13F HOLDINGS REPORT
Siren, L.L.C.
Quarter ended Q2 2025 · Filed August 13, 2025 · Accession 0002005369-25-000014
Total Value
$1.93B
Positions
111
Other Managers
2
Confidential Omitted
No
Holdings (111)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Scholar Rock Holding Corp | SRRK | 9,250,005 | $327.6M | 16.95% |
| 2 | Kymera Therapeutics Inc | KYMR | 3,428,150 | $149.6M | 7.74% |
| 3 | BeOne Medicines AG | BEIGF | 509,990 | $123.5M | 6.39% |
| 4 | Disc Medicine Inc | IRON | 1,099,401 | $58.2M | 3.01% |
| 5 | Crinetics Pharmaceuticals Inc | CRNX | 1,688,611 | $48.6M | 2.51% |
| 6 | Bicara Therapeutics Inc | BCAX | 5,216,969 | $48.5M | 2.51% |
| 7 | Dyne Therapeutics Inc | DYN | 4,836,437 | $46.0M | 2.38% |
| 8 | Centessa Pharmaceuticals PLC | CNTA | 3,460,029 | $45.5M | 2.35% |
| 9 | Merus NV | N5749R100 | 853,467 | $44.9M | 2.32% |
| 10 | Apellis Pharmaceuticals Inc | APLS | 2,578,396 | $44.6M | 2.31% |
| 11 | Ascendis Pharma A/S | ASND | 245,943 | $42.4M | 2.20% |
| 12 | Arrowhead Pharmaceuticals Inc | ARWR | 2,669,880 | $42.2M | 2.18% |
| 13 | Edgewise Therapeutics Inc | EWTX | 3,160,298 | $41.4M | 2.14% |
| 14 | Soleno Therapeutics Inc | SLNO | 467,342 | $39.2M | 2.03% |
| 15 | Lexicon Pharmaceuticals Inc | LXRX | 38,918,903 | $36.8M | 1.90% |
| 16 | Taboola.com Ltd | TBLAW | 9,969,495 | $36.5M | 1.89% |
| 17 | Solid Biosciences Inc | SLDB | 7,415,905 | $36.1M | 1.87% |
| 18 | Revolution Medicines Inc | RVMDW | 938,755 | $34.5M | 1.79% |
| 19 | Avidity Biosciences Inc | 05370A108 | 1,110,610 | $31.5M | 1.63% |
| 20 | Rhythm Pharmaceuticals Inc | RYTM | 409,742 | $25.9M | 1.34% |
| 21 | Apogee Therapeutics Inc | APGE | 594,994 | $25.8M | 1.34% |
| 22 | Stoke Therapeutics Inc | STOK | 2,247,347 | $25.5M | 1.32% |
| 23 | Taysha Gene Therapies Inc | TSHA | 11,014,737 | $25.4M | 1.32% |
| 24 | Xenon Pharmaceuticals Inc | XENE | 812,761 | $25.4M | 1.32% |
| 25 | WAVE Life Sciences Ltd | WVE | 3,696,322 | $24.0M | 1.24% |
| 26 | MoonLake Immunotherapeutics | MLTX | 508,267 | $24.0M | 1.24% |
| 27 | Septerna Inc | SEPN | 2,202,514 | $23.3M | 1.20% |
| 28 | NewAmsterdam Pharma Company NV | NAMSW | 1,194,240 | $21.6M | 1.12% |
| 29 | Trevi Therapeutics Inc | TRVI | 3,938,793 | $21.5M | 1.11% |
| 30 | Tango Therapeutics Inc | TNGX | 3,364,814 | $17.2M | 0.89% |
| 31 | Akero Therapeutics Inc | 00973Y108 | 318,647 | $17.0M | 0.88% |
| 32 | Silence Therapeutics PLC | SLNCF | 2,911,438 | $16.9M | 0.87% |
| 33 | Arrivent Biopharma Inc | AVBP | 700,000 | $15.2M | 0.79% |
| 34 | Bicycle Therapeutics PLC | BCYC | 2,012,752 | $14.0M | 0.72% |
| 35 | Arcus Biosciences Inc | RCUS | 1,612,077 | $13.1M | 0.68% |
| 36 | IHS Holding Limited | IHS | 2,357,520 | $13.1M | 0.68% |
| 37 | Amazon.com Inc | AMZN | 56,500 | $12.4M | 0.64% |
| 38 | Denali Therapeutics Inc | DNLI | 821,513 | $11.5M | 0.59% |
| 39 | Erasca Inc | ERAS | 8,757,249 | $11.1M | 0.58% |
| 40 | Oric Pharmaceuticals Inc | ORIC | 1,007,575 | $10.2M | 0.53% |
| 41 | Vaxcyte Inc | PCVX | 295,543 | $9.6M | 0.50% |
| 42 | CrowdStrike Holdings Inc | CRWD | 18,500 | $9.4M | 0.49% |
| 43 | Cullinan Therapeutics Inc | CGEM | 1,193,410 | $9.0M | 0.47% |
| 44 | Alphabet Inc | GOOG | 50,703 | $8.9M | 0.46% |
| 45 | Remitly Global Inc | RELY | 465,449 | $8.7M | 0.45% |
| 46 | Upstream Bio Inc | UPB | 788,450 | $8.7M | 0.45% |
| 47 | Seer Inc | SEER | 4,000,000 | $8.6M | 0.44% |
| 48 | Microsoft Corp | MSFT | 16,150 | $8.0M | 0.42% |
| 49 | NVIDIA Corp | NVDA | 49,985 | $7.9M | 0.41% |
| 50 | IONQ Inc | IONQ-WT | 170,000 | $7.3M | 0.38% |
| 51 | Taiwan Semiconductor Manufacturing Co Ltd | 874039100 | 30,500 | $6.9M | 0.36% |
| 52 | Gossamer Bio Inc | GOSS | 5,208,968 | $6.4M | 0.33% |
| 53 | Salesforce Inc | CRM | 22,600 | $6.2M | 0.32% |
| 54 | Cogent Biosciences Inc | COGT | 854,379 | $6.1M | 0.32% |
| 55 | Cartesian Therapeutics Inc | RNAC | 563,272 | $5.9M | 0.30% |
| 56 | Vera Therapeutics Inc | VERA | 247,216 | $5.8M | 0.30% |
| 57 | Adobe Inc | ADBE | 15,051 | $5.8M | 0.30% |
| 58 | Sionna Therapeutics Inc | SION | 325,000 | $5.6M | 0.29% |
| 59 | PDD Holdings Inc | PDD | 52,901 | $5.5M | 0.29% |
| 60 | Sagimet Biosciences Inc | SGMT | 724,771 | $5.5M | 0.29% |
| 61 | Spyre Therapeutics Inc | SYRE | 368,598 | $5.5M | 0.29% |
| 62 | Pacira Biosciences Inc | PCRX | 225,000 | $5.4M | 0.28% |
| 63 | ServiceNow Inc | NOW | 5,126 | $5.3M | 0.27% |
| 64 | Korro Bio Inc | KRRO | 418,833 | $5.2M | 0.27% |
| 65 | Datadog Inc | DDOG | 38,425 | $5.2M | 0.27% |
| 66 | Agenus Inc | AGEN | 1,064,250 | $4.9M | 0.25% |
| 67 | Jfrog Ltd | FROG | 107,116 | $4.7M | 0.24% |
| 68 | Rapport Therapeutics Inc | RAPP | 378,469 | $4.3M | 0.22% |
| 69 | Instil Bio Inc | TIL | 203,933 | $4.2M | 0.22% |
| 70 | Dynatrace Inc | DT | 75,229 | $4.2M | 0.21% |
| 71 | Whitehawk Therapeutics Inc | WHWK | 2,082,000 | $3.9M | 0.20% |
| 72 | New Oriental Education & Technology Group Inc | 647581206 | 72,000 | $3.9M | 0.20% |
| 73 | IGM Biosciences Inc | 449585108 | 3,255,826 | $3.6M | 0.19% |
| 74 | Foghorn Therapeutics Inc | FHTX | 720,720 | $3.4M | 0.18% |
| 75 | Vigil Neuroscience Inc | 92673K108 | 411,191 | $3.3M | 0.17% |
| 76 | Neumora Therapeutics Inc | NMRA | 4,358,283 | $3.2M | 0.17% |
| 77 | ProQR Therapeutics NV | N71542109 | 1,552,183 | $3.2M | 0.16% |
| 78 | Nebius Group NV | NBIS | 51,000 | $2.8M | 0.15% |
| 79 | Black Diamond Therapeutics Inc | BDTX | 1,046,517 | $2.6M | 0.13% |
| 80 | Lexeo Therapeutics Inc | LXEO | 603,435 | $2.4M | 0.13% |
| 81 | Palo Alto Networks Inc | PANW | 11,500 | $2.4M | 0.12% |
| 82 | Qualcomm Inc | QCOM | 14,000 | $2.2M | 0.12% |
| 83 | Workiva Inc | WK | 28,000 | $1.9M | 0.10% |
| 84 | Eledon Pharmaceuticals Inc | ELDN | 690,170 | $1.9M | 0.10% |
| 85 | Ke Holdings Inc | BEKE | 105,000 | $1.9M | 0.10% |
| 86 | HubSpot Inc | HUBS | 3,000 | $1.7M | 0.09% |
| 87 | UnitedHealth Group Inc | UNH | 5,076 | $1.6M | 0.08% |
| 88 | BIOAGE Labs Inc | BIOA | 382,406 | $1.6M | 0.08% |
| 89 | GitLab Inc | GTLB | 35,000 | $1.6M | 0.08% |
| 90 | Tourmaline Bio Inc | 89157D105 | 91,426 | $1.5M | 0.08% |
| 91 | Rocket Pharmaceuticals Inc | RCKTW | 591,263 | $1.4M | 0.07% |
| 92 | Tesla Inc | TSLA | 4,000 | $1.3M | 0.07% |
| 93 | Birkenstock Holding PLC | BIRK | 25,000 | $1.2M | 0.06% |
| 94 | SailPoint Inc | SAIL | 50,000 | $1.1M | 0.06% |
| 95 | SEMrush Holdings Inc | SEMR | 125,000 | $1.1M | 0.06% |
| 96 | Primo Brands Corp | PRMB | 37,500 | $1.1M | 0.06% |
| 97 | Cellebrite DI Ltd | CLBT | 60,000 | $960,000 | 0.05% |
| 98 | Generation Bio Co | 37148K100 | 2,968,925 | $950,353 | 0.05% |
| 99 | Remitly Global Inc | RELY | 50,000 | $938,500 | 0.05% |
| 100 | Kalaris Therapeutics Inc | KLRS | 282,586 | $754,505 | 0.04% |
| 101 | HOOKIPA Pharma Inc | HOOK | 566,640 | $711,133 | 0.04% |
| 102 | Atlassian Corp | TEAM | 3,500 | $710,815 | 0.04% |
| 103 | Procore Technologies Inc | PCOR | 10,000 | $684,200 | 0.04% |
| 104 | CCC Intelligent Solutions Holdings Inc | CCC | 50,000 | $470,500 | 0.02% |
| 105 | PG&E Corp | PCG-PX | 25,000 | $348,500 | 0.02% |
| 106 | Cyclerion Therapeutics Inc | CYCN | 116,155 | $338,011 | 0.02% |
| 107 | Reddit Inc | RDDT | 2,000 | $301,140 | 0.02% |
| 108 | Vertiv Holdings Co | VRT | 2,000 | $256,820 | 0.01% |
| 109 | Deckers Outdoor Corp | DECK | 2,000 | $206,140 | 0.01% |
| 110 | Caribou Biosciences Inc | CRBU | 105,347 | $132,737 | 0.01% |
| 111 | Ironwood Pharmaceuticals Inc | IRWD | 110,532 | $79,583 | 0.00% |