13F HOLDINGS REPORT
Siren, L.L.C.
Quarter ended Q3 2025 · Filed November 13, 2025 · Accession 0002005245-25-000012
Total Value
$2.56B
Positions
117
Other Managers
2
Confidential Omitted
No
Holdings (117)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Scholar Rock Holding Corp | SRRK | 9,250,005 | $344.5M | 13.48% |
| 2 | Kymera Therapeutics Inc | KYMR | 3,428,150 | $194.0M | 7.59% |
| 3 | BeOne Medicines AG | BEIGF | 492,990 | $168.0M | 6.57% |
| 4 | Arrowhead Pharmaceuticals Inc | ARWR | 2,669,880 | $92.1M | 3.60% |
| 5 | Bicara Therapeutics Inc | BCAX | 5,216,969 | $82.4M | 3.22% |
| 6 | Centessa Pharmaceuticals PLC | CNTA | 3,227,517 | $78.3M | 3.06% |
| 7 | Crinetics Pharmaceuticals Inc | CRNX | 1,688,611 | $70.3M | 2.75% |
| 8 | Edgewise Therapeutics Inc | EWTX | 3,897,099 | $63.2M | 2.47% |
| 9 | Disc Medicine Inc | IRON | 913,401 | $60.4M | 2.36% |
| 10 | Dyne Therapeutics Inc | DYN | 4,729,174 | $59.8M | 2.34% |
| 11 | Apellis Pharmaceuticals Inc | APLS | 2,578,396 | $58.3M | 2.28% |
| 12 | Avidity Biosciences Inc | 05370A108 | 1,285,610 | $56.0M | 2.19% |
| 13 | Stoke Therapeutics Inc | STOK | 2,247,347 | $52.8M | 2.07% |
| 14 | Lexicon Pharmaceuticals Inc | LXRX | 38,918,903 | $52.5M | 2.06% |
| 15 | Rhythm Pharmaceuticals Inc | RYTM | 499,975 | $50.5M | 1.98% |
| 16 | Tango Therapeutics Inc | TNGX | 5,883,188 | $49.4M | 1.93% |
| 17 | Revolution Medicines Inc | RVMDW | 1,043,720 | $48.7M | 1.91% |
| 18 | Ascendis Pharma A/S | ASND | 235,862 | $46.9M | 1.83% |
| 19 | Rezolute Inc | RZLT | 4,870,000 | $45.8M | 1.79% |
| 20 | Solid Biosciences Inc | SLDB | 7,415,905 | $45.8M | 1.79% |
| 21 | Septerna Inc | SEPN | 2,202,514 | $41.4M | 1.62% |
| 22 | Taysha Gene Therapies Inc | TSHA | 11,014,737 | $36.0M | 1.41% |
| 23 | Taboola.com Ltd | TBLAW | 9,969,495 | $34.0M | 1.33% |
| 24 | Xenon Pharmaceuticals Inc | XENE | 812,761 | $32.6M | 1.28% |
| 25 | Soleno Therapeutics Inc | SLNO | 467,342 | $31.6M | 1.24% |
| 26 | Rapport Therapeutics Inc | RAPP | 1,053,469 | $31.3M | 1.22% |
| 27 | Structure Therapeutics Inc | GPCR | 1,026,811 | $28.8M | 1.12% |
| 28 | WAVE Life Sciences Ltd | WVE | 3,696,322 | $27.1M | 1.06% |
| 29 | Remitly Global Inc | RELY | 1,543,271 | $25.2M | 0.98% |
| 30 | Cogent Biosciences Inc | COGT | 1,724,279 | $24.8M | 0.97% |
| 31 | Trevi Therapeutics Inc | TRVI | 2,536,867 | $23.2M | 0.91% |
| 32 | Arcus Biosciences Inc | RCUS | 1,612,077 | $21.9M | 0.86% |
| 33 | NewAmsterdam Pharma Company NV | NAMSW | 765,705 | $21.8M | 0.85% |
| 34 | Korro Bio Inc | KRRO | 418,833 | $20.1M | 0.78% |
| 35 | Erasca Inc | ERAS | 8,757,249 | $19.1M | 0.75% |
| 36 | Arcus Biosciences Inc | RCUS | 1,300,000 | $17.7M | 0.69% |
| 37 | IHS Holding Limited | IHS | 2,357,520 | $16.1M | 0.63% |
| 38 | Uniqure NV | QURE | 275,200 | $16.1M | 0.63% |
| 39 | Bicycle Therapeutics PLC | BCYC | 2,012,752 | $15.6M | 0.61% |
| 40 | Silence Therapeutics PLC | SLNCF | 2,911,438 | $15.1M | 0.59% |
| 41 | RAPT Therapeutics Inc | 75382E208 | 580,466 | $15.0M | 0.59% |
| 42 | Upstream Bio Inc | UPB | 788,450 | $14.8M | 0.58% |
| 43 | Gossamer Bio Inc | GOSS | 5,208,968 | $13.7M | 0.54% |
| 44 | Arrivent Biopharma Inc | AVBP | 700,000 | $12.9M | 0.51% |
| 45 | Amazon.com Inc | AMZN | 58,500 | $12.8M | 0.50% |
| 46 | Oric Pharmaceuticals Inc | ORIC | 1,007,575 | $12.1M | 0.47% |
| 47 | Denali Therapeutics Inc | DNLI | 821,513 | $11.9M | 0.47% |
| 48 | IONQ Inc | IONQ-WT | 170,000 | $10.5M | 0.41% |
| 49 | Sionna Therapeutics Inc | SION | 325,000 | $9.6M | 0.37% |
| 50 | CrowdStrike Holdings Inc | CRWD | 18,500 | $9.1M | 0.35% |
| 51 | Microsoft Corp | MSFT | 17,150 | $8.9M | 0.35% |
| 52 | Seer Inc | SEER | 4,000,000 | $8.7M | 0.34% |
| 53 | Nebius Group NV | NBIS | 72,600 | $8.2M | 0.32% |
| 54 | Neumora Therapeutics Inc | NMRA | 4,358,283 | $7.9M | 0.31% |
| 55 | Taiwan Semiconductor Manufacturing Co Ltd | 874039100 | 28,200 | $7.9M | 0.31% |
| 56 | Salesforce Inc | CRM | 30,100 | $7.1M | 0.28% |
| 57 | Cullinan Therapeutics Inc | CGEM | 1,193,410 | $7.1M | 0.28% |
| 58 | NVIDIA Corp | NVDA | 37,485 | $7.0M | 0.27% |
| 59 | ServiceNow Inc | NOW | 7,126 | $6.6M | 0.26% |
| 60 | Spyre Therapeutics Inc | SYRE | 368,598 | $6.2M | 0.24% |
| 61 | Cartesian Therapeutics Inc | RNAC | 563,272 | $5.8M | 0.23% |
| 62 | PDD Holdings Inc | PDD | 43,401 | $5.7M | 0.22% |
| 63 | Eledon Pharmaceuticals Inc | ELDN | 2,072,767 | $5.4M | 0.21% |
| 64 | Adobe Inc | ADBE | 15,051 | $5.3M | 0.21% |
| 65 | Alphabet Inc | GOOG | 21,203 | $5.2M | 0.20% |
| 66 | Jfrog Ltd | FROG | 107,116 | $5.1M | 0.20% |
| 67 | Sagimet Biosciences Inc | SGMT | 724,771 | $5.0M | 0.19% |
| 68 | Dynatrace Inc | DT | 100,229 | $4.9M | 0.19% |
| 69 | Datadog Inc | DDOG | 32,925 | $4.7M | 0.18% |
| 70 | I-Mab | NBP | 1,165,957 | $4.4M | 0.17% |
| 71 | Agenus Inc | AGEN | 1,064,250 | $4.1M | 0.16% |
| 72 | Lexeo Therapeutics Inc | LXEO | 603,435 | $4.0M | 0.16% |
| 73 | Black Diamond Therapeutics Inc | BDTX | 1,046,517 | $4.0M | 0.16% |
| 74 | Whitehawk Therapeutics Inc | WHWK | 2,082,000 | $4.0M | 0.15% |
| 75 | vTv Therapeutics Inc | VTVT | 163,000 | $3.8M | 0.15% |
| 76 | Instil Bio Inc | TIL | 203,933 | $3.6M | 0.14% |
| 77 | Foghorn Therapeutics Inc | FHTX | 720,720 | $3.5M | 0.14% |
| 78 | ProQR Therapeutics NV | N71542109 | 1,552,183 | $3.3M | 0.13% |
| 79 | New Oriental Education & Technology Group Inc | 647581206 | 62,000 | $3.3M | 0.13% |
| 80 | CoreWeave Inc | CRWV | 24,000 | $3.3M | 0.13% |
| 81 | PepGen Inc | PEPG | 700,000 | $3.2M | 0.13% |
| 82 | GitLab Inc | GTLB | 64,000 | $2.9M | 0.11% |
| 83 | Ke Holdings Inc | BEKE | 145,000 | $2.8M | 0.11% |
| 84 | Palo Alto Networks Inc | PANW | 13,450 | $2.7M | 0.11% |
| 85 | Tenax Therapeutics Inc | TENX | 352,441 | $2.7M | 0.10% |
| 86 | Workiva Inc | WK | 30,000 | $2.6M | 0.10% |
| 87 | Qualcomm Inc | QCOM | 14,000 | $2.3M | 0.09% |
| 88 | BIOAGE Labs Inc | BIOA | 382,406 | $2.2M | 0.09% |
| 89 | Keurig Dr Pepper Inc | KDP | 77,050 | $2.0M | 0.08% |
| 90 | HubSpot Inc | HUBS | 4,000 | $1.9M | 0.07% |
| 91 | Chipotle Mexican Grill Inc | CMG | 47,500 | $1.9M | 0.07% |
| 92 | Kalaris Therapeutics Inc | KLRS | 318,264 | $1.8M | 0.07% |
| 93 | Generation Bio Co | 37148K209 | 296,892 | $1.8M | 0.07% |
| 94 | Cellebrite DI Ltd | CLBT | 90,000 | $1.7M | 0.07% |
| 95 | Primo Brands Corp | PRMB | 75,000 | $1.7M | 0.06% |
| 96 | Spotify Technology SA | SPOT | 2,173 | $1.5M | 0.06% |
| 97 | NIQ Global Intelligence PLC | NIQ | 95,000 | $1.5M | 0.06% |
| 98 | monday.com Ltd | MNDY | 7,000 | $1.4M | 0.05% |
| 99 | Remitly Global Inc | RELY | 75,000 | $1.2M | 0.05% |
| 100 | SailPoint Inc | SAIL | 50,000 | $1.1M | 0.04% |
| 101 | Elastic NV | ESTC | 12,500 | $1.1M | 0.04% |
| 102 | IREN Ltd | IREN | 20,000 | $938,100 | 0.04% |
| 103 | SEMrush Holdings Inc | SEMR | 125,000 | $885,000 | 0.03% |
| 104 | Amer Sports Inc | AS | 25,000 | $868,750 | 0.03% |
| 105 | Pinterest Inc | PINS | 25,000 | $804,250 | 0.03% |
| 106 | Figma Inc | FIG | 15,000 | $778,050 | 0.03% |
| 107 | Confluent Inc | 20717M103 | 37,500 | $742,500 | 0.03% |
| 108 | Procore Technologies Inc | PCOR | 10,000 | $729,200 | 0.03% |
| 109 | Astera Labs Inc | ALAB | 3,500 | $685,300 | 0.03% |
| 110 | Tesla Inc | TSLA | 1,500 | $667,080 | 0.03% |
| 111 | Chime Financial Inc | 16935C109 | 25,000 | $504,250 | 0.02% |
| 112 | CCC Intelligent Solutions Holdings Inc | CCC | 50,000 | $455,500 | 0.02% |
| 113 | Kenvue Inc | KVUE | 25,000 | $405,750 | 0.02% |
| 114 | Vertiv Holdings Co | VRT | 2,000 | $301,720 | 0.01% |
| 115 | Cyclerion Therapeutics Inc | CYCN | 116,155 | $267,157 | 0.01% |
| 116 | Caribou Biosciences Inc | CRBU | 105,347 | $245,459 | 0.01% |
| 117 | Ironwood Pharmaceuticals Inc | IRWD | 110,532 | $144,797 | 0.01% |