13F HOLDINGS REPORT
ORBIMED ADVISORS LLC
Quarter ended Q1 2025 · Filed May 15, 2025 · Accession 0001172661-25-002355
Total Value
$4.19B
Positions
111
Other Managers
1
Confidential Omitted
No
Holdings (111)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | SINOVAC BIOTECH LTD | SVA | 2,718,735 | $334.0M | 7.96% |
| 2 | EDGEWISE THERAPEUTICS INC | EWTX | 15,021,721 | $330.5M | 7.88% |
| 3 | BOSTON SCIENTIFIC CORP | BSX | 2,813,200 | $283.8M | 6.77% |
| 4 | ELI LILLY & CO | LLY | 337,600 | $278.8M | 6.65% |
| 5 | ENLIVEN THERAPEUTICS INC | ELVN | 7,959,538 | $156.6M | 3.73% |
| 6 | INTUITIVE SURGICAL INC | ISRG | 291,000 | $144.1M | 3.44% |
| 7 | STRYKER CORPORATION | SYK | 359,200 | $133.7M | 3.19% |
| 8 | ARGENX SE | ARGX | 206,700 | $122.3M | 2.92% |
| 9 | EDWARDS LIFESCIENCES CORP | EW | 1,532,000 | $111.0M | 2.65% |
| 10 | UNITEDHEALTH GROUP INC | UNH | 201,200 | $105.4M | 2.51% |
| 11 | ARS PHARMACEUTICALS INC | SPRY | 8,288,510 | $104.3M | 2.49% |
| 12 | NEUROCRINE BIOSCIENCES INC | NBIX | 934,640 | $103.4M | 2.46% |
| 13 | PFIZER INC | PFE | 3,850,200 | $97.6M | 2.33% |
| 14 | ALNYLAM PHARMACEUTICALS INC | ALNY | 346,100 | $93.5M | 2.23% |
| 15 | INTEGER HLDGS CORP | ITGR | 662,500 | $78.2M | 1.86% |
| 16 | VERTEX PHARMACEUTICALS INC | VRTX | 159,900 | $77.5M | 1.85% |
| 17 | NATERA INC | NTRA | 547,000 | $77.4M | 1.84% |
| 18 | IONIS PHARMACEUTICALS INC | IONS | 2,540,136 | $76.6M | 1.83% |
| 19 | DISC MEDICINE INC | IRON | 1,415,020 | $70.2M | 1.67% |
| 20 | THERMO FISHER SCIENTIFIC INC | TMO | 129,000 | $64.2M | 1.53% |
| 21 | TENET HEALTHCARE CORP | THC | 465,000 | $62.5M | 1.49% |
| 22 | CYTOKINETICS INC | CYTK | 1,509,205 | $60.7M | 1.45% |
| 23 | CG ONCOLOGY INC | CGON | 2,471,994 | $60.5M | 1.44% |
| 24 | ARRIVENT BIOPHARMA INC | AVBP | 3,027,328 | $56.0M | 1.33% |
| 25 | AVIDITY BIOSCIENCES INC | 05370A108 | 1,812,886 | $53.5M | 1.28% |
| 26 | SI-BONE INC | SIBN | 3,442,853 | $48.3M | 1.15% |
| 27 | AXSOME THERAPEUTICS INC | AXSM | 386,700 | $45.1M | 1.08% |
| 28 | COMPASS THERAPEUTICS INC | CMPX | 22,362,850 | $42.5M | 1.01% |
| 29 | SPRINGWORKS THERAPEUTICS INC | 85205L107 | 950,200 | $41.9M | 1.00% |
| 30 | NEUROPACE INC | NPCE | 3,406,335 | $41.9M | 1.00% |
| 31 | SIONNA THERAPEUTICS INC | SION | 3,704,959 | $38.8M | 0.92% |
| 32 | UPSTREAM BIO INC | UPB | 5,693,589 | $34.8M | 0.83% |
| 33 | XTANT MED HLDGS INC | 98420P308 | 73,114,592 | $34.4M | 0.82% |
| 34 | TARSUS PHARMACEUTICALS INC | TARS | 653,743 | $33.6M | 0.80% |
| 35 | CRINETICS PHARMACEUTICALS IN | CRNX | 999,000 | $33.5M | 0.80% |
| 36 | XENON PHARMACEUTICALS INC | XENE | 947,877 | $31.8M | 0.76% |
| 37 | APELLIS PHARMACEUTICALS INC | APLS | 1,432,300 | $31.3M | 0.75% |
| 38 | MBX BIOSCIENCES INC | MBX | 4,002,887 | $29.5M | 0.70% |
| 39 | EXACT SCIENCES CORP | 30063P105 | 679,816 | $29.4M | 0.70% |
| 40 | GILEAD SCIENCES INC | GILD | 197,500 | $22.1M | 0.53% |
| 41 | CORVUS PHARMACEUTICALS INC | CRVS | 6,943,654 | $22.1M | 0.53% |
| 42 | TERNS PHARMACEUTICALS INC | TERN | 7,562,971 | $20.9M | 0.50% |
| 43 | JANUX THERAPEUTICS INC | JANX | 758,566 | $20.5M | 0.49% |
| 44 | RHYTHM PHARMACEUTICALS INC | RYTM | 380,000 | $20.1M | 0.48% |
| 45 | THIRD HARMONIC BIO INC | 88427A107 | 5,779,071 | $20.1M | 0.48% |
| 46 | AMICUS THERAPEUTICS INC | FOLD | 2,285,400 | $18.6M | 0.44% |
| 47 | VERASTEM INC | VSTM | 2,862,448 | $17.3M | 0.41% |
| 48 | TYRA BIOSCIENCES INC | TYRA | 1,752,831 | $16.3M | 0.39% |
| 49 | RAPT THERAPEUTICS INC | 75382E109 | 13,135,260 | $16.0M | 0.38% |
| 50 | SCPHARMACEUTICALS INC | 810648105 | 6,059,528 | $15.9M | 0.38% |
| 51 | VIR BIOTECHNOLOGY INC | VIR | 2,248,249 | $14.6M | 0.35% |
| 52 | CULLINAN THERAPEUTICS INC | CGEM | 1,923,855 | $14.6M | 0.35% |
| 53 | IMMATICS N.V | IMTX | 3,087,462 | $13.9M | 0.33% |
| 54 | AMGEN INC | AMGN | 44,200 | $13.8M | 0.33% |
| 55 | PFIZER INC | PFE | 500,000 | $12.7M | 0.30% |
| 56 | VERA THERAPEUTICS INC | VERA | 481,065 | $11.6M | 0.28% |
| 57 | STRUCTURE THERAPEUTICS INC | GPCR | 652,028 | $11.3M | 0.27% |
| 58 | C4 THERAPEUTICS INC | CCCC | 6,830,300 | $10.9M | 0.26% |
| 59 | DYNE THERAPEUTICS INC | DYN | 1,014,611 | $10.6M | 0.25% |
| 60 | KEROS THERAPEUTICS INC | KROS | 1,018,734 | $10.4M | 0.25% |
| 61 | ACELYRIN INC | 00445A100 | 4,001,711 | $9.9M | 0.24% |
| 62 | AGIOS PHARMACEUTICALS INC | AGIO | 325,500 | $9.5M | 0.23% |
| 63 | ABCELLERA BIOLOGICS INC | ABCL | 4,180,768 | $9.3M | 0.22% |
| 64 | ADICET BIO INC | ACET | 11,447,140 | $8.6M | 0.21% |
| 65 | ADC THERAPEUTICS SA | ADCT | 5,968,451 | $8.4M | 0.20% |
| 66 | PRELUDE THERAPEUTICS INC | PRLD | 10,909,256 | $8.4M | 0.20% |
| 67 | IKENA ONCOLOGY INC | 000000000 | 6,368,587 | $8.2M | 0.19% |
| 68 | SPDR SER TR | 78464A870 | 100,000 | $8.1M | 0.19% |
| 69 | AVALO THERAPEUTICS INC | AVTX | 967,000 | $7.7M | 0.18% |
| 70 | SPRINGWORKS THERAPEUTICS INC | 85205L107 | 172,600 | $7.6M | 0.18% |
| 71 | WHITEHAWK THERAPEUTICS INC | WHWK | 4,166,000 | $7.4M | 0.18% |
| 72 | AKERO THERAPEUTICS INC | 00973Y108 | 179,900 | $7.3M | 0.17% |
| 73 | PMV PHARMACEUTICALS INC | PMVP | 6,475,291 | $7.1M | 0.17% |
| 74 | TREVI THERAPEUTICS INC | TRVI | 1,120,000 | $7.0M | 0.17% |
| 75 | KESTRA MED TECHNOLOGIES LTD | BEKE | 250,000 | $6.2M | 0.15% |
| 76 | CORBUS PHARMACEUTICALS HLDGS | CRBP | 1,172,287 | $6.2M | 0.15% |
| 77 | INSPIREMD INC | NSPR | 2,133,405 | $5.7M | 0.14% |
| 78 | SCHOLAR ROCK HLDG CORP | SRRK | 151,800 | $4.9M | 0.12% |
| 79 | FORTE BIOSCIENCES INC | FBRX | 593,088 | $4.6M | 0.11% |
| 80 | IKENA ONCOLOGY INC | 45175G108 | 3,539,358 | $4.5M | 0.11% |
| 81 | PRELUDE THERAPEUTICS INC | 000000000 | 5,680,186 | $4.4M | 0.10% |
| 82 | KRYSTAL BIOTECH INC | KRYS | 23,500 | $4.2M | 0.10% |
| 83 | ENGENE HOLDINGS INC | ENGNW | 891,616 | $4.0M | 0.10% |
| 84 | ORIC PHARMACEUTICALS INC | ORIC | 700,000 | $3.9M | 0.09% |
| 85 | BICARA THERAPEUTICS INC | BCAX | 298,301 | $3.9M | 0.09% |
| 86 | Q32 BIO INC | QTTB | 2,252,987 | $3.7M | 0.09% |
| 87 | BIOAGE LABS INC | BIOA | 921,959 | $3.5M | 0.08% |
| 88 | REPARE THERAPEUTICS INC | 760273102 | 3,322,488 | $3.3M | 0.08% |
| 89 | STRUCTURE THERAPEUTICS INC | GPCR | 150,000 | $2.6M | 0.06% |
| 90 | PASSAGE BIO INC | PASG | 7,034,626 | $2.5M | 0.06% |
| 91 | INSMED INC | INSM | 28,659 | $2.2M | 0.05% |
| 92 | CERIBELL INC | CBLL | 112,500 | $2.2M | 0.05% |
| 93 | INSTIL BIO INC | TIL | 116,785 | $2.0M | 0.05% |
| 94 | CHEMOMAB THERAPEUTICS LTD | CMMB | 1,741,273 | $1.9M | 0.05% |
| 95 | CARDIFF ONCOLOGY INC | CRDF | 573,884 | $1.8M | 0.04% |
| 96 | X4 PHARMACEUTICALS INC | XFOR | 6,776,515 | $1.6M | 0.04% |
| 97 | NKARTA INC | NKTX | 821,400 | $1.5M | 0.04% |
| 98 | TRAWS PHARMA INC | TRAW | 605,531 | $1.4M | 0.03% |
| 99 | FATE THERAPEUTICS INC | FATE | 1,680,580 | $1.3M | 0.03% |
| 100 | TURNSTONE BIOLOGICS CORP | 90042W100 | 3,099,265 | $1.3M | 0.03% |
| 101 | AMYLYX PHARMACEUTICALS INC | AMLX | 348,000 | $1.2M | 0.03% |
| 102 | BIOMX INC | PHGE | 1,787,767 | $993,462 | 0.02% |
| 103 | KEZAR LIFE SCIENCES INC | KZR | 192,700 | $940,376 | 0.02% |
| 104 | TANGO THERAPEUTICS INC | TNGX | 550,000 | $753,500 | 0.02% |
| 105 | INVIVYD INC | IVVD | 933,500 | $565,048 | 0.01% |
| 106 | KORRO BIO INC | KRRO | 32,400 | $564,084 | 0.01% |
| 107 | NEXTCURE INC | NXTC | 1,141,200 | $548,118 | 0.01% |
| 108 | ALTO NEUROSCIENCE INC | ANRO | 250,000 | $540,000 | 0.01% |
| 109 | DIH HLDG US INC | 23290B106 | 1,915,000 | $442,940 | 0.01% |
| 110 | XERIS BIOPHARMA HOLDINGS INC | XERS | 80,420 | $441,506 | 0.01% |
| 111 | LAKESHORE BIOPHARMA CO LTD | LSBWF | 140,428 | $344,049 | 0.01% |