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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
Markets · Healthcare

Upstream Bio, Inc. (UPB)

NMS · Biotechnology

$6.400.00 (0.00%)Quote refreshed

Sources: Yahoo Finance (quote, statistics) · SEC EDGAR (filings, insider trades, 13F holders) · company filings & press wires

Market Cap
$348.3M
P/E (TTM)
EPS
$-2.90
Div Yield
52W Range
$5.85–$33.68
Beta

Company overview

Next earnings: 2026-08-05(8d)

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

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Recent press releases

Upstream Bio, Inc. has not issued a press release in this window.

SEC filings

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Upstream Bio, Inc. has not filed an SEC document in this window.

Upstream Bio, Inc. has no reported insider trades in the last 90 days.

Institutional holders

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As of 2025-12-31 · prior 2025-09-30
2,882,647 sh● NEW
FMR LLC$204.1M
7,518,202 sh-7.0%
5,693,589 sh0.0%
1,806,243 sh+563.4%
3,344,504 sh+28.4%
1,527,958 sh● NEW
3,143,078 sh-4.3%
773,148 sh● NEW

People at Upstream Bio, Inc.

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Quarterly financials

Full financials →
Revenue trend
03/25
$566.0K
NI -$27.3M
06/25
$937.0K
NI -$40.0M
09/25
$683.0K
NI -$33.7M
RevenueNI = Net Income
EPS trend (diluted)
Latest: $-0.63
Prior: $-0.74
Revenue sparkline