.9K | -$8.2K | 0.0% |
| TUDOR INVESTMENT CORP ET AL | 34,849 | 0 | $47.0K | -$5.6K | 0.0% |
| Regency Capital Management Inc.\DE | 29,500 | 0 | $39.8K | -$4.7K | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 19,895 | -700 | $26.9K | -$4.2K | -3.4% |
| Acorn Wealth Advisors, LLC | 20,000 | 0 | $27.0K | -$3.2K | 0.0% |
| Birchview Capital, LP | 17,000 | 0 | $22.9K | -$2.7K | 0.0% |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16,915 | 0 | $22.8K | -$2.7K | 0.0% |
| EverSource Wealth Advisors, LLC | 1,644 | -949 | $2.2K | -$1.7K | -36.6% |
| BRYN MAWR TRUST Co | 1,000 | 0 | $1.4K | -$160 | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 387 | 0 | $522 | -$62 | 0.0% |
| HighMark Wealth Management LLC | 130 | 0 | $175 | -$21 | 0.0% |
| ALGERT GLOBAL LLC | 48,496 | 0 | $65 | -$8 | 0.0% |
| CWM, LLC | 8,564 | -4,554 | $12 | -$8 | -34.7% |
| Optiver Holding B.V. | 44 | 0 | $59 | -$7 | 0.0% |
| SBI Securities Co., Ltd. | 27 | -1 | $36 | -$6 | -3.6% |
| Covestor Ltd | 51 | -1 | $0 | $0 | -1.9% |
Sold Out(24)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| 5AM Venture Management, LLC | 3,947,913 | $5.3M | +3,457,913 | 705.7% |
| RENAISSANCE TECHNOLOGIES LLC | 2,883,745 | $3.9M | +558,390 | 24.0% |
| VANGUARD GROUP INC | 2,855,590 | $3.9M | -48,810 | -1.7% |
| CITADEL ADVISORS LLC | 1,964,255 | $2.7M | -146,035 | -6.9% |
| D. E. Shaw & Co., Inc. | 1,660,378 | $2.2M | +251,575 | 17.9% |
| TWO SIGMA ADVISERS, LP | 1,483,500 | $2.0M | +22,300 | 1.5% |
| TWO SIGMA INVESTMENTS, LP | 1,471,414 | $2.0M | +108,067 | 7.9% |
| Opaleye Management Inc. | 1,400,906 | $1.9M | +1,084,356 | 342.6% |
| BANK OF AMERICA CORP /DE/ | 1,367,254 | $1.8M | -181,527 | -11.7% |
| Decheng Capital LLC | 1,323,327 | $1.8M | 0 | 0.0% |
| Ishara Investments LP | 1,320,000 | $1.8M | +1,320,000 | — |
| BlackRock, Inc. | 1,249,968 | $1.7M | +464 | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 957,420 | $1.3M | -5,200 | -0.5% |
| Pfizer Inc | 953,834 | $1.3M | 0 | 0.0% |
| MORGAN STANLEY | 803,654 | $1.1M | -604,175 | -42.9% |
| Connor, Clark & Lunn Investment Management Ltd. | 787,055 | $1.1M | +406,233 | 106.7% |
| UBS Group AG | 674,598 | $910.7K | +141,920 | 26.6% |
| MILLENNIUM MANAGEMENT LLC | 673,129 | $908.7K | -229,392 | -25.4% |
| Almitas Capital LLC | 610,073 | $823.6K | +152,751 | 33.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 589,105 | $795.7K | -117 | -0.0% |
New & Closed Positions this quarter
Closed Positions
24 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ZNTL against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.