New Positions
26 managers initiated
Top five by reported value
Vor Biopharma Inc NASDAQ NMS - GLOBAL MARKET:VOR
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
26 new20 added10 reduced10 exited
Total Institutional Holders
56
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$70.7M
Largest QoQ Increase
RA CAPITAL MANAGEMENT, L.P.
+3,422,697 sh
Largest QoQ Decrease
SUSQUEHANNA INTERNATIONAL GROUP, LLP
-4,278,281 sh
New Positions(26)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 2,543,939 | +2,543,939 | $33.3M | +$33.3M | — |
| Paradigm Biocapital Advisors LP | 1,750,000 | +1,750,000 | $22.9M | +$22.9M | — |
| GREAT POINT PARTNERS LLC | 1,370,107 | +1,370,107 | $17.9M | +$17.9M | — |
| NEXTBio Capital Management LP | 999,967 | +999,967 | $13.1M | +$13.1M | — |
| Caligan Partners LP | 925,067 | +925,067 | $10.0M | +$10.0M | — |
| SPHERA FUNDS MANAGEMENT LTD. | 410,417 | +410,417 | $5.4M | +$5.4M | — |
| Laurion Capital Management LP | 317,243 | +317,243 | $4.1M | +$4.1M | — |
| FINDELL CAPITAL MANAGEMENT LLC | 231,000 | +231,000 | $3.0M | +$3.0M | — |
| TUDOR INVESTMENT CORP ET AL | 167,673 | +167,673 | $2.2M | +$2.2M | — |
| AMERIPRISE FINANCIAL INC | 163,061 | +163,061 | $2.1M | +$2.1M | — |
| Logos Global Management LP | 100,000 | +100,000 | $1.3M | +$1.3M | — |
| NORTHERN TRUST CORP | 38,946 | +38,946 | $509.4K | +$509.4K | — |
| Engineers Gate Manager LP | 28,204 | +28,204 | $368.9K | +$368.9K | — |
| Quadrature Capital Ltd | 26,791 | +26,791 | $350.4K | +$350.4K | — |
| OMERS ADMINISTRATION Corp | 20,700 | +20,700 | $270.8K | +$270.8K | — |
| XTX Topco Ltd | 17,542 | +17,542 | $229.4K | +$229.4K | — |
| Persistent Asset Partners Ltd | 10,798 | +10,798 | $141.2K | +$141.2K | — |
| Susquehanna Portfolio Strategies, LLC | 10,207 | +10,207 | $133.5K | +$133.5K | — |
| DGS Capital Management, LLC | 110,600 | +110,600 | $129.3K | +$129.3K | — |
| Chung Wu Investment Group, LLC | 8,300 | +8,300 | $108.6K | +$108.6K | — |
| CITIGROUP INC | 6,340 | +6,340 | $82.9K | +$82.9K | — |
| China Universal Asset Management Co., Ltd. | 2,746 | +2,746 | $35.9K | +$35.9K | — |
| BARCLAYS PLC | 1,399 | +1,399 | $18.3K | +$18.3K | — |
| Mirae Asset Global Investments Co., Ltd. | 819 | +819 | $10.7K | +$10.7K | — |
| GF FUND MANAGEMENT CO. LTD. | 330 | +330 | $4.3K | +$4.3K | — |
| Allworth Financial LP | 3 | +3 | $40 | +$40 | — |
Added To(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FCPM III SERVICES B.V. | 3,617,354 | +3,237,714 | $47.3M | +$28.8M | 852.8% |
| RA CAPITAL MANAGEMENT, L.P. | 5,404,998 | +3,422,697 | $70.7M | -$25.9M | 172.7% |
| FMR LLC | 2,526,170 | +2,289,662 | $33.0M | +$21.5M | 968.1% |
| VANGUARD GROUP INC | 770,250 | +665,060 | $10.1M | +$5.0M | 632.2% |
| CITADEL ADVISORS LLC | 462,784 | +437,458 | $6.1M | +$4.8M | 1727.3% |
| BlackRock, Inc. | 465,636 | +431,106 | $6.1M | +$4.4M | 1248.5% |
| MILLENNIUM MANAGEMENT LLC | 224,534 | +199,770 | $2.9M | +$1.7M | 806.7% |
| GOLDMAN SACHS GROUP INC | 145,640 | +129,854 | $1.9M | +$1.1M | 822.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 185,808 | +158,416 | $2.4M | +$1.1M | 578.3% |
| VR Adviser, LLC | 1,943,766 | +1,443,800 | $25.4M | +$1.1M | 288.8% |
| STATE STREET CORP | 91,053 | +81,999 | $1.2M | +$749.9K | 905.7% |
| Hudson Bay Capital Management LP | 26,360 | +5,110 | $344.8K | -$690.5K | 24.0% |
| JANE STREET GROUP, LLC | 105,035 | +66,962 | $1.4M | -$481.1K | 175.9% |
| MORGAN STANLEY | 28,463 | +24,007 | $372.3K | +$155.2K | 538.8% |
| UBS Group AG | 292,118 | +216,209 | $3.8M | +$122.6K | 284.8% |
| JPMORGAN CHASE & CO | 2,312 | +2,234 | $30.2K | +$26.4K | 2864.1% |
| Tower Research Capital LLC (TRC) | 1,729 | +1,725 | $22.6K | +$22.4K | 43125.0% |
| Squarepoint Ops LLC | 18,459 | +13,730 | $241.4K | +$11.0K | 290.3% |
| Bollard Group LLC | 23,987 | +21,210 | $314 | +$179 | 763.8% |
| Royal Bank of Canada | 7 | +5 | $0 | $0 | 250.0% |
Reduced(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,370,019 | -4,278,281 | $17.9M | -$257.3M | -75.7% |
| Shay Capital LLC | 10,745 | -709,055 | $140.5K | -$34.9M | -98.5% |
| JOHNSON & JOHNSON | 53,732 | 0 | $702.8K | -$1.9M | 0.0% |
| Sarissa Capital Management LP | 25,399 | 0 | $332.2K | -$905.2K | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 291 | -5,784 | $3.8K | -$292.2K | -95.2% |
| Belvedere Trading LLC | 57,600 | -59,200 | $37.4K | -$247.6K | -50.7% |
| BANK OF AMERICA CORP /DE/ | 396 | -4,358 | $5.2K | -$226.4K | -91.7% |
| MAI Capital Management | 40 | 0 | $524 | -$1.4K | 0.0% |
| SBI Securities Co., Ltd. | 3 | 0 | $39 | -$107 | 0.0% |
| WELLS FARGO & COMPANY/MN | 1 | 0 | $13 | -$36 | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Ariose Capital Management Ltd | 0 | -110,173 | $0 | -$5.4M | — |
| TANG CAPITAL MANAGEMENT LLC | 0 | -50,000 | $0 | -$2.4M | — |
| Woodline Partners LP | 0 | -27,363 | $0 | -$1.3M | — |
| Polymer Capital Management (HK) LTD | 0 | -21,248 | $0 | -$1.0M | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -14,600 | $0 | -$711.3K | — |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | -6,250 | $0 | -$304.5K | — |
| Scientech Research LLC | 0 | -6,097 | $0 | -$297.0K | — |
| Trustees of Columbia University in the City of New York | 0 | -4,595 | $0 | -$223.9K | — |
| Caitong International Asset Management Co., Ltd | 0 | -110 | $0 | -$5.4K | — |
| Virtu Financial LLC | 0 | -8,104 | $0 | -$395 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 5,404,998 | $70.7M | +3,422,697 | 172.7% |
| FCPM III SERVICES B.V. | 3,617,354 | $47.3M | +3,237,714 | 852.8% |
| Frazier Life Sciences Management, L.P. | 2,543,939 | $33.3M | +2,543,939 | — |
| FMR LLC | 2,526,170 | $33.0M | +2,289,662 | 968.1% |
| VR Adviser, LLC | 1,943,766 | $25.4M | +1,443,800 | 288.8% |
| Paradigm Biocapital Advisors LP | 1,750,000 | $22.9M | +1,750,000 | — |
| GREAT POINT PARTNERS LLC | 1,370,107 | $17.9M | +1,370,107 | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,370,019 | $17.9M | -4,278,281 | -75.7% |
| NEXTBio Capital Management LP | 999,967 | $13.1M | +999,967 | — |
| VANGUARD GROUP INC | 770,250 | $10.1M | +665,060 | 632.2% |
| Caligan Partners LP | 925,067 | $10.0M | +925,067 | — |
| BlackRock, Inc. | 465,636 | $6.1M | +431,106 | 1248.5% |
| CITADEL ADVISORS LLC | 462,784 | $6.1M | +437,458 | 1727.3% |
| SPHERA FUNDS MANAGEMENT LTD. | 410,417 | $5.4M | +410,417 | — |
| Laurion Capital Management LP | 317,243 | $4.1M | +317,243 | — |
| UBS Group AG | 292,118 | $3.8M | +216,209 | 284.8% |
| FINDELL CAPITAL MANAGEMENT LLC | 231,000 | $3.0M | +231,000 | — |
| MILLENNIUM MANAGEMENT LLC | 224,534 | $2.9M | +199,770 | 806.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 185,808 | $2.4M | +158,416 | 578.3% |
| TUDOR INVESTMENT CORP ET AL | 167,673 | $2.2M | +167,673 | — |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for VOR against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.