13F HOLDINGS REPORT
ORBIMED ADVISORS LLC
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001172661-25-005047
Total Value
$4.26B
Positions
110
Other Managers
1
Confidential Omitted
No
Holdings (110)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | EDGEWISE THERAPEUTICS INC | EWTX | 15,518,492 | $251.7M | 5.92% |
| 2 | BOSTON SCIENTIFIC CORP | BSX | 2,429,300 | $237.2M | 5.57% |
| 3 | ELI LILLY & CO | LLY | 301,200 | $229.8M | 5.40% |
| 4 | SINOVAC BIOTECH LTD | SVA | 2,718,735 | $184.5M | 4.33% |
| 5 | ENLIVEN THERAPEUTICS INC | ELVN | 7,959,538 | $162.9M | 3.83% |
| 6 | ALNYLAM PHARMACEUTICALS INC | ALNY | 301,600 | $137.5M | 3.23% |
| 7 | STRYKER CORPORATION | SYK | 359,200 | $132.8M | 3.12% |
| 8 | EDWARDS LIFESCIENCES CORP | EW | 1,684,000 | $131.0M | 3.08% |
| 9 | INTUITIVE SURGICAL INC | ISRG | 287,200 | $128.4M | 3.02% |
| 10 | ARGENX SE | ARGX | 172,300 | $127.1M | 2.99% |
| 11 | SIONNA THERAPEUTICS INC | SION | 3,704,959 | $109.0M | 2.56% |
| 12 | UPSTREAM BIO INC | UPB | 5,693,589 | $107.1M | 2.52% |
| 13 | DISC MEDICINE INC | IRON | 1,415,020 | $93.5M | 2.20% |
| 14 | CARIS LIFE SCIENCES INC | CAI | 3,034,858 | $91.8M | 2.16% |
| 15 | ARS PHARMACEUTICALS INC | SPRY | 8,288,510 | $83.3M | 1.96% |
| 16 | AVIDITY BIOSCIENCES INC | 05370A108 | 1,638,886 | $71.4M | 1.68% |
| 17 | MBX BIOSCIENCES INC | MBX | 4,002,887 | $70.1M | 1.65% |
| 18 | CG ONCOLOGY INC | CGON | 1,726,850 | $69.6M | 1.63% |
| 19 | NATERA INC | NTRA | 429,300 | $69.1M | 1.62% |
| 20 | AXSOME THERAPEUTICS INC | AXSM | 531,800 | $64.6M | 1.52% |
| 21 | TERNS PHARMACEUTICALS INC | TERN | 7,562,971 | $56.8M | 1.33% |
| 22 | ARRIVENT BIOPHARMA INC | AVBP | 3,027,328 | $55.9M | 1.31% |
| 23 | MINERALYS THERAPEUTICS INC | MLYS | 1,469,494 | $55.7M | 1.31% |
| 24 | EXACT SCIENCES CORP | 30063P105 | 994,616 | $54.4M | 1.28% |
| 25 | COMPASS THERAPEUTICS INC | CMPX | 15,219,994 | $53.3M | 1.25% |
| 26 | CORVUS PHARMACEUTICALS INC | CRVS | 7,165,006 | $52.8M | 1.24% |
| 27 | APELLIS PHARMACEUTICALS INC | APLS | 2,323,368 | $52.6M | 1.24% |
| 28 | DANAHER CORPORATION | 235851102 | 263,100 | $52.2M | 1.23% |
| 29 | NEUROCRINE BIOSCIENCES INC | NBIX | 353,640 | $49.6M | 1.17% |
| 30 | UNITED THERAPEUTICS CORP DEL | UTHR | 114,900 | $48.2M | 1.13% |
| 31 | THE CIGNA GROUP | 125523100 | 162,800 | $46.9M | 1.10% |
| 32 | CRINETICS PHARMACEUTICALS IN | CRNX | 1,099,000 | $45.8M | 1.08% |
| 33 | ORIC PHARMACEUTICALS INC | ORIC | 3,641,756 | $43.7M | 1.03% |
| 34 | JANUX THERAPEUTICS INC | JANX | 1,766,100 | $43.2M | 1.01% |
| 35 | ROIVANT SCIENCES LTD | ROIV | 2,714,798 | $41.1M | 0.97% |
| 36 | ASCENDIS PHARMA A/S | ASND | 191,905 | $38.2M | 0.90% |
| 37 | SI-BONE INC | SIBN | 2,578,979 | $38.0M | 0.89% |
| 38 | SCPHARMACEUTICALS INC | 810648105 | 6,059,528 | $34.4M | 0.81% |
| 39 | ABIVAX SA | AAVXF | 380,000 | $32.3M | 0.76% |
| 40 | STRUCTURE THERAPEUTICS INC | GPCR | 1,139,300 | $31.9M | 0.75% |
| 41 | TREVI THERAPEUTICS INC | TRVI | 3,308,400 | $30.3M | 0.71% |
| 42 | INTEGER HLDGS CORP | ITGR | 290,000 | $30.0M | 0.70% |
| 43 | DYNE THERAPEUTICS INC | DYN | 2,314,184 | $29.3M | 0.69% |
| 44 | RAPT THERAPEUTICS INC | 75382E208 | 1,086,618 | $28.0M | 0.66% |
| 45 | CYTOMX THERAPEUTICS INC | CTMX | 8,461,500 | $27.0M | 0.63% |
| 46 | NEUROPACE INC | NPCE | 2,614,184 | $27.0M | 0.63% |
| 47 | UNIQURE NV | QURE | 458,500 | $26.8M | 0.63% |
| 48 | EYEPOINT PHARMACEUTICALS INC | EYPT | 1,796,000 | $25.6M | 0.60% |
| 49 | AKERO THERAPEUTICS INC | 00973Y108 | 526,200 | $25.0M | 0.59% |
| 50 | ADC THERAPEUTICS SA | ADCT | 5,907,351 | $23.6M | 0.56% |
| 51 | THERMO FISHER SCIENTIFIC INC | TMO | 46,500 | $22.6M | 0.53% |
| 52 | RHYTHM PHARMACEUTICALS INC | RYTM | 215,152 | $21.7M | 0.51% |
| 53 | ABBOTT LABS | ABLZF | 150,000 | $20.1M | 0.47% |
| 54 | BOSTON SCIENTIFIC CORP | BSX | 200,000 | $19.5M | 0.46% |
| 55 | KRYSTAL BIOTECH INC | KRYS | 102,745 | $18.1M | 0.43% |
| 56 | FORTE BIOSCIENCES INC | FBRX | 1,196,955 | $18.0M | 0.42% |
| 57 | AVALO THERAPEUTICS INC | AVTX | 1,349,300 | $17.1M | 0.40% |
| 58 | XENON PHARMACEUTICALS INC | XENE | 419,600 | $16.8M | 0.40% |
| 59 | CARLSMED INC | CARL | 1,252,600 | $16.8M | 0.39% |
| 60 | KEROS THERAPEUTICS INC | KROS | 1,018,734 | $16.1M | 0.38% |
| 61 | PRELUDE THERAPEUTICS INC | PRLD | 10,909,256 | $15.7M | 0.37% |
| 62 | SHATTUCK LABS INC | STTK | 6,306,127 | $15.1M | 0.35% |
| 63 | CORBUS PHARMACEUTICALS HLDGS | CRBP | 1,172,287 | $14.8M | 0.35% |
| 64 | UROGEN PHARMA LTD | URGN | 689,000 | $13.7M | 0.32% |
| 65 | VIR BIOTECHNOLOGY INC | VIR | 2,380,715 | $13.6M | 0.32% |
| 66 | AMICUS THERAPEUTICS INC | FOLD | 1,645,400 | $13.0M | 0.30% |
| 67 | PFIZER INC | PFE | 500,000 | $12.7M | 0.30% |
| 68 | TARSUS PHARMACEUTICALS INC | TARS | 197,900 | $11.8M | 0.28% |
| 69 | C4 THERAPEUTICS INC | CCCC | 5,235,146 | $11.6M | 0.27% |
| 70 | ASTRAZENECA PLC | AZN | 150,000 | $11.5M | 0.27% |
| 71 | CULLINAN THERAPEUTICS INC | CGEM | 1,923,855 | $11.4M | 0.27% |
| 72 | VISTAGEN THERAPEUTICS INC | VTGN | 3,060,000 | $10.9M | 0.26% |
| 73 | AMYLYX PHARMACEUTICALS INC | AMLX | 750,600 | $10.2M | 0.24% |
| 74 | ADICET BIO INC | ACET | 11,447,140 | $9.3M | 0.22% |
| 75 | PMV PHARMACEUTICALS INC | PMVP | 5,975,291 | $8.4M | 0.20% |
| 76 | PRELUDE THERAPEUTICS INC | 000000000 | 5,680,186 | $8.2M | 0.19% |
| 77 | WHITEHAWK THERAPEUTICS INC | WHWK | 4,166,000 | $7.9M | 0.19% |
| 78 | VERASTEM INC | VSTM | 887,561 | $7.8M | 0.18% |
| 79 | BRIGHTSPRING HEALTH SVCS INC | 10950A106 | 263,800 | $7.8M | 0.18% |
| 80 | ALUMIS INC | ALMS | 1,926,423 | $7.7M | 0.18% |
| 81 | BIOCRYST PHARMACEUTICALS INC | BCRX | 901,500 | $6.8M | 0.16% |
| 82 | MILESTONE PHARMACEUTICALS IN | MIST | 3,221,828 | $6.4M | 0.15% |
| 83 | REPARE THERAPEUTICS INC | 760273102 | 3,322,488 | $5.8M | 0.14% |
| 84 | APELLIS PHARMACEUTICALS INC | APLS | 250,000 | $5.7M | 0.13% |
| 85 | INSPIREMD INC | NSPR | 2,133,405 | $5.1M | 0.12% |
| 86 | BIOAGE LABS INC | BIOA | 790,901 | $4.7M | 0.11% |
| 87 | JADE BIOSCIENCES INC | JBIO | 531,163 | $4.6M | 0.11% |
| 88 | Q32 BIO INC | QTTB | 2,252,987 | $4.5M | 0.10% |
| 89 | BRIGHTSPRING HEALTH SVCS INC | 10950A106 | 150,000 | $4.4M | 0.10% |
| 90 | MIND MEDICINE MINDMED INC | 60255C885 | 367,824 | $4.3M | 0.10% |
| 91 | IMAGENEBIO INC | 000000000 | 530,713 | $4.3M | 0.10% |
| 92 | CRINETICS PHARMACEUTICALS IN | CRNX | 100,000 | $4.2M | 0.10% |
| 93 | CELCUITY INC | CELC | 84,020 | $4.2M | 0.10% |
| 94 | IMMATICS N.V | IMTX | 466,601 | $4.0M | 0.09% |
| 95 | SCHOLAR ROCK HLDG CORP | SRRK | 100,000 | $3.7M | 0.09% |
| 96 | TG THERAPEUTICS INC | TGTX | 100,000 | $3.6M | 0.08% |
| 97 | IMAGENEBIO INC | IMA | 378,556 | $3.1M | 0.07% |
| 98 | CELCUITY INC | CELC | 2,000,000 | $2.7M | 0.06% |
| 99 | INSMED INC | INSM | 13,459 | $1.9M | 0.05% |
| 100 | ATAI LIFE SCIENCES NV | N0731H103 | 347,000 | $1.8M | 0.04% |
| 101 | KORRO BIO INC | KRRO | 32,400 | $1.6M | 0.04% |
| 102 | MURAL ONCOLOGY PUB LTD CO | G63365103 | 588,800 | $1.2M | 0.03% |
| 103 | TRAWS PHARMA INC | TRAW | 605,531 | $1.1M | 0.03% |
| 104 | ALTO NEUROSCIENCE INC | ANRO | 250,000 | $1.0M | 0.02% |
| 105 | LYELL IMMUNOPHARMA INC | LYEL | 51,727 | $840,046 | 0.02% |
| 106 | KEZAR LIFE SCIENCES INC | KZR | 192,700 | $751,530 | 0.02% |
| 107 | XERIS BIOPHARMA HOLDINGS INC | XERS | 80,420 | $654,619 | 0.02% |
| 108 | PASSAGE BIO INC | PASG | 59,046 | $474,139 | 0.01% |
| 109 | DIH HLDG US INC | 23290B106 | 1,915,000 | $358,105 | 0.01% |
| 110 | VISTAGEN THERAPEUTICS INC | VTGN | 45,200 | $160,460 | 0.00% |