13F HOLDINGS REPORT
ORBIMED ADVISORS LLC
Quarter ended Q4 2024 · Filed February 14, 2025 · Accession 0001172661-25-001136
Total Value
$4.86B
Positions
119
Other Managers
1
Confidential Omitted
No
Holdings (119)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | EDGEWISE THERAPEUTICS INC | EWTX | 15,021,721 | $401.1M | 8.25% |
| 2 | SINOVAC BIOTECH LTD | SVA | 2,718,735 | $334.0M | 6.87% |
| 3 | BOSTON SCIENTIFIC CORP | BSX | 3,160,300 | $282.3M | 5.81% |
| 4 | ELI LILLY & CO | LLY | 337,600 | $260.6M | 5.36% |
| 5 | INTUITIVE SURGICAL INC | ISRG | 401,700 | $209.7M | 4.31% |
| 6 | ENLIVEN THERAPEUTICS INC | ELVN | 7,959,538 | $179.1M | 3.68% |
| 7 | NEUROCRINE BIOSCIENCES INC | NBIX | 938,120 | $128.1M | 2.63% |
| 8 | STRYKER CORPORATION | SYK | 344,400 | $124.0M | 2.55% |
| 9 | SAREPTA THERAPEUTICS INC | SRPT | 963,400 | $117.1M | 2.41% |
| 10 | ARGENX SE | ARGX | 189,700 | $116.7M | 2.40% |
| 11 | DISC MEDICINE INC | IRON | 1,785,571 | $113.2M | 2.33% |
| 12 | TENET HEALTHCARE CORP | THC | 792,000 | $100.0M | 2.06% |
| 13 | IONIS PHARMACEUTICALS INC | IONS | 2,817,347 | $98.5M | 2.03% |
| 14 | ALNYLAM PHARMACEUTICALS INC | ALNY | 415,600 | $97.8M | 2.01% |
| 15 | UPSTREAM BIO INC | UPB | 5,693,589 | $93.6M | 1.93% |
| 16 | ARS PHARMACEUTICALS INC | SPRY | 8,288,510 | $87.4M | 1.80% |
| 17 | EDWARDS LIFESCIENCES CORP | EW | 1,145,302 | $84.8M | 1.74% |
| 18 | MERCK & CO INC | MRK | 829,900 | $82.6M | 1.70% |
| 19 | ARRIVENT BIOPHARMA INC | AVBP | 3,027,328 | $80.6M | 1.66% |
| 20 | BIOGEN INC | BIIB | 509,100 | $77.9M | 1.60% |
| 21 | INTEGER HLDGS CORP | ITGR | 575,000 | $76.2M | 1.57% |
| 22 | CYTOKINETICS INC | CYTK | 1,584,005 | $74.5M | 1.53% |
| 23 | MBX BIOSCIENCES INC | MBX | 3,812,215 | $70.3M | 1.45% |
| 24 | UNITEDHEALTH GROUP INC | UNH | 130,900 | $66.2M | 1.36% |
| 25 | NATERA INC | NTRA | 413,000 | $65.4M | 1.34% |
| 26 | VERTEX PHARMACEUTICALS INC | VRTX | 151,000 | $60.8M | 1.25% |
| 27 | THIRD HARMONIC BIO INC | 88427A107 | 5,779,071 | $59.5M | 1.22% |
| 28 | CRINETICS PHARMACEUTICALS IN | CRNX | 999,000 | $51.1M | 1.05% |
| 29 | UNIVERSAL HLTH SVCS INC | 913903100 | 269,300 | $48.3M | 0.99% |
| 30 | SI-BONE INC | SIBN | 3,442,853 | $48.3M | 0.99% |
| 31 | SPRINGWORKS THERAPEUTICS INC | 85205L107 | 1,255,031 | $45.3M | 0.93% |
| 32 | THERMO FISHER SCIENTIFIC INC | TMO | 84,400 | $43.9M | 0.90% |
| 33 | TERNS PHARMACEUTICALS INC | TERN | 7,562,971 | $41.9M | 0.86% |
| 34 | CG ONCOLOGY INC | CGON | 1,431,114 | $41.0M | 0.84% |
| 35 | JANUX THERAPEUTICS INC | JANX | 758,566 | $40.6M | 0.84% |
| 36 | EXACT SCIENCES CORP | 30063P105 | 679,816 | $38.2M | 0.79% |
| 37 | NEUROPACE INC | NPCE | 3,406,335 | $38.1M | 0.78% |
| 38 | XENON PHARMACEUTICALS INC | XENE | 947,877 | $37.2M | 0.76% |
| 39 | CORVUS PHARMACEUTICALS INC | CRVS | 6,943,654 | $37.1M | 0.76% |
| 40 | SPDR SER TR | 78464A870 | 372,000 | $33.5M | 0.69% |
| 41 | COMPASS THERAPEUTICS INC | CMPX | 22,362,850 | $32.4M | 0.67% |
| 42 | XTANT MED HLDGS INC | 98420P308 | 73,114,592 | $32.4M | 0.67% |
| 43 | AVIDITY BIOSCIENCES INC | 05370A108 | 1,112,886 | $32.4M | 0.67% |
| 44 | VERA THERAPEUTICS INC | VERA | 742,572 | $31.4M | 0.65% |
| 45 | DYNE THERAPEUTICS INC | DYN | 1,227,080 | $28.9M | 0.59% |
| 46 | CULLINAN THERAPEUTICS INC | CGEM | 1,942,555 | $23.7M | 0.49% |
| 47 | VIR BIOTECHNOLOGY INC | VIR | 3,218,617 | $23.6M | 0.49% |
| 48 | GILEAD SCIENCES INC | GILD | 245,600 | $22.7M | 0.47% |
| 49 | RHYTHM PHARMACEUTICALS INC | RYTM | 400,000 | $22.4M | 0.46% |
| 50 | IMMATICS N.V | IMTX | 3,087,462 | $22.0M | 0.45% |
| 51 | AMICUS THERAPEUTICS INC | FOLD | 2,285,400 | $21.5M | 0.44% |
| 52 | SCPHARMACEUTICALS INC | 810648105 | 6,059,528 | $21.5M | 0.44% |
| 53 | RAPT THERAPEUTICS INC | 75382E109 | 13,135,260 | $20.8M | 0.43% |
| 54 | TYRA BIOSCIENCES INC | TYRA | 1,470,086 | $20.4M | 0.42% |
| 55 | MINERALYS THERAPEUTICS INC | MLYS | 1,611,637 | $19.8M | 0.41% |
| 56 | GILEAD SCIENCES INC | GILD | 200,000 | $18.5M | 0.38% |
| 57 | STRUCTURE THERAPEUTICS INC | GPCR | 652,028 | $17.7M | 0.36% |
| 58 | KEROS THERAPEUTICS INC | KROS | 1,018,734 | $16.1M | 0.33% |
| 59 | C4 THERAPEUTICS INC | CCCC | 4,377,900 | $15.8M | 0.32% |
| 60 | MEDPACE HLDGS INC | MEDP | 44,900 | $14.9M | 0.31% |
| 61 | VERASTEM INC | VSTM | 2,862,448 | $14.8M | 0.30% |
| 62 | PRELUDE THERAPEUTICS INC | PRLD | 10,909,256 | $13.9M | 0.29% |
| 63 | CORBUS PHARMACEUTICALS HLDGS | CRBP | 1,172,287 | $13.8M | 0.28% |
| 64 | FORTE BIOSCIENCES INC | FBRX | 600,000 | $13.6M | 0.28% |
| 65 | INTRA-CELLULAR THERAPIES INC | 46116X101 | 163,000 | $13.6M | 0.28% |
| 66 | ACELYRIN INC | 00445A100 | 4,001,711 | $12.6M | 0.26% |
| 67 | ABCELLERA BIOLOGICS INC | ABCL | 4,180,768 | $12.2M | 0.25% |
| 68 | ADC THERAPEUTICS SA | ADCT | 5,968,451 | $11.9M | 0.24% |
| 69 | ADICET BIO INC | ACET | 11,447,140 | $11.0M | 0.23% |
| 70 | IKENA ONCOLOGY INC | 000000000 | 6,368,587 | $10.4M | 0.21% |
| 71 | PMV PHARMACEUTICALS INC | PMVP | 6,475,291 | $9.8M | 0.20% |
| 72 | UNIVERSAL HLTH SVCS INC | 913903100 | 50,000 | $9.0M | 0.18% |
| 73 | NEUMORA THERAPEUTICS INC. | NMRA | 804,996 | $8.5M | 0.18% |
| 74 | Q32 BIO INC | QTTB | 2,252,987 | $7.8M | 0.16% |
| 75 | GERON CORP | GERN | 2,168,000 | $7.7M | 0.16% |
| 76 | PRELUDE THERAPEUTICS INC | 000000000 | 5,680,186 | $7.2M | 0.15% |
| 77 | AVALO THERAPEUTICS INC | AVTX | 967,000 | $7.2M | 0.15% |
| 78 | CARDIFF ONCOLOGY INC | CRDF | 1,538,462 | $6.7M | 0.14% |
| 79 | PFIZER INC | PFE | 250,000 | $6.6M | 0.14% |
| 80 | SCHOLAR ROCK HLDG CORP | SRRK | 151,800 | $6.6M | 0.13% |
| 81 | INSMED INC | INSM | 94,559 | $6.5M | 0.13% |
| 82 | ENGENE HOLDINGS INC | ENGNW | 920,339 | $6.1M | 0.13% |
| 83 | IKENA ONCOLOGY INC | 45175G108 | 3,539,358 | $5.8M | 0.12% |
| 84 | INSPIREMD INC | NSPR | 2,133,405 | $5.6M | 0.12% |
| 85 | TRAWS PHARMA INC | TRAW | 605,531 | $5.4M | 0.11% |
| 86 | BIOAGE LABS INC | BIOA | 921,959 | $5.3M | 0.11% |
| 87 | X4 PHARMACEUTICALS INC | XFOR | 7,133,515 | $5.2M | 0.11% |
| 88 | BICARA THERAPEUTICS INC | BCAX | 298,301 | $5.2M | 0.11% |
| 89 | MILESTONE PHARMACEUTICALS IN | MIST | 2,000,000 | $4.7M | 0.10% |
| 90 | REPARE THERAPEUTICS INC | 760273102 | 3,322,488 | $4.4M | 0.09% |
| 91 | PASSAGE BIO INC | PASG | 7,404,869 | $4.2M | 0.09% |
| 92 | STRUCTURE THERAPEUTICS INC | GPCR | 150,000 | $4.1M | 0.08% |
| 93 | KRYSTAL BIOTECH INC | KRYS | 23,500 | $3.7M | 0.08% |
| 94 | ARDENT HEALTH PARTNERS INC | ARDT | 206,000 | $3.5M | 0.07% |
| 95 | SI-BONE INC | SIBN | 250,000 | $3.5M | 0.07% |
| 96 | TENET HEALTHCARE CORP | THC | 25,000 | $3.2M | 0.06% |
| 97 | CHEMOMAB THERAPEUTICS LTD | CMMB | 1,741,273 | $3.2M | 0.06% |
| 98 | CERIBELL INC | CBLL | 112,500 | $2.9M | 0.06% |
| 99 | FATE THERAPEUTICS INC | FATE | 1,680,580 | $2.8M | 0.06% |
| 100 | PEPGEN INC | PEPG | 653,016 | $2.5M | 0.05% |
| 101 | INSTIL BIO INC | TIL | 116,785 | $2.2M | 0.05% |
| 102 | NKARTA INC | NKTX | 821,400 | $2.0M | 0.04% |
| 103 | LYELL IMMUNOPHARMA INC | LYEL | 3,103,623 | $2.0M | 0.04% |
| 104 | IMMUNOVANT INC | IMVT | 78,500 | $1.9M | 0.04% |
| 105 | AKERO THERAPEUTICS INC | 00973Y108 | 66,000 | $1.8M | 0.04% |
| 106 | TANGO THERAPEUTICS INC | TNGX | 550,000 | $1.7M | 0.03% |
| 107 | TURNSTONE BIOLOGICS CORP | 90042W100 | 3,099,265 | $1.5M | 0.03% |
| 108 | AMYLYX PHARMACEUTICALS INC | AMLX | 348,000 | $1.3M | 0.03% |
| 109 | BIOMX INC | PHGE | 1,787,767 | $1.3M | 0.03% |
| 110 | KEZAR LIFE SCIENCES INC | KZR | 192,700 | $1.3M | 0.03% |
| 111 | KORRO BIO INC | KRRO | 32,400 | $1.2M | 0.03% |
| 112 | ALTO NEUROSCIENCE INC | ANRO | 250,000 | $1.1M | 0.02% |
| 113 | NEXTCURE INC | NXTC | 1,141,200 | $879,865 | 0.02% |
| 114 | AGIOS PHARMACEUTICALS INC | AGIO | 26,700 | $877,362 | 0.02% |
| 115 | C4 THERAPEUTICS INC | CCCC | 150,000 | $540,000 | 0.01% |
| 116 | ELEVATION ONCOLOGY INC | 28623U101 | 941,275 | $529,561 | 0.01% |
| 117 | INVIVYD INC | IVVD | 1,149,300 | $509,255 | 0.01% |
| 118 | LAKESHORE BIOPHARMA CO LTD | LSBWF | 140,428 | $485,881 | 0.01% |
| 119 | XERIS BIOPHARMA HOLDINGS INC | XERS | 80,420 | $272,624 | 0.01% |