New Positions
14 managers initiated
Top five by reported value
- Avoro Capital Advisors LLC$22.9M
- Squadron Capital Management LLC$4.0M
- Trexquant Investment LP$695.7K
- BIT Capital GmbH$635.0K
- XTX Topco Ltd$564.5K
GH Research PLC NASDAQ NMS - GLOBAL MARKET:GHRS
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
14 new18 added21 reduced10 exited
Total Institutional Holders
53
as of 2025-12-31
Top Holder
Lynx1 Capital Management LP
$132.2M
Largest QoQ Increase
Lynx1 Capital Management LP
+1,805,386 sh
Largest QoQ Decrease
Deep Track Capital, LP
-1,250,000 sh
New Positions(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 1,800,000 | +1,800,000 | $22.9M | +$22.9M | — |
| Squadron Capital Management LLC | 315,000 | +315,000 | $4.0M | +$4.0M | — |
| Trexquant Investment LP | 54,776 | +54,776 | $695.7K | +$695.7K | — |
| BIT Capital GmbH | 50,000 | +50,000 | $635.0K | +$635.0K | — |
| XTX Topco Ltd | 44,446 | +44,446 | $564.5K | +$564.5K | — |
| Lion Point Capital, LP | 10,200 | +10,200 | $129.5K | +$129.5K | — |
| China Universal Asset Management Co., Ltd. | 10,107 | +10,107 | $128.4K | +$128.4K | — |
| Mirae Asset Global Investments Co., Ltd. | 3,014 | +3,014 | $38.3K | +$38.3K | — |
| GF FUND MANAGEMENT CO. LTD. | 1,218 | +1,218 | $15.5K | +$15.5K | — |
| Tower Research Capital LLC (TRC) | 770 | +770 | $9.8K | +$9.8K | — |
| SBI Securities Co., Ltd. | 20 | +20 | $254 | +$254 | — |
| GSA CAPITAL PARTNERS LLP | 18,565 | +18,565 | $236 | +$236 | — |
| HRT FINANCIAL LP | 15,936 | +15,936 | $202 | +$202 | — |
| Daiwa Securities Group Inc. | 207 | +207 | $3 | +$3 | — |
Added To(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 10,406,575 | +1,805,386 | $132.2M | +$27.9M | 21.0% |
| BlackRock, Inc. | 434,401 | +376,542 | $5.5M | +$4.7M | 650.8% |
| RTW INVESTMENTS, LP | 5,933,815 | +364,251 | $75.4M | -$4.3M | 6.5% |
| Troluce Capital Advisors LLC | 373,212 | +326,490 | $4.7M | +$4.1M | 698.8% |
| CenterBook Partners LP | 283,441 | +117,288 | $3.6M | +$1.2M | 70.6% |
| Jefferies Financial Group Inc. | 712,300 | +2,988 | $9.0M | -$1.1M | 0.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,277 | +75,777 | $1.3M | +$920.0K | 285.9% |
| GOLDMAN SACHS GROUP INC | 80,986 | +69,911 | $1.0M | +$870.1K | 631.3% |
| MARSHALL WACE, LLP | 240,764 | +71,264 | $3.1M | +$633.9K | 42.0% |
| MORGAN STANLEY | 51,404 | +47,162 | $652.8K | +$592.2K | 1111.8% |
| JANE STREET GROUP, LLC | 71,805 | +48,801 | $911.9K | +$583.0K | 212.1% |
| BOOTHBAY FUND MANAGEMENT, LLC | 112,184 | +28,634 | $1.4M | +$230.0K | 34.3% |
| Virtus Investment Advisers, Inc. | 20,408 | +11,539 | $259.2K | +$132.4K | 130.1% |
| AdvisorShares Investments LLC | 67,112 | +13,121 | $852.3K | +$80.3K | 24.3% |
| CITIGROUP INC | 4,404 | +4,373 | $55.9K | +$55.5K | 14106.5% |
| BANK OF AMERICA CORP /DE/ | 4,450 | +4,175 | $56.5K | +$52.6K | 1518.2% |
| JPMORGAN CHASE & CO | 18,881 | +4,981 | $239.8K | +$41.0K | 35.8% |
| BARCLAYS PLC | 2,118 | +822 | $26.9K | +$8.4K | 63.4% |
Reduced(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BVF INC/IL | 8,827,712 | 0 | $112.1M | -$14.1M | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | 0 | $97.5M | -$12.3M | 0.0% |
| FMR LLC | 5,136,045 | -191,000 | $65.2M | -$10.9M | -3.6% |
| Cormorant Asset Management, LP | 1,300,000 | -616,439 | $16.5M | -$10.9M | -32.2% |
| MILLENNIUM MANAGEMENT LLC | 295,926 | -567,676 | $3.8M | -$8.6M | -65.7% |
| UBS Group AG | 363,381 | -148,083 | $4.6M | -$2.7M | -28.9% |
| Verition Fund Management LLC | 673,735 | -4,754 | $8.6M | -$1.1M | -0.7% |
| 5AM Venture Management, LLC | 572,665 | 0 | $7.3M | -$916.3K | 0.0% |
| CITADEL ADVISORS LLC | 38,558 | -55,844 | $489.7K | -$860.3K | -59.1% |
| HighVista Strategies LLC | 240,524 | -1,370 | $3.1M | -$404.4K | -0.6% |
| Alyeska Investment Group, L.P. | 204,975 | 0 | $2.6M | -$328.0K | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 1,337 | -4,865 | $17.0K | -$71.7K | -78.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 35,645 | 0 | $452.7K | -$57.0K | 0.0% |
| NORTHERN TRUST CORP | 32,828 | -145 | $416.9K | -$54.6K | -0.4% |
| HighTower Advisors, LLC | 15,600 | -500 | $198.1K | -$32.1K | -3.1% |
| STATE STREET CORP | 10,821 | -171 | $137.4K | -$19.8K | -1.6% |
| Royal Bank of Canada | 1,810 | -1,152 | $23.0K | -$12.0K | -38.9% |
| ADVISOR GROUP HOLDINGS, INC. | 10,025 | -100 | $127.3K | -$9.4K | -1.0% |
| Global Retirement Partners, LLC | 400 | -400 | $5.1K | -$6.4K | -50.0% |
| WELLS FARGO & COMPANY/MN | 1,250 | 0 | $15.9K | -$2.0K | 0.0% |
| SIMPLEX TRADING, LLC | 48 | -4,161 | $609 | +$549 | -98.8% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | -1,250,000 | $0 | -$17.9M | — |
| STEMPOINT CAPITAL LP | 0 | -545,275 | $0 | -$7.8M | — |
| Point72 Asset Management, L.P. | 0 | -76,958 | $0 | -$1.1M | — |
| Squarepoint Ops LLC | 0 | -36,103 | $0 | -$516.3K | — |
| TANG CAPITAL MANAGEMENT LLC | 0 | -24,030 | $0 | -$343.6K | — |
| Cubist Systematic Strategies, LLC | 0 | -22,732 | $0 | -$325.1K | — |
| Man Group plc | 0 | -22,060 | $0 | -$315.5K | — |
| PEAK6 LLC | 0 | -20,000 | $0 | -$243.8K | — |
| Farther Finance Advisors, LLC | 0 | -200 | $0 | -$2.9K | — |
| GROUP ONE TRADING, L.P. | 0 | -100 | $0 | -$1.4K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Lynx1 Capital Management LP | 10,406,575 | $132.2M | +1,805,386 | 21.0% |
| BVF INC/IL | 8,827,712 | $112.1M | 0 | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | $97.5M | 0 | 0.0% |
| RTW INVESTMENTS, LP | 5,933,815 | $75.4M | +364,251 | 6.5% |
| FMR LLC | 5,136,045 | $65.2M | -191,000 | -3.6% |
| Avoro Capital Advisors LLC | 1,800,000 | $22.9M | +1,800,000 | — |
| Cormorant Asset Management, LP | 1,300,000 | $16.5M | -616,439 | -32.2% |
| Jefferies Financial Group Inc. | 712,300 | $9.0M | +2,988 | 0.4% |
| Verition Fund Management LLC | 673,735 | $8.6M | -4,754 | -0.7% |
| 5AM Venture Management, LLC | 572,665 | $7.3M | 0 | 0.0% |
| BlackRock, Inc. | 434,401 | $5.5M | +376,542 | 650.8% |
| Troluce Capital Advisors LLC | 373,212 | $4.7M | +326,490 | 698.8% |
| UBS Group AG | 363,381 | $4.6M | -148,083 | -28.9% |
| Squadron Capital Management LLC | 315,000 | $4.0M | +315,000 | — |
| MILLENNIUM MANAGEMENT LLC | 295,926 | $3.8M | -567,676 | -65.7% |
| CenterBook Partners LP | 283,441 | $3.6M | +117,288 | 70.6% |
| MARSHALL WACE, LLP | 240,764 | $3.1M | +71,264 | 42.0% |
| HighVista Strategies LLC | 240,524 | $3.1M | -1,370 | -0.6% |
| Alyeska Investment Group, L.P. | 204,975 | $2.6M | 0 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 112,184 | $1.4M | +28,634 | 34.3% |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
- Deep Track Capital, LP$17.9M
- STEMPOINT CAPITAL LP$7.8M
- Point72 Asset Management, L.P.$1.1M
- Squarepoint Ops LLC$516.3K
- TANG CAPITAL MANAGEMENT LLC$343.6K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for GHRS against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.