New Positions
27 managers initiated
Top five by reported value
- Stonepine Capital Management, LLC$1.3M
- Point72 Asset Management, L.P.$974.4K
- Squarepoint Ops LLC$503.7K
- NOMURA HOLDINGS INC$454.5K
- BNP PARIBAS ARBITRAGE, SNC$448.3K
Milestone Pharmaceuticals Inc NASDAQ NMS - GLOBAL MARKET:MIST
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
27 new23 added27 reduced10 exited
Total Institutional Holders
77
as of 2025-12-31
Top Holder
Propel Bio Management, LLC
$8.3M
Largest QoQ Increase
MARSHALL WACE, LLP
+1,231,793 sh
Largest QoQ Decrease
ADAGE CAPITAL PARTNERS GP, L.L.C.
-4,165,963 sh
New Positions(27)
Added To(23)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 1,656,821 | +1,231,793 | $3.3M | +$2.5M | 289.8% |
| TWO SIGMA INVESTMENTS, LP | 1,514,461 | +847,910 | $3.1M | +$1.7M | 127.2% |
| JANE STREET GROUP, LLC | 1,217,130 | +795,938 | $2.5M | +$1.6M | 189.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,249,400 | +704,428 | $2.5M | +$1.4M | 129.3% |
| Boxer Capital Management, LLC | 1,333,332 | +666,666 | $2.7M | +$1.3M | 100.0% |
| TWO SIGMA ADVISERS, LP | 619,592 | +385,551 | $1.3M | +$783.5K | 164.7% |
| GROUP ONE TRADING, L.P. | 195,099 | +188,077 | $394.1K | +$380.1K | 2678.4% |
| Lion Point Capital, LP | 755,000 | +96,447 | $1.5M | +$208.0K | 14.6% |
| UBS Group AG | 491,868 | +94,334 | $993.6K | +$198.5K | 23.7% |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 263,200 | +53,000 | $531.7K | +$111.3K | 25.2% |
| Aptus Capital Advisors, LLC | 263,200 | +53,000 | $531.7K | +$111.3K | 25.2% |
| Pathstone Holdings, LLC | 1,017,040 | +17,040 | $2.1M | +$104.4K | 1.7% |
| CITADEL ADVISORS LLC | 637,232 | +45,565 | $1.3M | +$103.9K | 7.7% |
| LPL Financial LLC | 142,463 | +47,163 | $287.8K | +$97.2K | 49.5% |
| CITIGROUP INC | 33,858 | +26,046 | $68.4K | +$52.8K | 333.4% |
| Bay Rivers Group | 28,861 | +12,170 | $58.3K | +$24.9K | 72.9% |
| JOURNEY STRATEGIC WEALTH LLC | 30,000 | +20,000 | $40.9K | +$20.9K | 200.0% |
| JONES FINANCIAL COMPANIES LLLP | 16,000 | +5,000 | $32.3K | +$10.3K | 45.5% |
| MILLENNIUM MANAGEMENT LLC | 402,635 | +1,076 | $813.3K | +$10.2K | 0.3% |
| Cascades Capital Asset Management, LLC | 77,510 | +175 | $156.6K | +$1.9K | 0.2% |
| SRS Capital Advisors, Inc. | 1,591 | +514 | $3.2K | +$1.1K | 47.7% |
| GSA CAPITAL PARTNERS LLP | 236,138 | +157,391 | $477 | +$320 | 199.9% |
| Cambridge Investment Research Advisors, Inc. | 47,140 | +34,442 | $95 | +$70 | 271.2% |
Reduced(27)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,810,037 | -4,165,963 | $5.7M | -$8.3M | -59.7% |
| MORGAN STANLEY | 781,875 | -2,187,192 | $1.6M | -$4.4M | -73.7% |
| Simplify Asset Management Inc. | 1,506,405 | -1,326,569 | $3.0M | -$2.6M | -46.8% |
| Propel Bio Management, LLC | 4,118,321 | -1,006,569 | $8.3M | -$1.9M | -19.6% |
| Royal Bank of Canada | 6,698 | -38,902 | $13.0K | -$64.0K | -85.3% |
| RTW INVESTMENTS, LP | 2,506,102 | 0 | $5.1M | +$50.1K | 0.0% |
| BANK OF AMERICA CORP /DE/ | 841 | -15,211 | $1.7K | -$30.4K | -94.8% |
| XTX Topco Ltd | 171,960 | -15,341 | $347.4K | -$27.2K | -8.2% |
| TORONTO DOMINION BANK | 750,000 | 0 | $1.5M | +$15.0K | 0.0% |
| Valeo Financial Advisors, LLC | 130,699 | 0 | $264.0K | +$2.6K | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 74,022 | 0 | $149.5K | +$1.5K | 0.0% |
| NORTHERN TRUST CORP | 39,258 | 0 | $79.3K | +$785 | 0.0% |
| Focus Partners Wealth | 36,000 | 0 | $72.7K | +$720 | 0.0% |
| Federation des caisses Desjardins du Quebec | 29,781 | 0 | $60.2K | +$596 | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 26,600 | 0 | $53.7K | +$532 | 0.0% |
| Safeguard Investment Advisory Group, LLC | 25,044 | 0 | $50.6K | +$501 | 0.0% |
| Mariner, LLC | 25,000 | 0 | $50.5K | +$500 | 0.0% |
| Creative Planning | 23,410 | 0 | $47.3K | +$468 | 0.0% |
| Stephenson & Company, Inc. | 20,000 | 0 | $40.4K | +$400 | 0.0% |
| NATIONAL BANK OF CANADA /FI/ | 18,700 | 0 | $37.8K | +$374 | 0.0% |
| Secure Asset Management, LLC | 10,000 | 0 | $20.2K | -$300 | 0.0% |
| Beta Wealth Group, Inc. | 14,127 | 0 | $28.5K | +$283 | 0.0% |
| STATE STREET CORP | 21,875 | -345 | $44.2K | -$252 | -1.6% |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | 0 | $20.2K | +$200 | 0.0% |
| Taylor Financial Group, Inc. | 10,000 | 0 | $20.2K | +$200 | 0.0% |
| US BANCORP \DE\ | 3,200 | 0 | $6.5K | +$64 | 0.0% |
| SBI Securities Co., Ltd. | 6 | 0 | $12 | $0 | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | -3,221,828 | $0 | -$6.4M | — |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | -820,000 | $0 | -$1.6M | — |
| Affinity Asset Advisors, LLC | 0 | -666,666 | $0 | -$1.3M | — |
| GOLDMAN SACHS GROUP INC | 0 | -356,567 | $0 | -$713.1K | — |
| AMH Equity Ltd | 0 | -231,671 | $0 | -$463.3K | — |
| Quadrature Capital Ltd | 0 | -223,470 | $0 | -$448.1K | — |
| SAPIENT CAPITAL LLC | 0 | -12,200 | $0 | -$24.8K | — |
| Wealthspire Advisors, LLC | 0 | -1,129 | $0 | -$2.3K | — |
| HRT FINANCIAL LP | 0 | -138,812 | $0 | -$277 | — |
| SIMPLEX TRADING, LLC | 0 | -66,920 | $0 | -$133 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Propel Bio Management, LLC | 4,118,321 | $8.3M | -1,006,569 | -19.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,810,037 | $5.7M | -4,165,963 | -59.7% |
| RTW INVESTMENTS, LP | 2,506,102 | $5.1M | 0 | 0.0% |
| MARSHALL WACE, LLP | 1,656,821 | $3.3M | +1,231,793 | 289.8% |
| TWO SIGMA INVESTMENTS, LP | 1,514,461 | $3.1M | +847,910 | 127.2% |
| Simplify Asset Management Inc. | 1,506,405 | $3.0M | -1,326,569 | -46.8% |
| Boxer Capital Management, LLC | 1,333,332 | $2.7M | +666,666 | 100.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,249,400 | $2.5M | +704,428 | 129.3% |
| JANE STREET GROUP, LLC | 1,217,130 | $2.5M | +795,938 | 189.0% |
| Pathstone Holdings, LLC | 1,017,040 | $2.1M | +17,040 | 1.7% |
| MORGAN STANLEY | 781,875 | $1.6M | -2,187,192 | -73.7% |
| Lion Point Capital, LP | 755,000 | $1.5M | +96,447 | 14.6% |
| TORONTO DOMINION BANK | 750,000 | $1.5M | 0 | 0.0% |
| Stonepine Capital Management, LLC | 662,666 | $1.3M | +662,666 | — |
| CITADEL ADVISORS LLC | 637,232 | $1.3M | +45,565 | 7.7% |
| TWO SIGMA ADVISERS, LP | 619,592 | $1.3M | +385,551 | 164.7% |
| UBS Group AG | 491,868 | $993.6K | +94,334 | 23.7% |
| Point72 Asset Management, L.P. | 482,355 | $974.4K | +482,355 | — |
| MILLENNIUM MANAGEMENT LLC | 402,635 | $813.3K | +1,076 | 0.3% |
| Aptus Capital Advisors, LLC | 263,200 | $531.7K | +53,000 | 25.2% |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
- ORBIMED ADVISORS LLC$6.4M
- SPHERA FUNDS MANAGEMENT LTD.$1.6M
- Affinity Asset Advisors, LLC$1.3M
- GOLDMAN SACHS GROUP INC$713.1K
- AMH Equity Ltd$463.3K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for MIST against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.