13F HOLDINGS REPORT
ORBIMED ADVISORS LLC
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001172661-26-001119
Total Value
$4.90B
Positions
108
Other Managers
1
Confidential Omitted
No
Holdings (108)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | EDGEWISE THERAPEUTICS INC | EWTX | 15,518,492 | $385.1M | 7.86% |
| 2 | ELI LILLY & CO | LLY | 301,200 | $323.7M | 6.61% |
| 3 | BOSTON SCIENTIFIC CORP | BSX | 2,419,300 | $230.7M | 4.71% |
| 4 | SINOVAC BIOTECH LTD | SVA | 2,718,735 | $184.5M | 3.77% |
| 5 | EDWARDS LIFESCIENCES CORP | EW | 1,842,900 | $157.1M | 3.21% |
| 6 | UPSTREAM BIO INC | UPB | 5,693,589 | $154.6M | 3.16% |
| 7 | INTUITIVE SURGICAL INC | ISRG | 263,400 | $149.2M | 3.04% |
| 8 | SIONNA THERAPEUTICS INC | SION | 3,561,655 | $146.5M | 2.99% |
| 9 | MBX BIOSCIENCES INC | MBX | 3,935,203 | $124.1M | 2.53% |
| 10 | ARGENX SE | ARGX | 146,000 | $122.8M | 2.51% |
| 11 | ENLIVEN THERAPEUTICS INC | ELVN | 7,959,538 | $122.6M | 2.50% |
| 12 | ALNYLAM PHARMACEUTICALS INC | ALNY | 288,800 | $114.8M | 2.34% |
| 13 | STRYKER CORPORATION | SYK | 325,000 | $114.2M | 2.33% |
| 14 | ARS PHARMACEUTICALS INC | SPRY | 8,288,510 | $96.6M | 1.97% |
| 15 | TERNS PHARMACEUTICALS INC | TERN | 2,153,300 | $87.0M | 1.78% |
| 16 | DISC MEDICINE INC | IRON | 1,067,550 | $84.8M | 1.73% |
| 17 | CARIS LIFE SCIENCES INC | CAI | 3,116,011 | $84.1M | 1.72% |
| 18 | NATERA INC | NTRA | 365,800 | $83.8M | 1.71% |
| 19 | COMPASS THERAPEUTICS INC | CMPX | 15,219,994 | $81.7M | 1.67% |
| 20 | STRUCTURE THERAPEUTICS INC | GPCR | 1,161,803 | $80.8M | 1.65% |
| 21 | DANAHER CORPORATION | 235851102 | 299,800 | $68.6M | 1.40% |
| 22 | CG ONCOLOGY INC | CGON | 1,516,550 | $63.0M | 1.29% |
| 23 | APELLIS PHARMACEUTICALS INC | APLS | 2,429,868 | $61.0M | 1.25% |
| 24 | ARRIVENT BIOPHARMA INC | AVBP | 3,027,328 | $60.9M | 1.24% |
| 25 | THE CIGNA GROUP | 125523100 | 205,000 | $56.4M | 1.15% |
| 26 | RAPT THERAPEUTICS INC | 75382E208 | 1,642,891 | $55.6M | 1.14% |
| 27 | CORVUS PHARMACEUTICALS INC | CRVS | 7,165,006 | $55.2M | 1.13% |
| 28 | UNITED THERAPEUTICS CORP DEL | UTHR | 105,200 | $51.3M | 1.05% |
| 29 | ABIVAX SA | AAVXF | 367,900 | $49.6M | 1.01% |
| 30 | ROIVANT SCIENCES LTD | ROIV | 2,190,907 | $47.5M | 0.97% |
| 31 | CRINETICS PHARMACEUTICALS IN | CRNX | 999,000 | $46.5M | 0.95% |
| 32 | AXSOME THERAPEUTICS INC | AXSM | 253,121 | $46.2M | 0.94% |
| 33 | EYEPOINT INC | EYPT | 2,468,314 | $45.1M | 0.92% |
| 34 | AVIDITY BIOSCIENCES INC | 05370A108 | 619,530 | $44.7M | 0.91% |
| 35 | NEUROCRINE BIOSCIENCES INC | NBIX | 314,240 | $44.6M | 0.91% |
| 36 | DYNE THERAPEUTICS INC | DYN | 2,202,184 | $43.1M | 0.88% |
| 37 | BRISTOL-MYERS SQUIBB CO | CELG-RI | 775,000 | $41.8M | 0.85% |
| 38 | PFIZER INC | PFE | 1,652,900 | $41.2M | 0.84% |
| 39 | TREVI THERAPEUTICS INC | TRVI | 3,190,700 | $39.9M | 0.82% |
| 40 | NEUROPACE INC | NPCE | 2,406,335 | $37.2M | 0.76% |
| 41 | ASCENDIS PHARMA A/S | ASND | 171,977 | $36.7M | 0.75% |
| 42 | EXACT SCIENCES CORP | 30063P105 | 351,716 | $35.7M | 0.73% |
| 43 | MINERALYS THERAPEUTICS INC | MLYS | 980,400 | $35.6M | 0.73% |
| 44 | ELEVANCE HEALTH INC FORMERLY | ELV | 99,100 | $34.7M | 0.71% |
| 45 | FORTE BIOSCIENCES INC | FBRX | 1,196,955 | $32.6M | 0.67% |
| 46 | PRELUDE THERAPEUTICS INC | PRLD | 10,909,256 | $31.6M | 0.65% |
| 47 | CYBIN INC | HELP | 3,840,500 | $31.4M | 0.64% |
| 48 | ORIC PHARMACEUTICALS INC | ORIC | 3,641,756 | $29.8M | 0.61% |
| 49 | KRYSTAL BIOTECH INC | KRYS | 119,800 | $29.5M | 0.60% |
| 50 | PRAXIS PRECISION MEDICINES I | PRAX | 94,500 | $27.9M | 0.57% |
| 51 | JANUX THERAPEUTICS INC | JANX | 1,954,426 | $27.0M | 0.55% |
| 52 | THERMO FISHER SCIENTIFIC INC | TMO | 46,500 | $26.9M | 0.55% |
| 53 | BRUKER CORP | BRKRP | 555,789 | $26.2M | 0.53% |
| 54 | RHYTHM PHARMACEUTICALS INC | RYTM | 239,800 | $25.7M | 0.52% |
| 55 | SHATTUCK LABS INC | STTK | 6,306,127 | $23.0M | 0.47% |
| 56 | ESPERION THERAPEUTICS INC NE | ESPR | 5,965,498 | $22.1M | 0.45% |
| 57 | AVALO THERAPEUTICS INC | AVTX | 1,187,300 | $21.6M | 0.44% |
| 58 | LEXEO THERAPEUTICS INC | LXEO | 2,125,000 | $21.1M | 0.43% |
| 59 | ADC THERAPEUTICS SA | ADCT | 5,822,854 | $20.6M | 0.42% |
| 60 | UROGEN PHARMA LTD | URGN | 875,487 | $20.5M | 0.42% |
| 61 | XENON PHARMACEUTICALS INC | XENE | 447,200 | $20.0M | 0.41% |
| 62 | BRIGHTSPRING HEALTH SVCS INC | 10950A106 | 488,500 | $18.3M | 0.37% |
| 63 | VERA THERAPEUTICS INC | VERA | 353,500 | $17.9M | 0.37% |
| 64 | UNIQURE NV | QURE | 737,400 | $17.6M | 0.36% |
| 65 | PRELUDE THERAPEUTICS INC | 000000000 | 5,680,186 | $16.5M | 0.34% |
| 66 | MIND MEDICINE MINDMED INC | 60255C885 | 1,226,700 | $16.4M | 0.34% |
| 67 | KEROS THERAPEUTICS INC | KROS | 804,212 | $16.4M | 0.33% |
| 68 | CARLSMED INC | CARL | 1,252,600 | $15.5M | 0.32% |
| 69 | CYTOMX THERAPEUTICS INC | CTMX | 3,525,650 | $15.0M | 0.31% |
| 70 | VIR BIOTECHNOLOGY INC | VIR | 2,380,715 | $14.4M | 0.29% |
| 71 | BIOCRYST PHARMACEUTICALS INC | BCRX | 1,741,800 | $13.6M | 0.28% |
| 72 | COGENT BIOSCIENCES INC | COGT | 371,000 | $13.2M | 0.27% |
| 73 | CORBUS PHARMACEUTICALS HLDGS | CRBP | 1,597,287 | $13.0M | 0.27% |
| 74 | EDWARDS LIFESCIENCES CORP | EW | 150,000 | $12.8M | 0.26% |
| 75 | TARSUS PHARMACEUTICALS INC | TARS | 154,400 | $12.6M | 0.26% |
| 76 | RELMADA THERAPEUTICS INC | RLMD | 2,610,600 | $12.6M | 0.26% |
| 77 | TECTONIC THERAPEUTIC INC | TECX | 574,600 | $12.0M | 0.24% |
| 78 | ALUMIS INC | ALMS | 1,102,730 | $10.8M | 0.22% |
| 79 | BIOAGE LABS INC | BIOA | 790,901 | $10.5M | 0.21% |
| 80 | AMICUS THERAPEUTICS INC | FOLD | 729,900 | $10.4M | 0.21% |
| 81 | WHITEHAWK THERAPEUTICS INC | WHWK | 4,166,000 | $10.1M | 0.21% |
| 82 | ADICET BIO INC | ACET | 1,027,944 | $8.7M | 0.18% |
| 83 | REPARE THERAPEUTICS INC | 760273102 | 3,322,488 | $8.6M | 0.18% |
| 84 | CELCUITY INC | CELC | 85,664 | $8.5M | 0.17% |
| 85 | JADE BIOSCIENCES INC | JBIO | 531,163 | $8.2M | 0.17% |
| 86 | KINIKSA PHARMACEUTICALS INTL | G52694109 | 187,199 | $7.7M | 0.16% |
| 87 | Q32 BIO INC | QTTB | 2,252,987 | $7.5M | 0.15% |
| 88 | PMV PHARMACEUTICALS INC | PMVP | 4,975,291 | $6.2M | 0.13% |
| 89 | KALVISTA PHARMACEUTICALS INC | KALV | 382,400 | $6.2M | 0.13% |
| 90 | PHARVARIS N V | PHVS | 205,400 | $5.7M | 0.12% |
| 91 | INSPIREMD INC | NSPR | 3,133,405 | $5.6M | 0.11% |
| 92 | INSMED INC | INSM | 25,400 | $4.4M | 0.09% |
| 93 | PALISADE BIO INC | PALI | 1,871,420 | $4.4M | 0.09% |
| 94 | IMAGENEBIO INC | 000000000 | 530,713 | $3.7M | 0.07% |
| 95 | BICARA THERAPEUTICS INC | BCAX | 209,100 | $3.5M | 0.07% |
| 96 | CULLINAN THERAPEUTICS INC | CGEM | 270,006 | $2.8M | 0.06% |
| 97 | C4 THERAPEUTICS INC | CCCC | 1,404,902 | $2.7M | 0.05% |
| 98 | IMAGENEBIO INC | IMA | 378,556 | $2.6M | 0.05% |
| 99 | ALTO NEUROSCIENCE INC | ANRO | 125,000 | $2.2M | 0.05% |
| 100 | REVOLUTION MEDICINES INC | RVMDW | 25,900 | $2.1M | 0.04% |
| 101 | VISTAGEN THERAPEUTICS INC | VTGN | 3,060,000 | $2.0M | 0.04% |
| 102 | OCULAR THERAPEUTIX INC | OCUL | 157,300 | $1.9M | 0.04% |
| 103 | PROTAGONIST THERAPEUTICS INC | PTGX | 21,700 | $1.9M | 0.04% |
| 104 | PTC THERAPEUTICS INC | PTCT | 23,200 | $1.8M | 0.04% |
| 105 | COGENT BIOSCIENCES INC | COGT | 1,000,000 | $1.2M | 0.02% |
| 106 | MAPLIGHT THERAPEUTICS INC | MPLT | 56,000 | $952,000 | 0.02% |
| 107 | TRAWS PHARMA INC | TRAW | 605,531 | $684,250 | 0.01% |
| 108 | VISTAGEN THERAPEUTICS INC | VTGN | 45,200 | $29,918 | 0.00% |