New Positions
9 managers initiated
Top five by reported value
- Opaleye Management Inc.$708.4K
- JANE STREET GROUP, LLC$84.2K
- XTX Topco Ltd$67.6K
- ADAR1 Capital Management, LLC$66.4K
- Scientech Research LLC$51.5K
Q32 Bio Inc NASDAQ NMS - GLOBAL MARKET:QTTB
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
9 new10 added34 reduced10 exited
Total Institutional Holders
53
as of 2025-12-31
Top Holder
ORBIMED ADVISORS LLC
$7.5M
Largest QoQ Increase
Opaleye Management Inc.
+213,363 sh
Largest QoQ Decrease
ACORN CAPITAL ADVISORS, LLC
-310,000 sh
New Positions(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 213,363 | +213,363 | $708.4K | +$708.4K | — |
| JANE STREET GROUP, LLC | 25,374 | +25,374 | $84.2K | +$84.2K | — |
| XTX Topco Ltd | 20,353 | +20,353 | $67.6K | +$67.6K | — |
| ADAR1 Capital Management, LLC | 20,000 | +20,000 | $66.4K | +$66.4K | — |
| Scientech Research LLC | 15,510 | +15,510 | $51.5K | +$51.5K | — |
| JONES FINANCIAL COMPANIES LLLP | 500 | +500 | $1.7K | +$1.7K | — |
| Clark Wealth Partners | 597 | +597 | $1.3K | +$1.3K | — |
| Allworth Financial LP | 98 | +98 | $326 | +$326 | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 30 | +30 | $100 | +$100 | — |
Added To(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 321,051 | +25,642 | $1.1M | +$481.0K | 8.7% |
| RENAISSANCE TECHNOLOGIES LLC | 99,600 | +52,300 | $330.7K | +$237.0K | 110.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 106,113 | +17,617 | $352.4K | +$177.1K | 19.9% |
| CITADEL ADVISORS LLC | 45,728 | +35,611 | $151.8K | +$131.8K | 352.0% |
| TWO SIGMA INVESTMENTS, LP | 46,825 | +15,319 | $155.5K | +$93.1K | 48.6% |
| UBS Group AG | 13,606 | +8,360 | $45.2K | +$34.8K | 159.3% |
| JPMORGAN CHASE & CO | 324 | +320 | $1.1K | +$1.1K | 8000.0% |
| ACADIAN ASSET MANAGEMENT LLC | 48,373 | +18,634 | $159 | +$101 | 62.6% |
| BARCLAYS PLC | 1,053 | +231 | $1.6K | -$59 | 28.1% |
| HRT FINANCIAL LP | 24,698 | +9,862 | $81 | +$52 | 66.5% |
Reduced(34)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 2,252,987 | 0 | $7.5M | +$3.0M | 0.0% |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 0 | $6.9M | +$2.8M | 0.0% |
| Carlyle Group Inc. | 1,102,741 | 0 | $3.6M | +$1.5M | 0.0% |
| Monaco Asset Management SAM | 50,919 | -260,218 | $169.1K | -$447.0K | -83.6% |
| ARCH Venture Management, LLC | 320,482 | 0 | $1.1M | +$429.4K | 0.0% |
| Pfizer Inc | 277,777 | 0 | $922.2K | +$372.2K | 0.0% |
| Sanofi | 244,083 | 0 | $810.4K | +$327.1K | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 493,425 | -310,000 | $1.6M | +$47.4K | -38.6% |
| MILLENNIUM MANAGEMENT LLC | 51,268 | -53,504 | $170.2K | -$37.2K | -51.1% |
| Affinity Asset Advisors, LLC | 27,777 | 0 | $92.2K | +$37.2K | 0.0% |
| STATE STREET CORP | 21,237 | 0 | $70.5K | +$28.5K | 0.0% |
| FMR LLC | 3,364 | -12,503 | $11.2K | -$20.2K | -78.8% |
| NORTHERN TRUST CORP | 25,033 | -6,920 | $83.1K | +$19.8K | -21.6% |
| SBI Securities Co., Ltd. | 157 | -7,999 | $521 | -$15.6K | -98.1% |
| BlackRock, Inc. | 59,932 | -33,073 | $199.0K | +$14.8K | -35.6% |
| Royal Bank of Canada | 235 | -7,771 | $1.0K | -$12.0K | -97.1% |
| Tower Research Capital LLC (TRC) | 976 | -5,506 | $3.2K | -$9.6K | -84.9% |
| EverSource Wealth Advisors, LLC | 4,640 | -385 | $15.4K | +$5.5K | -7.7% |
| Global Retirement Partners, LLC | 1,500 | -3,500 | $5.0K | -$4.9K | -70.0% |
| MORGAN STANLEY | 5,478 | -5,865 | $18.2K | -$4.3K | -51.7% |
| FEDERATED HERMES, INC. | 2,273 | -101 | $7.5K | +$2.8K | -4.3% |
| SRS Capital Advisors, Inc. | 1,111 | -104 | $3.7K | +$1.3K | -8.6% |
| Rockefeller Capital Management L.P. | 577 | 0 | $1.9K | +$774 | 0.0% |
| Russell Investments Group, Ltd. | 454 | 0 | $1.5K | +$608 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,035 | -490 | $3.4K | +$416 | -32.1% |
| NISA INVESTMENT ADVISORS, LLC | 166 | 0 | $551 | +$222 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 308 | -124 | $1.0K | +$168 | -28.7% |
| Federation des caisses Desjardins du Quebec | 70 | 0 | $231 | +$94 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 132 | -55 | $437 | +$70 | -29.4% |
| GROUP ONE TRADING, L.P. | 34 | 0 | $113 | +$46 | 0.0% |
| HARBOUR INVESTMENTS, INC. | 11 | 0 | $37 | +$15 | 0.0% |
| AdvisorNet Financial, Inc | 2 | 0 | $7 | +$3 | 0.0% |
| DANSKE BANK A/S | 1 | 0 | $3 | +$1 | 0.0% |
| CWM, LLC | 54 | -165 | $0 | $0 | -75.3% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Trustees of Columbia University in the City of New York | 0 | -133,903 | $0 | -$265.1K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -13,800 | $0 | -$241.7K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -13,749 | $0 | -$27.2K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -14,190 | $0 | -$23.4K | — |
| DLK Investment Management, LLC | 0 | -10,333 | $0 | -$20.5K | — |
| China Universal Asset Management Co., Ltd. | 0 | -2,138 | $0 | -$4.2K | — |
| Mirae Asset Global Investments Co., Ltd. | 0 | -472 | $0 | -$935 | — |
| CITIGROUP INC | 0 | -236 | $0 | -$467 | — |
| GF FUND MANAGEMENT CO. LTD. | 0 | -227 | $0 | -$449 | — |
| ST GERMAIN D J CO INC | 0 | -11 | $0 | -$22 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 2,252,987 | $7.5M | 0 | 0.0% |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | $6.9M | 0 | 0.0% |
| Carlyle Group Inc. | 1,102,741 | $3.6M | 0 | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 493,425 | $1.6M | -310,000 | -38.6% |
| VANGUARD GROUP INC | 321,051 | $1.1M | +25,642 | 8.7% |
| ARCH Venture Management, LLC | 320,482 | $1.1M | 0 | 0.0% |
| Pfizer Inc | 277,777 | $922.2K | 0 | 0.0% |
| Sanofi | 244,083 | $810.4K | 0 | 0.0% |
| Opaleye Management Inc. | 213,363 | $708.4K | +213,363 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 106,113 | $352.4K | +17,617 | 19.9% |
| RENAISSANCE TECHNOLOGIES LLC | 99,600 | $330.7K | +52,300 | 110.6% |
| BlackRock, Inc. | 59,932 | $199.0K | -33,073 | -35.6% |
| MILLENNIUM MANAGEMENT LLC | 51,268 | $170.2K | -53,504 | -51.1% |
| Monaco Asset Management SAM | 50,919 | $169.1K | -260,218 | -83.6% |
| TWO SIGMA INVESTMENTS, LP | 46,825 | $155.5K | +15,319 | 48.6% |
| CITADEL ADVISORS LLC | 45,728 | $151.8K | +35,611 | 352.0% |
| Affinity Asset Advisors, LLC | 27,777 | $92.2K | 0 | 0.0% |
| JANE STREET GROUP, LLC | 25,374 | $84.2K | +25,374 | — |
| NORTHERN TRUST CORP | 25,033 | $83.1K | -6,920 | -21.6% |
| STATE STREET CORP | 21,237 | $70.5K | 0 | 0.0% |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for QTTB against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.