New Positions
27 managers initiated
Top five by reported value
Prothena Corporation PLC NASDAQ NMS - GLOBAL MARKET:PRTA
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
27 new61 added93 reduced35 exited
Total Institutional Holders
181
as of 2025-12-31
Top Holder
FMR LLC
$72.1M
Largest QoQ Increase
Rubric Capital Management LP
+2,136,958 sh
Largest QoQ Decrease
SUSQUEHANNA INTERNATIONAL GROUP, LLP
-699,372 sh
New Positions(27)
Added To(61)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Rubric Capital Management LP | 3,677,331 | +2,136,958 | $35.1M | +$20.1M | 138.7% |
| STATE STREET CORP | 2,267,802 | +1,366,764 | $21.7M | +$12.9M | 151.7% |
| GOLDMAN SACHS GROUP INC | 935,333 | +582,112 | $8.9M | +$5.5M | 164.8% |
| BlackRock, Inc. | 4,107,459 | +509,042 | $39.2M | +$4.1M | 14.1% |
| MORGAN STANLEY | 1,246,775 | +447,101 | $11.9M | +$4.1M | 55.9% |
| D. E. Shaw & Co., Inc. | 1,681,369 | +365,951 | $16.1M | +$3.2M | 27.8% |
| FEDERATED HERMES, INC. | 974,367 | +281,549 | $9.3M | +$2.5M | 40.6% |
| Point72 Asset Management, L.P. | 919,418 | +272,672 | $8.8M | +$2.5M | 42.2% |
| TWO SIGMA INVESTMENTS, LP | 670,138 | +243,533 | $6.4M | +$2.2M | 57.1% |
| BNP PARIBAS ARBITRAGE, SNC | 423,955 | +195,945 | $4.0M | +$1.8M | 85.9% |
| TWO SIGMA ADVISERS, LP | 427,400 | +161,700 | $4.1M | +$1.5M | 60.9% |
| Qube Research & Technologies Ltd | 407,689 | +153,444 | $3.9M | +$1.4M | 60.4% |
| BANK OF AMERICA CORP /DE/ | 427,360 | +150,264 | $4.1M | +$1.4M | 54.2% |
| Walleye Capital LLC | 192,135 | +142,072 | $1.8M | +$1.3M | 283.8% |
| Man Group plc | 269,513 | +137,540 | $2.6M | +$1.3M | 104.2% |
| Squarepoint Ops LLC | 218,041 | +91,008 | $2.1M | +$842.5K | 71.6% |
| Y-Intercept (Hong Kong) Ltd | 100,510 | +88,339 | $959.9K | +$841.1K | 725.8% |
| CITADEL ADVISORS LLC | 1,076,282 | +104,577 | $10.3M | +$794.7K | 10.8% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 978,011 | +101,483 | $9.3M | +$785.1K | 11.6% |
| Nuveen, LLC | 759,107 | +90,817 | $7.2M | +$727.0K | 13.6% |
| ExodusPoint Capital Management, LP | 87,990 | +57,736 | $840.3K | +$545.0K | 190.8% |
| RENAISSANCE TECHNOLOGIES LLC | 435,515 | +64,215 | $4.2M | +$535.3K | 17.3% |
| Focused Wealth Management, Inc | 107,479 | +50,350 | $1.0M | +$468.8K | 88.1% |
| Jump Financial, LLC | 237,828 | +51,581 | $2.3M | +$453.5K | 27.7% |
| VANGUARD GROUP INC | 2,140,909 | +91,060 | $20.4M | +$439.2K | 4.4% |
| XTX Topco Ltd | 54,881 | +39,073 | $524.1K | +$369.8K | 247.2% |
| Susquehanna Portfolio Strategies, LLC | 58,853 | +29,878 | $562.0K | +$279.3K | 103.1% |
| RBF Capital, LLC | 58,400 | +29,200 | $557.7K | +$272.7K | 100.0% |
| BARCLAYS PLC | 115,848 | +17,773 | $703.2K | -$254.0K | 18.1% |
| NORTHERN TRUST CORP | 363,241 | +28,584 | $3.5M | +$202.7K | 8.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,063,069 | +43,586 | $10.2M | +$202.0K | 4.3% |
| WELLS FARGO & COMPANY/MN | 60,108 | +19,678 | $574.0K | +$179.4K | 48.7% |
| UBS Group AG | 426,360 | +25,513 | $4.1M | +$159.5K | 6.4% |
| PNC Financial Services Group, Inc. | 28,128 | +9,991 | $268.6K | +$91.6K | 55.1% |
| CITIGROUP INC | 12,318 | +8,726 | $117.6K | +$82.6K | 242.9% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,240 | +6,406 | $239.9K | +$56.1K | 34.0% |
| MetLife Investment Management, LLC | 25,501 | +6,139 | $243.5K | +$54.6K | 31.7% |
| AMERICAN CENTURY COMPANIES INC | 78,804 | +6,565 | $752.6K | +$47.5K | 9.1% |
| Hennion & Walsh Asset Management, Inc. | 91,284 | +6,686 | $871.8K | +$46.1K | 7.9% |
| Quadrature Capital Ltd | 31,090 | +3,875 | $296.9K | +$31.6K | 14.2% |
| Virtus Investment Advisers, Inc. | 25,679 | +3,236 | $245.2K | +$26.2K | 14.4% |
| JONES FINANCIAL COMPANIES LLLP | 15,900 | +1,900 | $151.8K | +$20.1K | 13.6% |
| Tower Research Capital LLC (TRC) | 2,826 | +1,541 | $27.0K | +$14.4K | 119.9% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 357,335 | +6,514 | $3.4M | -$11.5K | 1.9% |
| DEUTSCHE BANK AG\ | 35,482 | +1,709 | $338.9K | +$9.2K | 5.1% |
| INTECH INVESTMENT MANAGEMENT LLC | 20,601 | +1,213 | $196.7K | +$7.5K | 6.3% |
| Mirae Asset Global Investments Co., Ltd. | 2,616 | +535 | $25.0K | +$4.7K | 25.7% |
| Chicago Partners Investment Group LLC | 15,222 | +381 | $152.2K | -$4.2K | 2.6% |
| Legal & General Group Plc | 4,044 | +445 | $38.6K | +$3.5K | 12.4% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,710 | +295 | $25.9K | +$2.3K | 12.2% |
| Quantinno Capital Management LP | 103,618 | +2,431 | $989.6K | +$2.0K | 2.4% |
| ACADIAN ASSET MANAGEMENT LLC | 1,437,358 | +198,116 | $13.7K | +$1.6K | 16.0% |
| GAMMA Investing LLC | 510 | +124 | $4.9K | +$1.1K | 32.1% |
| Rockefeller Capital Management L.P. | 4,590 | +185 | $43.8K | +$842 | 4.2% |
| Inscription Capital, LLC | 10,652 | +172 | $101.7K | -$558 | 1.6% |
| US BANCORP \DE\ | 359 | +45 | $3.4K | +$364 | 14.3% |
| Larson Financial Group LLC | 26 | +20 | $248 | +$189 | 333.3% |
| SITTNER & NELSON, LLC | 185 | +30 | $1.6K | +$136 | 19.4% |
| SG Americas Securities, LLC | 63,018 | +6,299 | $602 | +$48 | 11.1% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 54 | +4 | $516 | +$28 | 8.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,515 | +2,968 | $779 | +$12 | 3.8% |
Reduced(93)
Sold Out(35)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FMR LLC | 7,551,218 | $72.1M | -350,000 | -4.4% |
| BlackRock, Inc. | 4,107,459 | $39.2M | +509,042 | 14.1% |
| Rubric Capital Management LP | 3,677,331 | $35.1M | +2,136,958 | 138.7% |
| STATE STREET CORP | 2,267,802 | $21.7M | +1,366,764 | 151.7% |
| VANGUARD GROUP INC | 2,140,909 | $20.4M | +91,060 | 4.4% |
| D. E. Shaw & Co., Inc. | 1,681,369 | $16.1M | +365,951 | 27.8% |
| ARMISTICE CAPITAL, LLC | 1,500,000 | $14.3M | -324,000 | -17.8% |
| ADAR1 Capital Management, LLC | 1,457,764 | $13.9M | -11,334 | -0.8% |
| Palo Alto Investors LP | 1,320,510 | $12.6M | -3,518 | -0.3% |
| MORGAN STANLEY | 1,246,775 | $11.9M | +447,101 | 55.9% |
| CITADEL ADVISORS LLC | 1,076,282 | $10.3M | +104,577 | 10.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,063,069 | $10.2M | +43,586 | 4.3% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 978,011 | $9.3M | +101,483 | 11.6% |
| FEDERATED HERMES, INC. | 974,367 | $9.3M | +281,549 | 40.6% |
| GOLDMAN SACHS GROUP INC | 935,333 | $8.9M | +582,112 | 164.8% |
| Point72 Asset Management, L.P. | 919,418 | $8.8M | +272,672 | 42.2% |
| Boxer Capital Management, LLC | 690,000 | $8.5M | +690,000 | — |
| DIMENSIONAL FUND ADVISORS LP | 775,207 | $7.4M | -31,781 | -3.9% |
| Nuveen, LLC | 759,107 | $7.2M | +90,817 | 13.6% |
| JANE STREET GROUP, LLC | 699,751 | $6.7M | -179,441 | -20.4% |
New & Closed Positions this quarter
Closed Positions
35 managers exited
Top five by prior-quarter value
- Cubist Systematic Strategies, LLC$1.9M
- NORGES BANK$961.2K
- Monaco Asset Management SAM$683.2K
- Engineers Gate Manager LP$547.3K
- Balyasny Asset Management LLC$544.3K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PRTA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.