| Point72 Asset Management, L.P. | 2,875,000 | -3,579,274 | $22.1M | -$25.4M | -55.5% |
| RTW INVESTMENTS, LP | 447,607 | -2,231,872 | $3.4M | -$16.3M | -83.3% |
| PERCEPTIVE ADVISORS LLC | 692,441 | -746,154 | $5.3M | -$5.3M | -51.9% |
| ORBIMED ADVISORS LLC | 7,165,006 | 0 | $55.2M | +$2.4M | 0.0% |
| Foresite Capital Management VI LLC | 1,381,233 | -350,000 | $10.6M | -$2.1M | -20.2% |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 0 | $25.2M | +$1.1M | 0.0% |
| TWO SIGMA ADVISERS, LP | 18,900 | -142,700 | $145.5K | -$1.0M | -88.3% |
| Vivo Capital, LLC | 2,234,566 | 0 | $17.2M | +$737.4K | 0.0% |
| Royal Bank of Canada | 1,622 | -113,332 | $12.0K | -$448.0K | -98.6% |
| TWO SIGMA INVESTMENTS, LP | 143,598 | -59,762 | $1.1M | -$393.1K | -29.4% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,700 | -40,000 | $205.6K | -$286.0K | -60.0% |
| TOWERVIEW LLC | 140,000 | -30,000 | $1.1M | -$174.9K | -17.6% |
| SPHERA FUNDS MANAGEMENT LTD. | 407,709 | 0 | $3.1M | +$134.5K | 0.0% |
| NORTHERN TRUST CORP | 429,771 | -36,715 | $3.3M | -$128.8K | -7.9% |
| AXQ CAPITAL, LP | 12,601 | -14,450 | $97.0K | -$102.3K | -53.4% |
| RHUMBLINE ADVISERS | 70,727 | -11,863 | $544.6K | -$64.1K | -14.4% |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 167,400 | -1,800 | $1.3M | +$42.0K | -1.1% |
| BNP PARIBAS FINANCIAL MARKETS | 6,566 | -5,950 | $50.6K | -$41.7K | -47.5% |
| Nuveen, LLC | 68,064 | 0 | $524.1K | +$22.5K | 0.0% |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 0 | $491.1K | +$21.0K | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 121,157 | -3,339 | $932.9K | +$15.4K | -2.7% |
| Tower Research Capital LLC (TRC) | 631 | -1,856 | $4.9K | -$13.5K | -74.6% |
| AVITY INVESTMENT MANAGEMENT INC. | 32,680 | 0 | $251.6K | +$10.8K | 0.0% |
| MetLife Investment Management, LLC | 30,782 | -2,812 | $237.0K | -$10.6K | -8.4% |
| Argent Advisors, Inc. | 30,000 | 0 | $231.0K | +$9.9K | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 171,173 | -6,615 | $1.3M | +$7.7K | -3.7% |
| Three Bridge Wealth Advisors, LLC | 22,371 | 0 | $172.3K | +$7.4K | 0.0% |
| COMMERCE BANK | 20,000 | 0 | $154.0K | +$6.6K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,800 | 0 | $144.8K | +$6.2K | 0.0% |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 0 | $74.8K | -$5.7K | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 17,120 | 0 | $131.8K | +$5.7K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 15,530 | 0 | $119.6K | +$5.1K | 0.0% |
| Balyasny Asset Management L.P. | 25,031 | -541 | $192.7K | +$4.3K | -2.1% |
| Legal & General Group Plc | 5,787 | -737 | $44.6K | -$3.5K | -11.3% |
| OneDigital Investment Advisors LLC | 10,000 | 0 | $77.0K | +$3.3K | 0.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,497 | -1,229 | $134.7K | -$3.3K | -6.6% |
| GSA CAPITAL PARTNERS LLP | 14,188 | -387,219 | $109 | -$2.8K | -96.5% |
| ROTHSCHILD INVESTMENT LLC | 7,000 | 0 | $53.9K | +$2.3K | 0.0% |
| Russell Investments Group, Ltd. | 6,661 | 0 | $51.3K | +$2.2K | 0.0% |
| Ameritas Investment Partners, Inc. | 5,348 | 0 | $41.2K | +$1.8K | 0.0% |
| JPMORGAN CHASE & CO | 30,655 | -1,577 | $236.0K | -$1.5K | -4.9% |
| PNC Financial Services Group, Inc. | 137 | -162 | $1.1K | -$1.1K | -54.2% |
| Northwest Capital Management Inc | 3,397 | 0 | $26.2K | +$1.1K | 0.0% |
| Arax Advisory Partners | 10 | -136 | $77 | -$999 | -93.2% |
| IFP Advisors, Inc | 0 | 0 | $685 | +$685 | — |
| Western Pacific Wealth Management, LP | 2,000 | 0 | $15.4K | +$660 | 0.0% |
| GF FUND MANAGEMENT CO. LTD. | 1,466 | -137 | $11.3K | -$526 | -8.5% |
| SBI Securities Co., Ltd. | 1,004 | -2 | $7.7K | +$317 | -0.2% |
| Physician Wealth Advisors, Inc. | 177 | 0 | $1.4K | +$58 | 0.0% |
| KELLEHER FINANCIAL ADVISORS | 75 | 0 | $578 | +$25 | 0.0% |
| SIGNATUREFD, LLC | 76 | 0 | $585 | +$25 | 0.0% |
| Hikari Power Ltd | 49,959 | 0 | $385 | +$17 | 0.0% |
| Daiwa Securities Group Inc. | 225 | -175 | $2 | -$1 | -43.8% |